diff --git "a/datasets/downstream/molecule/prediction/property/MoleculeNet/Lipophilicity/train.csv" "b/datasets/downstream/molecule/prediction/property/MoleculeNet/Lipophilicity/train.csv"
new file mode 100644--- /dev/null
+++ "b/datasets/downstream/molecule/prediction/property/MoleculeNet/Lipophilicity/train.csv"
@@ -0,0 +1,3361 @@
+SMILES,Text,Label
+Cn1c(CN2CCN(CC2)c3ccc(Cl)cc3)nc4ccccc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.54
+COc1cc(OC)c(cc1NC(=O)CSCC(=O)O)S(=O)(=O)N2C(C)CCc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.18
+COC(=O)[C@@H](N1CCc2sccc2C1)c3ccccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.69
+OC[C@H](O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+Cc1cccc(C[C@H](NC(=O)c2cc(nn2C)C(C)(C)C)C(=O)NCC#N)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)NCc2ccccc2N3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.72
+CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.34
+COc1ccc(cc1)C2=COc3cc(OC)cc(OC)c3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+CS(=O)(=O)c1ccc(Oc2ccc(cc2)C#C[C@]3(O)CN4CCC3CC4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.51
+C[C@H](Nc1nc(Nc2cc(C)[nH]n2)c(C)nc1C#N)c3ccc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.61
+O=C1CCCCCN1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.08
+CC1CCCCC1NC(=O)c2cnn(c2NS(=O)(=O)c3ccc(C)cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.34
+Nc1ccc(cc1)c2nc3ccc(O)cc3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+COc1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CO[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.32
+CC(C)(CCCCCOCCc1ccccc1)NCCc2ccc(O)c3nc(O)sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+Clc1ccc(cc1)C(=O)Nc2oc(nn2)C(=O)Nc3ccc(cc3)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+COc1ccc(Oc2cccc(CN3CCCC(C3)N4C=C(C)C(=O)NC4=O)c2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+OC(=O)c1cccc(c1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+CNCC[C@@H](Oc1ccccc1C)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+COc1cnc(nc1N(C)C)c2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+CSc1c(cnn1c2ccc(cc2)C(=O)O)C(=O)NC3C4CC5CC(CC3C5)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.94
+CS(=O)(=O)c1ccccc1C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+O=C(NCc1ccncc1)c2ccc(Oc3ccccc3C#N)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.57
+CN(C)c1ccnc2sc(C(=O)NCc3ccccc3)c(N)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.62
+CNC(=O)C1(CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(cc3ccccc23)C#N)c4ccc(Cl)c(Cl)c4)CC1)N5CCCCC5=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+CC(C)N(CCC(C(=O)N)(c1ccccc1)c2ccccn2)C(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.54
+CCS(=O)(=O)c1ccc(c(C)c1)c2cc(ccc2O[C@H](C)C(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.4
+OC(=O)COc1ccc(cc1c2cc(ccc2F)C#N)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.16
+CC(Nc1ncnc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+OC(=O)c1ccc(NC(=O)c2cc(OCc3ccccc3F)cc(OCc4ccccc4F)c2)nc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+NC(Cc1c[nH]c2ccccc12)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.17
+OC(=O)CCC[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4cc(F)ccc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C(=O)O)n4ccc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.99
+COCCNC(=O)c1cccc(Nc2ncc3cc(ccc3n2)c4ccncc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+CCC(CC)NC(=O)c1cnn(C)c1NS(=O)(=O)c2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.36
+NC(=O)c1cc(F)cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N(C)C)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+COc1cccc(c1)c2c[nH]c(n2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+COc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1NCCN(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+Clc1cccc2cn[nH]c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.33
+CNC(=O)c1ccc(CC(=O)N(C)C2CCN(Cc3ccc(cc3)C(F)(F)F)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+COCCNCc1ccc(CCNC[C@H](O)c2ccc(O)c3NC(=O)Sc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.54
+Cn1cncc1c2c3C(=O)N(CC#C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.16
+C[C@H](NC(=O)c1cccnc1Oc2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.91
+COc1cc(NS(=O)(=O)c2ccc(N)cc2)nc(OC)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+CC(=O)Nc1ccc2c(c1)c(cn2CCCO)c3cc(NC4CC4)n5ncc(C#N)c5n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+CC1COc2c(N3CCN(C)CC3)c(F)cc4C(=O)C(=CN1c24)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.45
+COc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Oc1cc(nc2ccnn12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+Fc1cc(cc(F)c1C2=CCN(CC2)C=O)N3C[C@H](COc4ccon4)OC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CC(C#C)N1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c3C1=O)c6cncn6C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.59
+C[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.18
+COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Br)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+Cc1nc(C)c(nc1C(=O)N)c2ccc([C@@H]3CC[C@@H](CC(=O)O)CC3)c(F)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+COc1ccnc(CCc2nc3c(C)ccnc3[nH]2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CN(C)C(=O)c1ccc(CN2CCc3cc4nc(N)sc4cc3CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+CCSc1c(Cc2ccccc2C(F)(F)F)sc3N(CC(C)C)C(=O)N(C)C(=O)c13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.49
+CCN(CCN(C)C)S(=O)(=O)c1ccc(cc1)c2cnc(N)c(n2)C(=O)Nc3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4ccccc4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.49
+CNC(=C[N+](=O)[O-])NCCSCc1oc(CN(C)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.95
+CC(C)CC(N1NC(=O)c2nc3cc(Cl)ccc3c(O)c2C1=O)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.64
+FC(F)c1nc2ccccc2[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.02
+COc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+COc1ccccc1CNc2cc(C)ccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.28
+Nc1nc(Nc2cccc(Br)c2)c3nc[nH]c3n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N(c2ccc(C)cc2)c3ccc(C)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.06
+OC(C(=O)c1ccc(F)cc1)c2ccc(F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+CC(C)COc1cccc(c1)C(=O)Nc2ccc(C)c(c2)C(=O)Nc3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+COc1ccc(OC)c(CNC(=O)c2cccnc2Oc3ccccc3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.52
+Clc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+OC(=O)Cc1ccc(cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.83
+COc1cc2ncc(C(=O)N)c(Nc3cccc(Cl)c3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)NCc4c(F)cccc4F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NCc4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+Cc1ncc(nc1C(=O)N)c2ccc(cc2)[C@@H]3CC[C@@H](CC(=O)O)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CNCC[C@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.89
+Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)cc4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+CC(C)NCC(O)COc1ccc(COCCOC(C)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.1
+Cc1ncc(nc1c2ccc(cc2)[C@@H]3CC[C@H](CC3)C(=O)O)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.22
+COc1cc(OC2CCN(CC2)C(=O)C)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+COc1ccc(cc1)C2=CC(=O)c3ccccc3N2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6cc(cn6C)C#N)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.67
+CN1SC(=NC1=O)NC(=O)c2cccc(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4nccn4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+CC(=O)Nc1ccc(cc1)C(=O)Nc2ccccc2N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.82
+Oc1ccc(cc1)N2C=Nc3cc(O)ccc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+COc1ccc(c(OC)n1)c2c(F)ccc3c(N)c(nnc23)C(=O)NC4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+NC(=O)Nc1cc(sc1C(=O)N)c2cccc(O)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+Nc1ccc(cc1)S(=O)(=O)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.37
+COC(=O)C1=Nc2c(N[C@H](C)CO)nc(SCc3cccc(F)c3F)nc2NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4ncc(C#N)s4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+Cc1ccc(NC(=N)N)cc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.34
+CC(C)(C#N)c1cnc(s1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+Cc1c(Sc2ccc(Cl)cc2)c3c(NS(=O)(=O)C)cccc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.21
+CCN1CCC[C@H]1CNC(=O)c2c(O)c(Cl)cc(Cl)c2OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.09
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4ccc(cc34)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CSc1ncccc1C(=O)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.43
+Cc1nc2ccc(Cl)cn2c1c3ccnc(N)n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccc(F)cc2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)C)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+CCOc1ccccc1c2ccc(cc2)c3nc4ccc(F)cc4c(N[C@H](C)C(=O)O)c3C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC[C@H](NC(=O)c1c(c(nc2ccccc12)c3ccccc3)S(=O)(=O)C)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+CC(C)OC(=O)N1CCC(CC1)Oc2ncnc(Nc3ccc(nc3C)S(=O)(=O)C)c2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Nc1nc(Nc2ccc(F)c(Cl)c2)c3nc[nH]c3n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+CCCSc1nc(N[C@@H]2C[C@H]2c3ccccc3)c4nnn([C@@H]5C[C@H](O)[C@@H](O)[C@H]5O)c4n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.97
+CSc1ccc(cc1)N2C(=NC(=NC2(C)C)N)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.84
+C[C@@H]1N[S@@](=O)(=NC1=O)c2cccc(c2)c3ccc(C)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Nc1nc(N)nc(n1)c2cccc(c2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Fc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+Clc1ccccc1CCNC(=O)c2cc(ccc2Cl)N3N=CC(=O)NC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.29
+C[C@H](NC(=O)[C@@H]1CCCC[C@H]1C(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)N)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.17
+Cc1ccc(cc1)c2cccc(c2)c3nn[nH]n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+Cc1cnc([nH]1)c2ccc(C)c(NC(=O)c3ccc(OCc4ccccn4)cc3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.19
+OC(=O)[C@@H](Cc1ccccc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+C[C@H](Nc1cnc(C)c(Nc2cc(C)[nH]n2)n1)c3ccc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.73
+CC(Cc1cccc(CNCCc2c(Cl)cccc2Cl)c1)NC[C@H](O)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+OCC[C@@]1(CCCNC1)c2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.61
+CCCNC[C@@H](O)COc1ccccc1C(=O)CCc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.56
+Cc1cc(OC2CCN(CC3CCN(CC3)[C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC2)ccc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+O=C(CCc1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.77
+OC(=O)[C@H](Cc1ccccc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+COc1cc(Nc2nccc(n2)N(C)c3cc(CO)ccc3C)cc(c1)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2ccccc12)c3ccc(F)cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.72
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4cccc(c4)C(F)(F)F)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.27
+COc1ccc2nc(N[C@H]3CCC[C@@H](C3)NCc4ccsc4)ccc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+CC(C)(C)OC(=O)N1CCN(CC1)c2ncc(OCc3ccc(cc3)S(=O)(=O)C)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+CC[C@H](C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@@H]12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.07
+CC1=CN([C@H]2CCCN(Cc3ccc(C(=O)O)c(Oc4cccc(c4)C(F)(F)F)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.38
+COc1cc(O)cc2OC=C(C(=O)c12)c3ccc(O)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Nc1cc(nc2ccc(Nc3cc(nc(N)n3)c4cccc(Cl)c4)cc12)c5ccc(F)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC(C(=O)O)n1c(C)c(Sc2ccc(Cl)cc2)c3cc(Cl)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+NC(=O)c1sc(cc1N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.33
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4cc(Cl)ccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.59
+CC(C)C(=O)NCCNCC(O)COc1ccc(O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.15
+OC(=O)COc1ccc(cc1CN2CCN(CC2)S(=O)(=O)c3ccccc3)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+COc1ccnc(CCc2nc3cccnc3[nH]2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+CC(C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+COc1ccc2nccc([C@H](O)C3CC4CCN3CC4C=C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+Clc1ccc(Cl)c(c1)S(=O)(=O)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.14
+Oc1ccc2nc(sc2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.99
+NS(=O)(=O)c1nc2ccccc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.35
+CS(=O)(=O)c1ccc(c(Cl)c1)c2cc(Cl)ccc2OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.75
+OC[C@H]1C[C@H]([C@H](O)[C@@H]1O)n2nnc3c(N[C@@H]4C[C@H]4c5ccc(F)c(F)c5)nc(SCCC(F)(F)F)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.99
+NC(=O)c1ccccc1OCc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+COc1ccc(cc1OC)C2=COc3cc(O)cc(O)c3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(=O)Nc1ccc2c(c1)c(Sc3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+COc1ccc(cc1OC)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+CCN(C1CCN(CCC(c2ccccc2)c3ccc(NS(=O)(=O)C)cc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.84
+O[C@@H](CNCCSCCCNCCc1ccccc1)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.12
+CC[C@H](NC(=O)c1c([S+]([O-])C(C)C)c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.81
+COc1cc(OC)c(cc1NC(=O)COC(=O)C)S(=O)(=O)N2C(C)CCc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.07
+O[C@@H](CNCCCSCCNCCc1cccc(Cl)c1Cl)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)c3cccc(F)c3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.32
+C[C@@](O)(C(=O)Nc1ccc(cc1Cl)S(=O)(=O)NCC=C)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+Oc1ccc(CCNCCCS(=O)(=O)NCCOCCc2cccc(Cl)c2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+NC12CC3CC(CC(C3)C1)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.98
+CNC(=O)c1cc(c2nc(cc(n2)C3(CC3)S(=O)(=O)C)N4CCOCC4)c5cc[nH]c5c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+O=C1Nc2ccccc2C(=O)C=C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.02
+CC[C@H](NC(=O)c1c(CN(C)C)c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.18
+CCOC(=O)Nc1cccc(c1)[C@H](N2CCN(Cc3nc[nH]c3C)CC2)c4ccc(cc4)C(=O)N(C)CC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+Nc1nc(cs1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+COc1ccnc(CCc2nc3cc(Br)cnc3[nH]2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+COc1ccc(Cl)c(Nc2ncnc3cc(OCC4CCN(C)CC4)c(OC)cc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CS(=O)(=O)C1(CC1)c2cc(nc(n2)c3cccc(N)c3)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.35
+CS(=O)(=O)NCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2cc(Br)ccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4c(F)cc(F)cn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+COc1cc(N2CCN(C)CC2)c3nc(cc(N(C)C)c3c1)C(=O)Nc4ccc(cc4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN1CCC(CC1)n2cc(c(C)n2)c3cnc(N)c(c3)c4oc5ccccc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2ccccc2)NC(=O)OCC(F)(F)F)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+Cc1ccc(Cl)c(Nc2ccccc2C(=O)O)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.33
+COc1ccc2N=CC(=O)N(CCN3CC[C@@H](NCc4cc5OCCOc5cn4)[C@@H](O)C3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+CCOc1cc2nccc(Oc3cnc(CC(=O)Nc4n[nH]c(CC)c4C)c(OC)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+CCNc1nc(Nc2ccccc2)nc(n1)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.11
+CNCC[C@@H](Oc1ccc(cc1)C(F)(F)F)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.96
+Cc1cc(Oc2ccc3OCOc3c2)nc(Oc4ccc(cc4)n5ccnc5)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.47
+COC(=O)CCCC(=O)Nc1ccc2C(=O)C(=O)c3ccccc3c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+OC(=O)C[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4sc(Cl)c(Cl)c4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.53
+CN1CCN(CC1)c2cc(F)cc3C(=O)C=C(Nc23)C(=O)Nc4ccc(cc4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+OCCCn1c(NC(=O)c2cccc(c2)[N+](=O)[O-])nc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CCC(CC)NC(=O)c1cnn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.65
+Clc1ccc2C(=O)C3=C(Nc2c1)C(=O)NN(Cc4ccsc4)C3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.11
+Cc1cc2cc(C)c3nnc(SCC(=O)N4CCN(CC4)C(=O)c5occc5)n3c2cc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Cc1cc(NC(=O)Nc2ccc(Cl)cc2)n(C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+CN(C)CC(O)COc1ccc(Nc2cc(Nc3cc(C)ccc3Cl)ncn2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+CN(C)S(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.13
+C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.67
+CC(CN(C)C)CN1c2ccccc2CCc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.95
+Cc1cc(Cl)ccc1OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.02
+CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CC#N)c3cc(Cl)ccc3Cl)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CCN1CCC[C@H]1CNC(=O)c2c(OC)ccc(Br)c2OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.05
+COc1ccc(cc1C(=O)N)c2ccc3c(nc(nc3n2)N4CCOC[C@@H]4C)N5CCOC[C@@H]5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.82
+Oc1cc(ccc1NC(=O)Nc2ccccc2Br)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+COc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.39
+C[C@H](CN(C)C(=O)CO)Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+COCCS(=O)(=O)N1CCN(CC1)c2ccc(Nc3nccc(n3)c4cnc(C)n4C(C)C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+Oc1ccc(cc1)C2=CC(=O)c3ccc(O)cc3O2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+Cc1cccc(Nc2ccccc2C(=O)O)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.89
+CCCc1c(O)c(ccc1OCc2ccc(C(=O)O)c(Br)c2)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CC1CCC(CC(=O)Nc2cccc3ncccc23)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+CCNC(=O)C[C@@H]1N=C(c2ccc(Cl)cc2)c3cc(OC)ccc3n4c(C)nnc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+Nc1ccccc1NC(=O)c2ccc(cc2)c3ncc(CN4CCC4)cc3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+O[C@@H](CNCCCSCCNCCc1ccccc1Cl)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1NC(=O)c3ccc4ncccc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.87
+CC(C)(C)NCC(O)COc1nsnc1N2CCOCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.35
+CCCCN(CCNC[C@H](O)c1ccc(O)c2NC(=O)Sc12)C(=O)CCOCCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Nc1[nH]ncc1c2cc(Cl)ccc2Oc3cc(F)c(cc3Cl)S(=O)(=O)Nc4cscn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+COCCNCc1cccc(CCNC[C@H](O)c2ccc(O)c3NC(=O)Sc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.01
+COc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.82
+O=C(Nc1cccc(NC(=O)c2ccccc2)n1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.02
+NCC[C@@H](Oc1cc(Cl)ccc1C#N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.76
+CCc1[nH]nc(NC(=O)Cc2ncc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CC#C)c3cc(Cl)ccc3Cl)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Nc1ccc2ncccc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+Brc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.42
+CC(C)N1CCN(Cc2cnc(c(Cl)c2)c3ccc(cc3)C(=O)Nc4ccccc4N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.68
+CC(C)CNc1nc(nc(N2CCNCC2)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+Cc1c(Oc2ccc(Cl)cc2)c3cc(ccc3n1CC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.28
+CN(C)CCCN1c2ccccc2CCc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.61
+COc1ccccc1Nc2cc(Oc3cc(C)c(C)nc3c4ccccn4)ccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+Fc1cc(C(=O)Nc2cccc(c2)c3nnn[nH]3)c4nc[nH]c4c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.29
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N4CC[C@@H](O)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+CC(=O)Nc1ccc2nc(cc(O)c2c1)c3cccc(F)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+COc1ccc2nc(N[C@H]3CCC[C@@H](C3)NCc4ccsc4)cc(C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4c(F)cccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CC(C)NCC(O)COc1ccccc1OCC=C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+Oc1ccc(cc1)C2CNCCc3c(Cl)c(O)c(O)cc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+CS(=O)(=O)c1cccc(Nc2nccc(Nc3c(Cl)ccc4OCOc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.13
+CCS(=O)(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.11
+COc1ccc(OC)c(c1)c2cccc3c(N)c(nnc23)C(=O)NC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccccc3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.58
+Oc1cc(O)c2C(=O)C(=COc2c1)c3ccc(O)c(O)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.45
+COc1ccc(cc1)C2=C(C)c3ccc(OC)cc3OC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+COc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.95
+CC(C)(C)OC(=O)N1CCN(CC1)c2ncc(OCc3ccncc3)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2F)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.5
+CNC(=O)[C@H]1CCCN1Cc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+CCn1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.95
+Cc1ccc(O)c(O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.37
+CCc1c2CN3C(=O)C4=C(C=C3c2nc5ccc(O)cc15)[C@@](O)(CC)C(=O)OC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Nc1n[nH]cc1c2cc(ccc2Oc3cc(F)c(cc3Cl)S(=O)(=O)Nc4cscn4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+Fc1ccc(cc1C#N)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+CCNC(=O)C[C@H]1N=C(c2ccc(Cl)cc2)c3cc(OC)ccc3n4c(C)nnc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+COc1ccc(cc1)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.13
+Cc1ncc(CO)c(CO)c1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.58
+CCCSc1nc2ccc(NC(=O)CCC(=O)O)cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.5
+CS(=O)(=O)Nc1ccc(CCOCCCS(=O)(=O)CCNCCc2ccc(O)c3nc(O)sc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.34
+Cc1cccc(c1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.84
+Nc1nc2ccc(F)cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Oc1ccc(cc1)S(=O)(=O)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.36
+Clc1cccc(Nc2ncnc3ccccc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+NC(=O)c1cnc(N[C@H]2CCCNC2)c3cc(sc13)c4ccc(F)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.94
+CN1CCN(CC1)C(=O)c2cc3cc(Br)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+Oc1nc2cc(Cl)cc(Cl)c2c(O)c1c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc3cnccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+Oc1ccc(cc1)C2CC(=O)c3ccc(O)cc3O2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+NCc1nc2ccccc2[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+Nc1nccc(n1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+OCCN1CC=CC[C@@H](C1)c2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+COc1ccc2[nH]c3CCN(Cc3c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+FC(F)(F)c1ccc2[nH]c3CCN(Cc3c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+OC(=O)c1cc(ccc1O)c2ccc(F)cc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.59
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4cc(F)cc(Cl)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+O[C@@H](CNCCSCCCNCCc1cccc(c1)C(F)(F)F)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.21
+Cc1c(Sc2ccc(Cl)cc2)c3cc(Cl)ccc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4cn(C)c(C)n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)NCc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+Oc1cccc(c1)N2C(=O)c3ccc(O)cc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CN1CC=CCC(C1)c2oc3ccccc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+CCN(C1CCN(CCC(c2ccc(NC(=O)C)cc2)c3cccc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+COc1ccc(cc1F)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+COc1cccc2c(O)cc(nc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+C(N(Cc1ccccc1)c2nn[nH]n2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.37
+CC(=O)c1ccc(nc1)N2CCN(CC2)S(=O)(=O)C[C@]34CC[C@H](CC3=O)C4(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+Clc1cccc(CN2C=CN3C(=O)C=C(N=C23)N4CCOCC4)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+C[C@H]1CN(Cc2cc(Cl)ccc2CCC(=O)O)CCN1C(=O)Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+CSc1nc(nn1Cc2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.83
+Nc1ccc2c3ccccc3C(=O)C(=O)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCOCC4)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+NC(=O)c1cc(O)cc2nc(oc12)c3ccc(O)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2cc(F)ccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.62
+CCc1ccccc1c2ccc(cc2)c3nc4ccncc4c(O)c3C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CN(C)CCOc1cc(NS(=O)(=O)c2c(Cl)cc(cc2Cl)C(F)(F)F)ccc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+Oc1ccc(cc1)C2=Cc3ccc(O)cc3OC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COc1ccc(cc1)c2cc(O)c3cc(Cl)ccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Cc1ccc2[nH]ccc2c1c3nc(cc(n3)C4(CC4)S(=O)(=O)C)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+Nc1ccc(Cl)c(c1)C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+CCCCSc1nc(N)c2ncn([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.51
+CCC(N(CCCN)C(=O)c1ccc(OC)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.39
+CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CC#N)c3ccc(C)cc3Br)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.24
+NC(=O)C1=CN(Cc2ccc(F)c(F)c2)C(=O)C=C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.37
+COc1ccc(c(C)n1)c2cccc3c(N)c4C(=O)N(Cc4nc23)C5CCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.92
+C[C@H]1CN(Cc2cc(Cl)ccc2OC(C)(C)C(=O)O)CCN1S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.54
+Cc1ccccc1CN2C=CN3C(=O)C=C(N=C23)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CCCCN(CCCC)CCCOC(=O)c1ccc(N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.93
+OC(=O)C(N1CCC(CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)CC1)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+OCC[C@]1(CCCNC1)c2oc3ccccc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.06
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N4CC(C)(O)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+Oc1ccc2OC(=O)C(=Cc2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+CN(C1CCN(Cc2ccc(cn2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+CN(C)CC(O)COc1ccc(Nc2nccc(Nc3ccccc3C#N)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+Oc1c(I)cc(I)c2cccnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+Clc1ccc2C(=O)C3=C(Nc2c1)C(=O)NN(CC#Cc4ccccc4)C3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+O[C@@H](CNCCc1ccc(CNCCc2ccccc2F)cc1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+Cc1cc(COc2cnc(nc2)N3CCN(CC3)C(=O)OC(C)(C)C)ccn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CCCN(C)c1nc(ccc1C(=O)NC2CCCCC2)N3CCC[C@@H](CC(=O)O)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.28
+CCc1nc2c(N)nc3ccccc3c2n1CCCCNS(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.24
+CNc1nc2ccccc2n1Cc3sc4N(CC(C)C)C(=O)N(C)C(=O)c4c3C(=O)N5CC[C@@H](O)C5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+CC(C)Oc1ccc(cc1)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CC(=O)Nc1nnc(s1)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.78
+CCC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.02
+CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(NC(=O)C)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC(=O)Nc1ccc2ccn(c3cc(NCCCCO)n4ncc(C#N)c4n3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.58
+CCC(CCNC)Oc1cc(Cl)ccc1C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.38
+COc1cc2ncnc(Nc3ccc(OCc4ccccn4)c(C)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+COCCC(=O)N[C@H](C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.08
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4c(F)cccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.53
+CCC(C)NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.66
+CN(C)c1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(C)c4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+COc1cccc(Nc2oc(nn2)C(=O)Nc3ccc(nc3)N4CCOCC4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(C)Oc1cc(OCCCN2CCCC2)cc3ncnc(Nc4c(Cl)ccc5OCOc45)c13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+C[C@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.84
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4c(Cl)cccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.27
+COc1cc(Nc2ncnc3cccc(O[C@H](C)C(=O)N4CCOCC4)c23)ccc1Oc5ccc(C)nc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+C[C@H](Oc1ccc(Cl)cc1CN2CCN([C@@H](C)C2)C(=O)Cc3ccc(Cl)cc3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.66
+CC(C)N1CCC[C@H](CN2C(=Nc3ccc(cc3C2=O)c4ccc(Cl)cc4)C)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+Clc1ccc2[nH]c3CCN(Cc3c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+COc1cccc(CNCc2cccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)c2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+Nc1ncc2cc(c(N)nc2n1)c3c(Br)cccc3Br,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+OC(=O)c1cccc(CN2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.41
+C[C@H]1CN(CCN1c2ncc(OCc3ccc(cc3)S(=O)(=O)C)cn2)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CC(C)(C(=O)O)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.42
+Nc1c(nnc2c(c(F)ccc12)c3ncccn3)C(=O)NC4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.59
+NC(=N)NCCC[C@H](NC(=O)COCC(c1ccccc1)c2ccccc2)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.18
+OC[C@H](O)C(=O)N1CCC(=CC1)c2ccc(cc2F)N3C[C@H](COc4ccon4)OC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.09
+Cc1nc(C)c(nc1C(=O)N)c2ccc3c(CC[C@@]34CC[C@@H](CC4)C(=O)O)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+COc1c2OC(=O)C=Cc2cc3ccoc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+Fc1cc(Cl)ccc1N2CCN(CC2)C(=O)COCc3ccncc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+OCCNCc1cc(Br)ccc1OCc2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+Cc1cccc(C(=O)N)c1NC(=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.09
+Cc1nnc(N)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.4
+Cc1cc(Cl)ccc1OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)c4c(F)cccc34)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CC(N1NC(=O)c2nc3cc(Cl)ccc3c(O)c2C1=O)c4ccccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.51
+C1Oc2ccc(Oc3ccnc(Oc4ccc(cc4)n5ccnc5)n3)cc2O1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+CC(C)Oc1cc(Oc2ccc(cc2)S(=O)(=O)C)cc(c1)C(=O)Nc3nccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.61
+C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc4C(=O)C(=CN1c24)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.35
+CC[C@H](NC(=O)c1c(N)c(nc2ccccc12)c3cccc(F)c3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.05
+CNC(=O)c1ccc(Oc2ccc(cc2)C#C[C@]3(O)CN4CCC3CC4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+CN1C(=O)C=C(CCc2ccccc2)N=C1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CN(C)c1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+COCCC(=O)Nc1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+Cc1cc(OC2CCN(CC3CCN(CC3)[C@@H](Cc4ccc(F)cc4)C(=O)O)CC2)ccc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+COc1cc2ncnc(Nc3ccc(Cl)c(O)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CS(=O)(=O)NCCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Cc1c(Sc2ccc(Cl)cc2)c3ccc(cc3n1CC(=O)O)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.79
+CN1CCN(CC1)c2ccc3ncc(C(=O)N)c(Nc4ccc(F)cc4F)c3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CCn1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)NC)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.53
+CCCc1cc(Nc2nc(NCc3onc(C)c3)ncc2Br)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.63
+CCNCc1cnc(s1)c2ccc(cc2)C(=O)Nc3ccccc3N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.95
+Fc1ccc2[nH]c3CCN(Cc3c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NCC#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+Clc1cc(Cl)cc(CS(=O)(=O)NCC(N2CCCCCC2)c3ccccc3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.23
+CS(=O)(=O)c1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.67
+FC(F)(F)c1nnc2ccc(nn12)N3CCN(Cc4ccc(cc4)C#N)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COc1ccnc(C[S+]([O-])c2nc3cc(OC(F)F)ccc3[nH]2)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccccc2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.46
+C[C@H](NC1=NC(=O)C(C)(S1)C(F)(F)F)c2ccccc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1ccc(Cl)cc1NC(=O)CCS(=O)(=O)c2ccc(Br)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+COCCNCc1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+CC[C@H](NC(=O)c1c(N)c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.89
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+CCc1csc(n1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CNc1c(Cl)cnc2[nH]c(nc12)c3ccc(OCCN4CCOCC4)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+CCS(=O)(=O)c1ccc(c(C)c1)c2cc(ccc2OCC(=O)N)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(NC4CC4)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.37
+Oc1cc(O)c2C(=O)C(=COc2c1)c3ccc(cc3)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N4CCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.46
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6cc(oc6C)C#N)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.26
+Cc1c(c2c(NS(=O)(=O)C)cccc2n1CC(=O)O)S(=O)(=O)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.83
+CN(c1ccc(c(C)c1)c2cc(ccc2OCC(=O)O)C(F)(F)F)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.59
+CC\C(=C(/c1ccccc1)\c2ccc(\C=C\C(=O)O)cc2)\c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.89
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccc(cc2)C(F)(F)F)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.85
+COc1c(Nc2ccc(nc2C)S(=O)(=O)C)ncnc1OC3CCN(CC3)C(=O)OC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CC(=O)Nc1ccc(cc1)c2ccnc(Nc3ccc(cc3)N4CCOCC4)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.91
+OC(=O)c1[nH]c2ccccc2c1CCCOc3cccc4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+C[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.21
+C[C@H](Nc1nc(Nc2cc(C)[nH]n2)cc(n1)N3CCOCC3)c4ncc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+CC1CC(CN)CC(CO)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.4
+COc1cc2nnc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+CCN(CC)CCOC(=O)C1(CCCC1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+OC1(CNCCc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+Cc1cnc(NC(=O)Cc2ccccc2)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+c1ccc2ncncc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CC(C)(C)NS(=O)(=O)c1cncc(c1)c2ccc3nc(N)nn3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.41
+C[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc3ccccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4ccccc4CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+CC(C)C(CCCN(C)CCc1ccccc1)(C#N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+C[C@@H](O)[C@@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+OC1(CN2CCC1CC2)C#Cc3ccc(Oc4ccc(cc4)C(=O)NCc5ccncc5)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+CS(=O)(=O)c1ccc2c3CN(CCc3[nH]c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+C[C@@H](NC(=O)C)c1ccc(Nc2ncc3cc(c(C)cc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+CC[C@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.22
+O=C1Nc2ccccc2C=C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.32
+CN(CCO)Cc1ccc(cc1)c2cc(C(=O)N)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.97
+OC(=O)COc1ccccc1N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+COc1ccc(CNC(=O)c2sc3nc(C)cc(C)c3c2N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.85
+Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)c4cc(ccc34)S(=O)(=O)C)CC2)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+COc1ccc(cc1)C(=O)C2CCN(CC2)C(=O)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+CC1=CN([C@H]2CCCN(Cc3ccc(C(=O)O)c(Oc4cccc(Br)c4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.51
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)c5ccc(cc5)C#N)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.73
+Fc1cccc2[nH]c3CCN(Cc3c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+Oc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.52
+COc1ccc2c(C)cc(N[C@H]3CCC[C@@H](C3)NCc4ccsc4)nc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+OCC[C@@]1(CCCNC1)c2oc3ccccc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.12
+Oc1ccc(cc1)c2nc3ccc(O)cc3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2cc(CN(C)C)ccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+CC(=O)c1ccc2NC(=CC(=O)c2c1)c3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.41
+OC(=O)c1cccc(c1)C(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.23
+Cc1c(Sc2ccc(Cl)cc2)c3cc(F)ccc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.84
+CCOc1cc2nnc(C(=O)N)c(Nc3cccc(Cl)c3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+COc1ccc(cc1OC)C(C)NC(=O)C2(N)CCN(CC2)c3ncnc4[nH]ccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+CN(c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc4ncccc4c3)c2)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(C)[C@H](N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3cc(Cl)ccc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+Cc1ccsc1CN2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.15
+CC(=O)N1CCN(CCOc2ccc(cc2)C3CCN(CC3)c4ccc5nnc(n5n4)C(F)(F)F)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+Cc1ccc(Nc2c(F)cccc2Cl)c(CC(=O)O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.02
+COC(=O)CCC(=O)Nc1ccc2C(=O)C(=O)c3ccccc3c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.72
+O=C1COc2ccc(CNC3CCN(CCN4C(=O)COc5ccc(cc45)C#N)CC3)nc2N1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.23
+CN1SC(=NC1=O)NC(=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.13
+CC(C)NCC(O)COc1cccc2[nH]ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.12
+C[C@H](Nc1ncc(C)c(Nc2cc(C)[nH]n2)n1)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+CN(C)CCNCc1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+Cc1ccccc1Nc2ncnc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.85
+Cn1c(CN2CCN(CC2)c3ccccc3)nc4ccccc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.11
+CCCCOc1nc(N)c2NC(=O)N(Cc3cccc(CC(=O)OC)c3)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.76
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccc(cn34)N(C)C)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+Fc1ccc2[nH]c3CCN(Cc3c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+O[C@H](CNC(=O)C1=CNC(=O)c2cc(ccc12)S(=O)(=O)N3CCC3)CN4CCC(CC4)Oc5ccc(Cl)c(Cl)c5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.02
+COc1cccc(c1)c2cc(O)c3cc(NC(=O)C)ccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+CCC(CC)C[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.68
+CN(c1ccnc(Nc2cccc(c2)S(=O)(=O)C)n1)c3cccc4[nH]ncc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+C[C@H](Nc1nc(Nc2cc(C)[nH]n2)c(C)nc1C#N)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+OCCc1cccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.83
+C[C@H](NC(=O)c1c(C)nn(C2CCN(C)CC2)c1NS(=O)(=O)c3ccc(C)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+CN1CCN(CC1)C(=O)c2cc3ccccc3n2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+CN(C)CC(O)COc1ccc(Nc2nccc(Nc3ccc(Cl)cc3)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4c(OC)cccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CCCSc1c(cnn1c2ccc(cc2)C(=O)O)C(=O)N(C)C3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.59
+O=S(=O)(Cc1cc(nc(n1)c2ccccn2)N3CCOCC3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.34
+CCOC(=O)C1(CCN(C)CC1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+CNC(=O)C[C@H](Nc1ncc(Cl)c(Nc2cc([nH]n2)C3CC3)n1)c4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+Cc1cc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cc(c1)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+CCCSc1ncccc1C(=O)N(C)[C@@H]2[C@@H]3CC4C[C@H]2C[C@@](O)(C4)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+CS(=O)(=O)c1ccc(cc1)[C@@H](O)[C@@H](CF)NC(=O)C(Cl)Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.44
+COCCNC(=O)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+Cc1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+COc1cccc2c(ccnc12)c3c(C)n(CC(=O)O)c4ccc(C)cc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.49
+CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.77
+CC(=O)NCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CC(=O)N1CCN(CC1)c2ccc(Nc3nccc(n3)c4cnc5ccccn45)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.82
+Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)c3c[nH]nc3C(F)(F)F)CC2)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.66
+ON=Cc1oc(cc1)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.31
+Clc1cccc(C(=O)N2CCN(CC2)c3ccccn3)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+CC(=O)Nc1ccc2[nH]cc(c3cc(NC4CC4)n5ncc(C#N)c5n3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+Oc1c(C#N)c(nc2ccncc12)c3ccc(cc3)c4ccccc4C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+C[Si](C)(C)C#Cc1cn(C[C@H]2CN(C(=O)O2)c3ccc(C4=CCS(=O)(=O)CC4)c(F)c3)nn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+C[C@@H](NC(=O)C)c1ccc(Nc2ncc3cc(cc(C)c3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.46
+CN1CCN(CC1)S(=O)(=O)c2ccc(c3cnc(N)c(n3)C(=O)Nc4cccnc4)c(c2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+CCC(CC)NC(=O)c1cnn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.79
+Cc1nc(C)c(nc1C(=O)N)c2ccc(cc2)C34CCC(CC3)(CC4)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+OC(=O)CCCS(=O)(=O)c1cccc(c1)C(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.66
+CN(C)CC(O)COc1ccc(Nc2ncc(Cl)c(Nc3ccccc3)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.25
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4occc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.07
+CCCSc1ncccc1C(=O)NC2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+C[C@@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+COc1ccc2N=CC(=O)N(CCN3CC[C@H](NCc4cc5OCCOc5cn4)[C@H](O)C3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.77
+CCCNCC(O)COc1ccccc1C(=O)CCc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+CCN(CC)c1ccc2C=C(C(=O)O)C(=O)Oc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.2
+C[C@@H]1CN(C[C@H](C)O1)c2nc(N3CCOC[C@@H]3C)c4ccc(nc4n2)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.75
+CN1N(C(=O)C=C1C)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.11
+CC1=CN([C@H]2CCCN(Cc3ccc(C(=O)O)c(Oc4cccc(F)c4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.03
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCCN(CCc3ccccc3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.65
+CNc1c(Br)cnc2[nH]c(nc12)c3ccc(cc3)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+CC(C)NC[C@H](O)COc1cccc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)Cc3ccccc3C(=O)O)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.14
+CCN(CC)c1ccc2C=C(C(=O)C)C(=O)Oc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CCOC(=O)c1c(nc2cc(C)ccn12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CN(c1ccc(cc1)c2cc(ccc2OCC(=O)O)C(F)(F)F)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.81
+CN(c1ccccc1)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.47
+CNC(=O)c1cnn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.54
+COCCNC(=O)c1ccc(Nc2ncc3cc(ccc3n2)c4ccnc(C)c4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+CNC(=O)Nc1nc2ccc(cn2n1)c3cncc(c3)S(=O)(=O)NC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.58
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CCO)CC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CC(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.37
+CCN(CC)CCOC(=O)c1ccc(N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.0
+CC1(O)CN(C1)S(=O)(=O)c2ccc3C(=CNC(=O)c3c2)C(=O)NC[C@@H](O)CN4CCC(CC4)Oc5ccc(Cl)c(Cl)c5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+NC(Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.97
+O=C1C(=O)c2ccccc2c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4ccoc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.52
+COC(=O)NC1=CN=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C1=O)c2ccc(F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.82
+CC(N)C(=O)Nc1c(C)cccc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.15
+COc1ccc(cc1)C(=O)N2CCC(CC2)C(=O)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+Cc1ccc(OC(=O)N2CCN3CCC2CC3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.02
+CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc4ccccc24)c(O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.77
+CCOC(=O)CN(c1ccccc1C)S(=O)(=O)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.03
+[O-][n+]1cc(ccc1Cl)C(=O)Nc2ccc(F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+Nc1ccccc1NC(=O)c2ccc(cc2)c3ncc(CN4CCC4)cc3C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.22
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)C(=O)OCC(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CN(C)CC(O)COc1ccc(Nc2nccc(n2)N(CC#N)c3cc(Cl)ccc3Cl)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Cn1nc(cc1NC(=O)Nc2ccc(Cl)cc2)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.97
+CNC(=O)c1cc(C(=O)c2ccc(Cl)cc2)c(Br)[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CN1CC(C1)n2nccc2c3cc(Cl)ccc3Oc4cc(F)c(cc4F)S(=O)(=O)Nc5ncns5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CCN(C1CCN(CCC(c2ccccc2)c3ccc(NC(=O)C)cc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.09
+Cc1ccc(cc1)S(=O)(=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+COc1ccc(Sc2c(C)n(CC(=O)O)c3ccc(C)cc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.01
+CC(NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.21
+Cc1ccc2c(c1)c(Sc3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+Clc1cccc(NC(=O)c2ccccn2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CC(C)N1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6cncn6C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.02
+OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+Nc1ccccc1NC(=O)c2ccc(cc2)c3nccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CCN1CCOc2cc(COc3ccccc3)cnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+COc1ccc(cc1)c2ccnc(N)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCc4[nH]c5ccccc5c4C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+COc1cc2nnc(C(=O)N)c(Nc3cccc(Cl)c3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+CS(=O)(=O)Cc1cc(nc(n1)c2cccc(CO)c2)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4c(cccc34)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.52
+CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+CCOc1ccc2nc(N)sc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+N(c1ccccc1)c2ccnc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+Cc1ccc(cc1)C(=O)N2CCC(CC2)C(=O)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.79
+c1ccc(nc1)c2nc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+OC(=O)CO[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4sc(Cl)c(Cl)c4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+Nc1cc(nc2ccc(Nc3cc(nc(N)n3)c4ccc(cc4)C(F)(F)F)cc12)c5ccc(F)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.54
+Fc1cnc(NC(=O)[C@H](CC2CCOCC2)c3ccc(cc3)S(=O)(=O)C4CC4)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.19
+NC(=N)SCc1ccc(Cl)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.28
+Cc1ccc(COC(=O)N2CCC(CNc3ncccn3)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+COc1cc(cc(OC)c1OC)C(=O)c2cc(Cl)ccc2N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+COc1ccc2cc(CCC(=O)C)ccc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.06
+Oc1ccc(NC(=O)c2ccc(O)cc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COC(=O)[C@H](Cc1ccc(cc1)[N+](=O)[O-])NC(=O)c2cccc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.58
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)N)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+CC1=C(Cc2ccccc2)C(=O)n3nc(NCc4ccc(Cl)cc4)nc3N1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+Fc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+N(c1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.33
+Oc1cccc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CCN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+COc1ccc2c(c1)cc(C(=O)O)n2Cc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.66
+NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+OC(c1ccc(cc1)N(CC(F)(F)F)S(=O)(=O)c2ccccc2)(C(F)(F)F)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.5
+C[C@H](Nc1nc(Nc2ncc(C#N)s2)cc(n1)N3CCOCC3)c4ncc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+CCN(CC)CCNC(=O)c1ccc(N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.92
+COc1ccc(cc1OC)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2Br,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.49
+COc1ccccc1CN[C@H]2CCCN[C@H]2c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)OCc3cc(C)nc(C)c3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.38
+COCCCNS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4ccccn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.41
+CN[C@@H](C)[C@H](O)c1ccccc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.15
+FC(F)(F)c1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.75
+COc1nc(N)nc2c1ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.58
+C[C@@H]1NC(C)(C)CO[C@@]1(O)c2cccc(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+CCN(C1CCN(CCC(N2CCN(CC2)c3ccccc3)c4ccccc4)CC1)C(=O)Cc5ccc(cc5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+Fc1ccc(cc1Cl)C2CNCC=CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+Clc1cc(Cl)cc(c1)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.36
+CN1CCC(CC1)(c2cc(nc(n2)c3cccc4[nH]ccc34)N5CCOCC5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+C[C@@H](NC(=O)c1cccnc1Oc2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4ccc(Cl)cc4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cc(C)cc(C)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.93
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccc(OC)cc2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.45
+COC(=O)COc1ccc(O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.92
+COc1ccccc1S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.89
+Fc1ccccc1COc2cc(OCCCN3CCCC3)ccc2C(=O)Nc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.85
+Oc1ccc(CC(=O)c2ccc(O)cc2O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+Clc1cccc(Cl)c1c2nnc3cccc(Cl)n23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+CNCCCN1c2ccccc2CCc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.24
+C[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.3
+CS(=O)(=O)C1(CC1)c2cc(nc(n2)c3ccccc3)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+COc1ccc2N=CC(=O)N(CCN3CC[C@H](NCc4ccc5OCC(=O)Nc5n4)[C@H](O)C3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.39
+CN([C@@H]1CCN(Cc2ccc(nc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)c4noc(C)n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CCCc1c(O)c(ccc1OCc2ccc(cc2)C(=O)O)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Clc1ccc(c(Cl)c1)c2nnc3cccc(Cl)n23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+CCn1c(C)ncc1c2ccnc(Nc3ccc(cc3)S(=O)(=O)NCCOC)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.44
+ONC(=O)c1ccc(NS(=O)(=O)c2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.75
+CN1CCCCC1CCN2c3ccccc3Sc4ccc(cc24)[S+](C)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Cc1nc(C)c(nc1C(=O)N)c2ccc(cc2)[C@@H]3CC[C@@H](CC(=O)N)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Cc1cccc(NS(=O)(=O)c2ccc(cc2)c3ccc(cc3)C#N)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+Cc1ccccc1C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.28
+OC(=O)c1ccccc1CN2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+CNc1nc(C)c(s1)c2nc(Nc3cccc(c3)N4CCCN(CC4)C(=O)C)ncc2C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+OC(=O)c1cc2cc(OCc3ccccc3)ccc2[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+OC(=O)c1ccccc1C(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.73
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4c[nH]c(C)n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.97
+CO[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@H]1NCc4cc5OCCOc5cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.63
+OC(=O)CCc1ccc(OCc2cc(Cl)ccc2c3ccccc3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CNC(=O)c1cc(sc1NC(=O)N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.19
+CC(O)(C(=O)Nc1ccc(cc1)S(=O)(=O)c2ccc(F)cc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+C[C@@H]1CN(C[C@H](C)N1)c2c(F)c(N)c3C(=O)C(=CN(C4CC4)c3c2F)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.15
+Cc1sc2c(C(=N[C@@H](CC(=O)OC(C)(C)C)c3nnc(C)n23)c4ccc(Cl)cc4)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.82
+Oc1ccc(cc1)c2nc3ccccc3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N4CCOCC4)c2Cl)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.85
+CCc1c(C(=O)C(=O)N)c2c(OCC(=O)N)cccc2n1Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Nc1cccc2C(=O)C(=O)c3ccccc3c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.31
+COc1ccc2cc(ccc2c1)C(C)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.23
+CCN(CC)S(=O)(=O)c1ccc(cc1)c2cc(ccc2OCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.67
+CN(C)CCOC(C)(c1ccccc1)c2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.2
+NCCc1ccc(O)c2nc(O)sc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.33
+CN(C)CC(O)COc1ccc(Nc2nccc(n2)N(CC#C)c3cc(Cl)ccc3Cl)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CCN(CC)C(C)C(=O)c1ccccc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.18
+Oc1cc(nc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+Cc1cc(O)ccc1N2C(=O)c3ccc(O)cc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+FC(F)(F)c1cc(COCC(N2CCNCC2)c3cccc(Cl)c3)cc(c1)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+CC(C)NC(=O)c1ccc(C)c(c1)N2C=Nc3ccc(cc3C2=O)N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.56
+C[C@H](Nc1nc(Nc2ncc(C)s2)c(F)c(n1)N3CCOCC3)c4ncc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+CC(C)NCC(O)COc1nccs1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.97
+CNC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.93
+CC(C)NCC(O)COc1ccccc1CC=C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+CC(=O)Nc1ccc2c(c1)c(cn2CCO)c3cc(NC4CC4)n5ncc(C#N)c5n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+OC(=O)c1ccccc1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.36
+CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.44
+CC(C)C[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+Cc1ccc2nc(CCNCCCO)ccc2c1NC(=O)CC34CC5CC(CC(C5)C3)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.18
+OCC(CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(NC4CC4)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.11
+CCN(C1CCN(CCC(c2ccccc2)c3ccc(cc3)C#N)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.76
+C[C@@H](COCCCS(=O)(=O)CCNCCc1ccc(O)c2nc(O)sc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+CN(C)CC(O)COc1ccc(Nc2ncc(C)c(Nc3ccccc3)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CCCSc1nc(ccc1C(=O)NC2CCCCC2)N3CCCC(C3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+C[C@@H]1CCCN1CCc2oc3ccc(cc3c2)c4ccc(cc4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.51
+COc1cc2ncc(C(=O)N)c(Nc3cccc(Cl)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Brc1ccc(cc1)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+NC(=O)N1c2ccccc2C[C@H](O)c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.79
+Nc1nnc(s1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+COc1ncnc(NS(=O)(=O)c2ccc(N)cc2)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.73
+C[C@H]1CCCN1CCc2oc3ccc(cc3c2)c4ccc(cc4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)ncc2Cl)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.53
+CC(N1NC(=O)C2=C(C1=O)C(=O)c3ccc(Cl)cc3N2)c4ccsc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CCN1CCN(CC1)C(=O)c2cc3cc(F)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.28
+CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+CC1=CN(C2CCCN(Cc3cccc(Oc4ccc(C)cc4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+CCCN(CCNCCc1ccc(O)c2NC(=O)Sc12)C(=O)CCOCCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+NC(=N)Nc1nc(CSCCC(=N)NS(=O)(=O)N)cs1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.6
+CN(CCO)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3ccc(F)cc3)CC2)c4cccc(NC(=O)C5CC5)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cccc(c3)C(F)(F)F)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+O[C@H](CNC(=O)C1=CNC(=O)c2c(F)cccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+CN(C)CCCN(C)S(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4ccccn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+CC(O)(C(=O)Nc1ccc(cc1)S(=O)(=O)c2ccc(O)cc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+CCCSc1ncccc1C(=O)N(C)[C@H]2[C@@H]3CC4C[C@H]2C[C@@](O)(C4)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+Cn1cncc1c2c3C(=O)N(CC#CCO)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+CS(=O)(=O)c1ccc(cc1)c2cc(C(=O)N[C@H]3CCCNC3)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.68
+Cc1onc(C(=O)N)c1C(=O)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.63
+CNCCC(Oc1ccc(cc1)C(F)(F)F)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+CCn1cnc(c2ccccc2)c1c3nc4c(N)ncnc4s3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.97
+CCCc1c(O)c(ccc1OCCCCSCC(=O)O)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+COCCOc1nc(N)c2NC(=O)N(Cc3cccc(CC(=O)OC)c3)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+C[S+]([O-])c1ccc(cc1)c2nc(c3ccc(F)cc3)c([nH]2)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.34
+CCC(CC)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.88
+CN1CCN(CC(=O)Nc2ccc(C3=CC=CN4C(=O)C=C(N=C34)N5CCOCC5)c6sc7ccccc7c26)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CNC(=O)OC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(C(=O)NCCN(C)C)c(F)c3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.96
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CO[C@@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@@H]1N(C)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1ccc2cc(ccc2c1)[C@H](C)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.13
+CN(C)C1=C(C)N(C)N(C1=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+CCC(CC)CNC(=O)c1ccc2c(c1)c(Cc3ccc(cc3OC)C(=O)NS(=O)(=O)c4ccccc4C)cn2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CC(C(=O)O)c1ccc(c(F)c1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.85
+COc1cc(ccc1Nc2ncc(c(n2)c3cnc4ccccn34)C(F)(F)F)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+COC[C@H](C)Oc1cc(Oc2cc(F)cc(F)c2)cc(c1)C(=O)Nc3ccc(cn3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.36
+CCC(C)(C)C[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.37
+Fc1cccc(c1)C(COCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)N3CCNCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CSCc1cc(nc(n1)c2ccccc2)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.26
+CN(C)CCCNc1cc(nc2c(cnn12)C#N)n3ccc4ccc(NC(=O)C)cc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.62
+Clc1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.59
+Oc1ccc(cc1)C2=COc3cc(O)ccc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+Fc1ccc(cc1)C(NC(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)C5=CNC(=O)C(=C5)Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC=O)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.84
+COc1cc(ccc1Nc2ncc(C)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.04
+Oc1ccc(CCNCCCCCCOCCc2ccccc2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+COC[C@H](C)Oc1cc(Oc2ccccc2)cc(c1)C(=O)Nc3ccc(cn3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.95
+NC(=N)Nc1ccc(cc1)C(=O)Oc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.21
+CCOc1ccc(NC(=O)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+OC(=O)Cc1csc(n1)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.22
+CC(C)Oc1cc(Nc2nc3c(cc2F)ncn3[C@@H](CO)c4ccc(F)cn4)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.97
+CN1CCN(CC1)C(=O)c2cc3cc(Cl)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+OC[C@H](Nc1ncc(Cl)c(Nc2cc([nH]n2)C3CC3)n1)c4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.75
+C[C@H]1COCCN1c2cc(CS(=O)(=O)C)nc(n2)c3ccc4[nH]ccc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.38
+COCCCc1cc(Nc2nc(NCc3onc(C)c3)ncc2Br)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+OCc1ccc(OC2CCN(CC3CCN(CC3)[C@@H](Cc4ccccc4)C(=O)O)CC2)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+OC(=O)CNCCNc1ccc(Cl)c(c1)C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+CCNC(=O)c1ccc(C)c(c1)N2C=Nc3ccc(cc3C2=O)N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.47
+CS(=O)(=O)n1c2ccccc2c3cc(NC(=O)CCc4ccncc4)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)C(=O)OCC(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+OC(=O)c1c(C#N)c2ccccc2n1Cc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+C[C@H](CO)Nc1nc(SCc2ccccc2F)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+OCC[C@]1(CCCNC1)c2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.62
+C[C@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(cc2)C#N)c3ccc(F)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.45
+OC(=O)[C@H](Cc1ccc(F)cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+COCCC(=O)N(C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.23
+C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3)C#N)cn2)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)S(=O)(=O)CCN(C)C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.52
+Nc1ccc2ccccc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+CN1C=C(C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)C(=CC1=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.76
+CC#CCN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c3C1=O)c6cncn6C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.61
+Cc1nccc(c1Cl)c2ccc(cc2)c3nc4ccncc4c(O)c3C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Cc1c(c2cc(F)ccc2n1CC(=O)O)S(=O)(=O)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.16
+NS(=O)(=O)c1ccc(Nc2nccc(Nc3c(Cl)ccc4OCOc34)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CCC(C)(CC)C[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Br)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N3CCN(CC3)c4ccc(cn4)C#N)C(=O)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.37
+Cc1nc2ncnn2c(O)c1CCOC(=O)c3ccccc3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+NC(=O)C1CCCCC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+COc1ccc(cc1)S(=O)(=O)Nc2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+Cc1ccc(cc1)c2csc3ncnc(O)c23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.59
+CCOc1ccccc1c2ccc(cc2)c3nc4ccncc4c(O)c3C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1ccc(NC(=O)C=C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.68
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4cccc(Br)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+Oc1ccc(cc1)c2oc3ccc(O)cc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Nc1nc(ns1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CC(N(O)C(=O)N)c1cc2ccccc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.05
+COc1c(cc2ccccc2c1C(=O)N(C)C[C@@H](CCN3CCC(CC3)N4CCCNC4=O)c5ccc(Cl)c(Cl)c5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CN1C(=O)N(C)c2ncn(CC(O)CO)c2C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.25
+Cc1ccc(cc1)c2nn(c3ncnc(N)c23)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC4CCN(CC(=O)N)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+NC(=O)c1ccc(Br)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+CCOc1cccc(Nc2oc(nn2)C(=O)Nc3ccc(nc3)N4CCOCC4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+C[C@H](Oc1ccc(SCCCCCc2ccccc2)cc1)C(=O)c3nc(C)c(CCCC(=O)O)s3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.03
+N[C@H](Cc1c[nH]c2ccccc12)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.92
+CC(C)CN1C(=O)N(C)C(=O)c2c(SCCCO)c(Cc3ccccc3C(F)(F)F)sc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.05
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6oc(cc6Cl)S(=O)(=O)C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.97
+Clc1ccc2C(=O)C3=C(Nc2c1)C(=O)NN(Cc4cccs4)C3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+COc1ccc2N=CC(=O)N(CCN3CC[C@@H](NCc4ccc5OCC(=O)Nc5n4)[C@@H](F)C3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.83
+Cc1ccc(cc1)S(=O)(=O)Nc2c(C(=O)NCC(C)(C)C)c(C)nn2c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.46
+CS(=O)(=O)Cc1cc(nc(n1)c2cccc3[nH]ccc23)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+CCn1c2ccccc2c3cc(NC(=O)CCc4ccncc4)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.75
+CCS(=O)(=O)c1ccc(c2cc(Cl)ccc2OCC(=O)O)c(c1)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.62
+COc1ccccc1C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+COc1cc2nnc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+Fc1ccc2cn[nH]c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+OC(=O)CCCc1ccc(cc1)N(CCCl)CCCl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.47
+NC1=NC2(CCN(CC2)C(=O)c3ccc(cc3)C#N)Nc4cccc(F)c14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.66
+CO[C@@H]1CN(CCN2C(=O)C=Nc3ccc(OC)cc23)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.97
+CN(C)CC(O)COc1ccc(Nc2cc(Nc3cc(Cl)ccc3Cl)ncn2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+O[C@@H](CNCCc1ccc(CNCCc2ccccc2)cc1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.11
+NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.92
+Fc1ccc(cc1)c2cn3ccccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CN(C)c1cccc2c(cccc12)S(=O)(=O)N(C)CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.45
+COc1ccnc(NC2CCN(CC2)C(=O)c3ccccc3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+Nc1c(cnn1c2ccc(F)cc2)C(=O)c3cccc(OC[C@H](O)CO)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+Cc1c[nH]c(\C=C\2/C(=O)Nc3ccccc23)c1CCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+COc1ccc(Nc2nccc(n2)c3cnc(C)n3C(C)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.43
+Clc1cnc(cc1C(=O)NCC23CC4CC(CC(C4)C2)C3)N5CCNCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.09
+CN(C)CCOC(c1ccccc1)c2ccccc2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.47
+CC(C)c1noc(n1)N2CCN([C@H](C)C2)c3ncc(OCc4ccncc4C#N)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CCOc1ccc2nc(NC(=O)CC)sc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.28
+[O-][N+](=O)c1ccc(cc1)C2=Nc3ccccc3C(=O)N2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CN1CCN(CC1)S(=O)(=O)c2ccc(cc2F)c3cnc(N)c(n3)C(=O)Nc4cccnc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+COc1ccccc1C2=COc3cc(O)ccc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+COc1ccc(cc1)C(=O)CS(=O)(=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.96
+COCCN(C)Cc1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+CC(COc1ccccc1)NC(C)C(O)c2ccc(O)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.56
+CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(NC(=O)C)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Cc1ccc2c(c1)c(Sc3ccccc3)c(CC(=O)O)n2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+NC(=O)c1cc2ccccc2nc1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.07
+O=C(N1CCNCC1)c2cc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+N#CCc1c[nH]c2ccc(OCc3ccccc3)cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.71
+CN([C@@H]1CCN(Cc2nc3ccccc3s2)C[C@@H]1F)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2ccc(F)cc2)N)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.05
+Cc1ccc(cc1)c2ccc(F)cc2COc3ccc(CCC(=O)O)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@@H](C)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+CC[C@H](NC(=O)c1c([S+]([O-])CC)c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+Nc1n[nH]c2c(Cl)cccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+Cc1cc(CN2Cc3ccccc3C2C(=O)Nc4ccc(Cl)cc4)ccc1OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+OC(=O)[C@H](Cc1cccc(F)c1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+CN([C@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+COC(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.83
+Clc1ccc2OCOc2c1Nc3ccnc(Nc4ccccc4)n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+COc1cc(OC2CCN(C)CC2)c3c(Nc4c(Cl)ccc5OCOc45)ncnc3c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+OB(O)c1ccccc1C=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.83
+Oc1ccc(CCNCCCS(=O)(=O)NCCOCCc2ccc(F)cc2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.57
+CCN(C1CCN(CC[C@H](c2ccc(cc2)S(=O)(=O)C)c3cc(F)c(F)c(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+O[C@@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@@H]1NCc4ccc5OCC(=O)Nc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.11
+CNC(=O)c1ccc2C(=O)C=C(Nc2c1)c3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.01
+Clc1n[nH]c2cccc(Nc3ccnc(Nc4cc(cc(c4)N5CCOCC5)N6CCOCC6)n3)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+CCCC(=O)Nc1ccc(Cl)c(c1)c2oc3cccnc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+O=C(Nc1cccc(c1)c2nnn[nH]2)c3cccc4[nH]cnc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.05
+Cc1c(Sc2ccc(Cl)cc2)c3cc(ccc3n1CC(=O)O)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.54
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)S(=O)(=O)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.06
+COc1ccc(cc1)S(=O)(=O)NC2=CC=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C2=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N2c3ccccc3Oc4ccccc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.53
+Oc1ccc(CCNCCCS(=O)(=O)NCCOCCc2cccc(c2)C(F)(F)F)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.62
+CCCSc1nc2ccc(NC(=O)CCNC(=O)N)cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+COc1cc(Nc2cc(nc(N[C@@H](C)c3ncc(F)cn3)n2)N4CCOCC4)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c(F)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Clc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.57
+CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2F)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.05
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)C(=O)C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6oc(cc6)S(=O)(=O)C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+COCCC(=O)NC(C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+CC(C)Cc1ccc(cc1)[C@@H](C)C(=O)NS(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.51
+COC(=O)CCCCCCC(=O)Nc1ccc2C(=O)C(=O)c3ccccc3c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+Oc1cc(O)c2C(=O)C(=COc2c1)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CC[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.44
+CC[C@H](CO)Nc1nc(SCc2ccccc2)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+COc1cc(cc(OC)c1OC)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+Fc1cccc(COc2cc(OCCCN3CCCC3)ccc2C(=O)Nc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.67
+C[C@H](NC(=O)c1c(NS(=O)(=O)c2ccc(C)cc2)n(nc1C(F)(F)F)c3ccccc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+COc1ccc(Oc2ncccc2C(=O)NCc3ccccc3Cl)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.59
+COc1cc2ncc(C(=O)N)c(Nc3ccccc3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+CC(C)NCCCOc1ccc(NC(=O)C)cc1CC=C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.01
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)N4CCOCC4)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.01
+CCOc1ccc(cc1)N2C(=Nc3ccccc3C2=O)CC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+CCCSc1nc(N[C@@H]2C[C@H]2c3ccccc3)c4nnn([C@@H]5C[C@@H]([C@@H](O)[C@H]5O)C(=O)N)c4n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.05
+O[C@@]1(CN2CCC1CC2)C#Cc3ccc(Oc4ccc(cc4)C(=O)NCc5ccncn5)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)c5ccccc5F)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+Oc1ccc(cc1)C2=COc3cc(O)cc(O)c3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.06
+CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(OC)c(OC)cc34)cc2OC)cn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+COCCNS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4cccnn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CN(c1ccnc(Nc2cc(cc(c2)S(=O)(=O)C)N3CCOCC3)n1)c4cc(CO)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2ccc(F)cc2)NC(=O)OCc3ccccc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+Cc1nc(C)c(nc1C(=O)N)c2ccc(cc2)C34CCC(CC(=O)O)(CC3)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Oc1ccc(C(=O)Cc2ccccc2)c(O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.09
+OC(=O)c1ccc2cccc(O)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+Nc1[nH]nc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CS(=O)(=O)NC(=O)CCCc1c([nH]c2ccc(cc12)C#N)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(c(F)c2)n3cnc(c3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.51
+COc1ncccc1c2cccc3c(N)c4C(=O)N(Cc4nc23)C5CCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.26
+COCCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+Nc1ccccc1NC(=O)c2ccc(cc2)C3CCN(Cc4ccccc4)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+NC(=O)c1cc(cc(c1)[N+](=O)[O-])[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.81
+NC(=O)COc1ccc(OCCNCC(O)COc2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.63
+NC(=O)c1ccn2c(c3ccccc3)c(nc2c1)c4ccc(cc4)C5(N)CCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4ccc[nH]4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+CC(C)N1CCN(Cc2cnc(c(F)c2)c3ccc(cc3)C(=O)Nc4ccccc4N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CN([C@@H]1CCN(Cc2ccc(cn2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CCCCCC\N=C\1/C=CN(Cc2ccccc2)c3cc(Cl)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.98
+CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.1
+OC(=O)CC(=O)N[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4sc(Cl)c(Cl)c4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.18
+Nc1nc2ccccc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)NCCO)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.09
+Cc1ccc(F)c(Nc2ccnc(Nc3ccc(cc3)S(=O)(=O)N)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+Cc1cc(ccn1)c2ccc(cc2)c3nc4ccncc4c(O)c3C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Cc1cc(C)c(C(=O)N[C@@H](Cc2ccc(OCCCNc3ccccn3)cc2)C(=O)O)c(C)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.49
+COc1cc2ncc(C(=O)N)c(Nc3ccc(F)c(Cl)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+OC(=O)c1cc(nc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.7
+C[C@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.26
+COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c3occc3CO)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.37
+NC(Cc1ccc(cc1)N(CCCl)CCCl)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.39
+CC(C)Nc1nc(NCc2ccccc2)c3sccc3n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+CNS(=O)(=O)c1ccc(Oc2ccc(cc2)C#C[C@]3(O)CN4CCC3CC4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.03
+Cc1ccc(Oc2ccnc(Nc3ccc(cc3)S(=O)(=O)N)c2)c(C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+CS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(C#N)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.41
+C[C@H]1O[C@H]([C@H](O)[C@H]1Cl)n2cnc3c(N)nc(OC4CCCC4)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Clc1ccc2[nH]ncc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.44
+CN1CCN(CC1)C(=O)c2cc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+NC(=O)C[S+]([O-])C(c1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.12
+Cc1ccc2c(c(C)n(CC(=O)O)c2c1)c3ccnc4cc(Cl)ccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+Oc1ccc(Cl)cc1C(=O)Nc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccnc4ccccc34)c2C(=O)N5C[C@@H](O)[C@@H](O)C5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.18
+COc1ccc2C=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.31
+CC(C)COc1cc(OC(C)C)cc(c1)C(=O)Nc2ccc(cn2)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CC(C)CC(N1NC(=O)c2nc3cc(Cl)ccc3c(O)c2C1=O)c4ccccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.83
+CCN(CC)CC(=O)Nc1c(cnn1c2ccccc2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+CCC(=O)O[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CCCC(C)(COC(=O)N)COC(=O)NC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN2CCC3(CC2)Cc4cc(Cl)ccc4O3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.76
+[O-][N+](=O)c1ccc2[nH]ncc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Cc1cc(C)cc(c1)c2[nH]c3ccccc3c2CCNCCCCc4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+O=S(=O)(Cc1ccccc1)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+OC(=O)[C@H](Cc1ccccc1C#N)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+Cc1ccc(C)c(OCCCC(C)(C)C(=O)O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.72
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+COCCOc1cc2nccc(Nc3cc(O)c(Cl)cc3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+CC(C)N1CCN(Cc2cnc(c3ccc(cc3)C(=O)Nc4ccccc4N)c(c2)C#N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.28
+O=C(Nc1oc(nn1)C(=O)Nc2ccc(cc2)N3CCOCC3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.02
+COc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cc1OCCCN4CCN(C)CC4)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+C[C@H](Nc1ncc(F)c(Nc2cc([nH]n2)N(C)C)n1)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.98
+CCNC1=CC=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C1=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(F)c(F)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.75
+CCOC(=O)Nc1cccc(c1)[C@H](N2CCN(Cc3c[nH]c(C)n3)CC2)c4ccc(cc4)C(=O)N(C)CC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.11
+Cc1ccc(NC(=O)c2ccc(Cl)c(c2)C(F)(F)F)cc1C(=O)Nc3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(F)cccc3Cl)C(=O)O)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.42
+CCS(=O)(=O)c1cccc(c1)c2cc(ccc2OCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.66
+CN1CCN(CC1)c2cc3c(Nc4ccc(F)cc4F)c(cnc3cc2F)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CC6CN(CCO)CC(C5)O6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CN(C)C(=O)N[C@@H]1CC[C@H](CCN2[C@@H]3CC[C@H]2C[C@H](C3)Oc4cccc(c4)C(=O)N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.22
+C=CCOc1cc(ccc1NC(=O)CN2CCOCC2)c3cccc4C(=O)C=C(Oc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CCc1cccc2c(cn(CC(=O)NCCOC)c12)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+COc1cccc2sc(NC(=O)c3ccccc3)nc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.96
+Nc1nc(nn1Cc2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+COc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.24
+COc1ccnc(c1)N(C)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+Nc1nc(OC2CCCC2)nc3c1ncn3[C@@H]4O[C@H](CF)[C@@H](O)[C@H]4O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+Oc1oc(c2ccccc2)c(n1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+CC(C)(C)c1ccc(cc1)C(O)CCCN2CCC(CC2)C(O)(c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.99
+NC(=O)c1cnc(N[C@H]2CCCNC2)c3cc(sc13)c4ccc(F)c(F)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+FC(F)(F)c1csc(n1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CC(C)Nc1nc(nc(N2CCOCC2)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.04
+Fc1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+C[C@@H](NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+COc1ccc(Cl)c(c1)C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.39
+C[C@@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)C[C@H](C)N1C(=O)Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+Cc1ccc(cc1)C(=O)N(CCCN)CC2=Nc3cc(Cl)ccc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.47
+COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.35
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccc(O)cc2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.77
+COc1ccc(C)c(c1)N(C)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+Clc1ccc(CN(Cc2ccc(Cl)cc2)c3nn[nH]n3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+Cc1c(F)ccc2c1c(Sc3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+CN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.94
+CCCCSc1nc(N)c2ncn(Cc3c(F)ccc(C)c3F)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1ccc(cc1CNCCO)c2ccc3c(nc(nc3n2)N4C[C@@H](C)O[C@@H](C)C4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.31
+OC(=O)c1cc2ccccc2n1Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+COc1cccc(c1)C(COCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)N3CCNCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Nc1ccc2C(=O)C(=O)c3ccccc3c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+Cc1cc(CNc2ncc(Br)c(Nc3cc(C)[nH]n3)n2)on1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+CC(=O)Nc1nc(ns1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.15
+NS(=O)(=O)NC(=O)CCCc1c([nH]c2ccc(cc12)C#N)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+O[C@@H](CNCCSCCCNCCc1cccc(Cl)c1Cl)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+C[C@@](Cc1ccc(O)c(O)c1)(NN)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.7
+CC(=O)Nc1cccc2c1c(Oc3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.41
+COC[C@H](C)Oc1cc(Oc2ccc(cc2)S(=O)(=O)C)cc(c1)C(=O)Nc3ccc(cn3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.41
+Cc1nc(CS(=O)(=O)c2ccc(Cl)cc2)cc(n1)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+COc1c(N2CCNC(C)C2)c(F)cc3C(=O)C(=CN(C4CC4)c13)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.82
+OC(=O)[C@H](Cc1ccc(F)cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)cc4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+CCCCCCCN(CC)CCCC(O)c1ccc(NS(=O)(=O)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Cc1ccc2c(c1)c(Sc3cccc(Cl)c3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+COc1ccc2c(C)nc(NC(=N)N)nc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.51
+CC[C@H](NC(=O)c1c(O)c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.91
+Fc1ccc(CNc2ncc(Br)c(Nc3cc([nH]n3)C4CC4)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.28
+OC(=O)COc1ccc(cc1c2ccc(Cl)cc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+COCCCc1cc(Nc2ccnc(NCc3onc(C)c3)n2)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.04
+CC(O)(C(=O)c1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+COc1cc(CO)cc(c1)N(C)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CC(C)NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.46
+COC1=CC=C2C(=CC1=O)C(CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.12
+COc1ccccc1CCNCc2cccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.82
+Cn1c(C(=O)O)c(CCCOc2cccc3ccccc23)c4ccccc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+FC(F)(F)c1ccc(cc1)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.29
+Cc1nc(N)c2nc(O)n(Cc3ccccc3)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.04
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+O=C(Nc1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CCC(CO)NCCNC(CC)CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.42
+CCCNC(=O)NS(=O)(=O)c1ccc(Cl)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.33
+CCN1CCO[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+COc1ccc(cc1OC)S(=O)(=O)Nc2ccc(\C=C\C(=O)Nc3ccccc3N)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)C)[C@@]3(C)C[C@H](O)[C@]2(F)[C@@]4(C)C=CC(=O)C=C14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+C[C@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.44
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)Cc3cccc(c3)C(=O)O)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.68
+OC(=O)CCC(=O)c1ccc(cc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.58
+CCCSc1c(cnn1[C@@H]2CC[C@@H](CC2)C(=O)O)C(=O)NC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.39
+COc1cc(Nc2c(cnc3cc(OCCCN4CCN(C)CC4)c(OC)cc23)C#N)c(Cl)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Nc1c(nnc2c(cccc12)c3ncccn3)C(=O)NC4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+C[C@H](NC(=O)c1c(C)nn(CC(F)(F)F)c1NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.93
+CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5c(CN(C)C)c(O)ccc5nc34)C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.31
+Clc1ccccc1CNC(=O)c2cccnc2Oc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.68
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(C(=O)NCCN(C)C)c(F)c3)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+CN1CCN(CC1)C(=O)c2cc3cc(C)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.22
+Fc1cccc(c1F)c2cncc(CNCC3CC3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.82
+OC1N=C(c2ccccc2Cl)c3cc(Cl)ccc3NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.38
+CS(=O)(=O)c1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+CN(C)CCCNS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4cccnn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+Cn1cc(nc1c2c3C(=O)N(CC#C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4cc(F)ccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+O[C@]1(CN2CCC1CC2)C#Cc3ccc(Oc4ccc(cc4)C(=O)NCc5ccncn5)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CN(C)CCNC(=O)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.29
+CCCCC[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Br)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+CC1=C(OCc2ccccc2)C(=O)C=CO1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.87
+O=C(CC12CC3CC(CC(C3)C1)C2)Nc4cccc5ncccc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.83
+COc1ccccc1OCC(O)CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.24
+CN1CC(c2ccccc2)c3cccc(N)c3C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+Nc1cccc(NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CCc1c(cnn1c2ccc(cc2)C(=O)O)C(=O)NC3C4CC5CC(CC3C5)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+CC(C)CCCC(C)\N=C\1/C=CN(Cc2ccccc2)c3cc(Cl)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.58
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6cncn6C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+NC(=O)c1cnc(N[C@H]2CCCNC2)c3cc(sc13)c4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+Cc1c(Sc2ccc(Cl)cc2)c3cccc(Cl)c3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Fc1ccc(N2CCN(CC2)C(=O)COCc3ccncc3)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+CC1=CN([C@H]2CCCN(Cc3cccc(Oc4cccc(Br)c4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.68
+CCN(C1CCN(CC[C@H](c2ccc(cc2)S(=O)(=O)C)c3cccc(Cl)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4cc(F)ccc34)cc2OC)cn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.93
+Cn1cc(cc1c2c3C(=O)N(CC=C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.27
+O=C(NCC#N)c1ccc(cc1)c2ccnc(Nc3ccc(cc3)N4CCOCC4)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+CNC(=O)C1(CCN(CC[C@H](CN(C)C(=O)c2cc(cc3ccccc23)C#N)c4ccc(Cl)c(Cl)c4)CC1)N5CCCCC5=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C(F)(F)F)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.39
+Cc1cc(N)n(n1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.25
+Cn1cc(nc1c2c3C(=O)N(CC=C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.92
+OC(=O)C[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4cc(F)ccc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.09
+O=S(=O)(NCC(N1CCCCCC1)c2ccccc2)c3ccc(cc3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2ccccc2)NC(=O)OCc3ccccc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+COc1cc2c(Nc3cccc(Cl)c3Cl)c(cnc2cc1NCCN(C)C)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.41
+CC1=CN([C@H]2CCCN(Cc3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.55
+Cc1ccn2c(c(C)nc2c1)c3ccnc(N)n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+Cc1cc2NC(=O)C(=CC(=O)c2cc1C)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+CC(C)(c1cc(nc(n1)c2cccc3[nH]ccc23)N4CCOCC4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+COc1cc2ncnc(Nc3cccc(O)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CC[C@H](NC(=O)c1c(CC[S+](C)[O-])c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+CCS(=O)(=O)c1ccc(c(C)c1)c2cc(Cl)ccc2OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.65
+Fc1ccccc1Nc2oc(nn2)C(=O)Nc3ccc(cc3)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+Nc1ccc2c(c1)C(=O)C(=O)c3cc(N)ccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+COC(=O)N1CCOc2cc(COc3ccccc3)cnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)c3ccccc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+N[C@@H]1CCCN(C1)c2c(Cl)cccc2\C=C\3/SC(=O)NC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+CCN(C)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4ccccc4NC(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+Nc1nccc(n1)c2cc3C(=O)NC[C@@H](CCF)c3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.51
+OCC(CO)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+CS(=O)(=O)c1ccc(c[n+]1[O-])C(=O)Nc2ccc(F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.84
+CCN(CC)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3ccc(F)cc3)CC2)c4cccc(NC(=O)C5CC5)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.99
+CC(C)Cc1ccc(cc1)C(C)C(=O)NS(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3NC(=O)C=Nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CC1=CN([C@H]2CCCN(C2)[C@@H](CC(C)(C)C)c3ccc(C(=O)O)c(Oc4cccc(Br)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.12
+Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c2nc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Nc1nc2ccc(cc2[nH]1)C(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.29
+NC1=NC(=O)N(C=C1)[C@@H]2O[C@H](CO)[C@@H](O)C2(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.5
+CC(C)Oc1ccc2C(=O)C(=COc2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.07
+CCCNC(=O)c1nnc2c(cccc2c1N)c3cc(C)ccc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.99
+CNC(=O)c1ccc(CN2CCC(CC2)c3ccc(cc3)C(=O)Nc4ccccc4N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+NC1=CC2=NNC(=O)N2c3cc(ccc13)c4ccc[nH]4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CCOc1cccc(\C=C\2/SC(=O)NC2=O)c1N3CCC[C@@H](N)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)OCc3ccncc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+Cc1ccc(cc1)S(=O)(=O)Nc2c(C(=O)NC3CCCCC3)c(C)nn2c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.68
+O=C1Oc2ccccc2C=C1c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+COc1ccccc1C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.43
+Cc1nc(cs1)C(=O)N2CCCC3(CCN(Cc4ccccc4)CC3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.24
+CS(=O)(=O)n1c2ccccc2c3cc(NC(=O)N4CCOCC4)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CCOc1ccccc1c2ccc(cc2)c3nc4ccc(F)cc4c(C(=O)O)c3C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.18
+CC(C)(C)C(=O)Nc1ccc2c(c1)C(=O)C(=O)c3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+OC(=O)c1ccc(Nc2ncc(Br)c(Nc3ccccc3)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.65
+CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.24
+C[C@@H](Oc1cccc2ncnc(Nc3ccc(OCc4ccccn4)c(Cl)c3)c12)C(=O)N(C)CCO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+Oc1ccc2C(=O)C(=COc2c1)c3ccc(O)c(O)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.88
+Brc1ccc2oc3C(=O)NC(=Nc3c2c1)[C@@H]4CCCN4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3C#N)S(=O)(=O)C)cn2)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+Cc1cnc(NS(=O)(=O)c2ccccc2)c(C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.03
+CCCC(=O)NCc1cncc(c1)c2ccc(F)cc2OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)Cc3ccc(cc3)C(=O)O)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.35
+Cc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4n12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+Cn1cc(cc1c2c3C(=O)N(CCO)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+Cc1cccc(n1)c2nc3cc(Cl)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+COC(=O)c1ccc(CC(=O)N(C)C2CCN(CCC(c3ccccc3)c4ccccc4)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+F[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.66
+C[C@H](NC(=O)c1c(C)nn(C2CCN(CC(F)(F)F)CC2)c1NS(=O)(=O)c3ccc(C)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.08
+c1ccc2[nH]ncc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+COCCS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc(C)n3C(C)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+Oc1ccc(CCNCCS(=O)(=O)CCCOCCc2ccccc2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.61
+COc1ccc(OC(F)(F)F)cc1CN[C@H]2CCCN[C@H]2c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Nc1nc(cs1)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+CCOC(=O)c1ccc(N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.83
+CNCC[C@@H](Oc1cc(OC)ccc1C#N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+CCc1c(C)nc2sc(C(=O)N)c(N)c2c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.62
+OC(=O)c1ccc(OCC(=O)COc2ccc(SCCCCCc3ccccc3)cc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.63
+COc1cc2ncc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1NCCN4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+OCCCN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.49
+OC(=O)CC[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4sc(Cl)c(Cl)c4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.84
+OCCO[C@H]1C[C@H]([C@H](O)[C@@H]1O)n2nnc3c(N[C@@H]4C[C@H]4c5ccc(F)c(F)c5)nc(SCCC(F)(F)F)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.17
+Cc1cc(CNc2ncc(Cl)c(Nc3cc(C)[nH]n3)n2)on1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+CCCc1cc(cc(OC)c1OC)C2=N[C@H](CO2)C(=O)NO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+ON(C=O)C1(CS(=O)(=O)N2CCN(CC2)c3ccc(F)cc3)CCOCC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.85
+CC(C)[C@@H](CN1CC[C@](C)([C@@H](C)C1)c2cccc(O)c2)NC(=O)[C@H]3Cc4ccc(O)cc4CN3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+OC(=O)c1cccc(c1)c2cccc(c2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.3
+CC1(C)[C@@H]2CC[C@@]1(CS(=O)(=O)N3CCN(CC3)c4ccc(cn4)C(F)(F)F)C(=O)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CC1=CN([C@H]2CCCN(C2)[C@H](CC(C)(C)C)c3ccc(C(=O)O)c(Oc4cccc(Br)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.09
+COc1cc2ncc(C(=O)N)c(Nc3cc(C)ccc3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.16
+COc1cc(Oc2ccnc3ccc(F)cc23)ccc1CC(=O)Nc4noc(C)c4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.06
+Cc1cc(NC(=O)c2ccc(Cl)cc2)n(n1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+OC(=O)c1ccc(cc1)n2ncc(C(=O)NC3C4CC5CC(CC3C5)C4)c2C6CCCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+CC1=C(CCC(=O)O)C(=O)Oc2cc(O)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.7
+CC(C)(O)c1ccc(Nc2nc3ccc(cc3[nH]2)C#N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.73
+CN(C)CC(O)COc1ccc(Nc2cc(Nc3ccc(F)cc3F)ncn2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.48
+COc1cc2ncc(C(=O)N)c(Nc3ccccc3Cl)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+C1CNCC(C1)c2nc3ccccc3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+[O-][N+](=O)c1cccc2ccc(nc12)C(Cl)(Cl)Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+C[C@H](Nc1ncc(Cl)c(Nc2cc([nH]n2)N(C)C)n1)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.33
+CN(C)C(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+CN(C)c1ccccc1S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+O=C1NC(=NC(=C1C#N)c2ccccc2)SCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.56
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)NCc3ccncc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+C[C@H](CO)Nc1nc(SCc2cccc(Cl)c2)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+CCN1CCN(Cc2ccc(cc2)c3cc4c(N[C@H](C)c5ccccc5)ncnc4[nH]3)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.97
+OC(CN1CCOCC1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CC(=O)Nc1ccc2ccn(c3cc(NCCCN4CCCC4)n5ncc(C#N)c5n3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.87
+CN(C)c1cccc2c(cccc12)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+Cc1[nH]c(C(=O)NC2CCN(CC2)c3nc(cs3)C(=O)O)c(Cl)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.14
+CCC[C@H](CO)Nc1nc(S[C@@H](C)c2cccc(c2)C#N)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+O[C@H](CNC(=O)C1=CNC(=O)C=C1C(F)(F)F)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)C(F)(F)F)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.01
+Fc1ccc(cc1)C(=O)C2CCN(CC2)C(=O)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC(C(=O)O)c1cccc(c1)C(=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.12
+Nc1nccc(\C=C\c2ccc(Cl)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)C)C=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+OC(=O)c1cccnc1Nc2cccc(c2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CC1(C)COCc2sc(nc12)N3CCN(CC3)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+COc1cc2ncc(C(=O)N)c(Nc3cccc(F)c3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.82
+OCCN1CCN(Cc2ccc3c(NC(=O)CC45CC6CC(CC(C6)C4)C5)c(Cl)ccc3n2)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+O=C1CCOc2cc(OCc3cccc(c3)C#N)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Cc1nc(C)c(nc1C(=O)N)c2ccc([C@@H]3CC[C@H](CC(=O)O)CC3)c(F)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+Cn1cnc(c1Sc2ncnc3nc[nH]c23)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.19
+CC(C)(C)OC(=O)NCCCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCc4[nH]c5ncccc5c4C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.13
+Nc1scc2C(=NN(C(=O)c12)c3ccc(F)cc3)C(=O)NC4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+O[C@@H](CNCCc1ccc(NC[C@H](O)c2ccccc2)cc1)c3ccc(O)c(NC=O)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.02
+CCCC1CCCCC(=N1)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+NNC1=Nc2ccccc2NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.44
+Clc1c(NCC2CCNCC2)nccc1C(=O)NCC34CC5CC(CC(C5)C3)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+COCCOC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OC(C)C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)C(=O)CN(C)C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+COCC[C@H](Oc1ncnc2c1cnn2c3ccccc3Cl)C(=O)Nc4ccc(C)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+OC(=O)[C@H](N1CCC(CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)CC1)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+Cn1c(CN2CCN(CC2)c3cccc(Cl)c3)nc4ccccc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.75
+CCN1C(=O)C2=C(OC(=CC2=O)O)c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.13
+CN([C@@H]1CCN(Cc2ccc(cc2)C(F)(F)F)C[C@@H]1F)C(=O)Cc3ccc(cc3)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Cc1ccc(Oc2ccc(cc2)C(=O)NCc3ccncc3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+O[C@H](CNC(=O)C1=CNC(=O)c2ccccc12)CN3CCC(CC3)Oc4ccc(C#N)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+NC(=N)Nc1ccc(Cl)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.31
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4c(cccc34)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.34
+CCOC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)c2cccc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+FC(F)(F)c1cccc(c1)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4cccc(F)c4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+NCCCCN(Cc1nc2ccccc2[nH]1)C3CCCc4cccnc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.83
+CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(N3CCN(CC3)c4cnccn4)c(F)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.49
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4cccc(c4)C#N)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+CCN(CC)CCOCCOC(=O)C1(CCCC1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+Fc1cccc(COc2ccc3C(=O)CCOc3c2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Fc1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NCC#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+Fc1ccc(Nc2oc(nn2)C(=O)Nc3ccc(nc3)N4CCOCC4)cc1F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Cc1c(Sc2ccc(Cl)cc2)c3cc(ccc3n1CC(=O)O)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+FC(F)(F)c1cc(COCC(N2CCNCC2)c3ccccc3)cc(c1)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COc1cc2ncnc(Nc3cccc(C)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+C[C@H](NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+CN1C(=O)N(CCCCC(=O)C)C(=O)c2c1ncn2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.22
+C[C@H]1CN(Cc2cc(Cl)ccc2CC(=O)O)CCN1S(=O)(=O)Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.12
+C(Nc1nc2ccccc2[nH]1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.76
+CS(=O)(=O)N1CCOc2cc(COc3ccccc3)cnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+OCCOCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.08
+COc1ccc(CN(CCN(C)C)c2ccccn2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.39
+OC(=O)c1ccc(CN2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+OC[C@H]1CCCN1CCCOc2ccc3c(Nc4cc(CC(=O)Nc5cccc(F)c5F)[nH]n4)ncnc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+FC1(CCN(CC1)C(=O)COCc2ccncc2)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.03
+COc1cnccc1COc2cnc(nc2)N3CCN(CC3)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+NC(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CN(C)CCNC(=O)c1c(C)[nH]c(\C=C\2/C(=O)Nc3ccc(F)cc23)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+Fc1ccc(Nc2oc(nn2)C(=O)Nc3ccc(nc3)N4CCOCC4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CN([C@H]1CC[C@@]2(CCCO2)C[C@@H]1N3CCCC3)C(=O)Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+Cc1[nH]c(C(=O)NC2CCN(CC2)c3cc(cc(Cl)n3)C(=O)O)c(Cl)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+COc1ccc(cc1)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+Cc1cc(C)cc(c1)c2[nH]c3ccc(cc3c2CCNCCCCc4ccncc4)C(C)(C)C(=O)N5C6CCC5CC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+C[C@H]([C@H](O)c1ccc(O)cc1)N2CCC(O)(CC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+CCCSc1nc(ccc1C(=O)NC2CCCCC2)N3CCC[C@H](CC(=O)O)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+NC(=O)Nc1sc(cc1C(=O)N[C@H]2CCCNC2)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.76
+CCCSc1nc(ccc1C(=O)NC2CCCCC2)N3CCCCC3C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.36
+Oc1ccc(cc1)C(c2ccc(O)cc2)C(Cl)(Cl)Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.86
+CNc1c(Br)cnc2[nH]c(nc12)c3ccc(OCCCN4CCOCC4)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+CSc1ccc(OCc2ccccc2)c(\C=C\c3ccc(cn3)C(=O)O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.45
+CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(C)cc(C)cc3C)C(=O)O)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.52
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6cc(cn6C)S(=O)(=O)C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+CCCc1c(O)c(ccc1OCc2ccc(\C=C\c3nn[nH]n3)cc2)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+C1CN=C(N1)c2ccc3ccccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CCCNCc1cnc(s1)c2ccc(cc2)C(=O)Nc3ccccc3N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+COC(=O)CCn1cc(c2cc(NC3CC3)n4ncc(C#N)c4n2)c5cc(NC(=O)C)ccc15,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.72
+CC(C#Cc1ccccc1)N2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+CC1=CC(=O)Oc2cc3NCCCc3cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+OC(=O)COc1ccc(cc1c2cccc(c2)C#N)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.05
+CNc1nc(C)c(s1)c2nc(Nc3cccc(c3)N4CCCNCC4)ncc2C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.64
+O[C@@H](CNCCCSCCOCCc1ccccc1)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C(=O)N)n4ccc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+C\N=C(/S)\n1nc(nc1N)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.12
+CC1=C(CCC(=O)O)C(=O)Oc2c(C)c(O)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.3
+CC(Cc1ccccc1)N(C)CC#C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+C[C@H](NC(=O)c1c(C)nn(C2CCOCC2)c1NS(=O)(=O)c3ccc(C)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.5
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)NCc3ccccc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.57
+Cc1c(CC(=O)O)c2cc(F)ccc2n1S(=O)(=O)c3ccc(cc3)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.44
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(C1)S(=O)(=O)c2ccccc2)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CCCN(CCC)CCc1cccc2NC(=O)Cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.76
+CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4cccnc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+Clc1ccc(cc1C(=O)NCCc2ccccc2)N3N=CC(=O)NC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.74
+Cc1ccc2c(c1)c([S+]([O-])c3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.05
+CCN(CC)C(=O)c1ccc(cc1)C(=C2CCNCC2)c3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+OC(=O)[C@H](Cc1cccc(c1)C#N)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+COc1ccccc1C(=O)Nc2nc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CNc1ncc(s1)C(=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+COc1cc2ncnc(Nc3ccccc3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+CN1CCN(CC1)c2ccc(Nc3ccnc4ccccc34)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+CNC[C@H](O)c1ccc(Cl)c(c1)C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.41
+OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+COc1ccc(CNC(=O)CSc2nc3cccnc3s2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+C[C@@H](NC(=O)C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+CC1=CN([C@H]2CCCN(Cc3ccc(C(=O)O)c(Oc4cccc(C)c4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.82
+CCCc1c(O)c(O)c(C(=O)O)c2cc(Cc3ccccc3)c(C)cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CS(=O)(=O)Nc1cccc(NC(=O)CN2CCN([C@H](Cc3ccccc3)C2)C(=O)C[C@H](N)Cc4ccc(F)c(F)c4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+O=S1NC(=NO1)Cc2ccc3ccccc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+O=C(N1CCN(CC1)c2ccccn2)c3cccc(CC4=NNC(=O)c5ccccc45)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+COc1cnc(nc1N(C)c2ccccc2)c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+CS(=O)(=O)c1ccc(cc1Cl)[C@@H](C[C@H]2CCC(=O)C2)C(=O)Nc3cnccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.39
+Cc1nc(cs1)C(=O)N2CCOC3(CCN(Cc4ccc(Cl)cc4)CC3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+CN(C(=O)N1CCC(CC1)N2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)S(=O)(=O)c4ccc(C)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.49
+Cc1ccnc(NCc2ccccc2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.08
+CN1C=CNC1=S,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.42
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN4CCC[C@@H]4C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.58
+CS(=O)(=O)c1cccc(Nc2nccc(Nc3c(Cl)ccc4ccoc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(cc2)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.5
+CCN(C1CCN(CCC(C2CCN(Cc3ccccc3)CC2)c4ccccc4)CC1)C(=O)Cc5ccc(cc5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+CN(C)C(=O)CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Clc1cccc(c1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.62
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4c(C)cccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CS(=O)(=O)c1ccc(nc1)c2nnc(\C=C\c3oc(nn3)c4ccc(cc4)C#N)n2c5ccccc5Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+Oc1ccc(cc1)C2=Cc3cc(O)ccc3OC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CN1C(=O)CN=C(c2ccccc2F)c3cc(ccc13)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CCN1CCN(CC(=O)Nc2ccc(c3cccc4C(=O)C=C(Oc34)N5CCOCC5)c6sc7ccccc7c26)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+COc1ccc(CNCc2ccc(cc2)c3cc(C(=O)N)c(NC(=O)N)s3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(F)cc3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.62
+COc1ccc2C(=NC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.29
+COC(=O)C1C(CC2CCC1N2C)OC(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.06
+Cc1nc2ccc(NC(=O)CCNC(=O)N)cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+O[C@H](CNC(=O)c1c[nH]c2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.91
+C[C@H](CO)Nc1nc(SCc2occc2)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+Clc1ccc(CNc2nc(nc3ncccc23)N4CCN(CC4)C(=O)[C@@H]5CCCN5)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+O=C(CN1CCN(CC1)c2ccccc2)Nc3c(cnn3c4ccccc4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+Cc1ncc([N+](=O)[O-])n1CCO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.11
+COCCN1CCN(CC(=O)Nc2ccc(C3=CC=CN4C(=O)C=C(N=C34)N5CCOCC5)c6sc7ccccc7c26)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CNS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+OC1(CN2CCC1CC2)c3ccc(cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+Oc1nnc(Cc2cccc(c2)C(=O)N3CCOCC3)c4ccccc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+C[C@H](Nc1ncc(Br)c(Nc2cc(C)[nH]n2)n1)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+CN(C1CCCCC1)C(=O)c2cnn(c2NS(=O)(=O)c3ccc(C)cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CSc1ncccc1C(=O)NCc2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+CNCC[C@@H](Oc1cc(ccc1C#N)C(F)(F)F)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+CCC(C)Nc1nc(nc(N2CCOCC2)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+C1Cc2ccccc2CN1c3ccncc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+CC(N)(COP(=O)(O)O)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+Oc1ccc(Cl)cc1C(=O)Nc2ccc(F)cc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CN(C)C(=O)N[C@@H]1CC[C@@H](CCN2[C@@H]3CC[C@H]2C[C@H](C3)Oc4cccc(c4)C(=O)N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.12
+C[C@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)C2CCCCC2)c3ccccc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+NC(=O)c1cnc(N[C@H]2CCCNC2)c3cc(sc13)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4ccc(NC(=O)OC)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.01
+Cc1ccccc1CCOCCCS(=O)(=O)CCNCCc2ccc(O)c3nc(O)sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.84
+CCN(C)C(=O)c1ccc(cc1)[C@@H](N2CCN(Cc3cccnc3)CC2)c4cccc(NC(=O)C5CCC5)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+CC(C)CN1C(=O)N(C)C(=O)c2cn(Cc3cccc4ccccc34)cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.41
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)c4onc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+C[C@H](O)C(=O)N1CCN(Cc2sc3c(nc(nc3c2C)c4cnc(N)nc4)N5CCOCC5)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+Oc1ccc(cc1)C2=Cc3ccccc3OC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1cc(OC)c2nc(C)c3CCN(c4ccc(O)cc4)c3c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1ccccc1N2CCN(CC3=C(Br)C(=O)N(N3C)c4ccccc4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(ccc4C)C(=O)Nc5ccon5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.87
+O[C@@H](CNCCSCCCNCCc1cccc(Cl)c1)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.98
+CCc1[nH]c2nc(Sc3cnc4ccc[n+]([O-])c4c3)nc(N5CC[C@@H](N)C5)c2c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+OC1(C(=O)Nc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+NC(=O)c1ccccc1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.09
+OCC(CO)NC(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.61
+CC(C)Oc1cc(OCCN2CCOCC2)cc3ncnc(Nc4c(Cl)ccc5OCOc45)c13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.68
+Brc1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+NC(Cc1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.32
+CCOC(=O)c1ccc(OC(=O)CCCCCN=C(N)N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+COc1ccc2c(c1)[nH]c3c(C)nccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Cc1cc(ccc1O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+OCCNCCNc1ccc2c(NC(=O)CC34CC5CC(CC(C5)C3)C4)cccc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+Clc1cccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+COc1ccccc1CNCCc2cccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+Cn1ncc(Cl)c1c2cc(sc2Cl)C(=O)N[C@H](CN)Cc3cccc(F)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+Nc1nc(O)c2ncn(COCCO)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.42
+CN(C)C(=O)N[C@@H]1CC[C@@H](CCN2CCN(CC2)c3cccc(Cl)c3Cl)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+O[C@H](CNC(=O)c1c[nH]nc1C(F)(F)F)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.34
+Cc1ccc(COC(=O)N2CC[C@H](CNc3ncccn3)[C@H](F)C2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+Clc1ccc2C(=O)C3=C(Nc2c1)C(=O)NN(Cc4ccncc4)C3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.16
+C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.87
+CS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4CCOc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CS(=O)(=O)c1ccc(s1)C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+COc1cccc(c1)S(=O)(=O)c2c(C)n(CC(=O)O)c3ccc(C)cc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.42
+Clc1ccc2C(=C3CCNCC3)c4ncccc4CCc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.48
+OC(=O)CCCCn1nnc(n1)c2ccc(cc2)C(=O)N3CCC(CC3)N4CCC(CC4)Oc5ccc(Cl)c(Cl)c5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4nc5ccncc5s4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+O=C(C1CCN(CC1)c2nnc(s2)n3cccc3)N4CCN(Cc5ccc6OCOc6c5)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CCN1CCOC(C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+O=C1COC2(CCN(CC2)S(=O)(=O)c3ccc(cc3)c4ccc5cccnc5c4)CN1C6CC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+COc1cc2c(Nc3ccc(Br)cc3F)ncnc2cc1OC[C@@H]4CCCN(C)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+NC(=N)NC(=O)c1nc(Cl)c(NCc2ccncc2)nc1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.51
+Oc1ccccc1OCC(=O)NC2CCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.31
+Clc1ccc(cc1C(=O)NCC23CC4CC(CC(C4)C2)C3)C5CCNCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.58
+CCC[C@@H](CNC(=O)c1nc(Cl)c(N)nc1N)[N+](C)(C)CCCc2ccc(OC)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+Oc1ccc(cc1)c2oc3cc(O)ccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+NC(=O)c1sc(cc1NS(=O)(=O)c2ccc(cc2)C(F)(F)F)c3ccsc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+Clc1ccc(N2CCN(CC2)C(=O)COCc3ccncc3)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)c5oncc5)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+CS(=O)(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.51
+CCOC(=O)N1CCN(CC1)C(=O)[C@H](Cc2cccc(c2)C(=N)N)NS(=O)(=O)c3c(cc(cc3C(C)C)C(C)C)C(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.67
+CNC1=Nc2ncccc2C(=NC1c3cccs3)c4cc[nH]c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.73
+CC1(C)CC(=O)c2c(N)c3ccccc3nc2C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+C[C@H]1O[C@H]([C@H](O)[C@H]1Cl)n2cnc3c(N)nc(OCC4CC45CC5)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.68
+CC(C)Oc1cc(Nc2nc(N[C@@H](C)c3ccc(F)cn3)nc(OC(CO)CO)c2Cl)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+CCS(=O)(=O)c1ccc(c(F)c1)c2cc(Cl)ccc2OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.92
+C[S+]([O-])CCN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+Clc1c(ccnc1N2CCNCC2)C(=O)NCC34CC5CC(CC(C5)C3)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+COc1ccc(cc1OC)N2CCN([C@H](C)C2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+O[C@H](CNC(=O)C1=CNC(=O)c2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+Nc1cc(cc(c1)C(F)(F)F)C(=O)Nc2cccc(c2)c3nnn[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+CCN(CC)C(=O)c1ccc(cc1)C(=C2CCNCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N(C)C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.51
+Fc1ccc(cc1)C(=O)N2CCC[C@@H](C2)c3onc(n3)c4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.73
+CC(C)c1c(O)c(O)c(C=O)c2c(O)c(c(C)cc12)c3c(C)cc4c(C(C)C)c(O)c(O)c(C=O)c4c3O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+CN(CCCOCCOCCc1ccccc1)CCc2ccc(O)c3nc(O)sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.44
+CCn1cc(NC(=O)Cc2ccc(Oc3ccnc4ccc(F)cc34)cc2OC)cn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.88
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)NCc3ccc[n+]([O-])c3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.48
+OC(=O)c1ccc2c(c1)nc(Nc3cccc(c3)C#C)c4ncncc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.92
+CCS(=O)(=O)c1ccc(Oc2cc3nc([nH]c3cc2CN4C(=O)CCC4=O)c5ccccn5)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Oc1ccc(CCNCCCS(=O)(=O)NCCSCCc2ccccc2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+Clc1ccc(cc1C(=O)NCC23CC4CC(CC(C4)C2)C3)N5N=CC(=O)NC5=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+Cc1ccccc1C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+CNC(=O)c1nc(cnc1N)c2ccc(Cl)c(c2)S(=O)(=O)Nc3cccc(F)c3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+O=C(Nc1nccs1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+Fc1ccc(cc1Cl)C(=O)Nc2ccc(Cl)nc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.64
+CC(C)CN1C(=O)N(C)C(=O)c2c(SC3CCCCC3)c(Cc4ccccc4C(F)(F)F)sc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.14
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCNCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CC(C)NC(=O)NS(=O)(=O)c1cnccc1Nc2cccc(C)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.3
+OC(=O)c1cncc(c1)c2cnc3[nH]c(cc3c2n4ccc(n4)C(F)(F)F)C(=O)NC5CC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.98
+NC(=O)c1sc(cc1N)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN1C(=O)N(Cc2ccc(Br)cc2)c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+Nc1nc2cc3CCN(Cc4cccc(F)c4)CCc3cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+COc1ccc(Cl)cc1C(=O)Nc2nc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.05
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c3C1=O)c6nc(cn6C)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+CN(CCN(C)C(=O)CCOCCc1ccccc1)CCc2ccc(O)c3nc(O)sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.59
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC4CCN(CC4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.82
+CC1(C)C(=O)Nc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CNS(=O)(=O)CCc1ccc2[nH]cc(C3CCN(C)CC3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.48
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3cc(C)nc4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+C1CN(CCO1)c2cc(Nc3nccc(Nc4cccc5[nH]ncc45)n3)cc(c2)N6CCOCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+CC(C)(C)CNc1nc(nc(N2CCOCC2)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.08
+O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N3CCC[C@H]3CNc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Fc1ccc(cc1)C(=O)N2CCC(CC2)C(=O)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.49
+OC(=O)COc1ccc(Cl)cc1CN2CCN(CC2)S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.49
+Nc1[nH]nc2cccc(Cl)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N2CCC3(CC2)CN(c4ccccc34)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+C[C@H]1C[C@H](CN1C#N)NS(=O)(=O)c2cc(Br)ccc2Br,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.13
+CC(C)(C)NC(=O)Nc1ccc(cc1)c2c(N)nc(N)nc2COCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.09
+COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c3ccoc3Cl)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+C[C@H](Nc1nc(Nc2cc(C)[nH]n2)cnc1C#N)c3ccc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+CC(=O)Nc1ccc2ccn(c3cc(NC4CC4)n5ncc(C#N)c5n3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+CCN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6cncn6C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+CCCNC[C@H](O)COc1ccccc1C(=O)CCc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+Fc1ccc(Oc2cc(F)c(cc2F)S(=O)(=O)Nc3ncc(Cl)s3)c(c1)c4cn[nH]c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CC1=CN([C@H]2CCCN(C2)[C@H](CC3CCOCC3)c4ccc(C(=O)O)c(Oc5cccc(Cl)c5)c4)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.25
+CC(=O)Nc1nc(cs1)c2cccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+O=C1N(Cc2ccccc12)C3CCN(CCC(c4ccccc4)c5ccccc5)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C(=O)O)n4nc(cc4C)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.88
+OC(=O)[C@H](Cc1ccccc1F)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.58
+COc1cc2cc(nc(C)c2cc1OC)c3ccc(O)cc3O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+Cc1cc(NC(=O)Nc2ccc(Cl)cc2)n(n1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.15
+[O-][N+](=O)c1cccc(c1)c2ccc(OCC(CCc3ccc(cc3)C(=O)N4CCCC4)N5C(=O)CCCC5=O)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.31
+Oc1ccc(cc1)C2=Cc3cccc(O)c3OC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+OC(=O)Cc1cccc(c1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.58
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)N4CCN(CC4)C(=O)CO)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+Cc1ccc(cc1)S(=O)(=O)Nc2c(cnn2c3ccccc3)C(=O)NC4CCCCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+Cn1cncc1c2c3C(=O)N(C4CC4)C(=O)N(CC5CC5)c3nn2Cc6ccnc7ccc(Cl)cc67,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.53
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4cccc(F)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CC(C)[C@H](NC(=O)CCc1ccccc1)C(=O)N2CCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+COc1ccccc1C(=O)Nc2nc3ccccc3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.61
+COc1ccc(cc1)c2csc(n2)N(CCCN3CCOCC3)C(=O)c4occc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.34
+O=C1CCCc2nc(ccc12)C#Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.53
+C(CCNc1cc(nc2ccccc12)c3ccccc3)CNc4cc(nc5ccccc45)c6ccccc6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+CCCSc1nc(N[C@@H]2C[C@H]2c3ccccc3)c4nnn([C@@H]5C[C@H](CO)[C@@H](O)[C@H]5O)c4n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.99
+NC(=O)c1cccc(C[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.19
+OC(CN1CCCCC1)(C(=O)c2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.41
+CCc1ccc(CCNCCCSCCNC[C@H](O)c2ccc(O)c3NC(=O)Sc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.86
+CN1CCN(CC1)S(=O)(=O)c2ccc(c(C)c2)c3cnc(N)c(n3)C(=O)Nc4cccnc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+C[C@H](O)C(=O)N1CCN(CC1)c2ccc(Nc3nccc(n3)c4cnc(C)n4C(C)C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+CN(C)c1nc(nc(n1)N(C)C)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.44
+COC(=O)c1ccc(NC(=O)c2cc(OC)c(OC)c(OC)c2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+OC1=NC(=O)CN1N=Cc2oc(cc2)c3ccc(cc3)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.35
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(CCCN4CCCC4)c5ccc(Cl)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+O=C(CS(=O)(=O)c1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)cc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+COc1cccc(NC(=O)CC23CC4CC(CC(C4)C2)C3)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.21
+O=C(Cc1ccccc1)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+O=C(Nc1cccc2cccnc12)[C@@H]3CC[C@H](CC3)N4C(=O)[C@@H]5[C@@H]6CC[C@@H](C6)[C@@H]5C4=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.94
+O=C(Cc1cccc2ccccc12)Nc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+CNC1(C)C2CCC(C2)C1(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.84
+N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc3cc(F)c(F)cc3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.31
+CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.46
+C[C@H](CO)Nc1nc(SCc2csc(C)n2)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.73
+COc1cc(cc(OC)c1OC)C(=O)N2CC[C@@](CCN3CCC(CC3)(C(=O)N)c4ccccc4)(C2)c5ccc(Cl)c(Cl)c5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.23
+C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc5cscn5)c3)c12)C(=O)N6CCOCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+O=S(=O)(Nc1cccnc1)c2cccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.54
+Brc1ccc(cc1)C(=O)Cn2cnc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CCCc1nc2c(N)nc3ccccc3c2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.09
+OC(=O)C1Cc2c([nH]c3ccccc23)C(N1)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+COc1cc(CNc2nc3ccccc3[nH]2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+OC1=C(C(=O)Nc2cc(Cl)ccc12)c3cccc(Oc4ccccc4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+CCn1c2ccccc2c3cc(NC(=O)C(C)C)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+COc1ccc(CNC(=O)N(CC=C)C2CCN(CCC(c3ccccc3)c4ccccc4)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OC[C@@H]4CCCN(C)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CN(c1cccc(CO)c1)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+C[C@H](CO)Nc1nc(SCc2csc(C)n2)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.73
+Cn1nnc(n1)c2ccc(cn2)c3ccc(cc3F)N4C[C@H](COc5ccon5)OC4=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.24
+CS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4OCOc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+NC(=O)c1cnc(N[C@H]2CCCNC2)c3cc(sc13)c4ccc(F)cc4F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+CCN(C(=O)c1oc(cc1)c2ccc(Cl)cc2)c3ccc(cc3)N4CCNCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+O=C(CCN1CCCCC1)Nc2ccc(C3=CC=CN4C(=O)C=C(N=C34)N5CCOCC5)c6sc7ccccc7c26,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Cc1ccc(cc1)S(=O)(=O)N2CCN(CC2)C(=O)c3occc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+CC(C)(C)OC(=O)N1CCN(CC1)c2ncc(OCc3ccncc3F)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+Cc1ccc(CN2C(=O)CCSc3ccc(Cl)cc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CC(C)C(NC(=O)CN1C(=O)c2nc(O)nc(O)c2C=C1c3ccccc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.88
+NC(=O)c1cccc(C[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.11
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3c(C)n[nH]c3C)c2C(=O)N4C[C@H](O)CO4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.07
+O=C1N(C(=Nc2c1cnn2c3ccccc3)c4occc4)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+Clc1ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)C4=CNC(=O)c5ccccc45)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.51
+COc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+Nc1ncnc2c1nc(Sc3nc4cccc(Cl)c4s3)n2CCO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+COc1cc2ncnc(Nc3cc(NC(=O)c4cccc(c4)N5CCOCC5)ccc3C)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+Cc1ccccc1C(=O)N2CCN(CC2)c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+OC(=O)[C@H](Cc1ccc(F)cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)cc4Cl)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+COc1ccc(c(OC)c1)c2cncc(CNC3CCCC3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+COC1CCN(CC1)C(=O)C2CCN(CCc3c([nH]c4sc(cc34)C(C)(C)C(=O)N5C6CCC5CC6)c7cc(C)cc(C)c7)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.09
+C1NCC(CC=C1)c2oc3ccccc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+O[C@H](CNC(=O)C1=CC(=O)Nc2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.48
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1C(C)C)NC(=O)OCc2ccccc2)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+CCN(CC)C(=O)c1ccc(cc1)[C@@H](N2CCN(CCOC)CC2)c3cccc(NC(=O)C4CC4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+CN(C)CCCNS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4ccccn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+Cc1nc2ncnn2c(O)c1CCOC(=O)c3c(F)cccc3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.16
+COc1ccc(F)c(F)c1C(=O)c2cnc(NC3CCN(CC3)S(=O)(=O)C)nc2N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+NC(=O)c1cccc(N[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.01
+Clc1ccc(cc1)c2cn3ccccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+CCN1C(=O)NC(C1=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CN1CCC(CC1)Oc2nccc(Nc3cc(NC(=O)c4ccnc(c4)N5CCOCC5)ccc3C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+Nc1nc(NCc2ccccc2)nc3c1nc(O)n3Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.69
+CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cccc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.44
+Cc1nc(C)c(nc1C(=O)N)c2ccc([C@@H]3CC[C@H](CC(=O)O)CC3)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c3ccccc3)cc(c1)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(=O)O)cc1)c4oc5ccccc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+Cc1cccc(c1)C(=O)N2CCC(CC2)C(=O)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Clc1ccc(cc1Cl)[C@@H]2CNCC=CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+COC(=O)c1ccc(CN2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.17
+CCN(CC)c1ncnc2c1ncn2Cc3c(Cl)cccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.25
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CC6CNCC(C5)O6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CCCS(=O)(=O)N1N=Cc2cc(Cl)ccc2B1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.4
+CNc1ccc2ncc(c3cccc(O)c3)n2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+CC(=O)Nc1cccc(Nc2nc(NC3CC3)n4ncc(C#N)c4n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CN1CCN(CC1)C(=O)c2cc(CC3=NNC(=O)c4ccccc34)ccc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.03
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(N)cnc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4c3n2)c5c(F)cccc5F)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.58
+Cc1cc(CN2Cc3ccccc3C2C(=O)Nc4ccc(Cl)cc4Cl)ccc1OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.62
+CCO\N=C(\C1CCN(CC1)C2(C)CCN(CC2)C(=O)c3c(C)cc[n+]([O-])c3C)/c4ccc(Br)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)N)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+CCOc1ccc(cc1)N2C(=O)c3cccnc3N=C2[C@@H](C)N(Cc4cccnc4)C(=O)Cc5ccc(OC(F)(F)F)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+COc1cc2nc(Nc3ccc(cc3)[C@@H](C)NC(=O)C)ncc2cc1c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.11
+O=C(Nc1nccs1)[C@H](CC2CCOCC2)c3ccc(cc3)S(=O)(=O)C4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+Cc1cccc(NS(=O)(=O)c2cccc3nonc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CCOc1cc2nnc(C(=O)N)c(Nc3cc(C)ccc3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.02
+O=S(=O)(Nc1ccccc1c2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.96
+CC1=C(C)C(=O)C(=C(C)C1=O)C(CCCCCC(=O)O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+Cc1c(Cl)ccc(OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)C=C3C(F)(F)F)CC2)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4ccc(N)nn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2cc(Cl)ccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+Fc1ccc(cc1)C(NC(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2)C5=CNC(=O)C=C5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+CCS(=O)(=O)c1ccc(c(C)c1)c2cc(ccc2OCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.45
+CC(N1NC(=O)C2=C(C1=O)C(=O)c3ccc(Cl)cc3N2)c4oc5ccccc5c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Cc1cc(CNc2nccc(Nc3cc(C)[nH]n3)n2)on1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+CCCC(=O)Nc1ccc2c3ccccc3C(=O)C(=O)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+CC(C)(O)c1ccccc1CC[C@@H](SCC2(CC(=O)O)CC2)c3cccc(\C=C\c4ccc5ccc(Cl)cc5n4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+Clc1ccc(Nc2nnc(Cc3ccncc3)c4ccccc24)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+Nc1ccc(cc1)S(=O)(=O)c2ccc(N)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.88
+COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+Cc1nc(C)c(nc1C(=O)N)c2ccc(cc2)[C@@H]3CC[C@@H](CCC(=O)O)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+NC(=O)Cc1ccccc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.3
+CC(=O)O[C@H]1CC[C@]2(C=O)[C@H]3CC[C@]4(C)[C@H](CC[C@]4(O)[C@@H]3CC[C@]2(O)C1)C5=CC(=O)OC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.64
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN4CCC[C@H]4C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.58
+CC(C)NNC(=O)c1ccncc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.33
+NC(=O)Nc1sc(cc1C(=O)N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+Nc1ccc(N=Nc2ccccc2)c(N)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CCCSc1nc(NC)ccc1C(=O)N[C@@H]2C3CC4CC2C[C@@](O)(C4)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+Oc1ccc(cc1)c2oc3c(cc(O)cc3n2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+OC(=O)[C@H](Cc1ccc(cc1)C#CCCNc2ccccn2)NC(=O)c3c(Cl)cccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.27
+O=C1CCOc2nc(ccc12)C#CC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+Cc1ccc(cc1)N2NC(=O)c3cccnc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+COc1ccc(cc1)C(=O)N2CCCC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.93
+CNCc1ccc(cc1)c2[nH]c3cc(F)cc4C(=O)NCCc2c34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.17
+Oc1ccc2C[C@H]3N(CC4CC4)CC[C@@]56[C@@H](Oc1c25)c7[nH]c8[C@@H]9Oc%10c(O)ccc%11C[C@H]%12N(CC%13CC%13)CC[C@@]9(c%10%11)[C@@]%12(O)Cc8c7C[C@@]36O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.41
+Clc1cccc2[nH]ncc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+Brc1ccccc1NC(=O)Nc2ccc(C#N)c3[nH]nnc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.64
+Nc1ccc(Cl)c(c1)c2oc3cccnc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+C[C@@H]1CN(Cc2ccc(F)cc2)CCN1C(=O)COc3ccc(Cl)cc3NC(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C#N)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.62
+O[C@@H]1CCN(C1)c2ccc3c(NC(=O)CNc4cccc(c4)C#N)c(Cl)ccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4nc5CCOCc5s4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.42
+Fc1ccc(CC2=NNC(=O)c3ccccc23)cc1C(=O)N4CCN(CC4)c5ccccn5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+Cc1ccc(cc1)C(=O)Oc2ccc(cc2OC(=O)c3ccc(C)cc3)C(O)CNC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.57
+CCCCC(CC)CNC(=O)c1ccc2c(c1)c(Cc3ccc(cc3OC)C(=O)NS(=O)(=O)c4ccccc4C)cn2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.66
+CCN(C1CCN(CCC(c2ccccc2)c3ccc(cc3)S(=O)(=O)C)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.73
+C[C@H](NC(=O)c1c(C)nn(C2CCS(=O)(=O)CC2)c1NS(=O)(=O)c3ccc(C)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.25
+COCCOc1nc(N)c2NC(=O)N(Cc3ccccc3)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+CC(C)N(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+NC(=O)c1cc(C(=O)N)n(n1)c2cccc(c2)c3cc(ccc3C(F)(F)F)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CS(=O)(=O)Nc1cc(Nc2nccc(Nc3c(Cl)ccc4OCOc34)n2)cc(c1)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.28
+Oc1cc(cc(c1)C(F)(F)F)C(=O)Nc2cccc(c2)c3nnn[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+N#Cc1cccc(c1)c2cccc(c2)c3nn[nH]n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+COc1ccc(CC(C)(C)NC[C@H](O)c2cc(O)cc3NC(=O)COc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.79
+NC1(CCC1)c2ccc(cc2)c3ncc4cnccc4c3c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Fc1ccccc1C(=O)Nc2c(cnn2c3ccccc3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+CC1=CC(=O)Nc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+C[C@H](Cc1cccc(CC(=O)NC23CC4CC(CC(C4)C2)C3)c1)NC[C@H](O)c5ccc(O)c(CO)c5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Oc1ccc(cc1)c2ccc(cc2)C3(O)CN4CCC3CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.95
+CNC(=O)c1snnc1c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.23
+CC(C)(C)NC(=O)Nc1cccc(CN2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+CN1CCN(CC1)c2nc(NCCNc3ccc(cc3)[N+](=O)[O-])c4ccccc4n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.91
+OC(=O)CSCC(=O)Nc1nc(cs1)c2ccc(F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.2
+OC(=O)[C@H](Cc1ccc(OCCNc2ccccn2)cc1)NC(=O)c3c(Cl)cccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.48
+CC(C)(C)OC(=O)N1CCC(CC1)c2ncc(OCc3ccc(cc3)S(=O)(=O)C)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(C)CN1C(=O)NC(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N4CCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+Nc1ncnc2c1c(COc3cccc(Cl)c3)nn2C4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+O=C(COCc1ccccc1)Nc2ccc3c(c2)C(=O)C(=O)c4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+OCc1ccc2ccn(c3cc(NC4CC4)n5ncc(C#N)c5n3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.09
+CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.96
+NC1(CCC1)c2ccc(cc2)c3c(ccc4ccnn34)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccoc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.37
+COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c3occc3C)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.04
+CCCc1c(O)c(ccc1OCc2cccc(NC(=O)Cc3ccccc3C(=O)O)c2)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.95
+CC(C)OC(=O)N1CC2COCC(C1)C2Oc3ncnc(Oc4cccnc4C)c3C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3nccnc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+NC(=O)c1cnc(c2ccc(cc2)C3(N)CCC3)c(c1)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+C[C@H](CO)Nc1nc(SCc2ccccc2)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+NCC[C@@H](Oc1cc(Cl)c(F)cc1C#N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.77
+CN(c1ccnc(Nc2cc(OC3CCOCC3)cc(c2)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CC(C)(CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.83
+CC(C)(C)NS(=O)(=O)c1cncc(c1)c2ccc3nc(NC(=O)NCC(=O)N4CCCC4)nn3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.37
+O=C(Nc1ccccn1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+ON1C(=O)N(CC2COc3ccccc3O2)c4ccsc4C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.44
+S(c1ccccc1)c2ccc3ccccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.92
+FC(F)(F)c1cc(C(=O)Nc2cccc(c2)c3nnn[nH]3)c4nc[nH]c4c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+COC[C@H](C)Oc1cc(Oc2ccc(Cl)cc2)cc(c1)C(=O)Nc3ccc(cn3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+C[C@@H]1CN(CCN1C(=O)[C@@H]2CCCC[C@H]2C(=O)NC3(CC3)C#N)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+COc1ccc2N=CC(=O)N(CCN3CC[C@@H](NCc4cc5OCCOc5cn4)[C@H](O)C3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+COCCOCCOc1ccc(cc1)c2cc(C(=O)N)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+CCc1nc(N)nc(N)c1c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.31
+C[C@@H](C(=O)NCCN1CCCC1)c2ccc(OS(=O)(=O)C(F)(F)F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.64
+Nc1ccc(OCCc2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+OC(=O)CCc1ccc(OCc2cccc(Br)c2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.67
+Fc1cnc(NC(=O)C(CC2CCOCC2)c3ccc(cc3)S(=O)(=O)C4CC4)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)NC4CCN(C)CC4)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.13
+Oc1ccc2OC(=CC(=O)c2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2cccs2)NC(=O)OCC(F)(F)F)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+ONC(=O)C1COC(=N1)c2ccc(F)c(c2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.53
+CCCc1c(O)c(ccc1OCCCOc2ccc3C(=O)C=C(Oc3c2CCC)C(=O)O)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+NS(=O)(=O)c1ccc(Nc2nccc(n2)c3ccccc3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+CC(C)[N+](C)(CCOC(=O)C1c2ccccc2Oc3ccccc13)C(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+CCN(CC)CCNc1ncnc2c1sc3nc(N4CCOCC4)c5CCCCc5c23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC1CC(NC(=O)C)c2ccccc2N1C(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CCN(CCNCCc1ccc(O)c2NC(=O)Sc12)C(=O)CCOCCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+OCC(O)CN1CCN(CC1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+C[C@@H](CO)Oc1cc(Oc2ccc(cc2)S(=O)(=O)C)cc(c1)C(=O)Nc3nccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+COc1cc(OC)c(cc1NC(=O)Cc2ccnc(F)c2)S(=O)(=O)N3C(C)CCc4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+Cc1sc2ncnc(N3CCN(CC3)c4ncccn4)c2c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.66
+OC[C@H](O)CN1C(=O)[C@@H](Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+Nc1n[nH]c2nnc(c3ccccc3)c(c4ccccc4)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+O[C@@]1(CN2CCC1CC2)C#Cc3ccc(Oc4ccc(cc4)C(=O)NCc5ccncc5)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.31
+Oc1ccc(N2C(=O)c3ccc(O)cc3C2=O)c(F)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+C[C@H]1COCCN1c2cc(nc(n2)c3cccc4[nH]ccc34)C5(CC5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Cc1ccc(C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.01
+COc1ccc(CC(=O)NC(N\C(=N\C#N)\Nc2ccccc2C)C(C)(C)C)cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+CN1CC(c2ccc(Cl)cc2)c3ccccc3C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.64
+OC(=O)CSc1c[nH]c2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.31
+OC1=C(CC2=C(O)c3ccccc3OC2=O)C(=O)Oc4ccccc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.22
+C[C@@H](Oc1ccc(cc1C(=O)N2CCN(CC2)c3ncc(cc3F)C(F)(F)F)S(=O)(=O)C)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.49
+O=C(NCC#N)[C@@H]1CCCC[C@H]1C(=O)N2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3ccccc3Cl)C(=O)O)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.31
+Cc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4n12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.98
+COCCC(=O)N[C@@H](C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+COc1ccc(cc1OC2CCCC2)[C@@]3(CC[C@H](CC3)C(=O)O)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.76
+CCOc1ccccc1c2ccc(cc2)c3nc4ccc(F)cc4c(C(=O)NCCOCCN)c3C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+Cc1ccc(cc1c2cc(ccc2OCC(=O)O)C(F)(F)F)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.15
+CS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.91
+COCCNS(=O)(=O)c1ccc(cc1)c2cnc(N)c(n2)C(=O)Nc3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCCN(C2)C(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+Oc1c(NC(=O)Nc2cccc(F)c2Cl)ccc(Cl)c1S(=O)(=O)N3CCNCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CN1CCC(=CC1)c2cccc(O)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.53
+OC(=O)COc1ccc(C(=O)c2cccs2)c(Cl)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.84
+COCC1=C(N2[C@H](SC1)[C@H](NC(=O)\C(=N/OC)\c3csc(N)n3)C2=O)C(=O)OC(C)OC(=O)OC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.97
+CS(=O)(=O)c1ccc(cc1)C(CCNC(=O)c2ccc(cc2)C#N)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Cc1cccc2c(CCNCc3cccc(CCNC[C@H](O)c4ccc(O)c5NC(=O)Sc45)c3)c[nH]c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.13
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(CO)c(Oc4cccc(Cl)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+Nc1ncnc2c1ncn2[C@@H]3O[C@H](CSCCCNC(=O)Nc4ccccc4)[C@@H](O)[C@H]3O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+CCN(CC)CCOC(=O)C1(CCCCC1)C2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.72
+CC12NC(Cc3ccccc13)c4ccccc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+COc1ccc(cc1)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+C[C@@H]1CN([C@@H](CO1)c2ccccc2)c3ccc4OCC(=O)Nc4n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+CC(C)c1ccc2[nH]c3CCN(Cc3c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+Cc1nc2ccccn2c1c3ccnc(Nc4cccc(Cl)c4)n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+OC(=O)COc1ccc(Cl)cc1CN2CCN(CC2)S(=O)(=O)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+Oc1ccc(CCNCCCS(=O)(=O)NCCOCCSc2ccccc2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.84
+CCc1nc2ccc(cn2c1N(C)Cc3cccs3)C(=O)NCc4ccc5OCOc5c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+COCc1ccoc1C(=O)N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)c3ccc(OC)cc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.98
+CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(O)cc3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+COc1cc(F)ccc1c2cncc(CNC3CCC3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+Cc1cccc(Nc2ncnc3ccc(NC(=O)C=C)cc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+COc1cc2CC(CC3CCN(Cc4ccccc4)CC3)C(=O)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+CCN(CC)C(=O)c1ccc2[nH]c(c(CCNCCCCc3ccncc3)c2c1)c4cc(C)cc(C)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+Cc1cnc(Nc2ccc(OCCN3CCCC3)cc2)nc1Nc4cccc(c4)S(=O)(=O)NC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.11
+Nc1ncc(cc1c2oc3ccccc3n2)c4cnn(c4)C5CCNCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+Nc1cc(nc2c(cnn12)C#N)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+NS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+C[C@@H](N(c1cc(F)ccc1F)S(=O)(=O)c2ccc(Cl)cc2)c3ccc(F)cc3CCCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Cc1nc(CS(=O)(=O)c2ccccc2)cc(n1)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.07
+COc1ccc(cc1)[C@@H]2Sc3ccccc3N(CCN(C)C)C(=O)[C@@H]2OC(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+Cc1ccc(cc1)S(=O)(=O)N2N=Cc3ccccc3B2O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.05
+S=C(NC1CCCCC1)N2CCC(CC2)c3cnc[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+Nc1cc(nc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CN(C1CCN(Cc2ccc(nc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+COc1ccc(cc1)c2cc3c(N[C@H]4CCCNC4)ncc(C(=O)N)c3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.82
+C[N+]1(C)[C@@H]2C[C@H](C[C@H]1[C@@H]3O[C@H]23)OC(=O)C(O)(c4cccs4)c5cccs5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.25
+NC(=N)c1cc2c(cccc2s1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.27
+Clc1ccc(CN2C(=O)C(=O)c3ccccc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1ccccc1O[C@H]([C@@H]2CNCCO2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CCCNC(=O)c1nnc2c(cccc2c1N)c3ncccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+O[C@@H](CNCCc1ccc(CNCCc2c(Cl)cccc2Cl)cc1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CC1CN(CCN1Cc2cc(Cl)ccc2OCC(=O)O)S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.69
+Clc1ccc(cc1)C2CCN(CC2)C(=O)COCc3ccncc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+CC(O)(C(=O)Nc1ccc(cc1)S(=O)(=O)c2ccncc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2Cl)c3c1cc(cc3C(F)(F)F)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+OCCNS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+CN(c1ccnc(Nc2cc(nc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.44
+Clc1ccc(cc1)C(=O)N[C@H]2CN3CCC2CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CC1=C(OCc2ccc(F)cc2)C(=O)C=CO1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+Clc1ccc(cc1)C(=O)Cc2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+COc1nc(Br)cnc1NS(=O)(=O)c2cccc3c(cccc23)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+NC(=O)c1sc2nccc(Nc3ccccc3)c2c1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.91
+COc1ccccc1OCC(O)COC(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.36
+Clc1ccc2C(=O)NC(=Nc2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+Oc1cc(O)c2C(=O)c3ccccc3Oc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.39
+CCC(Oc1ccc(cc1c2ccc(cc2C)S(=O)(=O)CC)C(F)(F)F)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.31
+COC(=O)N1CCN([C@@H](CN2CCCC2)C1)C(=O)Cc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)S(=O)(=O)CCCN(C)C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.32
+CC1(C)CCC(CC1)NC(=O)[C@@H](N)CCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.27
+NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C3CC4CC3C=C4)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+Oc1ccc(Br)c2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+CNC(=O)c1ccc(cc1F)N2C(=S)N(C(=O)C23CCC3)c4ccc(C#N)c(c4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCCN(CCc3cccc(F)c3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+CCCC1=CC(=CC(=O)N1Cc2ccc(cc2)c3ccccc3c4nn[nH]n4)OCc5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4nccs4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+CCSc1ccc(cc1)c2cc(ccc2OCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.54
+COc1ccc(CN2C(=O)CCC2(C)C(=O)NC3CCCCC3)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.38
+O=C1C(=O)c2cc(ccc2c3ccccc13)c4ccsc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CN(C)CC(O)COc1ccc(Nc2nccc(Nc3cc(Cl)ccc3Cl)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CN(C)CCCNC(=O)c1nc(Cl)c(N)nc1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.0
+Cc1ccc(cc1)\C(=C/CN2CCCC2)\c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.88
+COc1cc(ccc1Nc2ncc(C#N)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CCCCC(CC)CNC(=O)c1cc(ccc1Cl)N2N=CC(=O)NC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+CN(C)C(=O)N[C@@H]1CC[C@@H](CCN2CCN(CC2)c3ccc(Cl)c(Cl)c3)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+Oc1c2ncc3ccccc3c2nn1c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+Cc1c(Sc2ccc(Cl)cc2)c3c(cccc3n1CC(=O)O)c4cnccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.03
+C(Oc1ccccc1)C2CNCCO2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+COc1ncc(C)cc1c2cccc3c(N)c(nnc23)C(=O)NC4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+OC(=O)COc1ccc(Cl)cc1CN2CCCN(CC2)S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.01
+O[C@@H](CNCCc1cccc(CNCCc2c(Cl)cccc2Cl)c1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C\2/C(=O)Nc3ccc(F)cc23)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+Clc1ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)NS(=O)(=O)c4ccccc4)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+O=C(N1CCOCC1)N2CCn3cc(C4=C(C(=O)NC4=O)c5cnc6ccccn56)c7cccc(C2)c37,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+CN1CCN(CCCOc2ccc(cc2)c3onc(c3)c4ccc(F)cc4)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.81
+N#Cc1nc(nc(n1)N2CCOCC2)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.51
+CNc1ccc(cc1)c2nc3ccc(O)cc3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CN1CCN(CC1)C(=O)c2cc3cc(F)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+Clc1ccc(cc1)C(=O)\C=C\Sc2nc[nH]n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+O=C1C2CCC(N2)C(=O)N1Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+CN1N=Nc2c(ncn2C1=O)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.08
+Fc1cc2[nH]cnc2cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+CC(=O)Nc1ccc(CNc2[nH]nc3cccc(Oc4ccc(F)cc4)c23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.28
+N[C@H](CNC(=O)c1cc2c(cccc2[nH]1)c3ccccc3Cc4ccccc4)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)NCc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.67
+CCCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+CCCc1c(cnn1c2ccccc2)C(=O)Nc3cc(C)on3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+O=C(CC1CCCCCC1)Nc2cccc3C(=O)N(C=Cc23)[C@H]4CCNC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.15
+OC(=O)c1cc(ccc1O)N=Nc2ccc(cc2)S(=O)(=O)Nc3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.58
+OC(=O)c1c(Sc2ccccc2)c3cc(Cl)ccc3n1Cc4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4ncc(CN5CCOCC5)s4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Cc1oc(cc1C(=O)Nc2cccc(c2)C(=O)O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.63
+CCN(CC)C(=O)c1ccc(cc1)C(=C2CCN(Cc3ccc(F)cc3)CC2)c4cccc5cccnc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.86
+CCN(CC)S(=O)(=O)c1ccc(NC(=O)C(C)(O)C(F)(F)F)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+COc1ccc2NC(=O)C(NC(=O)c3ccccc3OC)N=C(c4ccccc4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CC(CO)(CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+C[C@@H](Oc1ccc(SCCCCCc2ccccc2)cc1)C(=O)c3nc(C)c(CCCC(=O)O)s3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.58
+COC(=O)COc1ccc(OCCNCC(O)COc2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.54
+COc1ccnc(CSc2nc3ccccc3[nH]2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+Oc1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+Oc1c2C(=O)N(NC(=O)c2nc3cc(Cl)ccc13)C(C4CC4)c5ccccn5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3F)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Fc1ncccc1OC[C@@H]2CCN2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.2
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4ccccc4C#N)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+COc1ccc(cc1)c2nc3c(NCCCNC(=O)C)c(Br)cnc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.28
+COc1ccc(N(C(C(=O)NC2CCCC2)c3ccccc3F)C(=O)c4ccccc4)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.86
+Cc1ccnc(NCc2ccc(Cl)cc2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CCN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CCN(CCO)CCCOc1cc2ncnc(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+CCCc1c(O)c(ccc1OCc2ccc(cc2OC)c3nn[nH]n3)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Nc1nc(N)c(c(COCc2ccccc2)n1)c3ccc(NC(=O)C4CC4)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+O=C(N1CCOCC1)c2ccc(cc2)C(=C3CCN(Cc4cscn4)CC3)c5cccc6cccnc56,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+Clc1ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)NS(=O)(=O)Cc4ccccc4)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.13
+C[C@@H](Oc1nc(Nc2cc(C)[nH]n2)c(C)nc1C#N)c3ccc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.72
+O[C@]1(CN2CCC1CC2)C#Cc3ccc(Oc4ccc(cc4)C(=O)NCc5ccncc5)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+COc1cc(Nc2cc(Oc3cc(C)c(C)nc3c4ccccn4)ccn2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CSc1nc(C(=O)N)c(N)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.21
+COc1ccccc1CN(C(=O)C)c2cnccc2Oc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1cccc(CNc2nc(NC(C)C)nc3ccsc23)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+OCCN1C=Cc2c(NC(=O)Cc3ccc(Cl)c(c3)C(F)(F)F)cccc2C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.36
+C[C@H](NC(=O)c1c(C)nn(C2CCOCC2)c1NS(=O)(=O)c3ccc(cc3)C4CC4)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.23
+CCC(NC(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.14
+OC[C@@H](O)CN1C(=O)[C@H](Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+COc1ccc2N=CC(=O)N(CCN3CC[C@@H](NCc4ccc5OCC(=O)Nc5n4)[C@@H](O)C3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.37
+c1ccc2ncccc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.09
+C[C@H](NC1=NC(=O)[C@@](C)(S1)C(F)(F)F)c2ccccc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+C[C@@H](N)COc1c(C)cccc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CC1N=C(N)N=C(N)N1c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.8
+COc1cc2ncnc(Nc3cc(Cl)ccc3F)c2cc1OCCCN4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Cc1ccccc1N2C(=Nc3cccc(C)c3C2=O)Cn4cnc5c(N)ncnc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+COc1ccc2nc3ccccc3c(N)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4c(cccc34)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.27
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2ccccc12)c3ccsc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+Cc1oncc1C(=O)Nc2ccc(cc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+C[C@@H]1CN(C[C@H](C)O1)c2nc(N3CCOCC3)c4ccc(Nc5ccccc5)nc4n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.12
+OCC(=O)N1CCC(CC1)c2n[nH]c(c3ccc(Cl)cc3)c2c4ccncn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+COc1ccc(cc1OC)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+CNCc1cccc(c1)c2ccc3c(nc(nc3n2)N4C[C@@H](C)O[C@@H](C)C4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+COc1ccc(cc1)c2nc3c(OCC4CCNCC4)c(Br)cnc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.55
+COc1ccc(cc1)c2nc3c(NCCCNC(=O)c4ccccc4)c(Br)cnc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.25
+C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(OCC4CC(F)(F)C4(F)F)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.42
+O=C(NC1CC1)Nc2c[nH]nc2c3nc4cc(CN5CCOCC5)ccc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4ncc[nH]4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.01
+Nc1cc(ncn1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.56
+Clc1ccc2C(=O)C3=C(Nc2c1)C(=O)NN(Cc4cc5ccccc5s4)C3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+OC(=O)[C@H](Cc1ccc(OCCCNc2ccccn2)cc1)NC(=O)c3c(Cl)cccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.22
+CC(C)(C)OC(=O)N1CCN(CC1)c2cnc(OCc3ccc(cc3)S(=O)(=O)C)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CC(C)c1cc(C(=O)N2Cc3ccc(CN4CCN(C)CC4)cc3C2)c(O)cc1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+COC1(CCOCC1)c2cc(F)cc(OCc3ccc4N(C)C(=O)C=Cc4c3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.52
+Oc1ccc(CCNCCS(=O)(=O)CCCOCCNc2ccccc2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.98
+C[C@H](Nc1ncc(F)c(Nc2cc(C)[nH]n2)n1)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+COc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cc1OCCN(C)CCO)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+C(Nc1ncnc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+CC(N1C(=O)c2ccccc2C1=O)C(=O)N3CCc4ccccc4C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+Nc1ccc(cc1)C2(CCCCC2)c3ccc(N)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CS(=O)(=O)c1ccc(cc1)[C@@H](CC2CCCC2)C(=O)Nc3nccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.86
+CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C\2/C(=O)Nc3ccc(Cl)cc23)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+CC(C)(C)OC(=O)N1CCC(CC1)OCc2onc(n2)c3ccncc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+C[C@@](O)(C(=O)Nc1ccc(cc1Cl)S(=O)(=O)C)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+Clc1ccc2nsnc2c1NC3=NCCN3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.71
+CCS(=O)(=O)Nc1cccc2c1c(Oc3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.29
+CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3ccc(F)cc3Cl)C(=O)O)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.04
+CCCc1c(O)c(ccc1OCc2ccc(cc2)c3nn[nH]n3)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1cc(OC)c(cc1NC(=O)C)S(=O)(=O)N(C)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+OCCCN(Cc1ccc(F)cc1)C(=O)CC2CCN(Cc3ccn(c3)c4ccc(cc4)C(F)(F)F)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+CN(C1CCN(Cc2ccc(cc2)c3noc(C)n3)CC1)C(=O)Cc4ccc(cc4)n5cnnn5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CN1CCN(Cc2ccc(cc2)C(=O)Nc3ccc(C)c(Nc4nccc(n4)c5cccnc5)c3)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CCCCNc1nc(SCCC)nc2c1nnn2[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccccn2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.55
+OC(=O)c1ccccc1Nc2cccc(c2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CC1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.31
+O[C@H](CNC(=O)C1=CNC(=O)c2ccc(F)cc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.93
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2S(=O)(=O)N4CC[C@@H](O)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.32
+Cc1ccccc1S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+COc1cccc(n1)N(C)c2ccnc(Nc3cc(cc(c3)N4CCOCC4)N5CCOCC5)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.41
+OC(=O)c1cn(Cc2ccccc2)c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.19
+CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(NC(=O)c3ccc(OCc4ccccn4)cc3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+CC(C)(C)Cn1c(CN2C(=O)CC3(CCNCC3)C2=O)cc4cnc(nc14)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.75
+CCN1CCN(Cc2cnc(c(Cl)c2)c3ccc(cc3)C(=O)Nc4ccccc4N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+CNC(=O)Nc1cc(sc1C(=O)N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+CCCSc1ncccc1C(=O)NC2CCC(F)(F)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.85
+Cc1ccc(cc1)C(=O)C2CCN(CC2)C(=O)c3ccc(C)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.43
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4cc(CO)ccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Cc1ncc(c2ccnc(Nc3ccc(cc3)S(=O)(=O)N)n2)n1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CNc1nc(C)c(s1)c2nc(Nc3cccc(c3)N4CCNCC4)ncc2C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+Clc1ccc(NC(=O)N2CCN(C[C@H]3CN(CCO3)C4CC4)CC2)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.32
+CCC(N(CCCN)C(=O)c1ccccc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+NC1=NC(Nc2cccc(F)c12)c3cccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+CN1C(=O)CN=C(c2ccccc2)c3cc(Cl)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+Cn1cncc1c2c3C(=O)N(CC=C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.62
+CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc3c[nH]c4ccccc34)NC=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+c1ccc(cc1)c2c[nH]c(n2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CCC1(NC(=O)N(C)C1=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.59
+O[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@H]1NCc4cc5OCCOc5cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.45
+Cc1c(CCC(=O)O)c[nH]c1\C=C\2/C(=O)Nc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.05
+COCCOc1cc2ncc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.24
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.72
+Clc1cccc(Cl)c1\C(=C\n2cncn2)\OC3CCCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+Brc1oc(cc1)c2nc3cc(NS(=O)(=O)c4ccccc4)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.38
+Nc1c2C(=O)N(Cc2nc3c(cccc13)c4ncccn4)C5CCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+COc1ccc(cc1)c2c(C)[nH]nc2c3ccc(O)cc3O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+CNCC[C@H](Oc1cccc2ccccc12)c3cccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.09
+CC(N1Cc2ccccc2C1=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1ccc(N(C(C)C(=O)NC2CCCC2)C(=O)c3ccccc3)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.02
+NC1=NC(=CC(=O)N1)CCc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+COCCOc1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+C[C@H](Nc1nc(Nc2cc(C)[nH]n2)c(F)cc1C#N)c3ccc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.11
+OC(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4sc(Cl)c(Cl)c4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.67
+CC(C)n1c2ccccc2c3c(C)c(NC(=O)N4CCOCC4)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Fc1ccccc1c2ccc3c(c2)C(=O)C(=O)c4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+Cc1cc(C)cc(CCOCCS(=O)(=O)NCCNCCc2ccc(O)c3nc(O)sc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.45
+Cc1ccc2c(N)c(C#N)sc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+O=S(=O)(Nc1ccc(cc1)S(=O)(=O)Nc2nccs2)c3ccc4OCCOc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+COc1ccc(cc1)C(CNC(=O)Nc2ccccc2)N3CCN(C)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1ccc(Nc2cc(Oc3cc(C)c(C)nc3c4ccccn4)ccn2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.51
+COc1ccc(NC(=O)c2ccc(c(C)c2)c3ccncc3)cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+CCCSc1ncccc1C(=O)N(C)C2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.36
+CCOC(=O)C1=Cc2ccc(O)cc2OC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.67
+OC(=O)COc1ccc(cc1c2ccccc2)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.69
+CCCSc1c(cnn1c2cccc(c2)C(=O)O)C(=O)NC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+Nc1ncnc(Nc2ccccc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+NC(=O)Nc1sc(cc1C(=O)N[C@H]2CCCNC2)c3ccsc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.06
+CCN(CC)CCOc1ccc(cc1)\C(=C(\Cl)/c2ccccc2)\c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.09
+COc1cc(O)c2C(=O)O[C@@H](C)C\C=C/C(=O)[C@@H](O)[C@@H](O)C\C=C\c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.64
+CCN1N(C2CCCC2)c3nc(Nc4ccc(cc4OC)C(=O)NC5CCN(C)CC5)ncc3N(C)C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+COc1ccccc1Oc2ccc(cc2)N(Cc3cccnc3)S(=O)(=O)CC(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+O=C1C=C(C=CN1c2ccc3c(cnn3CCN4CCCC4)c2)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CC1=NC(=C(NC1=O)c2ccccc2)c3ccc(CN4CCC(CC4)N5C(=O)Nc6ccccc56)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+Clc1ccc(N2CCN(CC2)C(=O)COCc3ccccn3)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.47
+CC(C)C[C@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.93
+C[C@H](c1c[nH]cn1)c2cccc(C)c2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+OC1CCN(CC1)C(=O)c2ccc(cc2)C(=C3CCN(Cc4cscn4)CC3)c5cccc6cccnc56,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.89
+COc1ccc(cc1)N2Sc3ccccc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.02
+CCC(N(CC1CCNCC1)C(=O)c2ccc(C)cc2)C3=Nc4ccsc4C(=O)N3Cc5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+CC(=O)Nc1nc(CCc2ccc(NC(=N)N)cc2)cs1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.82
+CN1C[C@H](c2ccccc2)c3cccc(N)c3C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.11
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N4CC[C@@H](C4)N(C)C)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+COc1ccc(NC(=O)c2oc(Nc3ccccc3F)nn2)cn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+Cc1ccc(CCCOCCS(=O)(=O)CCCNCCc2ccc(O)c3nc(O)sc23)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+O[C@H](CNC(=O)c1cn2cc(F)ccc2n1)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.33
+OC(=O)[C@H](Cc1ccc(CCCCNc2ccccn2)cc1)NC(=O)c3c(Cl)cccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.51
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C(=O)NC)n4ccc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+COc1cc(ccc1Cn2cnc3ccc(NC(=O)CC4CCCC4)cc23)C(=O)NS(=O)(=O)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+NC(=N)c1cc2c(I)cccc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.74
+Oc1ccc(cc1)C2=CC(=O)c3ccccc3N2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+CN(C)N(C)C(=O)[C@@]1(Cc2ccccc2)CCCN(C1)C(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(C)(C)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Cc1nc(Nc2ncc(s2)C(=O)Nc3c(C)cccc3Cl)cc(n1)N4CCN(CCO)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.41
+Cc1ccc(CCOCCNS(=O)(=O)CCCNCCc2ccc(O)c3nc(O)sc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.07
+Cc1ccc2NC(=O)OC3(CCN(CCc4nc(oc4C)c5ccccc5)CC3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+CCn1c(SCC(=O)Nc2c(cnn2c3ccccc3)C#N)nnc1c4cccs4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Nc1ncnc2c1ncn2Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.53
+CC(C)C[C@@H](CO)NS(=O)(=O)c1ccc(Cl)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(C)OC(=O)N1CCC(CC1)Oc2ncnc(Oc3ccc(cc3F)S(=O)(=O)C)c2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+Nc1c(cnn1c2ccc(F)cc2)C(=O)c3cccc(OC[C@@H](O)CO)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+CCC(N(CCCN)C(=O)c1ccc(cc1)C(C)C)C2=Nc3ccsc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.72
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2cccc(c2)C(=O)O)NC(=O)OCc3ccccc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+Cc1ccc(cc1)C(=O)c2ccc(CC(=O)O)n2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.02
+COc1cc(ccc1Cc2c[nH]c3ccc(NC(=O)CC4CCCC4)cc23)C(=O)NS(=O)(=O)c5ccccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CC(=O)Nc1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+COCCNc1nc(N)c2nc(O)n(Cc3ccccc3)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+OC(=O)C1=CN(C2CC2)c3cc(N4CCN(CC4)C(=O)CC[N+](=O)[O-])c(F)cc3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.22
+Cc1ccc(CN2[C@@H]3CC[C@H]2C[C@@H](C3)Oc4cccc(c4)C(=O)N)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.44
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3NC(=O)C=Cc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.36
+COc1cc2ncnc(Nc3ccc(F)cc3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+C[C@H](Nc1nc(Nc2ncc(C#N)s2)cc(n1)N3CCOCC3)c4ccc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+COc1cc(OC)c(cc1NC(=S)NCC(=O)O)S(=O)(=O)N2C(C)CCc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.04
+COc1ccccc1CNC(=O)c2ccc3cnccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+CC(=O)Nc1ccc2c(c1)c(cn2C)c3cc(NC4CC4)n5ncc(C#N)c5n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.94
+CCOc1cc(Nc2nc3c(cc2F)ncn3[C@@H](CO)c4ccc(F)cn4)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+CCN(CC)CCOc1ccc(cc1)C(O)(Cc2ccc(Cl)cc2)c3ccc(C)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.98
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(C(=O)N)c(Oc4cccc(Cl)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.96
+NC1=CC2=NNC(=O)N2c3cc(ccc13)c4occc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+Clc1ccccc1C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.05
+Nc1nccc(n1)c2cccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+CN1CCC(CC1)(C#N)c2cccc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.73
+COc1cc2ncc(C(=O)N)c(Nc3cccc(Cl)c3Cl)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+N\C(=C(\C#N)/c1ccccc1C(F)(F)F)\Sc2ccc(N)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN(C)c1ccc2N=C3C=CC(=[N+](C)C)C=C3Sc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.88
+CC[C@H](NC(=O)c1c(CS(=O)(=O)C)c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.63
+Cc1nsc(C)c1CCC2CCN(CC2)S(=O)(=O)CC3(CCOCC3)N(O)C=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4cc(Cl)ccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.16
+Nc1nc(OC2CCCC2)nc3c1ncn3[C@@H]4O[C@H](CO)[C@H](Cl)[C@H]4O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+COc1cc2N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)C(=O)C=Cc2cn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.68
+O=C(NCC12CC3CC(CC(C3)C1)C2)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.21
+Cc1ccn2c(NC(=O)c3ccccc3)c(nc2c1)c4cccs4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+Fc1cc(ccc1C2=CCOCC2)N3C[C@H](COc4ccon4)OC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.61
+CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc3ccccc3)C(=O)N[C@@H]4[C@H](O)Cc5ccccc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+OC(=O)COc1cccc(c1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4ccc(F)cc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CC(=O)Nc1ccc(O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.25
+Cc1cc(NCc2ccccc2)nc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.69
+Cc1c(cnn1c2ccc(cc2)C(=O)O)C(=O)NC3C4CC5CC(CC3C5)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+NC(=O)Nc1sc(cc1C(=O)N[C@H]2CCCNC2)c3cc(F)cc(F)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+COc1ccc(cc1)c2cc(ccc2OCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.29
+Nc1ccccc1NC(=O)c2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+O=C(Nc1nccs1)c2cccnc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.25
+Nc1nc(nc(N)c1Cc2ccccc2F)c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+COc1ccc2C(=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+N#Cc1cnn2c(NC3CC3)cc(nc12)c4cccs4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+OC(=O)COc1ccc(Cl)cc1c2cccc(c2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.25
+CCC(CC)NC(=O)c1cn(nc1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+FC(F)(F)c1nnc2ccc(nn12)N3CCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+COc1cc2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2cc1OCCCN5CCC[C@@H]5CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.96
+c1ccc2ccccc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+O=C1COc2ccc(CNC3CCN(CCN4C(=O)COc5ccc(cc45)c6occc6)CC3)nc2N1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3sccc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+O=C(CN1CCOCC1)Nc2ccc(cc2c3ccccc3)c4cccc5C(=O)C=C(Oc45)N6CCOCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Cc1onc(CO)c1C(=O)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.53
+Cc1ccnc(NCc2c(O)ccc3ccccc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.24
+CC(C)CN1C(=O)N(C)C(=O)c2c1nn(Cc3cccc4ccccc34)c2c5ccncc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+COc1ccc(C(CN2CCCC2)N(C)C(=O)Cc3ccc(Cl)c(Cl)c3)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+CNC(=O)c1ccc(Nc2ncc(F)c(n2)c3cnc(C)n3C(C)C)cc1F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCCCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN[C@H]1CCN(C1)C(=O)c2ccc(Nc3nccc(n3)c4cnc(C)n4C(C)C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.22
+Cc1cc(C)n(n1)c2cccc(Cl)c2C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+Fc1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.03
+NCCCC(=O)OCCN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+Cn1ccc2c(cccc12)c3nc(CS(=O)(=O)C)cc(n3)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Oc1nc2ccccc2nc1NCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccc(Br)cc2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.92
+CCCCCCN1CC[C@@]2(C)[C@@H](C)C1Cc3ccc(O)cc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC(C)NC[C@@H](O)COc1cccc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.13
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)OCc3ccc(cc3)C(=O)O)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.84
+Cc1nc(CSc2ccc(Cl)cc2)cc(n1)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+Cc1nc(C)c(nc1C(=O)N)c2ccc3c(CC[C@@]34CC[C@H](CC4)C(=O)O)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+C[C@H]1COCCN1c2nc(N3CCOC[C@@H]3C)c4ccc(nc4n2)c5cccc(c5)C(=O)NCCO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+Clc1ccc(cc1Cl)[C@]23CNC[C@H]2C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.96
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)C5CC5)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+O=C1C=C(OCc2ccccc2)C=CN1c3ccc4c(cnn4CCN5CCCC5)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Fc1ccc(cc1)C(=O)C2CCN(CC2)C(=O)NCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+CN(C)S(=O)(=O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.15
+O\N=C\1/C(=O)N(Cc2ccccc2[N+](=O)[O-])c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.07
+Cc1ccc(NC(=O)[C@H]2CCCN2S(=O)(=O)c3cccc4cccnc34)c(C)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+Cc1cccc(C[C@H](N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2)C(=O)O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.84
+Cc1cc(nn1C[C@H](O)CN)c2ccc(Cl)c(c2)C(=O)NCC3(O)CCCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.57
+CCCSc1nc(ccc1C(=O)N[C@@H]2C3CC4CC2C[C@@](O)(C4)C3)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N(c2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.8
+OC1(CCN(CC1)c2ccc3nnc(n3n2)C(F)(F)F)c4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Cc1cc(Cl)ccc1OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)c4cc(ccc34)S(=O)(=O)C)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+CC(=O)Nc1cc2c(ccn2c3cc(NC4CC4)n5ncc(C#N)c5n3)cc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)NCc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+OC(=O)\C=C\c1cccc(c1)c2cnc3[nH]ccc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.58
+Clc1ccccc1N2CCN(CC2)C(=O)NC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.78
+COc1cc(OC)c(cc1NC(=O)C)S(=O)(=O)N2C(C)Cc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(N3CCN(CC3)c4ccc(cn4)C#N)c(F)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.98
+O=C1Nc2ccc(cc2C1=O)S(=O)(=O)N3CCC[C@H]3COc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Clc1cc(Cl)cc(NC(=O)NCC2(CCN(CC3CC3)CC2)c4ccc(cc4)c5cccc(c5)C#N)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+Oc1ccc(CCc2ccc(O)cc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC(C)c1ccc(NC(=O)NCCCSC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cnc4c(N)ncnc34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CCO[C@@H]1OC(=O)C[C@@H]1NC(=O)[C@@H]2CCCN3N2C(=O)[C@H](CCC3=O)NC(=O)c4nccc5ccccc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.16
+CCCSc1ncccc1C(=O)N[C@@H]2[C@@H]3CC4C[C@H]2C[C@@](O)(C4)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.27
+CCCC(C)(C)C[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.99
+CC(C)(C)NC[C@H](O)COc1nsnc1N2CCOCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.22
+CN(C(CN1CCCC1)c2ccccc2)C(=O)Cc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+[O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.72
+CN(CCCc1ccccc1)S(=O)(=O)c2cc(C(=O)N3CCc4ccc(cc4C3)S(=O)(=O)NCCc5ccccc5)c(O)c(O)c2O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.75
+COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c3ccccc3)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCCN(CCc3ccccc3F)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+COc1cc(Nc2ncnc(Nc3c(Cl)ccc4OCOc34)n2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.01
+CCCNC(=O)c1nnc2c(cccc2c1N)c3cnc(OC)nc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.26
+CN(Cc1ccc(Cl)cc1)C(=O)C2(N)CCN(CC2)c3ncnc4[nH]ccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Fc1ccc(cc1)S(=O)(=O)Cc2cc(nc(n2)c3ccccn3)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.59
+OC(=O)[C@H](Cc1ccc(NC(=O)Cc2ccc3CCCNc3n2)cc1)NC(=O)c4c(Cl)cccc4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.63
+OC(=O)C(N1CCO[C@@H](CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)C1)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+NC(=O)c1cc(sc1N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+OC1=CC(=O)C2=C(O1)c3ccccc3N(C2=O)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.96
+Clc1ccc(NCCNCC(=O)N2CCC[C@H]2C#N)nc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+Clc1ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)c4ccc(cc4)c5nn[nH]n5)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.53
+CCc1[nH]c2nc(Sc3cnc4ccc[n+]([O-])c4c3)nc(N5C[C@@H]6[C@@H](N)[C@@H]6C5)c2c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+O=C1NC(=O)c2cc(OCc3ccccc3)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Fc1cc(c(F)cc1Oc2ccc(Cl)cc2c3ccnn3C4CNC4)S(=O)(=O)Nc5ncns5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+Clc1cccc(c1)c2cnc3ccc(NC4CCOCC4)nn23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+CC(C)(C)OC(=O)N1CCN(CC1)c2ccc(OCc3ccc(cc3)S(=O)(=O)C)nn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+COc1ccccc1N2CCN(CCCCNC(=O)c3ccc4ccccc4c3)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.53
+CCOC(=O)\C=C\[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@H](CC#C)N2C=CC=C(NC(=O)c3cc(C)on3)C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+CC[C@@H]1COCCN1c2cc(nc(n2)c3cccc4[nH]ccc34)C5(CC5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N4CC[C@H](C4)N(C)C)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+CC1=C(C(=O)N(C[C@H](N)c2ccccc2)C(=O)N1Cc3c(F)cccc3F)c4ccc5OCOc5c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+Oc1ccc(cc1)C2=CC(=O)c3cc(O)ccc3O2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN(C1CCN(Cc2nc3cc(F)ccc3s2)CC1)C(=O)Cc4ccc(cc4)n5cnnn5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.85
+ONC(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CCN1C=C(C(=O)O)C(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.1
+O=C1C=COc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+CS(=O)(=O)N1CC[C@@H](C1)N(Cc2ccccc2Cl)c3ccc(C#N)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+Cc1nccn1CC2CCc3c(C2=O)c4ccccc4n3C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.67
+Oc1ccccc1NC(=O)c2cc(ccc2Cl)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+CCN1CCC[C@H]1CNC(=O)c2cc(ccc2OC)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.84
+CS(=O)(=O)c1cccc(Nc2nccc(Nc3cccc4ocnc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+ONC(=O)Cc1ccc(Oc2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.03
+Cc1cn(C[C@H]2CN(C(=O)O2)c3ccc(C4=CCS(=O)(=O)CC4)c(F)c3)nn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.25
+C[C@H](CNCCc1ccncc1)c2c([nH]c3ccc(cc23)C(C)(C)C(=O)N4C5CCC4CC5)c6cc(C)cc(C)c6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.35
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)C(=O)CO)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+CCN1CCC[C@H](C1)C(=O)N2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Cc1ccc(cc1)c2cc(nn2c3ccc(cc3)S(=O)(=O)N)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+C(Oc1cccc2ccccc12)C3=NCCN3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.68
+CC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.97
+CCOC(=O)c1ncn2c1CN(C)C(=O)c3cc(F)ccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)c4ccccc4c5nn[nH]n5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.29
+CCNC(=O)OC[C@@H](C)N(c1cc(Cl)ccc1CO)S(=O)(=O)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+C1Oc2ccc(Oc3cc(Oc4ccc(cc4)n5ccnc5)ncn3)cc2O1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+O=C1NN=C(Cc2ccccc2)c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Cc1[nH]c(\C=C\2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.22
+COc1ccc(NC(=O)CCc2c(C)nc3nc(C)nn3c2C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+Cc1nc(C)c(nc1C(=O)N)c2ccc3c(CC[C@@]34CC[C@H](Cc5nnn[nH]5)CC4)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CO[C@H]1CN(Cc2ccc(cc2)C(F)(F)F)CC[C@H]1N(C)C(=O)Cc3ccc(cc3)n4cnnn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CCOC(=O)c1ccc(OCCC2CCN(CC2)c3ccc(C)nn3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.42
+COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.23
+CN(C)CCOc1ccc(cc1)c2cc(C(=O)N)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.16
+Fc1cccc(COc2ccc(Nc3ncnc4ccc(cc34)c5cccc(c5)N6CCOCC6)cc2Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+Clc1ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)NS(=O)(=O)c4cccc(c4)C#N)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+Cc1ccc(cc1)c2cc(C(=O)N3CCOCC3)c4cc(C)ccc4n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+N[C@@H](Cc1cccs1)C(=O)N[C@@]2(C[C@@H]2c3ccccc3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+CCCSc1nc(ccc1C(=O)NC2CCCCC2)N3CCC(CC3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Fc1ccc(cc1)C(COCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)N3CCNCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CC(C)(C)C(O)\C(=C/c1ccc(Cl)cc1Cl)\n2cncn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+C[C@@H]1C2CCCC1(CCN2C)c3cccc(O)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.52
+Fc1cc2N=CNC(=O)c2cc1F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+CCOc1ccc2C=CC(=O)Oc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+COc1cc2c(Nc3cnc(NC(=O)c4ccccc4)nc3)ncnc2cc1OCCCN5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CN1C(=O)N(C)c2nc[nH]c2C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.09
+CCCS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc(C)n3C(C)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+COc1cc(ccc1Cn2ccc3ccc(NC(=O)OC4CCCC4)cc23)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Brc1cnc(Nc2cccc(NC(=O)N3CCCC3)c2)nc1NCCCNC(=O)c4cccs4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.13
+CCOc1ccc(CCNCCCSCCNC[C@H](O)c2ccc(O)c3NC(=O)Sc23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.41
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)N4CCN(CC4)S(=O)(=O)C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.57
+OC(=O)CCc1oc(c2ccccc2)c(n1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+C[C@@H](Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12)C(=O)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.14
+COc1ccc(nc1OC)N2CCN([C@H](C)C2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CC(C)OC(=O)N1CCC(CC1)Oc2ncnc3c2cnn3c4ccc(cc4F)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)[C@H](C)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.44
+N(c1cccnc1)c2ncnc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.57
+CCOc1ccc2oc(C(=O)NC(CCSC)c3nc4cnccc4[nH]3)c(C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.31
+COCCOc1ccc(cc1)C(=O)Nc2cc(NC(=O)c3cccc(c3)N(C)C)ccc2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+O=C(CSC1=NC2=C(SCC2)C(=O)N1c3ccccc3)Nc4ncc(s4)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.95
+CC(C)(C)OC(=O)N1CCN(CC1)c2ncc(OCc3ccncc3C#N)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)c3ccc(cc3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.61
+CC(C)Cn1cnc2c(N)nc3ccccc3c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.52
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4ncc(C)n4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+C[S+]([O-])c1ccc(\C=C/2\C(=C(CC(=O)O)c3cc(F)ccc23)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.01
+CN1C2CC(CC1C3OC23)OC(=O)C(CO)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.17
+CN(CCNC[C@H](O)c1ccc(O)c2NC(=O)Sc12)C(=O)CCOCCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.21
+Cc1oc(nc1CCOc2ccc(C[C@H](Nc3ccccc3C(=O)c4ccccc4)C(=O)O)cc2)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CN(C)CCCN1c2ccccc2Sc3ccc(cc13)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.59
+CCN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c3C1=O)c6cc(cn6C)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.13
+CN(C)c1ccnc2sc(C(=O)N)c(N)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+CC1=C(C(=O)c2cc(O)c(O)c(Cc3ccccc3)c2C1=O)C4=C(C)C(=O)c5c(Cc6ccccc6)c(O)c(O)cc5C4=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.73
+CN(C)CCCOc1ccc(cc1)c2cc(C(=O)N)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.64
+COc1cccc(c1)c2cc3c(N[C@H]4CCCNC4)ncc(C(=O)N)c3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.82
+COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+Cc1cc(CN2CCC2)cnc1c3ccc(cc3)C(=O)Nc4ccccc4N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.18
+Cc1oc2C=NN(B(O)c2c1)S(=O)(=O)c3ccc(C)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.28
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)N4CCN(C)CC4)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Oc1ccc(CCNCCNS(=O)(=O)CCOCCCc2ccccc2)c3sc(O)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.22
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4cc(ccn34)C#N)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+COC(=O)c1ccc(cc1)C(C)N2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+NC(=O)C([C@@H]1CCN(CCc2ccc3OCCc3c2)C1)(c4ccccc4)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccc(C)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+NCC[C@@H](Oc1nc(ccc1C#N)C(F)(F)F)c2oncc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.49
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4cc(ccc34)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CN(C)CCN(Cc1ccccc1)c2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.28
+COc1ncc(cc1NS(=O)(=O)c2ccc(F)cc2F)c3ccc4nccc(c5ccnnc5)c4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+Clc1ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)NS(=O)(=O)c4ccccc4Cl)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.93
+CC(CCc1ccccc1)NCC(O)c2ccc(O)c(c2)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.06
+CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.34
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)NCc3ccccn3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+OC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.08
+COc1ccccc1CCNCc2ccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+NC(=O)C1=CN(Cc2ccc(Cl)cc2Cl)C(=O)C=C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+CCc1cc(ccn1)C(=S)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+COc1cccc(NC(=O)c2cccc(Cc3c(C)nn(CCO)c3c4ccccc4)c2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.29
+COc1ccc(CC(=O)Nc2nc3ccccc3[nH]2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COc1cc(OC)cc(c1)c2cc3cnc(N)nc3nc2N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+COc1ccc(cc1CO)c2ccc3c(nc(nc3n2)N4C[C@@H](C)O[C@@H](C)C4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+CC(=O)N1CCN(CCOc2ccc(cc2)C3(O)CCN(CC3)c4ccc5nnc(n5n4)C(F)(F)F)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Clc1ccc2nc(ccc2c1C(=O)NCC34CC5CC(CC(C5)C3)C4)N6CCC[C@@H](C6)NCCc7nnn[nH]7,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.08
+Cc1c(Sc2ccc(Cl)cc2)c3ccc(Cl)cc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+Cc1nc2c(cnn2c(O)c1Cc3ccccc3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.68
+CNC(=O)c1ccc(Nc2nccc(n2)c3cnc(C)n3C(C)C)cc1F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.95
+CC12CCC3C(CCC4=CC(=O)CCC34C)C1CCC2O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N4CCCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+O=C1N2CCS(=O)(=O)C2=Nc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+CCOC(=O)c1c(C)n(Cc2occc2)c3ccc(O)cc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Cc1cccc(NC(=O)c2ccc(c3ccccc3)c(c2)C#N)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.71
+CONC(=O)c1cnc(s1)N2CCC(CC2)NC(=O)c3[nH]c(C)c(Cl)c3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+NC(=O)c1ccc(cc1)c2cc3c(N[C@H]4CCCNC4)ncc(C(=O)N)c3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.28
+COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC(=O)O)c1c2ccc(F)cc2)C(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+[O-][N+](=O)c1ccc2C(=O)C(=O)c3ccccc3c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+CCC[C@H](CO)Nc1nc(SCc2ccccc2)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(C(=O)N(C)C)c(C)c3)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+CNC(=O)C1(CCN(CC[C@H](CN(C)C(=O)c2c(OC)c(cc3ccccc23)C#N)c4ccc(Cl)c(Cl)c4)CC1)N5CCCNC5=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4cccnc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.59
+CC12CC3CC(C)(C1)CC(N)(C3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.06
+CO[C@H]1CN(CCN2C(=O)C=Nc3ccc(OC)cc23)CC[C@@H]1NCc4cc5OCCOc5cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.25
+Brc1ccc(s1)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.52
+Cc1cc(Nc2ccc(F)cc2)nc(N)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+CC(=O)Nc1ccccn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.5
+Clc1ccc(cc1)c2oc(cc2)C(=O)Nc3ccc(cc3)N4CCNCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Nc1cc(nc(N)[n+]1[O-])N2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.77
+NC1(CCC1)c2ccc(cc2)c3c(ccn4ccnc34)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Oc1ccc(CCNCCS(=O)(=O)CCCOCCc2nccc3ccccc23)c4sc(O)nc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+CCOC(=O)c1ccccc1c2csc(NS(=O)(=O)c3ccc(Cl)cc3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+CN1CCN(CC1)C(=O)c2cc(sc2NC(=O)N)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+Oc1ccc(cc1)N2C(=O)c3ccccc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+COCCNc1nc(NCc2ccccc2F)c3sccc3n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Cn1cc(cc1C=O)C(=O)CCCCOc2ccc(cc2)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.14
+Nc1ccccc1NC(=O)c2ccc(CNC(=O)OCc3cccnc3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+Cc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(C)c4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CN1CCC(CC1)n2cc(cn2)c3cnc(N)c(c3)c4oc5cc(F)ccc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.35
+C[C@H](Nc1nc(Nc2cc(C)[nH]n2)cnc1C#N)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.96
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccc(C)cc2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.05
+CC(C)[C@@H](CN1CCCCC1)N(C)C(=O)Cc2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+COc1ccc(cc1OC)C(=O)Nc2cccc(NC(=O)c3ccc(OC)c(OC)c3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN4CCCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.28
+CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(c(F)c2)n3ccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+CN1SC(=O)c2cc(ccc12)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.3
+Nc1nc(OC2CCCC2)nc3c1ncn3[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.79
+Cc1ncsc1CCOCCCS(=O)(=O)CCNCCc2ccc(O)c3nc(O)sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.44
+COc1ccccc1CN(C)Cc2cccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+OC1CCN(CC1)C(=O)CN2C(=O)C(Cc3ccccc23)NC(=O)c4cc5cc(Cl)sc5[nH]4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+C(Cc1nc2ccccc2[nH]1)Cc3nc4ccccc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Cc1ccc2c(c1)c(Sc3ccccc3Cl)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+Oc1ccc(cc1)c2ccc3cc(O)ccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6oc(cc6C)C#N)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.34
+CO[C@H]1CN(CCN2C(=O)C=Nc3ccc(OC)cc23)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.51
+CCN(C1CCN(CC[C@H](N2CCN(CC2)S(=O)(=O)C(F)(F)F)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+NC1=NC(=CC(=O)N1)CCc2cccc(Br)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.52
+COc1ccc(C[C@@H](C)NC[C@H](O)c2ccc(O)c(NC=O)c2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.42
+OC[C@H](O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)ccc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CC(=O)C1=C(C)c2cnc(Nc3ccc(cn3)N4CCNCC4)nc2N(C5CCCC5)C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2ccccc12)c3cccc(F)c3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+CC(C)C[C@H](CO)Nc1nc(SCc2ccccc2)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+CC(=O)N1CCN(CC1)c2ccc(NC(=O)c3oc(Nc4ccccc4F)nn3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+CC1=C(C(=O)N(C[C@H](N)c2ccccc2)C(=O)N1Cc3c(F)cccc3F)c4ccccc4F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.76
+OS(=N)(=O)Cc1noc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.55
+Clc1ccc2[nH]ccc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.28
+CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c2cc3cc(F)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+COc1cc(NC(=O)Nc2cccc(CNC(=O)O[C@H]3CCOC3)c2)ccc1c4ocnc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CCN1C(=O)N(CC)c2[nH]c(nc2C1=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CN(C)C(=O)N[C@@H]1CC[C@@H](CCN2CCN(CC2)c3ccc(Cl)cc3)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+Clc1ccc(cc1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.59
+CN1C(=O)NC(=O)C(C)(C2=CCCCC2)C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1cc(Nc2nccc(Oc3cnc4ccccc4c3)n2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.41
+Clc1ccc2N(C3CCN(CCCN4C(=O)Nc5ccccc45)CC3)C(=O)Nc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+COc1cc(cc(OC)c1O)[C@H]2[C@@H]3C(COC3=O)C(O[C@@H]4O[C@@H]5CO[C@@H](C)O[C@H]5[C@H](O)[C@H]4O)c6cc7OCOc7cc26,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+CC1=C(C(=O)Oc2cc(O)ccc12)c3ccc(O)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CCN1C=C(C(=O)O)C(=O)c2cc(F)c(cc12)N3CCNCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.87
+COc1cc(OC)c(cc1NC(=O)C)S(=O)(=O)N(C(C)C)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+COC(=O)c1c(O)cccc1OC\C=C\c2ccc(F)c(c2)c3onc(c3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.66
+Nc1nccc(n1)c2c[nH]c3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.68
+OC(=O)c1ccc(cc1)n2ncc(C(=O)NC3C4CC5CC(CC3C5)C4)c2C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+Fc1ccc(cc1)c2ncn(C3CCNCC3)c2c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.3
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccc(OC)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+Cc1cc(nc(n1)n2ccnc2)N3CCC[C@@H]3C(=O)NCCc4ccc5OCOc5c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC(C)c1c(cnn1c2ccc(cc2)C(=O)O)C(=O)NC3C4CC5CC(CC3C5)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.15
+CCn1cnc2cnc(c3ccc(cc3)C4(N)CCC4)c(c5ccccc5)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)N(C)C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.45
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3cncc4ccccc34)c2C(=O)N5CC[C@@H](O)C5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+OCCNC(=O)COc1ccc(OCCNCC(O)COc2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.42
+CCc1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)n(C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)NC4CC4)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.06
+Cc1cnccc1COc2cnc(nc2)N3CCN(CC3)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+C=CCCCCCCCCC(=O)N[C@H]1CCC(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+COc1cc2nnc(C(=O)N)c(Nc3cc(C)ccc3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.57
+O[C@H](CNC(=O)c1cnnc2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.28
+CCCCc1nc2c(N)nc3ccccc3c2n1Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.17
+COc1ccccc1CNC(=O)NS(=O)(=O)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4cscn4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.56
+CC(C)(C)OC(=O)N1CCN(CC1)c2ncc(OCc3c(F)cncc3F)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+Clc1ccc(cc1)C(=O)CN2C3=NCCN3c4ccccc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.62
+COc1cc(C)c(c(C)c1)S(=O)(=O)N(C)CCOCC(=O)N2CCC(CC2)C3CCN(C)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.3
+CCC(CC)NC(=O)c1cnn(c1NS(=O)(=O)c2ccc(cc2)c3ocnc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3cccc(Oc4ccccc4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+COc1nccnc1NS(=O)(=O)c2ccc(N)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.65
+NC(=O)c1cnc(N[C@H]2CCCNC2)c3cc(sc13)c4ccc(Cl)c(F)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.76
+CC(=O)Nc1cccc2c1c(c(C)n2CC(=O)O)S(=O)(=O)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+CCCNc1nc(ccc1C(=O)NC2CCCCC2)N3CCC[C@@H](CC(=O)O)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.33
+NC1CCc2cc(OC(=O)c3ccccc3)c(OC(=O)c4ccccc4)cc2C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CC(C)C(=O)Nc1ccc2C(=O)NC(=O)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.55
+Cc1ccc(cc1)C(=O)c2cc(O)c(O)c(c2)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.74
+COc1cc(F)ccc1c2cncc(CNC(C)C)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+Cc1c(Oc2ccc(Cl)cc2)c3cc(F)ccc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+COc1cccc2c1c(NS(=O)(=O)c3ccc(Cl)s3)nn2Cc4cccc(CNC(=O)C(C)(C)O)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.09
+CC(=O)Nc1cc(CN2C(=O)N(C(=O)C2(C)C)c3ccc(SC(F)(F)F)cc3)ccn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+COc1ccc2SCC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4c(CO)cccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CCOc1ccc(cc1)N2C(=O)c3ccccc3N=C2[C@@H](C)N(Cc4cccnc4)C(=O)Cc5ccc(cc5)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.25
+CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+Brc1ccccc1C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.15
+COc1ccc(cc1)c2nc3c(NCCCNC(=O)C4CCCC4)c(cnc3[nH]2)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.13
+CN1C(=O)CC(C1=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.68
+[O-][N+](=O)c1ccc2[nH]c(nc2c1)c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+c1ccc(cc1)C#Cc2n[nH]c3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.31
+CSc1ccc(cc1)C(=O)C(C)(C)N2CCOCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.49
+CCN1C(=O)C=Cc2cnc(Nc3ccc(OC)c(OC)c3)nc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CN(CCOc1ccc(NS(=O)(=O)C)cc1)CCc2ccc(NS(=O)(=O)C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CCOc1nc2cccc(C(=O)O)c2n1Cc3ccc(cc3)c4ccccc4c5nnn[nH]5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.3
+CCN1CCC[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+CC(C)N1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N4CCS(=O)(=O)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+COc1cc(OC)cc(c1)C2=CC=C(NC(=O)OCc3ccccc3)C(=O)N2CC(=O)NC(C(C)C)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+COc1cc2c(Nc3ncc(NC(=O)c4ccccc4)cn3)ncnc2cc1OCCCN5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C#N)n4ccc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.62
+CCS(=O)(=O)c1ccc(c(Cl)c1)c2cc(Cl)ccc2OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.43
+CCCOc1nc(ccc1C(=O)NC2CCCCC2)N3CCC[C@@H](CC(=O)O)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+CNC(=O)c1ccc(cc1)c2cc(C(=O)N[C@H]3CCCNC3)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+CC(C)(C)OC(=O)N1CCN(CC1)c2ccc(OCc3ccc(cc3)S(=O)(=O)C)nc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1cnc(nc1Oc2ccc(F)cc2F)c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CN1CCN(CC1)c2ccc3nc([nH]c3c2)C4=C(N)c5c(F)cccc5NC4=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+CN(C(=O)C)c1ccc2ccn(c3cc(NC4CC4)n5ncc(C#N)c5n3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COc1cc2ncnc(Nc3cc(NC(=O)c4ccnc(c4)N5CCOCC5)ccc3C)c2cc1OCCN(C(C)C)C(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Cc1cc(O)nc(n1)n2nc(C)c(Oc3ccccc3O)c2C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+NC(=O)c1c(N)sc2CCCCc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.84
+Fc1ccc(C2CCN(CC2)C(=O)COCc3ccncc3)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+FC(F)(F)c1nnc2ccc(nn12)N3CCCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+OCCN(C(=O)CNC(=O)c1cc2cc(Cl)ccc2[nH]1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+Cc1ccc(NC(=O)c2ccnc(c2)N3CCOCC3)cc1NC(=O)c4ccc(OCc5ccccn5)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.47
+COc1ccc(OC)c(CNc2[nH]nc3cccc(Oc4ccc(cc4)S(=O)(=O)C)c23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.71
+CCN(C1CCN(CC[C@H](c2ccc(cc2)S(=O)(=O)C)c3cc(F)cc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Nc1cccc(CCc2ccc3cc[nH]c3c2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CNc1nc2ccccc2n1Cc3sc4N(CC(C)C)C(=O)N(C)C(=O)c4c3C(=O)N5C[C@H](O)CO5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+CN1CCN(CC(=O)Nc2c(cnn2c3ccccc3)C#N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.0
+Cc1cc(Oc2ccnc(Nc3ccc(cc3)S(=O)(=O)N)c2)c(nc1C)c4ccccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CN(C)CCOc1ccc(cc1)c2oc3ncnc(NC[C@@H]4CCCO4)c3c2c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CCN(CCCOCCOCCc1ccccc1)CCc2ccc(O)c3nc(O)sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.45
+Fc1ccccc1Nc2oc(nn2)C(=O)Nc3ccc(N4CCOCC4)c(F)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CC1=NS(=O)(=O)c2cc(Cl)ccc2N1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.05
+CN(Cc1oc2ccccc2c1C)C(=O)\C=C\c3cnc4NC(=O)CCc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+COc1ccc(cc1Oc2cccc(Cl)c2)S(=O)(=O)N3CCC[C@@H](C3)N4C=C(C)C(=O)NC4=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.73
+CCOC(=O)C1=C(C)NC(=C([C@H]1c2cccc3C(=O)C=C(C)Oc23)C(=O)C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+Nc1nc2OC(COc3ccccc3)Cc2c(N)c1C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+COc1ncc(cn1)c2cccc3OC[C@H](Cc23)NC(=O)c4ccc(OCC(F)(F)F)nc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+Fc1ccc(F)c(NS(=O)(=O)c2ccc(Cl)cc2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COC(=O)N1CCN([C@H](CN2CCCC2)C1)C(=O)Cc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.05
+CCN(C(=O)Nc1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Clc1ccc2[nH]c(cc2c1)C(=O)N3CCNCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.65
+O=C(Nc1cccnc1C(=O)NCC2CCOCC2)c3cccc4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.4
+COc1cnc(nc1NC(C)C)c2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CCCCN(CCNCCc1ccc(O)c2NC(=O)Sc12)C(=O)CCOCCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CCN(CC)CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.9
+CC(C)(CS(=O)(=O)N1CCN(CC1)c2ccc(F)cc2)N(O)C=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.07
+CC(C)N1CCC[C@H](CN2C(=O)c3cc(ccc3N=C2C(C)C)c4ccc(F)cc4)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+COCCN1CCC(Cc2ccc(cc2)C(=O)NCc3cnc(nc3NCC(C)(C)C)C#N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cn3c(C)nc4ccccc34)c2C(=O)N5CC[C@@H](O)C5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.34
+COc1cc(OC)c(cc1NC(=O)C)S(=O)(=O)N2C(C)CCc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+Brc1ccc(s1)N2C[C@@]3(CN4CCC3CC4)OC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+OC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1\C=C\3/CCN(C3=O)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+CCN(C1CCN(CC[C@H](c2ccc(cc2)S(=O)(=O)C)c3cc(F)cc(Cl)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+CO[C@@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@H]1NCc4ccc5OCC(=O)Nc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.81
+CNC1CCN(C1)c2ccc(NC(=O)c3ccc(cc3)c4ccccc4)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+FC1(F)Oc2ccc(\C=C\3/SC(=O)NC3=O)cc2O1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+C[C@H](NC(=O)C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+OC(=O)COc1ccc(cc1c2ccccc2)c3nccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.16
+O[C@H](CNC(=O)C1=NNC(=O)c2ccccc12)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.69
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)NCc3cc[n+]([O-])cc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.13
+COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)\CCC(=O)OCCN3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+CC(=N)NCc1ccccc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.28
+OC1CS(=O)(=O)CC1N2CCC(CC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+COc1ccc2[nH]c(cc2c1)C(=O)N3CCN(C)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.62
+CC(C)C1NCCc2c1sc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Nc1nc(Nc2ccc(cc2)S(=O)(=O)N)nn1C(=O)c3c(F)cccc3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.87
+CCCCCc1ccc(cc1)c2nnc(N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.13
+Cc1sc2ncnc(SCC(=O)N3CCCC3)c2c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+OC(=O)[C@H](Cc1cccc(OCCCNc2ccccn2)c1)NC(=O)c3c(Cl)cccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.16
+Cc1ccc(cc1)S(=O)(=O)Nc2c(C(=O)NC3CCOCC3)c(C)nn2c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.16
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4cc(Cl)ccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+Cc1cc(F)ccc1OC2CCN(CC3CCN(CC3)[C@@H](Cc4ccc(F)cc4)C(=O)O)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+FC(F)(F)c1nnc2ccc(NCn3nnc4ccccc34)nn12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+C[C@@H]1N[S@@](=O)(=NC1=O)c2cccc(c2)c3cccc(c3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+CCCSc1ncccc1C(=O)N(C)C2CCOCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.63
+CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.03
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)C)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CN(C)CCCN1c2ccccc2CCc3ccc(Cl)cc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.36
+COc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c3occc3Cl)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+OC(=O)c1ccccc1C2=C3C=CC(=O)C=C3Oc4cc(O)ccc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.0
+Oc1nc2ccccc2c(O)c1c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.73
+COc1ccc(OC)c(c1)C(O)CNC(=O)CN,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.71
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)c5cccnc5)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1ccc(cc1CO)c2ccc3c(nc(nc3n2)n4ccnc4)N5CCOC[C@@H]5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+C[C@H](C(=O)O)c1cccc(c1)C(=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.06
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)c5cncs5)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.11
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(C(=O)N(C)C)c(F)c3)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+COC(=O)CCC(=O)Nc1ccc2c(c1)C(=O)C(=O)c3cc(NC(=O)CCC(=O)OC)ccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+CCS(=O)(=O)c1ccc(Oc2c(C)n(CC(=O)O)c3ccc(cc23)C(F)(F)F)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.29
+O=C(NC1CCCCC1)C2CCCN(C2)S(=O)(=O)c3cccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(CS(=O)(=O)N)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CCC(N1NC(=O)C2=C(C1=O)C(=O)c3ccc(Cl)cc3N2)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+O=C(Nc1ccc(nc1)N2CCOCC2)c3oc(Nc4cccc(OCc5cccnc5)c4)nn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CCOC(=O)c1ccc(OCCC2CN(CCO2)c3ccc(C)nn3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Cc1nc(C)c(nc1C(=O)N)c2ccc3c(CC[C@@]34CC[C@H](CC(=O)O)CC4)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COC[C@@H](O)CN1C(=O)C=NN(C1=O)c2ccc(Cl)c(c2)C(=O)NCC3(O)CCCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.44
+Nc1nc2nc(SCc3ccccc3)nc(N)c2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CCN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COc1cc(O)c(C(CC(=O)N2CC(C)CC(C)C2)c3ccc4OCOc4c3)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+CCNc1nc(N)c(s1)C(=O)c2ccc(Cl)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.63
+CS(=O)(=O)c1ccc(c(Cl)c1)c2cc(ccc2OCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.52
+Oc1ccc(cc1)N2C(=O)c3ccc(O)cc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+C1CCC(CC1)NC2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.38
+CN1CC=CCC(C1)c2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.32
+Oc1ccc(Br)cc1C(=O)C(=O)c2cc(Br)ccc2O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.85
+CNc1c(cnc2[nH]c(nc12)c3ccc(OCCN4CCOCC4)cc3)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+CC[C@H](CO)Nc1nc(SCc2ccccc2)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+C[C@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(cc2)C(F)(F)F)c3ccc(F)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+Nc1nc2nc(SCc3cccc(F)c3F)nc(O)c2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC(N)COc1c(C)cccc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.62
+CCCCC(O)c1[nH]c2cc(C)c(cc2c1CCc3ccccc3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.59
+CC(C(=O)Nc1ccc(Cl)cc1)c2ncc(cc2Cl)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.19
+CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(=O)O)cc1)c4ccccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+CN(C)CC(O)COc1ccc(Nc2nccc(Nc3ccccc3)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.58
+C(CN1CCCC1)Oc2ccc(Nc3ncc4cc(ccc4n3)c5ccncc5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+OC(=O)C1=CN(C2CC2)c3cc(N4CCNCC4)c(F)cc3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.96
+CN(C)C(=O)[C@H](O)[C@H](Cc1ccccc1)NC(=O)c2cc3cc(Cl)ccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CO[C@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@@H]1NCc4cc5OCCOc5cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.05
+CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.56
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccc(cc2)[N+](=O)[O-])C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.54
+CCc1nc2c(N)nc3ccccc3c2n1CC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.55
+COc1ccc(cc1)c2nc3c(NCCCNC(=O)C4CC4)c(Br)cnc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(cc12)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.27
+CCCNC(=O)c1nnc2c(cccc2c1N)c3cnccc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+CC(N)Cc1c[nH]c2ccc(OCc3cccs3)cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.48
+C1CC2(CCN1)OC(c3ccccc3)c4ccccc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.75
+COc1cc(ccc1Nc2ncc(Br)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CCN(C1CCN(CC[C@@H](c2ccccc2)c3ccc(cc3)S(=O)(=O)C)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+CN1CCN(CC1)C2=Nc3ccccc3Oc4ccc(Cl)cc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+COc1cc(O)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N2C(C)CCc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.27
+Cn1ncc2C(=O)NC(=Nc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+CN(C)CCCn1c2CCCCCCc2c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+COc1ccc(cc1)C2=COc3cc(O)ccc3C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+NC(=O)c1cccnc1Oc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.13
+N(c1ccccc1)c2ccnc(Nc3ccccc3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.06
+CCN1CCC[C@H]1CNC(=O)c2cc(Br)cc(OC)c2OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+CC(O)c1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.25
+CCN(CC)C(=O)c1ccc(cc1)C2=CC3(CCNCC3)Oc4cccc(O)c24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.54
+CN(C)CC(O)COc1ccc(Nc2nccc(Nc3cccc(Cl)c3)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC(=O)Nc1ccccc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+Clc1ccc(OC2CCNCC2)cc1C(=O)NCC34CC5CC(CC(C5)C3)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.83
+COc1cccc(\C=C\2/SC(=O)NC2=O)c1N3CCC[C@@H](N)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.27
+COc1ccccc1CN2C(C(=O)NC3CCC(C)CC3)c4ccccc4C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.74
+C[C@@H](Oc1cccc2ncnc(Nc3ccc4c(cnn4Cc5ccccn5)c3)c12)C(=O)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+COCCNC(=O)c1cccc(CN2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4[nH]cnc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+CCn1c2ccccc2c3cc(NC(=O)C)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CNc1c(Br)cnc2[nH]c(nc12)c3ccc(OCCN4CCCCC4)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+Cc1c(Sc2ccc(Cl)cc2)c3c(Cl)cccc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+Oc1cccc(c1)c2nc3ccc(O)cc3s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CN(C)C(=O)C1(CCN(CC[C@H](CN(C)C(=O)c2cc(cc3ccccc23)C#N)c4ccc(Cl)c(Cl)c4)CC1)N5CCCCC5=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.52
+Cc1c(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cccc1C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+[O-][N+](=O)c1oc(C=NN2CCOC2=O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.12
+Cc1ccc2c(c1)c(Sc3ccc(cc3)S(=O)(=O)C)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.08
+Cc1ccc(cc1S(=O)(=O)n2ccc(n2)c3c(C)nc4ccc(Br)cn34)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.52
+OC1(CCc2ccc(Oc3ccc(cc3)C(=O)NCc4ccncn4)cc2)CN5CCC1CC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.76
+CC(C)CN1C(=O)N(C)C(=O)c2c(SC(C)C)c(Cc3ccccc3C(F)(F)F)sc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.42
+O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4ncccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+c1ccc2cnccc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+C[C@](N)(Cc1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+Clc1ccc2oc3C(=O)NC(=Nc3c2c1)[C@@H]4CCCN4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(C1)S(=O)(=O)Cc2ccccc2)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C(=O)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+O=C(NCCN1CCCC1)c2ccc(Nc3ncc4cc(ccc4n3)c5ccncc5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(C(=O)NC4CCN(C)CC4)c(F)c3)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+Cc1nc(C)c(nc1C(=O)N)c2ccc([C@@H]3CC[C@@H](CC(=O)O)CC3)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N4CCCN(C)CC4)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.02
+C[C@H](CO)Nc1nc(SCc2ccccc2)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+O=C(CCc1ccncc1)Nc2ccc(cc2)C(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)c4noc(n4)C(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.85
+CCN(C1CCN(CCC(c2ccccc2)c3ccc(NC(=O)C(C)(C)C)cc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCCCN4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Cc1c(Cl)ccc(OC2CCN(CC2)C3CCN(CC3)C(=O)c4cccc(c4)S(=O)(=O)C)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.33
+CCCCc1nc2c(N)nc3ccccc3c2n1CC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.82
+CCN(CC)CCNC(=O)c1cc(Br)c(N)cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.54
+OC(=O)Cc1ccc(cc1)c2ccc(NC(=O)c3oc(Nc4ccccc4F)nn3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+O=S(=O)(N1CCCC1)c2ccccc2c3ccc(CNC4CCOCC4)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+Cc1ccc(NC(=O)C=C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.25
+COc1cc(F)ccc1c2cncc(CNC3CCCC3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.29
+CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.06
+C[C@@H](Oc1cccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c12)C(=O)N(C)CCO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.85
+COc1cc(ccc1N)C(=O)NC[C@@H](O)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+CNc1c(Br)cnc2[nH]c(nc12)c3ccc(OCCN4CCN(C)CC4)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.91
+COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4occc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+Cc1c(sc2ncnc(O)c12)C(=O)Nc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.13
+COCC(=O)N1CCC(CC1)n2cc(cn2)c3cnc(N)c(c3)c4oc5ccccc5n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CCCC(=O)C1(CCN(CC1)C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](N)Cc3cncn3C)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.51
+CCN(C1CCN(CC[C@H](N2CCN(CC2)S(=O)(=O)CC(F)(F)F)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+CCN1C(=O)C=Cc2cc(COc3cc(F)cc(c3)C4(CCOCC4)OC)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.89
+CC(=O)OCCn1c(Sc2nc3cccc(Cl)c3s2)nc4c(N)ncnc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.16
+CN1CCN(CC1)[C@@H]2C[C@@H](C2)c3nc(c4ccc5ccc(nc5c4)c6ccccc6)c7c(N)nccn37,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(C(=O)N)c(F)c3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C4=NNC(=O)O4)n5ccc(n5)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.65
+CN(C)CCCN1c2ccccc2Sc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+Cc1cc(Cl)ccc1OC2CCN(CC3CCN(CC3)[C@@H](Cc4ccc(F)cc4)C(=O)O)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.53
+Nc1ncc(cc1c2oc3ccccc3n2)c4cnn(c4)C5CCN(CC5)C(=O)CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CCc1cc(OCc2ccc(cc2)c3ccccc3c4nn[nH]n4)c5CCCCc5n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+C[C@@H]1CN(Cc2oc(nn2)c3cc(cc4[nH]ncc34)c5cccc6[nH]ccc56)C[C@H](C)O1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.01
+NC(=O)Nc1sc(cc1C(=O)N2CCOCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.24
+O=C(NCCCN1CCCCC1)C(c2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+Nc1c(Nc2ccccc2)nc(nc1N3CCOCC3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.72
+COc1cc(N2CCN(C)CC2)c3NC(=CC(=O)c3c1)C(=O)Nc4ccc(cc4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+O=C(NCc1occc1)c2ccc3[nH]c(COc4ccc(cc4)C56CC7CC(CC(C7)C5)C6)nc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+NC(=O)Nc1cc(sc1C(=O)N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NS(=O)(=O)c3cccc(NC(=O)C)c3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+CCN(c1ccccc1)c2cc(NC)[n+](C)c(C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.91
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ncccc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.04
+Nc1ncnc2OCCN(C(=O)c12)c3ccc(cc3)[C@@H]4CC[C@@H](CC(=O)O)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.5
+Cc1cnc(Oc2ccc(cc2)n3ccnc3)nc1Oc4ccc5OCOc5c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+Cc1csc(NC(=O)c2cc(Sc3nncn3C)ccc2N)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+C[C@@](CCc1ccc(cc1)c2ccc(Cl)cc2)(C(=O)NO)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc4cccnc24)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.49
+O=C(NCC#N)[C@@H]1CCCC[C@H]1C(=O)N2CCN(CC2)c3ccc(cc3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+Nc1ccc2nc(sc2c1)c3ccc(O)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COCCC(Oc1ncnc2c1cnn2c3ccccc3C(F)(F)F)C(=O)Nc4ccc(C)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CCN(C)C(=O)c1ccc(cc1)C(=C2CCN(Cc3cscn3)CC2)c4cccc5cccnc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(OC4CC5CC5C4)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.66
+Cc1cccc(n1)c2nn3CCCc3c2c4ccnc5ccc(cc45)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+CC1=C(Oc2c(cccc2C1=O)C(=O)OCCN3CCCCC3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+CCC(CC)NC(=O)c1cnn(c1NS(=O)(=O)C2CCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.69
+CC[C@@H](CO)Nc1nc(SCc2ccccc2)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+Nc1nc(N)c2cc(Br)ccc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CCC(=C)C(=O)c1ccc(OCC(=O)O)c(Cl)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.02
+Oc1c2C(=O)N(NC(=O)c2nc3cc(Cl)ccc13)C(c4ccccc4)c5ccncc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+CSc1ccc2Sc3ccccc3N(CCC4CCCCN4C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.76
+C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(OC4CCOC4)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.06
+COc1cc(Nc2cc(Nc3c(Cl)ccc4OCOc34)ncn2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+CC1=CN(C2CCCN(Cc3cccc(Oc4ccc(Cl)cc4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[C@@H]2O[C@H](C)[C@@H](O)[C@H]2O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.67
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)N4CC[C@H](C4)NC(=O)C)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.22
+COc1ccc(cc1OC)c2csc(NC(=O)c3c(C)onc3C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.16
+CS(=O)(=O)Cc1cc(nc(n1)c2ccccc2)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+CN([C@@H]1CCN(Cc2nc3cc(F)ccc3s2)C[C@@H]1F)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CC(C)N1CCN[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+Cn1cnc(c2ccccc2)c1c3nc4c(N)ncnc4s3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+CCCN(CCO)CCCOc1cc2ncnc(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.28
+CC(C)C[C@H](N[C@@H](c1ccc(cc1)c2ccc(cc2)S(=O)(=O)C)C(F)(F)F)C(=O)NCC#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3)S(=O)(=O)C)cn2)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4cn[nH]c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.13
+CNc1cccc(CCOc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.15
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3nccnc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.14
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2cccnc2)NC(=O)OCc3ccccc3)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+OC(=O)CCn1c2ccccc2c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CSc1ncccc1C(=O)NCCc2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+COc1nc(Cl)cnc1NS(=O)(=O)c2cccc3c(cccc23)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+O[C@@H](CNCCc1cccc(CNCCCc2ccccc2)c1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.11
+CCCN(CCCOCCOCCc1ccccc1)CCc2ccc(O)c3nc(O)sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+C[C@H](CO)Nc1nc(SCc2cccc(Cl)c2F)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.53
+C1CC(CCN1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.54
+Nc1cccc(NS(=O)(=O)c2ccc(cc2)c3ccc(cc3)C#N)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CS(=O)(=O)c1ccc(CC(=O)N(CC=C)C2CCN(CCC(c3ccccc3)c4ccccc4)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1cc2c(Nc3c(Cl)ccc4OCOc34)ncnc2cc1OCCCN5CCCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.62
+CN(C)CCOc1ccccc1Cc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.53
+Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.33
+Cc1c[nH]c(n1)c2cnc(NCCNc3ccc(cn3)C#N)nc2c4ccc(Cl)cc4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.86
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4c[nH]cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+ONC(=O)[C@@H](Cc1ccc2ccccc2c1)NS(=O)(=O)c3ccc4ccccc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.23
+COc1cc(\C=C/2\SC(=O)NC2=O)cc(OC)c1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.74
+NC(=O)c1sc(cc1N)c2ccsc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+CC(C)CNc1nc(nc(N2CCOCC2)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4ccc(CO)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+Fc1ccc(cc1F)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.84
+CCc1cc(O)c(Oc2ccc(cc2F)C(=O)N)cc1F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+Clc1ccc(OC2CCN(CC2)C3CCN(CC3)S(=O)(=O)NC(=O)c4ccccc4)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+OC(=O)c1cc2cc(ccc2n1Cc3ccc(Cl)c(Cl)c3)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+C[C@H](CO)N1C=Cc2c(NC(=O)Cc3ccc(Cl)c(c3)C(F)(F)F)cccc2C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.49
+COc1ccc2COC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.5
+Nc1ncnc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cc(cnc3OC)C4=NNC(=O)O4)n5ccc(n5)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.91
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3[nH]c(N)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CCN(CC)CCn1c2ccccc2c3cnc(N)c(C#N)c13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)C(O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.29
+C[C@H](N)COc1c(C)cccc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CC(C(=O)O)c1ccc2oc(nc2c1)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+Cn1c(CN2CCC(CC2)c3ccccc3)nc4ccccc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+COc1cccc(c1OC)c2ccc(\C=C\3/SC(=S)N([C@@H](Cc4ccccc4)C(=O)O)C3=O)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+Cc1cnc([nH]1)c2cc(NC(=O)c3ccc(nc3C)C(F)(F)F)ccc2Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+Nc1cccc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+Nc1c(nc(nc1N2CCOCC2)C#N)N3CCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.25
+COCCNCc1cncc(n1)c2ccc(F)cc2OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+CCN1CCN(Cc2cnc(c3ccc(cc3)C(=O)Nc4ccccc4N)c(c2)C#N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.14
+CSc1nc(N)nc(n1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+O=C1N=C2C(=C1C#N)c3ccc(N4CCSCC4)c5cccc2c35,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CC1=C(C(=O)c2ccc(O)cc2O1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.95
+COc1ccc(OC)c(c1)c2c(F)ccc3c(N)c(nnc23)C(=O)NC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.77
+Oc1c2ncc3ccccc3c2nn1c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+CC(NC(=O)C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CCN(C1CCN(CC[C@@H](c2ccc(F)cc2)c3ccc(cc3)S(=O)(=O)C)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.88
+O=C(Nc1ccc(nc1)N2CCOCC2)c3oc(Nc4ccccc4)nn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC1(C)CNC(=O)c2sc(nc2C1)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.29
+C[C@]12CC[C@H]3[C@@H](CC(=C)C4=CC(=O)C=C[C@]34C)[C@@H]1CCC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+Clc1ccc2OCOc2c1Nc3ccnc(Nc4cc(cc(c4)N5CCOCC5)N6CCOCC6)n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+CC(C)Cn1cnc(c2ccccc2)c1c3nc4c(N)ncnc4s3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.72
+NC(=O)Nc1sc(cc1C(=O)N[C@H]2CCCNC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.27
+CCN(CC)C(=O)c1ccc(cc1)C(=C2CCNCC2)c3ccccc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+COc1c(C)cnc(Cn2cnc3c(Cl)nc(N)nc23)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.67
+CC(C)(C(=O)N)C(=O)NCCCNc1nc(Nc2cccc(NC(=O)N3CCCC3)c2)ncc1Br,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N(C)[C@H]2CCCN(CCc3ccccc3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.29
+COc1cc2CC[C@H](NC(=O)C)c3cc(O)ccc3c2c(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+Nc1ncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(F)(F)F)ccc2Cl)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.26
+CCCCNc1ccc(cc1)C(=O)OCCN(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.11
+CC(Oc1c(Cl)cccc1Cl)C2=NCCN2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.48
+C[C@H](NC(=O)c1c(C)nn(c1NS(=O)(=O)c2cccnc2)c3ccc(F)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+Cc1c(Oc2ccc(Cl)cc2)c3c(NS(=O)(=O)C)cccc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.98
+c1ccc(nc1)c2n[nH]c(n2)c3ccncc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.48
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+C[C@H](COc1cn2ncnc(Oc3ccc4[nH]c(C)cc4c3F)c2c1C)OC(=O)[C@H](C)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.19
+Fc1ccc(CN2CCN(CC2)c3ccc4nnc(n4n3)C(F)(F)F)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.46
+Oc1c2C(=O)NNC(=O)c2nc3cc(Cl)cc(Cl)c13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.89
+CCN(CC)C(=O)c1ccc(cc1)C(=C2CCNCC2)c3cccc(c3)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+CC[C@H](C)[C@@H](CO)NS(=O)(=O)c1ccc(Cl)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+COCCCOc1ccnc(C[S+]([O-])c2nc3ccccc3[nH]2)c1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.69
+NS(=O)(=O)c1ccc2C(=CNC(=O)c2c1)C(=O)NC[C@@H](O)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+O=C1OC(=Cc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.84
+CC(C)[C@@H]1N(C)c2ccccc2C[C@@H](CO)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.03
+CC(=O)NCc1ccc(CN2CCN(CC2)c3ccccc3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+COc1ccc(CN2C(=O)NC3=C(C=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C3=O)c4ccccc4)C2=O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CCOC(=O)c1ccc(COC2CN(C2)c3ccc(C)nn3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC1=CC(=O)Oc2c(C)c3oc(C)cc3cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.47
+CC(C)N1CCC[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.62
+CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N3CCCCC3)ccc1C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.31
+CS(=O)(=O)N1CCC(CC1)NC(=O)NC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Oc1ncnc2onc(c3ccc(F)cc3)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+Cc1c(Sc2ccc(Cl)cc2)c3c(cccc3n1CC(=O)O)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.58
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(CCO)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+OC(=O)c1ccc2[nH]c(nc2c1)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.08
+CN(C)CCCN1c2ccccc2Sc3ccc(Cl)cc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+C[C@H]1NC(C)(C)CO[C@]1(O)c2cccc(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+CS(=O)(=O)C1(CC1)c2cc(nc(n2)c3cccc4[nH]ccc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Cc1nc(C)c(nc1C(=O)N)c2ccc(cc2)[C@@H]3CC[C@@H](Cc4nnn[nH]4)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+COc1cc2c(Nc3ccc(F)cc3F)c(cnc2cc1NCCN(C)C)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+COc1cccc(Nc2c(cnc3c(C)cc(cc23)S(=O)(=O)c4cccc(c4)C(=O)N(C)C)C(=O)N)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+O=C1C=C(N=C2N1C=Cc3ccccc23)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+O=S(=O)(N1CCOCC1)c2cccc(c2)c3cn4cccnc4n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+CC(C)Oc1cc(ccc1NC(=O)CN2CCOCC2)c3cccc4C(=O)C=C(Oc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1ccnc(NC2CCN(CC2)C(=O)c3ccc(Cl)cc3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.82
+CN1CCN(CC1)C(=O)c2cccc(CC3=NNC(=O)c4ccccc34)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.92
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCCCN(Cc3ccccc3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+Clc1ccc(cc1)C(N2CCNCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+CC(=O)N1CCOc2nc(OCc3ccccc3)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(ccc4C)C(=O)NC5CCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.25
+NC1(CCC1)c2ccc(cc2)c3nc4ccccn4c3c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(C)(C)NC(=O)C(N(Cc1occc1)C(=O)c2ccc([nH]2)c3ccccc3)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.13
+Cc1cc(Nc2nc(NCc3ccccn3)ncc2Br)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+CC(C)CC1(CC=C)C(=O)NC(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.48
+CCOC(=O)C1=COc2ccccc2C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+CN(C(=O)C)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.88
+CC1CCCCC1NC(=O)c2c(C)nn(c2NS(=O)(=O)c3ccc(C)cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccnc4ccc(F)cc34)c2C(=O)N5CC[C@@H](O)C5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+COc1ccccc1CNCc2ccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.15
+C[C@@](O)(C(=O)Nc1ccc(cc1Cl)S(=O)(=O)NCCCO)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CN1c2ccccc2C(NCCCCCCC(=O)O)c3ccc(Cl)cc3S1(=O)=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+COc1ccc(\C=C\2/SC(=S)NC2=O)cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.42
+CS(=O)(=O)c1ccc2[nH]c3CCN(Cc3c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1cc2ncc(C(=O)N)c(Nc3cc(F)ccc3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Cc1cc(C)cc(c1)c2oc(SCC(=O)N3CCN(CC3)C(=O)c4occc4)nn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1cc(ccc1Nc2ncc(OC)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+OC(=O)[C@H](Cc1ccc(OCCc2ccc3CCCNc3n2)cc1)NC(=O)c4c(Cl)cccc4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.33
+COc1cc(CCc2cc(Nc3ccnc(NCc4onc(C)c4)n3)n[nH]2)cc(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CS(=O)(=O)Cc1cc(nc(n1)c2ccc(NS(=O)(=O)C)cc2)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.85
+COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.27
+NS(=O)(=O)c1cc(cc(N2CCCC2)c1Oc3ccccc3)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.94
+Cc1nccn1CCC(C(=O)N)(c2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+CC(C(=O)O)c1cccc(Oc2ccccc2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.71
+CNC(=O)c1cccc2c1c(Sc3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.89
+O=C1C=C(Oc2c1cccc2c3cccc4c5CCCCc5sc34)N6CCOCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+CN1CCCC1CCNC(=O)c2ccc(Nc3ncc4cc(ccc4n3)c5ccncc5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CC(=O)c1noc(C)c1C(=O)Nc2nccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4c(N)cccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+O=C(N[C@@H]1CN2CCC1CC2)c3ccc(s3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+Cc1c(c2ccc(O)cc2)n(C)c3ccc(O)cc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CNC(=O)c1ccc(Nc2ncc(F)c(n2)c3cnc(C)n3C(C)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COC(=O)C1=C(C)NC(=C([C@@H]1c2cccc3nonc23)C(=O)OC(C)C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.77
+COc1cc(F)ccc1c2cncc(CNC(=O)C3CCC3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+Oc1cc(Cl)cc(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.58
+CSc1ccc(cc1)c2nc(c3ccc(F)cc3)c([nH]2)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.97
+COc1c(N2C[C@@H]3CCCN[C@@H]3C2)c(F)cc4C(=O)C(=CN(C5CC5)c14)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.18
+CCOc1cc2nnc(C(=O)N)c(Nc3ccc(F)cc3F)c2cc1N4CCN(C)CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cc3ccncc3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+NC(=O)c1cccc(OC2CCN(Cc3ccccc3)CC2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+C[C@H](Nc1nc(Nc2cc(C)[nH]n2)c(Cl)c(n1)N3CCOCC3)c4ncc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.61
+CN(C(=O)C)c1ccccc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+CN(C)C(=O)c1ccc(CN2CCC(CC2)c3ccc(cc3)C(=O)Nc4ccccc4N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.53
+COC1=CC=C2C(=CC1=O)[C@H](CCc3cc(OC)c(OC)c(OC)c23)NC(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.82
+CC(C)(C)c1ccc(cc1)c2n[nH]c(NC(=O)c3ccccc3Cl)c2Br,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+CC(C)[C@@H]1N=C(c2ccccc2)c3ccccc3NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+OC(=O)COc1cccc(c1)C(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.09
+O=C1COc2ccccc2N1CCN3CCC(CC3)NCc4cc5OCCOc5cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.04
+CNCCC=C1c2ccccc2CCc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.58
+CN1CCCC(CC1)N2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+O=C(Nc1ccccc1)N2CCOCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CCn1c2ccccc2c3cc(NC(=O)N4CCOCC4)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+Cc1ccc(NC(=O)c2cccc(c2)N3CCOCC3)cc1NC(=O)c4ccc(OCc5ccncc5)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CN(C)CC(O)COc1ccc(Nc2nccc(Nc3cc(C)ccc3Cl)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CC(=O)Nc1cccc(OCc2cnc(Cl)s2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.38
+OCC(=O)N1CCC[C@H]1COc2cccc3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.62
+COc1ccc(cc1)c2nc(nc(O)c2C#N)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+CN1CCC(COc2cc(OC3CCOCC3)c4c(Nc5c(Cl)ccc6OCOc56)ncnc4c2)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.59
+COc1cc2ncnc(NCc3ccccc3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccccc3C(F)(F)F)c2C(=O)N4CC=CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.53
+CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc3ccc(OC)cc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+Cc1ccc(Oc2ccc(OCC(=O)Nc3ccncc3)cc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+Cn1cnc2cc(OC(=O)c3ccccc3)cnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Brc1cc(Br)cc(COC[C@@H](N2CCNCC2)c3ccccc3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Cc1ccc(cc1)S(=O)(=O)NC(=O)NN2CCCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.01
+Oc1ccc(cc1)C2CC(=O)c3c(O)cc(O)cc3O2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+Nc1c(c(CN2CCOCC2)nn1c3ccc(F)cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.33
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3NC(=O)C(=Cc13)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.32
+Nc1nc2ccc(Cl)cc2c3nc(nn13)c4occc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.98
+COc1ccc2ncc(F)c(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CCN(CC)CCN1C(=O)CN=C(c2ccccc2F)c3cc(Cl)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.38
+NC1(CCC1)c2ccc(cc2)c3ncc4ccccc4c3c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CS(=O)(=O)c1ccc(cc1Cl)[C@@H](CC2CCCC2)C(=O)Nc3cnc(cn3)[C@H](O)CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.58
+CCN(C(=O)C)c1cccc2c1c(Sc3ccc(Cl)cc3)c(C)n2CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+COc1ccc(COC(=O)N2CCC(CNc3ncccn3)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+CC[C@H](C)C(=O)O[C@H]1C[C@H](O)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@@H]12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.76
+O[C@H](CNC(=O)c1cccc(c1)C#N)CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.48
+CN(C)C(=O)Nc1ccc(CN2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+COc1cc(Nc2cc(Oc3cccnc3C)ccn2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.19
+CCOc1ccccc1c2ccc3c(c2)C(=O)C(=O)c4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+Cc1cccc(NC(=O)NCC(N2CCOCC2)c3cccnc3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+Fc1ccc2c3CN(CCc3[nH]c2c1)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+CNC1=Nc2ncccc2C(=NC1c3cccs3)c4ccns4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+CCC(N(CCCN)C(=O)c1ccc(C)nc1)C2=Nc3ccsc3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cc3F)S(=O)(=O)C)cn2)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CN1CCN(CCCN2c3ccccc3Sc4ccc(Cl)cc24)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.92
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(c4ccccc4)c5ccc(Cl)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](C(c3ccccc3)c4ccccc4)C(=O)OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+O=C1C=C(Nc2cc(Cc3ccccc3)ccc12)c4cccnc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.46
+COc1cc(O)ccc1\C=C\2/CCCN=C2c3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CCCNC(=O)c1nnc2c(cccc2c1N)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+COc1cc(ccc1Cn2ncc3ccc(NC(=O)CC4CCCC4)cc23)C(=O)NS(=O)(=O)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+COc1cc2c(ncnc2cc1OCCCN3CCCCC3)N4CCN(CC4)C(=O)Nc5ccc(OC(C)C)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CC1=CC(=O)Nc2sc(C(=O)c3ccc(Br)cc3)c(N)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.57
+COC(=O)CCCCCCC(=O)Nc1ccc2c(c1)C(=O)C(=O)c3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Cc1cc(Cl)ccc1OC2CCN(C[C@H](O)CNC(=O)C3=CNC(=O)C=C3C(F)(F)F)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+CCCSc1c(cnn1C)C(=O)NC2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+CS(=O)(=O)c1ccc(cc1)c2cc(ccc2OCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.87
+O=C(OCCN1CCCCC1)c2c[nH]c3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CO[C@H]1CN(CCCOc2ccc(F)cc2)CC[C@H]1NC(=O)c3cc(Cl)c(N)cc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+CN(C)CC(C)(C)COc1nccc(Nc2cc(NC(=O)c3ccnc(c3)N4CCOCC4)ccc2C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CCc1cc2C(=NCc3nnc(C)n3c2s1)c4ccccc4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.52
+OC(=O)COc1ccc(cc1c2ccccc2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.08
+CS(=O)(=O)Cc1cc(nc(n1)c2ccc3[nH]ccc3c2)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+FC(F)(F)c1nn(cc1C(=O)NCCNC(=O)c2ccc(Cl)cn2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CNC(=O)c1cccc(NC(=O)Nc2cccc(c2)C#N)c1CN3CCC(Cc4ccc(F)cc4)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.97
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(Cc4ccccc4)c5ccc(Cl)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+Cc1oc(cc1C(=O)O)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.67
+CSc1nc2cc(Cl)ccc2[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CC(C)C[C@H](CO)Nc1nc(SCc2cccc(c2)C#N)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+OC(=O)C[C@@H]1CC[C@H](CC1)c2ccc(cc2)c3ccc(Nc4ccc(nc4)C(F)(F)F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+COc1cc(Cc2cnc(N)nc2N)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.63
+CN(C)C(=O)N[C@@H]1CC[C@@H](CN2[C@@H]3CC[C@H]2C[C@H](C3)Oc4cccc(c4)C(=O)N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.07
+O[C@@H](CNCCc1cccc(CNCCc2ccccc2F)c1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.06
+Cc1ccc(CNC(=O)C2CCCN2S(=O)(=O)c3ccc(F)cc3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+OC(=O)COCCN1CCN(CC1)C(c2ccccc2)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.27
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)C(=O)OC(C)(C)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(c(F)c3)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CCOc1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Oc1cc(nc2ncnn12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.21
+NC(=O)c1nnn(c1N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.74
+OC(c1ccccc1)c2cccnc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(ccc4C)C(=O)Nc5nccs5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.56
+CN1C(=O)N(CC2CC2)c3nn(Cc4cn(C)c5ccc(Cl)cc45)c(c6cc(oc6C)S(=O)(=O)C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.48
+CC(CN1c2ccccc2Sc3ccccc13)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+CCc1nc2c(N)nc3ccccc3c2n1Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+NCC[C@@H](Oc1ccc(Cl)cc1C#N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+CCn1c(nc2c(ncc(OCC3CCCNC3)c12)C#CC(C)(C)O)c4nonc4N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+Cc1cc(Oc2ccnc(Nc3cccc(c3)N4CCOCC4)c2)c(nc1C)c5ccccn5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+Cc1c(Cl)c(ccc1OC2CCN(CC3CCN(CC3)[C@@H](Cc4ccc(F)cc4)C(=O)O)CC2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+c1ccc2[nH]c(nc2c1)c3cscn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3cc(Cl)cc(Cl)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(C)cnc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.55
+COc1ccc2Sc3ccccc3N(C[C@H](C)CN(C)C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+Oc1nc(nc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+CN1C(=O)N(CC2CC2)c3nn(Cc4ccnc5ccc(Cl)cc45)c(c6cc(oc6C)S(=O)(=O)C)c3C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCN(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.26
+NC(=N)Nc1ccc(cc1)C(=O)Oc2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+C[C@@](O)(C(=O)Nc1ccc(cc1Cl)C(=O)N2CCCCC2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.62
+CC1(CC(=O)NC(=N1)N)c2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.59
+CC(C)[C@H](NC(=O)C[C@H](NC(=O)\C=C\c1ccccc1)c2ccccc2)C(=O)[C@H]3[C@H](C)C(=O)NC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+O=C1O[C@]2(CN3CCC2CC3)CN1c4cccs4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CCN(CCO)CCCOc1cc2ncnc(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+OC[C@H](O)CN1C(=O)[C@H](Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC(O)C(C)OC(=O)[C@@H]1CC2C(Cc3cn(C(C)C)c4cccc2c34)N(C)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CC6COCC(C5)N6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+COc1ccnc(NC2CCN(CC2)C(=O)c3ccc(cc3)C#N)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.73
+Cc1c(Cl)c(Cl)ccc1OC2CCN(CC3CCN(CC3)[C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+O=C(Nc1ccc(nc1)N2CCOCC2)c3oc(Nc4cccc(OCc5ccccn5)c4)nn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CC(O)(C(=O)Nc1ccc(cc1)S(=O)(=O)Nc2ccccc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+CNc1nc2nc(SCc3cccc(F)c3F)nc(N[C@H](C)CO)c2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CC(C)CN1C(=O)N(C)C(=O)c2c(SCCCO)n(Cc3cccc4ccccc34)cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.36
+CC(C)C(NC(=O)CN1C(=O)C(=CC=C1c2ccccc2)NC(=O)CN3C(=O)CCC3=O)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.96
+CN1CCC(CC1)NC(=O)c2ccc(Oc3ccc(cc3)C#C[C@]4(O)CN5CCC4CC5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+CN1CCN(CC1)c2ccc3ncc(C(=O)N)c(Nc4ccc(Cl)cc4Cl)c3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.23
+COc1ccc(CNCc2cccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)c2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.86
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCCN(CCc3ccc(F)cc3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+COc1cc2c(Nc3ccc(Cl)cc3F)ncnc2cc1OCC4CCNCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+Nc1nc2cc3CCN(Cc4cnc[nH]4)CCc3cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.12
+CCN(C1CCN(CCC(c2ccccc2)c3ccc(NC(=O)Cc4ccccc4)cc3)CC1)C(=O)Cc5ccc(cc5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.61
+FC(F)(F)CCS(=O)(=O)Oc1ccc(NC(=O)c2ccc(Cn3ccnn3)c4ccccc24)c(n1)C(=O)NCC5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.2
+CC(CC(=O)NCc1ccccc1)C2CCCO2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCN(CCCc3ccccc3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+CNc1cc(nc2c(cc(OC)cc12)N3CCN(C)CC3)C(=O)Nc4ccc(cc4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+CS(=O)(=O)Cc1ccc2ccn(c3cc(NC4CC4)n5ncc(C#N)c5n3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+CCn1c2ccccc2c3cc(NC(=O)CN(C)C)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+OC(=O)COc1ccc(Cl)cc1C2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.93
+Oc1ccc2[nH]c(CN3CCC(Cc4ccc(F)cc4)CC3)nc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+Fc1ccc(CC2=NNC(=O)c3ccccc23)cc1C(=O)N4CCCNCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.1
+Cn1cc(cc1c2c3C(=O)N(CC#N)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.33
+Clc1ccccc1NC(=O)c2cc[nH]n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.58
+CN(C)S(=O)(=O)c1ccc(CC(=O)N(C)C2CCN(CCC(c3ccccc3)c4ccccc4)CC2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+C[C@@H](NC1=CC(=O)CCC1)c2ccc(Nc3ncc4cc(ccc4n3)c5ccncc5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+O=C1C=C(Nc2ccccc12)c3occc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.21
+Nc1nc2cc3CCN(Cc4ccccc4)CCc3cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+Cc1onc(C)c1CCC2CCN(CC2)S(=O)(=O)CC3(CCC(F)(F)CC3)N(O)C=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Oc1ccc(CCNCCCNS(=O)(=O)CCOCc2cccc3ccccc23)c4sc(O)nc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+c1ccc(cc1)c2ccc3ccccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+O=C(NCC#N)[C@@H]1CCCC[C@H]1C(=O)N2CCC=CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CNS(=O)(=O)NC1=CC=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C1=O)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+O=S(=O)(NCCNc1ncccn1)c2cccc3cnccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.61
+COc1ccc2nc(C)cc(c2c1)n3cc(CNC(=O)C)nn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+Oc1ccc(CCNCCN(C2CCCCC2)C(=O)CCNCCc3ccc(Cl)c(Cl)c3)c4OCC(=O)Nc14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.23
+CCCCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(N)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+CCCS(=O)(=O)c1ccc(cc1)C(CNS(=O)(=O)c2ccc(cc2)C(F)(F)F)N3CCCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.32
+NC(=N)c1cc2c(\C=C\c3ccc4OCOc4c3)cccc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+OC(=O)C(N1CCCC(CN2CCC(CC2)Oc3ccc(Cl)c(Cl)c3)C1)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CCOC(=O)c1cc(O)c(nn1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.69
+c1ccc2c(c1)nnn2c3ccncc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+Cc1cccc(CN2C=CN3C(=O)C=C(N=C23)N4CCOCC4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Nc1nc(O)cc(n1)c2ccc(O)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.05
+O=C(NCc1ccccc1)c2cccnc2Oc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CC(C)CNc1nc(nc(N2CC(O)C2)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CN(C)C(=O)N1CCC(CC1)C(=O)NCc2cccs2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+CN(c1ccnc(Nc2cc(cc(c2)C(=O)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Fc1ccc(cc1Cl)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.98
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+Clc1ccc(cc1)c2c[nH]nn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.97
+COc1cc(cc2cnc(Nc3ccc(cc3)[C@@H](C)NC(=O)C)nc12)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.73
+CC(C)N1C(=O)N(C)C(=O)c2cn(Cc3cccc4ccccc34)cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.97
+CCCCCCCCCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H]3[C@@H](C)OC(=O)[C@H](CC(=O)c4ccccc4N)NC(=O)[C@@H](NC(=O)[C@@H](CO)NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCN)NC(=O)CNC3=O)[C@H](C)CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.94
+C[C@H](Nc1nc(Nc2ncc(C)s2)cc(n1)N3CCOCC3)c4ncc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+CC(C)N1CCN(Cc2cnc(c(C)c2)c3ccc(cc3)C(=O)Nc4ccccc4N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.44
+COc1ccccc1OCCNCC(O)COc2cccc3[nH]c4ccccc4c23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.27
+NC1(CCC1)c2ccc(cc2)c3nc4ccccc4cc3c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+OC(=O)c1ccc(cc1)n2ncc(C(=O)NC3C4CC5CC(CC3C5)C4)c2C6CCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+O=C1Nc2cc(ccc2C1c3ncnc4cc(OCCCN5CCOCC5)ccc34)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+CC(C)(C)C(=O)NCc1ccc(NC(=O)N2CCCC(O)(C2)c3ccc(Cl)c(Cl)c3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.93
+CC[C@H]1N(C2CCCC2)c3nc(Nc4ccc(cc4OC)C(=O)NC5CCN(C)CC5)ncc3N(C)C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+CCCCn1c(Cc2cc(OC)c(OC)c(OC)c2)nc3c(N)ncnc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.39
+NC(=N)c1cc2c(OCc3ccccc3)cccc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.16
+OC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CCCSc1nc(N[C@@H]2C[C@H]2c3ccccc3)c4nnn([C@@H]5C[C@H](OCCO)[C@@H](O)[C@H]5O)c4n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.87
+Cc1c(N)cccc1CN2C=CC(=CC2=O)OCCc3cccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+Cc1ccc(NC(=O)c2ccnc(c2)N3CCOCC3)cc1Nc4ccnc(Cl)n4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+OC(=O)C[C@H]1[C@@H](Cc2ccccc12)NC(=O)c3cc4cc(Cl)ccc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+COc1ccc(cc1Cl)C(=O)NCCN2CCN(Cc3ccc(Cl)c(Cl)c3)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.74
+O[C@@H](CNCCc1cccc(CNCc2ccccc2Cl)c1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.85
+CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+Cc1cc(CNc2nccc(Nc3cc(CCc4ccccc4)[nH]n3)n2)on1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.56
+NC(=O)c1cccc(O[C@@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.76
+COc1cc(Nc2c(cnc3cc(OC)c(OC)cc23)C#N)cc(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+Cc1cc(CNc2ncc(Br)c(Nc3cc([nH]n3)C4CC4)n2)on1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.43
+CCCCC1(CC)C(=O)NC(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN4CCC[C@H]4CC(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+COc1cc2ncnc(NCc3cccc(C)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+COc1ccc(cc1)c2cc(O)nc(N)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+OC(=O)c1ccc(NC(=O)c2cc(OCc3ccccc3)cc(OCc4ccccc4)c2)nc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+OCC(CO)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)ccc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.64
+CO[C@@H](C(=O)N1Cc2n[nH]c(NC(=O)c3ccc(cc3)N4CCN(C)CC4)c2C1)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CCN(C1CCN(CC[C@H](N2CCN(CC2)S(=O)(=O)C)c3cc(F)cc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.25
+Cc1ccc(cc1)S(=O)(=O)Nc2ccc(\C=C\C(=O)Nc3ccccc3N)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.82
+Clc1ccc(C2CCN(CC2)C(=O)COCc3ccncc3)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+CC(C)N(CCNCCc1ccc(O)c2NC(=O)Sc12)C(=O)CCOCCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.33
+CN(C\C=C\C#CC(C)(C)C)Cc1cccc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+CCOc1ccc(cc1)c2cnc3CCCn23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+C[C@@H](NC(=O)[C@@H]1CCCC[C@H]1C(=O)N2CCc3[nH]c4ccc(F)cc4c3C2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1ccc2nc(C)cc(OCC(=O)NCc3ccccc3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CNC1=CN=C(N(CC(=O)NC(C(C)C)C(=O)C(F)(F)F)C1=O)c2ccc(F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+CC(=O)Nc1ccc2c(c1)c(cn2CCC(=O)O)c3cc(NC4CC4)n5ncc(C#N)c5n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.87
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)N(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+CN1CCN(CC1)c2nc3ccccc3cc2Cn4nc(c5ccc6nc(N)sc6c5)c7c(N)ncnc47,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.09
+Oc1cccc2ccc(nc12)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.81
+COCCNC(=O)c1ccc(Nc2ncc3cc(ccc3n2)c4ccncc4OC)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+NCCCCCc1c[nH]c2ccc(F)cc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CN1C(=O)N(Cc2ccc(cc2)C(=O)O)C(=O)c3cc(ccc13)C#CCc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+COc1c(cc2ccccc2c1C(=O)N(C)C[C@@H](CCN3CCC(CC3)c4ccc(O)cc4[S+](C)[O-])c5ccc(Cl)c(Cl)c5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CN1C(=O)N(C)c2ncn(C)c2C1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.03
+Cn1c(ccc1c2cc(F)c3NC(=O)C(C)(C)c3c2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+CN(C)CC(O)COc1ccc(Nc2cc(ncn2)N(CCC#N)c3cc(Cl)ccc3Cl)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+OC1(CNC(=O)c2cc(ccc2Cl)N3N=CC(=O)NC3=O)CCCCCC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.26
+COc1ccccc1N2CCN(CCN(C(=O)C3CCCCC3)c4ccccn4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+Fc1ccccc1NC(=O)N[C@H]2N=C(c3ccccc3)c4ccccc4NC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+CCC[C@@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.6
+CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c2cc3sccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Cc1cccc(Br)c1C(=O)N[C@@H](Cc2ccc(NC(=O)c3c(Cl)cccc3Cl)cc2)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.13
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3nc(NS(=O)(=O)C)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.92
+Cc1nc(C)c(nc1C(=O)N)c2ccc3c(CC[C@@]34CC[C@@H](CC4)c5nnn[nH]5)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+Brc1cnc(NCc2ccccc2)nc1Nc3cc([nH]n3)C4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.11
+Cc1ccc(cc1NC(=O)CC23CC4CC(CC(C4)C2)C3)C(=O)N5CC6CNCC(C5)O6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+C[C@H]1C[C@H]2[C@@H]3CC[C@](O)(C(=O)CO)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)C=CC(=O)C=C14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+C[C@H](Nc1nc(Nc2ncc(C)s2)cc(n1)N3CCN(C)CC3)c4ccc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+CN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cccc6[nH]ncc56,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.23
+Fc1ccccc1NC(=O)NC2N=C(c3ccccc3)c4ccccc4NC2=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CN1C(=O)C=C(CCc2ccc3cc[nH]c3c2)N=C1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CC1=C(Cc2ccccc2)C(=O)n3nc(NCc4cccc(Cl)c4)nc3N1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+Clc1ccc(Cl)c(c1)S(=O)(=O)Nc2nc(cs2)c3sccc3Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.11
+COc1cc2ncc(C(=O)N)c(Nc3ccccc3C)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+N[C@@H](Cc1cccs1)C(=O)N[C@]2(C[C@H]2c3ccccc3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+COc1ccc(C)c(NC(=O)CC23CC4CC(CC(C4)C2)C3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.96
+CC1=CN(C2CCCN(Cc3cccc(Oc4ccccc4)c3)C2)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4ccccc4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.07
+C[C@@H](NC1=CC(=O)CNC1)c2ccc(Nc3ncc4cc(ccc4n3)c5ccncc5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+CN1CCOc2cc(COc3ccccc3)cnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+O[C@H](CNC(=O)c1c[nH]nc1C2CC2)CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+CCOc1noc2cc(OCCC3CCN(CC3)c4ccc(C)nn4)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.23
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccsc3C(=O)N2Cc4cscn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.02
+C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(OC4CCC(F)(F)CC4)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.42
+O[C@@H](CNCCc1cccc(CNCCc2ccccc2Cl)c1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.63
+CC(C)n1c2ccccc2c3cc(NC(=O)N4CCOCC4)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.55
+CC(C)Oc1ccc(cc1C(=O)N2CCN(CC2)c3ccc(cc3)C(F)(F)F)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.33
+CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@H]2CCCN(Cc3ccccc3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.01
+CN1CCN(CC1)C(=O)Cc2csc(NS(=O)(=O)c3cccc(Cl)c3C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.57
+CCOC(=O)c1cnc2c(N)cccc2c1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+CN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.08
+NS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4ccccn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+COc1cc(OC)c(cc1NC(=O)CCC(=O)O)S(=O)(=O)N2C(C)CCc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.87
+Cc1cc(CN2Cc3cccnc3CC2C(=O)Nc4ccc(Cl)cc4Cl)ccc1OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.15
+C1CN2CCC1C(C2)c3oc(nn3)c4oc(cc4)c5cccnc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+O=C(NC1(CC1)C#N)[C@@H]2CCCC[C@H]2C(=O)N3CCN(CC3)c4nc(cs4)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+NC1=CC2=NNC(=O)N2c3cc(ccc13)c4ccsc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+CCc1cccc(CC)c1NC(=O)N2Cc3[nH]nc(NC(=O)c4ccc(cc4)N5CCN(C)CC5)c3C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(C(=O)N)c(F)c3)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+[O-][N+](=O)c1cc(C(=O)NCC=C)c2N=C(Nc3ccc(Cl)c(Cl)c3)NC(=O)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+c1ccc(cc1)c2cn3ccccc3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COC[C@H](O)CN1C(=O)C=NN(C1=O)c2ccc(Cl)c(c2)C(=O)NCC3(O)CCCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.46
+FC(F)(F)c1cc(NC(=O)c2cnc(Cl)nc2C(F)(F)F)cc(c1)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+CCC(C)(C)C(=O)O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(=O)O)[C@@H]12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.55
+NC(=O)c1cccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3CC4CCCCC4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.55
+Oc1ccc(cc1)c2sc3cc(O)ccc3c2C(=O)c4ccc(OCCN5CCCCC5)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.13
+OC(=O)c1ccccc1N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+COc1ccc(CC(=O)N(C)C2CCN(CCC(c3ccccc3)c4ccccc4)CC2)cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CCN1CCN(Cc2cnc(c(C)c2)c3ccc(cc3)C(=O)Nc4ccccc4N)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3snc(C)c3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+CCOC(=O)Cc1csc(NS(=O)(=O)c2ccc(Cl)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.32
+Clc1ccc2Oc3ccccc3N=C(N4CCNCC4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.28
+Cc1cc2nc(NC(=N)N)nc(C)c2cc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+CN[C@@H](C)C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(c3ccccc3)c4ccccc4)C(=O)CC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.82
+Cc1nc(C)c(s1)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+COc1ccc(cc1)c2nc3CCCn3c2Br,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+OC(=O)[C@H](Cc1ccc(cc1)C#N)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.17
+CN1C[C@@H](c2ccccc2)c3cccc(N)c3C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.11
+Cn1c(ccc1c2ccc3NC(=O)OC(C)(C)c3c2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.85
+CN([C@H](CN1CCCC1)c2ccccc2)C(=O)Cc3ccc(Cl)c(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+Cn1c2ccccc2c3cc(NC(=O)CCc4ccncc4)ccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+OC(c1ccccc1)c2ccc3C(=O)C=C(Nc3c2)c4cccnc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.27
+CC(C)COc1ccc(cc1C#N)c2nc(C)c(s2)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.94
+O[C@@H](CNCCc1cccc(CNCc2ccccc2F)c1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.69
+CN1C(=O)C=C(CCc2cccc(c2)c3cccnc3)N=C1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+NS(=O)(=O)c1cccc(Nc2nccc(Nc3c(Cl)ccc4OCOc34)n2)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.97
+CC(=O)NC[C@H]1CN(C(=O)O1)c2ccc(N3Cc4ccncc4C3)c(F)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.02
+CC1=C(Cc2ccccc2)C(=O)n3nc(NCc4cccc(Br)c4)nc3N1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.68
+CC(C)n1nc(c2ccc(C)cc2)c3c(N)ncnc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+O=C1CCOc2nc(OCc3ccccc3)ccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1ccc(OC)c(c1)c2c(F)ccc3c(N)c(nnc23)C(=O)NC4CC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.47
+CC(C)N1CCO[C@@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.77
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2cccc(OC)c2)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.47
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(C(=O)N(C)C)c(F)c3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+OC(=O)[C@H](Cc1ccc(Cl)cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+Cc1cc(C)nc(N)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.85
+C[C@@H]1COCCN1c2cc(nc(n2)c3cccc4[nH]ccc34)C5(CC5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+Fc1cccc(CN2CCN(CC2)c3ccc4nnc(n4n3)C(F)(F)F)c1F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CCCCCCCN(CCc1ccc(OC(C)(C)C(=O)O)cc1)C(=O)Nc2ccc(F)cc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.93
+COc1ccc(cn1)[C@@]2(O)CC[C@H](CC2)N3CC[C@H](C3)NC(=O)CNC(=O)c4cccc(c4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.72
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)N[C@@H](CCN4CCCCC4)c5ccc(Cl)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CN(C)CCNc1cc(nc2cc(nn12)c3ccc(F)cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.5
+O=S(=O)(Nc1cccnc1)c2ccc3OCCOc3c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.34
+CNCCC(Oc1ccccc1OC)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.22
+OC[C@H]1C[C@H]([C@H](O)[C@@H]1O)n2nnc3c(N[C@@H]4C[C@H]4c5ccccc5)nc(SCCC(F)(F)F)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.06
+CC(=O)NCc1ccc(CN2CCN(CC2)c3ccc(F)cc3F)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+O=C(N1CCC1)c2ccc(cc2)C(=C3CCN(Cc4cscn4)CC3)c5cccc6cccnc56,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.52
+Clc1ccc(cc1C(=O)NCC23CC4CC(CC(C4)C2)C3)N5CCNCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.77
+Fc1ccccc1Nc2oc(nn2)C(=O)Nc3ccc(cn3)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CN(C)CCC=C1c2ccccc2COc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.15
+CC[C@H](CO)Nc1nc(NCc2ccccc2)c3ncn(C(C)C)c3n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.63
+NCC(O)(c1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+[O-][N+](=O)c1cccc(c1)c2ccc(OCC(CCc3ccncc3)N4C(=O)CCC4=O)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.88
+CC(Nc1ccccc1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+Cc1cc(N)c2cc(NC(=O)CC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.35
+COc1cc2OC[C@H]3Oc4c5C[C@@H](Oc5ccc4C(=O)[C@H]3c2cc1OC)C(=C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.57
+Nc1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+Fc1ccc(cc1F)C(=O)Nc2ccc(Cl)nc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.31
+CCN(CC)S(=O)(=O)c1ccc(NC(=O)[C@@](C)(O)C(F)(F)F)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.66
+COc1cc(F)ccc1c2cncc(c2)C3CCCN3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+COc1ccc(Nc2ccccc2C(=O)O)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.2
+CN(C)CCCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+C[C@H](CO)Nc1nc(SCc2cccc(F)c2F)nc3ncc(C)nc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+COc1ccc2c(Oc3ccc(CC(=O)Nc4n[nH]c(C)c4C)c(OC)c3)ccnc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.78
+C[C@H](Nc1nc(NC[C@@H](O)CO)c(Cl)c(Nc2cc([nH]n2)C3CC3)n1)c4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.39
+CCCSc1c(cnn1[C@@H]2CC[C@H](CC2)C(=O)O)C(=O)NC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.03
+c1cnc2cccnc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.89
+Oc1c(C#N)c(nc2ccncc12)c3ccc(cc3)c4ccccc4CN5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CS(=O)(=O)C1(CCNCC1)c2cc(nc(n2)c3cccc4[nH]ccc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+O=C(C1CC1)c2ccc(OCCCc3c[nH]cn3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+Nc1nc2ccc(OC(F)(F)F)cc2s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.34
+CN(C)Cc1ccccc1Sc2ccc(C)cc2N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+Cc1cc(CN2CCc3ccccc3C2C(=O)Nc4ccc(Cl)cc4Cl)ccc1OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+CN(C1CCN(Cc2ccc(cc2)C(F)(F)F)CC1)C(=O)Cc3ccc(cc3)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+O=C(N1CCCCC1)c2csc3CCCCc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+SC1=Nc2[nH]cnc2C(=O)N1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.48
+Nc1ncnc2c1ncn2[C@@H]3O[C@H](CSCCCNC(=O)Nc4ccc(Cl)cc4)[C@@H](O)[C@H]3O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+N#Cc1cccc(c1)c2onc(n2)c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+COc1ccc2nccc(C(O)C3CC4(CCN3CC4)C=C)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+Cn1cc(cn1)c2cccc(C[C@H](NC(=O)c3cc(nn3C)C(C)(C)C)C(=O)NCC#N)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+OC1=NC(=O)C(N1)(c2ccccc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+C[C@H](Nc1ncc(F)c(Nc2cc([nH]n2)C3CC3)n1)c4ccc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.14
+CCC[C@@H](CN1CCCC1)N(C)C(=O)Cc2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.27
+COc1ccc2N=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.93
+CCN(CC)C(=O)c1ccc(cc1)C(N2CCNCC2)c3cccc4cccnc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.7
+CC1=C2C(=CC(=O)N1Cc3ccccn3)NN(C2=O)c4ccccc4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.2
+COc1ccc2N=NC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.65
+Cc1ccccc1CN2CCC(CC2)N3CCC(CC3)N4C(=O)Nc5ccccc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+O=C(CSc1ccccc1)N2CCN(CC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CCN(CC)CCCNCc1cc(Cl)c2cccnc2c1O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.72
+O[C@@H](CNCCc1ccc(CNCCc2ccccn2)cc1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.25
+Clc1ccc2OCOc2c1Nc3ncnc4cc(OCCN5CCCC5)cc(OC6CCOCC6)c34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CCN1C=C(C(=O)O)C(=O)c2ccc(C)nc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.1
+CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc2ccccc2)NC(=O)OCc3cncs3)Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.3
+CSc1ncccc1C(=O)NCC2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+Cc1c(F)cc(cc1c2ccc(cn2)C(=O)NCC(C)(C)C)C(=O)NC3CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+COc1ccccc1C(=O)Nc2ccc(C)c(c2)N3C=Nc4ccc(cc4C3=O)N5CCN(C)CC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+COc1ccc(cc1)c2cc(N)n3ncc(C#N)c3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+CN(C)CCNS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4ccccn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+COCCCCC(=NOCCN)c1ccc(cc1)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.55
+CNC1=Nc2ncccc2C(=NC1c3cccs3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+CCN1C2=NC(=O)N(C)C(=O)C2=Cc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+CN(C)c1cccc(c1)C(=O)Nc2ccc(C)c(c2)C(=O)Nc3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.01
+NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)cn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.51
+CCc1nn(C2CCCC2)c3c1CCn4c(nnc34)c5cccs5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CCCN1CCC(CC1)Oc2nccc(Nc3cc(NC(=O)c4cccc(c4)N5CCOCC5)ccc3C)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4cc(C)ccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+COc1cnc(nc1N2CCOCC2)c3ccccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+C[C@@H]1CN(CCN1c2ncc(OCc3ccc(cn3)S(=O)(=O)C)cn2)C(=O)OC(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+Nc1nccc(n1)c2cc3C(=O)NC[C@H](CCF)c3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.51
+COc1ccc(cc1)c2nc3c(NCC4CCNCC4)c(Br)cnc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.36
+CCCSc1nc(Oc2ccc(CC(=O)O)cc2)ccc1C(=O)NC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+O=C(Nc1ccc(cc1)N2CCOCC2)c3oc(Nc4ccccc4)nn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+CNC(=O)c1[nH]cnc1C(=O)Nc2ccc(OC)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+Cc1ccc([nH]1)C(=O)NC2CCN(CC2)c3cc(cc(Cl)n3)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OC)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+Fc1ccc(CC2=NNC(=O)c3ccccc23)cc1C(=O)N4CCN(CC4)C(=O)C5CCCO5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.9
+O=C(Nc1ccccc1)c2ccc(OCCCN3CCCC3)cc2OCc4ccccc4C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+COc1cccc(c1)[C@@H](C)NCCCc2ccccc2Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)c5cocc5)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+COc1cccc(c1)C(=O)Nc2ccc(C)c(c2)N3C=Nc4ccc(cc4C3=O)N5CCN(C)CC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.08
+COc1ccc(CNC(=O)c2ccc(Oc3ccc(cc3)C#C[C@]4(O)CN5CCC4CC5)cc2)nc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Cn1cc(cc1c2c3C(=O)N(CC#CCn4cncn4)C(=O)N(CC5CC5)c3nn2Cc6ccnc7ccc(Cl)cc67)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.43
+CCNCc1cncc(n1)c2ccc(F)cc2OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.18
+COc1cc(cc(OC)c1OC)C(=O)NCc2ccc(OCCN(C)C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.74
+CCCNC(=O)c1nnc2c(c(F)ccc2c1N)c3ccc(OC)cc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.52
+CC(C)OC(=O)N1CCC(CC1)Oc2ncnc3N(CCc23)c4ccc(cc4F)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+CCO\N=C(\C1CCN(CC1)C2(C)CCN(CC2)C(=O)c3c(Cl)cncc3Cl)/c4ccc(Br)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(OCC4CC45CC5)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CCN(C1CCN(CCC(N2CCN(CC2)c3cccc(F)c3)c4ccccc4)CC1)C(=O)Cc5ccc(cc5)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+FC(F)(F)c1cccc(c1)S(=O)(=O)NC(=O)N2CCC(CC2)N3CCC(CC3)Oc4ccc(Cl)c(Cl)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.94
+OC(=O)CCC(=O)N1CCC(CC1)c2onc(n2)c3cccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.27
+Oc1ccc2C(=O)N(C(=O)c2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+COc1ccc2C=CC(=O)N(CCN3CCC(CC3)NCc4cc5OCCOc5cn4)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.16
+Cc1cc(C)nc(SCC(=O)N)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.23
+Cc1oc(CN2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3)cc1C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+O[C@@H](CNCCCSCCNCCc1cccc(Cl)c1)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.06
+Cc1ccsc1C(=CCCN2CCC[C@H](C2)C(=O)O)c3sccc3C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.49
+CC1Cc2ccccc2N1NC(=O)c3ccc(Cl)c(c3)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.83
+C[C@H]1CN(Cc2cc(Cl)ccc2CC(=O)O)CCN1C(=O)Cc3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.66
+C[C@@](N)(Cc1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+Cc1cc(CN2Cc3ccccc3C2C(=O)Nc4cc(Cl)ccc4Cl)ccc1OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+CCC(CC)NC(=O)c1c(C)nn(C(C)C)c1NS(=O)(=O)c2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.92
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4cc(n[nH]4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.44
+ONC(=O)Cc1ccc(OCc2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.92
+CS(=O)(=O)c1cccc(Nc2nccc(n2)N(CC#N)c3c(Cl)ccc4OCOc34)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.16
+CN(CCOc1ccccc1c2cc(C(=O)N)c(NC(=O)N)s2)Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.46
+Nc1nc(N)c2nc(CO)cnc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.45
+CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.22
+OC(=O)c1ccccc1NC(=O)Nc2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.12
+CC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+Cc1nc(NC(=N)N)nc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.49
+CNC(=O)c1ccc(Nc2nccc(n2)c3cnc(C)n3C(C)C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+COC(=O)C1=C(C)NC(=C(C1c2ccccc2[N+](=O)[O-])C(=O)OCC(C)C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.59
+Clc1ccccc1CN2CCc3sccc3C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.46
+Cc1[nH]c2ccccc2c1CCNCc3ccc(\C=C\C(=O)NO)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+OCCN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+NC(=O)c1ccc(O[C@H]2C[C@H]3CC[C@@H](C2)N3Cc4ccccc4)nc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.25
+NC(=O)c1cnc(N[C@H]2CCCNC2)c3cc(Br)sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.08
+CCC(CC)NC(=O)c1c(C)nn(c1NS(=O)(=O)c2ccc(C)cc2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.35
+OC(=O)C[C@@H]1CC[C@H](CC1)c2ccc(NC(=O)c3oc(Nc4ccccc4F)nn3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+NCC[C@@H](Sc1cc(Cl)ccc1C#N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.26
+FC(F)(F)Oc1cccc2c3CN(CCc3[nH]c12)C(=O)[C@@H]4CCCC[C@H]4C(=O)NC5(CC5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.01
+Clc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(CC4CC4)C3)CC2)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+CN1CCN(CC1)c2ccc3N=CN(C(=O)c3c2)c4cc(NC(=O)c5cccc(c5)N6CCOCC6)ccc4C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+OC(=O)c1cncc(c1)c2ccc(Cl)c(c2)C(=O)NCC34CC5CC(CC(C5)C3)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.85
+COc1cncc(NC(=O)c2cc(NC(=O)c3cccc(c3)C(C)(C)C#N)ccc2C)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+Nc1nc(nc2c1nc(O)n2Cc3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.16
+[O-][N+](=O)c1ccc2c(c1)C(=O)C(=O)c3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.42
+CC(C)Nc1ccc2cnn(c3cncc(n3)n4ccc(CC(=O)O)c4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.24
+NC1=NC(c2cccc(c2)c3cncnc3)(c4ccnc(c4)C(F)(F)F)c5cccc(F)c15,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+Cc1sc(nc1C(F)(F)F)N2CCN(CC2)C(=O)[C@@H]3CCCC[C@H]3C(=O)NC4(CC4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1CN(C)C4(CCN(C)CC4)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.16
+COC(=O)c1c(C)[nH]c(C)c1C(=O)c2ccccc2Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+CNc1c(Br)cnc2[nH]c(nc12)c3ccc(O)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+CCNC(=O)c1ccc(CN2CCC(CC2)c3ccc(cc3)C(=O)Nc4ccccc4N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.24
+COCCOc1cc(Nc2nccc(n2)N(C)c3cc(CO)ccc3C)cc(c1)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+COc1cc(Nc2cc(Oc3cccnc3)ccn2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.66
+C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc3ccc(F)cc3)C(=O)NCCCc4ccccc4O1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2c(F)cccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.84
+Cc1ccc2cc(C)c3nnc(SCC(=O)N4CCN(CC4)C(=O)c5occc5)n3c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+Nc1ccc2cccc(Nc3ncccn3)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+O=C1C=C(N=C2C=CC=CN12)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.0
+Clc1ccc(cc1Cl)C2CNCC=CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+Oc1cc(O)c2C(=O)C(=COc2c1)c3ccc4OCOc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+N(c1ccccc1)c2ncnc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.94
+FC(F)(F)Oc1ccc2OCC(=O)N(CCN3CCC(CC3)NCc4ccc5OCC(=O)Nc5n4)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.82
+Nc1c(NC2CCCCC2)nc(nc1N3CCOCC3)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+COc1cc(F)ccc1c2cncc(CNC(=O)c3cnccn3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+COc1cc(cc(OC)c1OC)c2nnc(S)n2c3cccc(c3)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.27
+COCCOc1ccc(cc1)c2cc(C(=O)N)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+C[C@H](NC1=NC(=O)[C@](C)(S1)C(F)(F)F)c2ccccc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+Fc1ccc(NC(=S)N2CCC(CC2)C(=O)c3ccc(F)cc3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+COc1cc(F)ccc1c2cccc(CNC3CCCC3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.06
+CC(C)n1c(C)ncc1c2ccnc(Nc3ccc(cc3)C(=O)NC4CCN(C)CC4)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.87
+NS(=O)(=O)c1cccc2c3nc(O)c(O)nc3cc(c12)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.36
+Nc1c(nc(nc1N2CCOCC2)C#N)N3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.71
+Brc1ccc(OC(=O)N2CCN3CCC2CC3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.58
+COc1ccc(COc2nc(Br)cnc2NS(=O)(=O)c3ccc(C)cc3)cc1OCCN(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.68
+CCN(C1CCN(CC[C@H](c2ccc(cc2)S(=O)(=O)C)c3cccc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+COc1ccc(cc1OC)C(=O)Nc2cccc(NC(=O)c3cccc(c3)N(C)C)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.67
+OC(=O)COc1ccc(Cl)cc1CN2CCC(CC2)S(=O)(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.48
+COc1cc(OC2CCN(C)CC2)c3c(Nc4cccc5OCOc45)ncnc3c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.02
+CC[C@H](N)C(=O)N[C@@H](Cc1ccc(cc1)c2ccccc2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+OC(=O)CCc1ccc(OCc2cccc(Oc3ccccc3)c2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.47
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)C(CO)CO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1cc2c3N([C@H](C)c4ccccn4)C(=O)Nc3cnc2cc1c5c(C)onc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CNS(=O)(=O)c1ccc(Nc2nccc(n2)c3cnc4cccnn34)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+OCCn1cc(cn1)c2cnc3nnn(Cc4ccc5ncccc5c4)c3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+NC(=O)C(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+NC(=O)C1CCN(CC(=O)Nc2ccc3OCOc3c2)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+CC(O)(C(=O)Nc1ccc(cc1)S(=O)(=O)c2ccccc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.98
+CC(C)(Cc1cccc(CC(=O)NCc2cccc(c2)c3ccc(O)cc3)c1)NC[C@H](O)c4ccc(O)c(NS(=O)(=O)C)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+COCCN(c1ccnc(Nc2cc(cc(c2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Cc1ccc(NC(=O)[C@@H]2CCCN2S(=O)(=O)c3cccc4cccnc34)c(C)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+OCCCNc1ccc2c(NC(=O)CC3CCCCC3)c(Cl)ccc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.29
+O=C(Nc1ccncc1)c2cccc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+O[C@@H]1CN(CCN2C(=O)C=Cc3ccc(cc23)C#N)CC[C@@H]1NCc4cc5OCCOc5cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.46
+CNc1ncnc2c(CNc3cc(NC(=O)c4ccc5OCCOc5c4)ccc3C)cccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+Oc1cccc2nc(cc(O)c12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+CC(C)Oc1cc(OCCN2CCN(CC2)C(=O)C)cc3ncnc(Nc4c(F)ccc5OCOc45)c13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.06
+NC(=O)Cc1nc(cs1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+COC(=O)N1CCN(C(CC(=O)NCc2ccc3OCOc3c2)C1)c4ccnc(n4)n5ccnc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.88
+C(C1NCCc2ccccc12)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.89
+CC(C)N1CCC(CC1)N(C(=O)Cc2ccccc2)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(O)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+OC(=O)c1cc2cc(ccc2n1Cc3ccc(Cl)c(Cl)c3)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.79
+CN1CCN(CC1)C2=Nc3ccccc3Nc4sc(C)cc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+Cc1cc(F)ccc1OC2CCN(CC3CCN(CC3)[C@@](C)(Cc4ccc(F)cc4)C(=O)O)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.0
+CCN1CCC[C@H](CN2CCN(CC2)C(=O)Nc3ccc(Cl)c(Cl)c3)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+COCC(C)n1nc(C)c(C(=O)N[C@@H](C)C(C)(C)C)c1NS(=O)(=O)c2ccc(C)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.61
+OC(Cn1cncn1)(Cn2cncn2)c3ccc(F)cc3F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.48
+COc1ccc(N(C(C(=O)NC2CCCC2)c3ccccc3F)C(=O)C)c(OC)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.81
+c1ccc(nc1)c2n[nH]cc2c3ccnc4ccccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.57
+Clc1ccccc1CNC[C@@H]2CC[C@@H](CNCc3ccccc3Cl)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.74
+CCC[C@H](N1CCC[C@@H](C1)N2C=C(C)C(=O)NC2=O)c3ccc(C(=O)O)c(Oc4cccc(Cl)c4)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.5
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(O)c(Oc4ccc(Cl)c(C)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+C[C@H](NC(=O)\C=C\c1ccccc1)c2cccc(c2)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+CC(C)CN1C(=O)N(C)C(=O)c2c1nn(Cc3cccc4ccccc34)c2c5cncn5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.1
+COCCNc1nc(nc(NCC(C)C)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Nc1nccc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+CC(C)n1c(C)ncc1c2nc(Nc3ccc(cc3)C(=O)N4CCN(C)CC4)ncc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.49
+CO[C@@H]1C[C@@H](N(Cc2cc3c(Nc4cccc(Cl)c4F)ncnc3cc2OC)C1)C(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.09
+CN[C@@H](C)C(=O)N[C@H](C(=O)N[C@H]1CCCN(CCc2ccccc2OC)C1)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+Nc1ncc(cc1c2oc3ccccc3n2)c4cnn(c4)C5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+CCN(C1CCN(CC[C@H](C2CCN(CC2)S(=O)(=O)C)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.05
+O=C1N2C=CC=CC2=Nc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CN(c1ccnc(Nc2cc(nc(n2)N3CCOCC3)N4CCOCC4)n1)c5cc(CO)ccc5C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+CCCNC(=O)c1nnc2c(c(F)ccc2c1N)c3ncccn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.07
+CCC(N(CCCN)C(=O)c1ccc(C)cc1)C2=Nc3ccn(C)c3C(=O)N2Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+COC(=O)c1cccc(CN2NC(=O)C3=C(C2=O)C(=O)c4ccc(Cl)cc4N3)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.1
+CCN1CCN(CC1)C(=O)c2cc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.95
+C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)nc(Oc4ccccc4)nc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.05
+Cc1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.37
+COc1cc(Nc2ncc(C)s2)nc(N[C@@H](C)c3ncc(F)cn3)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.99
+OC(=O)c1[nH]c2ccccc2c1CC(=O)Nc3cccc(c3)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+CC(C)(C)c1ccc(cc1)C2=NC(=O)C(CC(=O)O)S2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.1
+C[C@H]1CN(Cc2cc(Cl)ccc2OCC(=O)O)CCN1C(=O)Cc3cccc(Cl)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.78
+O=C(Oc1ccc2C(=O)CCOc2c1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+COc1ccc2c(Oc3ccc(CC(=O)Nc4cn(C)nc4C)c(OC)c3)ccnc2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+O=C(Nc1cc(ccn1)c2ccnc(Nc3ccccc3)c2)C4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+COc1ccc(cc1)c2nc3c(NCCCNC(=O)C4(CN)CC4)c(Br)cnc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+COc1cccc(OC)c1c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.27
+COc1cc(OC)c(cc1NC(=O)\C=C\C(=O)O)S(=O)(=O)N2c3ccccc3Oc4ccccc24,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.71
+C[C@H](Nc1nc(Nc2cc([nH]n2)C3CC3)cnc1C#N)c4ccc(F)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.18
+COc1ccccc1Oc2c(NS(=O)(=O)c3ccc(cc3)C(C)(C)C)nc(nc2OCCO)c4ncccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.03
+NC1(CCC1)c2ccc(cc2)C3=Nc4ccccc4C(=O)N3c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+OC(C(=O)c1ccccc1)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.13
+CC(=O)Nc1ccc(O)cc1OC[C@@H](O)CN2CCC3(CC2)Cc4cc(F)ccc4O3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+COc1cccc(Nc2ncnc3cc(OC)c(OC)cc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1cc2ncc(C(=O)N)c(Nc3ccc(C)cc3F)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.34
+CN(c1ccc(c(Cl)c1)c2cc(F)ccc2OCC(=O)O)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.17
+Nc1cc(nc2c(cnn12)C#N)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.48
+CN1CCN(CC1)S(=O)(=O)c2ccc(cc2)c3cnc(N)c(n3)C(=O)Nc4cnccc4CN5CCCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.28
+N[C@@H](Cc1ccc(F)cc1)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.06
+CN1[C@@H]2CC[C@H]1C[C@H](C2)OC(=O)C(CO)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.66
+Brc1ccc(cc1)C2NC(=O)c3ccccc3N2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.68
+COc1cc(nc2c(cc(F)cc12)N3CCN(C)CC3)C(=O)Nc4ccc(cc4)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.85
+CCCC(=O)Nc1ccc(OCC(O)CNC(C)C)c(c1)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.27
+CN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)Cc4ccc(cc4)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+Cc1c(Cl)ccc(OC2CCN(CC3CCN(CC3)[C@@H](Cc4ccc(F)cc4)C(=O)O)CC2)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.15
+OC(=O)C1CCn2c1ccc2C(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.93
+CN1C2CCC1CC(C2)OC(=O)C(CO)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.09
+C[C@@H]1CN(CCN1c2ncc(OCc3ccncc3C#N)cn2)c4noc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.95
+CC(=O)c1ccc(cc1)S(=O)(=O)NC(=O)NC2CCCCC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.49
+NC(=O)Nc1sc(cc1C(=O)N)c2ccc(CN3CCCCC3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+Cc1oc(CN2CCNCC2)cc1C(=O)NCC34CC5CC(CC(C5)C3)C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.03
+C[C@H](CO)Nc1nc(SCc2ccccc2F)nc3NC(=O)Sc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+OC(=O)COc1ccc(Br)cc1c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.15
+CN1CCC(=C2c3ccccc3C=Cc4ccccc24)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.06
+CCC(=O)N1CCN(CC1)C(=O)c2cc(CC3=NNC(=O)c4ccccc34)ccc2F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.22
+CCCOc1cc(OCCCN2CCCC2)ccc1C(=O)Nc3cccc(O)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.46
+CC(=O)N1CCOc2cc(COc3ccccc3)cnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+Cc1sc(N)nc1c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.75
+CN(C)C(=O)c1ccc(cc1)C(=C2CCN(Cc3cscn3)CC2)c4cccc5cccnc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+Cc1ccc(\C=C(/C#N)\C(=O)N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.09
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4cccnc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.72
+Nc1ccccc1[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.96
+C1CN2CCC1C(=C2)c3oc4ccccc4c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.59
+OCC1=CC2=NNC(=O)N2c3cc(ccc13)c4ccc[nH]4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+Nc1ccc2c3ccccc3C(=O)c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Clc1ccc(CNc2nc(nc3ncccc23)N4CCN(CC4)C(=O)[C@H]5CCCCN5)c(Cl)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.27
+Nc1ncnc2sc(nc12)c3c(ncn3Cc4ccccc4N5CCOCC5)c6ccccc6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.58
+CC1=CN([C@H]2CCCN(C2)[C@H](CC3CCCCC3)c4ccc(C(=O)O)c(Oc5cccc(Cl)c5)c4)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.83
+CN1CCN(CCOc2n[nH]c3ncnc(Nc4ccc(OCc5ccccn5)c(Cl)c4)c23)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.45
+NC(=O)N1c2ccccc2C=Cc3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.65
+CCCN1CCN(CC1)c2ccc(cc2)C(=O)NC3(CCCCC3)C(=O)NCC#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.33
+CC(C)Oc1cccc(CC(=O)N2CCC[C@@](CC[N+]34CCC(CC3)(CC4)c5ccccc5)(C2)c6ccc(Cl)c(Cl)c6)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.23
+COc1nc(Br)cnc1NS(=O)(=O)c2ccc(Cl)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.99
+CC(C)NC(=O)c1ccc2c(Nc3ccc(Cl)cc3)nc(nc2c1)N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.78
+Oc1ncnc2scc(c3ccccc3)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.07
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(CCCN4CCOCC4)c5ccc(Cl)cc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7
+COc1cc(ccc1Nc2nccc(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.0
+Cc1onc(c2ccccc2)c1c3ccc(cc3)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.37
+O=C1NC(=O)C(Cc2cccc(Oc3ccccc3)c2)S1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.84
+CCCc1c(cnn1c2ccccc2)C(=O)Nc3ccc(F)cc3C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.89
+OCCNC(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c3cc4cc(Cl)sc4[nH]3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.05
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4nc5ccccc5[nH]4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.24
+O[C@@H](CNCCOc1cccc(CNCCc2ccccc2F)c1)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.86
+Clc1ccc2OCOc2c1Nc3ncnc4cc(OCCCN5CCCC5)cc(OC6CCOCC6)c34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+O=C(NCC#N)[C@@H]1CCCC[C@H]1C(=O)N2CCN(CC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.75
+CC1=CN([C@H]2CCCN(C2)S(=O)(=O)c3ccc(C(=O)O)c(Oc4ccc(Cl)c(Cl)c4)c3)C(=O)NC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.87
+CC(C)C(NC(=O)CN1C(=O)C2=C(C=C1c3ccccc3)C(=O)N(CCN4CCOCC4)C(=O)N2)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+Clc1cccc(c1)S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.39
+C[C@H](Oc1nc(Nc2cc(C)[nH]n2)c(C)nc1C#N)c3ccc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.86
+CO[C@@H]1CC[C@@]2(CC1)Cc3ccc(cc3C24N=C(C)C(=N4)N)c5cc(Cl)cc(c5)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+Cn1cnc2c(c3ccc(cc3)C4(N)CCC4)c(ccc12)c5ccccc5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.5
+CC(C)NC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C(=O)O)n4ccc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.62
+Cc1[nH]c(C(=O)NC2CCN(CC2)c3ncc(s3)C(=O)O)c(Cl)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.02
+COc1cc(OC2CCNCC2)ccc1Nc3ncc(Cl)c(n3)c4cnc5ccccn45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+CC(C)CCOc1ccc(N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.67
+CC(C)c1ccc(Sc2cnc(O)c(c2)C(=O)NCc3ccccc3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.7
+Cc1ccc2c(c1)c(c(C)n2CC(=O)O)c3ccnc4c(C)cccc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.29
+Fc1ccccc1Nc2oc(nn2)C(=O)Nc3ccc(Oc4cccnc4)nc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CN(C)CCCOc1nn(Cc2ccccc2)c3ccccc13,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Cc1ccc(cc1)c2nnc(N3CCN(CC3)C(=O)c4occc4)c5ccccc25,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.78
+CC(=O)Nc1ccc(CNc2[nH]nc3cccc(Oc4ccc(cc4)S(=O)(=O)C)c23)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.63
+CCS(=O)(=O)c1ccc(c(C)c1)c2cc(ccc2CCC(=O)O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.76
+COc1ccc(OC)c(CNc2n[nH]c3ccnc(Oc4ccccc4)c23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.25
+CC(C)Cc1ccc(cc1)[C@H](C)C(=O)NS(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.56
+COCCC(NC(=O)C1(N)CCN(CC1)c2ncnc3[nH]ccc23)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.95
+COc1cc(OC)c(cc1NC(=O)NCC(=O)O)S(=O)(=O)N2C(C)CCc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.02
+NC(=O)Nc1cc(sc1C(=O)N)c2ccsc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+COc1cc(F)ccc1c2cncc(CNCC3CC3)n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.8
+CCCNC(=O)c1cc2c(c(cnc2[nH]1)c3cncc(c3)C(=O)O)n4ccc(n4)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.79
+COc1cc(OC2CCN(C)CC2)c3c(Nc4cccc5OCCOc45)ncnc3c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.26
+FC(F)(F)Oc1ccccc1S(=O)(=O)NCC(N2CCCCCC2)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.09
+CC(C)COc1cc(ccc1NC(=O)CN2CCOCC2)c3cccc4C(=O)C=C(Oc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+CN1CCOc2cc(OC(=O)c3ccccc3)cnc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+Nc1sc2CCCCc2c1C(=O)NCc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.52
+CN1CCC(CC1)Oc2cccc3ncnc(Nc4ccc(OCc5cnccn5)c(Cl)c4)c23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+CC(C)CNc1nc(nc(N2CCN(CC2)C(=O)C)c1N)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CC(C)COCC(CN(Cc1ccccc1)c2ccccc2)N3CCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.66
+CC1=CC2=NNC(=O)N2c3cc(ccc13)c4cccc(CO)c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.36
+O[C@H](C[C@H](O)\C=C\c1c(nc2ccccc2c1c3ccc(F)cc3)C4CC4)CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.91
+Nc1cccc2c3ccccc3C(=O)C(=O)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.95
+CC(C)(C)OC(=O)N1CCN(CC1)c2ncc(OCc3ccncc3S(=O)(=O)C)cn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+C[C@](O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.87
+CNc1cccc(CCCc2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(=O)O)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.57
+O=C(NCc1ccncc1)c2ccc(Oc3ccccc3)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.26
+OC(=O)COc1ccc(Cl)cc1CN2CCN(CC2)S(=O)(=O)Cc3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.33
+C[C@@H](NC(=O)C1CCNCC1)c2ccc(Nc3ncc4cc(ccc4n3)c5ccncc5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.4
+CN(C)C[C@H](O)Cc1ccc(Cl)c(c1)C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+Oc1ccnc2ccccc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.31
+COc1cc(Nc2cc(Oc3ccc(C)nc3)ccn2)cc(OC)c1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+CC1=NC(C)(N=C1N)c2cccc(c2)c3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+COc1cc(F)ccc1c2cc(CNC3CCCC3)ccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.71
+NC(=N)Nc1oc2ccccc2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+Cc1nc2nc(NC(=O)c3ccc(F)cc3)nn2c(O)c1Cc4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+CN(C)C(=O)C(CCN1CCC(O)(CC1)c2ccc(Cl)cc2)(c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.47
+CN(C)CCCOc1nccc(Nc2cc(NC(=O)c3ccnc(c3)N4CCOCC4)ccc2C)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.3
+NNC(=O)c1ccncc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.57
+CCS(=O)(=O)c1ccc(cc1)c2cc(Cl)ccc2OCC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.78
+Cn1cc(cc1c2c3C(=O)N(CC#C)C(=O)N(CC4CC4)c3nn2Cc5ccnc6ccc(Cl)cc56)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.96
+COc1cc(Nc2nc(N[C@@H](C)c3ncc(F)cn3)nc(N4CCOCC4)c2F)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.64
+Cc1cccc(Nc2ncnc3ccccc23)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+OCCCNCCCOc1ccc(Cl)c(c1)C(=O)NCC23CC4CC(CC(C4)C2)C3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.41
+CCOC(=O)c1ccc(OCCC2(CCN(CC2)c3ccc(C)nn3)C#N)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.54
+C[C@H]1C[C@H]2[C@@H]3CC[C@H](C(=O)C)[C@@]3(C)C[C@H](O)[C@@H]2[C@@]4(C)CCC(=O)C=C14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.25
+Fc1ccc(cc1)C(=O)C2CCN(CC2)C(=O)N3CCOCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.61
+Cc1cc(Cl)ccc1N2CCN(CC2)C(=O)COCc3ccncc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.22
+CC1CN(CCN1)C(=O)c2cc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.94
+Clc1ccc(cc1)C2(CCNCC2)c3ccc(cc3)c4cn[nH]c4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.51
+Cc1cc(C)cc(c1)c2c(O)nc3cc(Cl)c(cc3c2OCCC4CCCCN4)C(=O)Nc5ccncn5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+Clc1cccc(C(=O)NCC23CC4CC(CC(C4)C2)C3)c1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.37
+CCOc1ccc(cc1)c2cnc3CCCCCn23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.01
+CNc1c(Br)cnc2[nH]c(nc12)c3ccnc(N)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.83
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CC5)C(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.65
+FC(F)(F)c1ccc(NC(=O)N2CCN(C[C@@H]3CCCN(C3)C4CC4)CC2)cc1Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.06
+OCC(O)COC(=O)c1ccccc1Nc2ccnc3cc(Cl)ccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+CN[C@@H](C)C(=O)N[C@H](C(=O)N1CC[C@H]2CC[C@H](NC(=O)c3cccc4ccccc34)[C@@H]12)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.94
+COc1cc(F)ccc1c2cccc(CNC3CCCC3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.29
+COc1cc(ccc1NC(=O)CN2CCOCC2)c3cccc4C(=O)C=C(Oc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.3
+CCOc1cc(ccc1NC(=O)CN2CCOCC2)c3cccc4C(=O)C=C(Oc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.8
+C1CN2CCC1C(C2)c3ccc(cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.76
+Cc1cc(NC(=O)c2oc(Nc3ccccc3F)nn2)ccc1N4CCOCC4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",4.0
+Nc1ccc(cc1)S(=O)(=O)Nc2ccccn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.01
+Fc1ccc(CC2=NNC(=O)c3ccccc23)cc1C(=O)N4CCN(CC4)C(=O)C5CCOC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+CCNC(=O)c1cc2c(c(cnc2[nH]1)c3cnc(OC)c(c3)C4=NNC(=O)O4)n5ccc(n5)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.32
+Clc1cc(Cl)c2c3C(=O)NNC(=O)c3[nH]c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.02
+CCCCC(NC(=O)CC1CCN(Cc2ccn(c2)c3ccc(cc3)C(F)(F)F)CC1)C4=CNC(=O)C=C4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+Fc1cccc(Nc2oc(nn2)C(=O)Nc3ccc(nc3)N4CCOCC4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.2
+CN(C)CC(O)COc1ccc(Nc2nccc(Nc3cc(C)ccc3F)n2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+O=C(NC1CC1)c2cc(on2)c3cccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+CCOc1ccc(NC(=O)CCc2c(C)nc3nc(C)nn3c2C)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+CNc1c(Br)cnc2[nH]c(nc12)c3cccc(N)c3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+Nc1nc(N)nc(n1)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.12
+COc1cc(c2nc(cc(n2)C3(CC3)S(=O)(=O)C)N4CCOCC4)c5cc[nH]c5c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CN(C1CCCCC1)C(=O)c2c(C)nn(c2NS(=O)(=O)c3ccc(C)cc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+CN(C)CCC[C@]1(OCc2cc(ccc12)C#N)c3ccc(F)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.48
+COc1ccc(Nc2cc(Nc3ccc(OCC(O)CN(C)C)cc3)ncn2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+CC(C)S(=O)(=O)NCC(C)c1ccc(cc1)c2ccc(cc2)C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.5
+O=C(CSc1ccccc1)N2CCN(CC2)C(=O)c3occc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+NC1=NC2(CCN(CC2)C(=O)c3ccc(cc3)C#N)Nc4c(F)ccc(F)c14,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.86
+CCN1CCCC1CNC(=O)c2cc(ccc2OC)S(=O)(=O)N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.2
+CNC1=Nc2ccc(Cl)cc2C(=[N+]([O-])C1)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c2cc3ccsc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2cc(F)cc(F)c2)N)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+CC(C)N(C(C)C)c1nnc(N)s1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.49
+CS(=O)(=O)c1ccc(CC(=O)N(C2CC2)C3CCN(CCC(c4ccccc4)c5ccccc5)CC3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.89
+Nc1ccc(OCc2ccccc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.2
+NNCCc1ccccc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.01
+CCN(C1CCN(CCC(c2ccccc2)c3ccccc3)CC1)C(=O)NCc4ccc(F)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.9
+Nc1n[nH]c2ncc3CCCCCCc3c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+C[C@@H](NC(=O)[C@H]1CCCNC1)c2ccc(Nc3ncc4cc(ccc4n3)c5ccncc5)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.69
+Cc1c(Sc2ccc(Cl)cc2)c3c(C#N)c(Cl)ccc3n1CC(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.6
+CC1(C)NC(=O)N(C1=O)c2ccc(c(c2)C(F)(F)F)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.74
+NS(=O)(=O)c1ccc2NC(C3CC=CC3c2c1)c4cccc5ccccc45,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.9
+CC[C@H](NC(=O)c1c([S+](C)[O-])c(nc2ccccc12)c3ccccc3)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.17
+Cc1ccnc(NCc2ccccc2O)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.35
+CC(C)c1onc(n1)N2CCN([C@H](C)C2)c3ncc(OCc4ccncc4C#N)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+O[C@@H](CNCCCSCCOCCc1cccc2ccccc12)c3ccc(O)c4NC(=O)Sc34,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.12
+COc1cc(ccc1Nc2ncc(Cl)c(n2)c3cnc4ccccn34)N5CCN(CCS(=O)(=O)C)CC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1ccc(cc1)c2nc(N)s[n+]2c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.19
+O=C1NC(=O)C(Cc2ccc3ccccc3c2)S1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4cn(C)cn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.54
+O=C(CN1CCOCC1)Nc2ccc(cc2OCC3CC3)c4cccc5C(=O)C=C(Oc45)N6CCOCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.3
+c1ccc(cc1)c2[nH]nc3ccccc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.79
+CC(O)(C(=O)Nc1ccc(cc1)S(=O)(=O)c2cccnc2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.08
+CCCCC(N1NC(=O)c2nc3cc(Cl)ccc3c(O)c2C1=O)c4ccncc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.4
+OC12CC3CC(C1)CC(C3)(C2)NCC(=O)N4CCC[C@H]4C#N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.48
+CCOc1ccccc1N2CCN(Cc3c[nH]nc3c4ccc(F)cc4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.38
+COC(=O)Nc1nc2ccc(cc2[nH]1)C(=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.9
+Fc1cc(ccc1C2=CCS(=O)(=O)CC2)N3C[C@H](Cn4nncc4F)OC3=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.54
+C[C@@H]1CC[C@H](CC1)Oc2nc(N)c3ncn([C@@H]4O[C@H](C)[C@@H](O)[C@H]4O)c3n2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.35
+CC(C)CN1C(=O)N(C)C(=O)c2c1sc(Cc3ccnc4ccccc34)c2C(=O)N5CC[C@@H](O)C5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.65
+CC(=O)C1=Cc2ccc(O)cc2OC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+C[C@@](O)(C(=O)Nc1ccc(cc1Cl)S(=O)(=O)NCCN2CCOCC2)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.14
+[O-][N+](=O)c1cccc2C(=O)C(=O)c3ccccc3c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4[nH]c5ccccc5c4c3)CC2)c6ccccc16,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.96
+CC(C)(C)C(=O)N[C@H]1CCCCNC1=O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.58
+Oc1cc(ccc1NC(=O)CN2CCOCC2)c3cccc4C(=O)C=C(Oc34)N5CCOCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CCCSc1c(cnn1c2ccc(cc2)C(=O)O)C(=O)NC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.64
+Cc1ccc(cc1)c2c[nH]nn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.58
+CCCCOc1nc(N)c2NC(=O)N(Cc3cccc(CC(=O)O)c3)c2n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.14
+O=S(=O)(Nc1cccc2[nH]ncc12)c3cccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.7
+COc1cc(OC)c(cc1NC(=O)C)S(=O)(=O)NCc2ccccc2N3CCC(CO)CC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.03
+COCCNCc1ccc(cc1)c2cc(C(=O)N)c(NC(=O)N)s2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.87
+C[C@H](NC(=O)c1c(C)nn(C2CCCCC2)c1NS(=O)(=O)c3ccc(C)cc3)C(C)(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.97
+CC(C)N1CCC[C@H](CN2C(=Nc3ccc(Oc4ccc(F)cc4)cc3C2=O)C)C1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+Nc1ccc2cn[nH]c2c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.52
+Cc1cc(n[nH]1)c2ccc(Cl)c(c2)C(=O)NCC3(O)CCCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.41
+Nc1ccc(cn1)C(=O)Nc2cccc(c2)c3nc(N4CCOCC4)c5oc6ncccc6c5n3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.44
+Fc1ccc(CNC(=O)CCS(=O)(=O)c2ccc(Br)cc2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+CC1(CC(=O)NC(=N1)N)c2ccccc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.62
+CN(C)C(=O)[C@H](Cc1ccccc1)NC(=O)c2cc3ccccc3[nH]2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+C[C@H](Nc1cncc(Nc2ncc(C)s2)n1)c3ncc(F)cn3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.91
+Cc1ccc(Oc2ccc(Nc3ncnc4[nH]nc(OCCN5CCC(O)CC5)c34)cc2Cl)cn1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.4
+OC(=O)c1ccc(cc1)N2CCC(CN3CCC(CC3)Oc4ccc(Cl)c(Cl)c4)CC2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.31
+COc1ccc(cc1N2CC(=O)NS2(=O)=O)c3ccccc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-1.01
+CCOc1ccccc1CNCc2cccc(CCNC[C@H](O)c3ccc(O)c4NC(=O)Sc34)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.13
+CCCCNc1cc(cc(c1Oc2ccccc2)S(=O)(=O)N)C(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.3
+OC(=O)COc1ccc(cc1c2ccccc2c3ccccc3)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.38
+Cc1nc(cs1)C(=O)N2CCCC3(CCN(Cc4ccc(Cl)cc4)CC3)C2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.64
+COc1cc(Nc2nc3c(cc2F)ncn3[C@@H](CO)c4ccc(F)cn4)n[nH]1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.18
+CC1(CCN(CC1)C(=O)COCc2ccncc2)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.79
+NC1(CCN(CC1)c2ncnc3[nH]ccc23)C(=O)NC(CO)c4ccc(Cl)cc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.4
+CNC(=O)c1cccc(c1c2ccc(CC(C)C)cc2)S(=O)(=O)Nc3ncc(C)nc3OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.68
+Oc1ccc(cc1)[N+](=O)[O-],"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.5
+CCC(CC)NC(=O)c1cnn(Cc2ccccc2)c1NS(=O)(=O)c3ccc(C)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.52
+Oc1cccc2Oc3ccccc3C(=O)c12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.8
+COc1cc2c(Nc3cc(CC(=O)Nc4cccc(F)c4F)[nH]n3)ncnc2cc1OCCCN(CCO)CC(C)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.61
+COc1cc2c(Nc3c(Cl)ccc4OCOc34)ncnc2cc1OCCCN5CCCCC5,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.05
+COc1cc2ncnc(Oc3cnn(CC(=O)Nc4ccc(cn4)N(C)C)c3)c2cc1OC,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.36
+C(Cn1c2CCCCc2c3c(nc(nc13)N4CCCC4)N5CCCC5)N6CCOCC6,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.6
+CC(C)(C)OC(=O)N1CCN(CC1)c2ncc(OCc3ccc(cc3)S(=O)(=O)C)nn2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+CC(C)C(NC(=O)CN1C(=O)C(=CN=C1c2cccs2)N)C(=O)C(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.68
+Cc1ccnc2nc(nn12)C(=O)Nc3nccs3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.31
+OC(=O)[C@H](Cc1ccc(cc1)N2CCN(CC2)c3ccccc3)NC(=O)c4c(Cl)cccc4Cl,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.08
+CCNC(=O)Nc1nc2cc(ccc2[nH]1)c3cccnc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.34
+CCCCC(CC)COC(=O)CC(C(=O)OCC(CC)CCCC)S(=O)(=O)O,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.93
+CN1CCCC1CCOC(C)(c2ccccc2)c3ccc(Cl)cc3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.04
+NC1=NC(CC(=O)N1)c2ccc(Cl)c(Cl)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.46
+Oc1c(C#N)c(nc2ccncc12)c3ccc(cc3)c4ccccc4OC(F)(F)F,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.45
+NCC(O)(c1ccc(Cl)cc1)c2ccc(Cl)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.69
+Cc1ccnc(NS(=O)(=O)c2ccc(N)cc2)n1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",-0.51
+O[C@@H](CNCCOCCCNCCc1cccc(Cl)c1)c2ccc(O)c3NC(=O)Sc23,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.83
+CN1CCC[C@@H]([C@H]1C(=O)Nc2ccc(OCc3cc(C)nc4ccccc34)cc2)C(=O)NO,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.41
+COC(=O)COc1ccc(cn1)C(=O)Nc2ccc(F)cc2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.43
+CCC(N1NC(=O)c2nc3cc(Cl)ccc3c(O)c2C1=O)c4ccccn4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",0.8
+Cc1cccc(Nc2oc(nn2)C(=O)Nc3ccc(nc3)N4CCOCC4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.42
+CCOC(=O)c1ccc(OCC2CN(C2)c3ccc(C)nn3)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.1
+COc1cc(F)ccc1c2cncc(CNC3CCCCC3)c2,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.6
+Oc1cccc(NC(=O)c2ccc(OCCCN3CCCC3)cc2OCc4ccccn4)c1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",1.78
+CC1CC(N(C(=O)C)c2ccccc2)c3ccccc3N1S(=O)(=O)c4ccccc4,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.68
+OCCc1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.85
+CCN(C1CCN(CCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",3.21
+COc1cccc2[nH]ncc12,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.1
+Clc1ccc2ncccc2c1C(=O)NCC3CCCCC3,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.65
+CN1C(=O)C=C(CCc2ccc3ccccc3c2)N=C1N,"Lipophilicity is an important feature of drug molecules that affects both membrane permeability and solubility, measured by octanol/water distribution coefficient (logD at pH 7.4). What's the octanol/water distribution coefficient (logD at pH 7.4) of this molecule?",2.7