In May 1769, Gaspar de Portolà established the Fort Presidio of San Diego on a hill near the San Diego River. It was the first settlement by Europeans in what is now the state of California. In July of the same year, Mission San Diego de Alcalá was founded by Franciscan friars under Junípero Serra. By 1797, the mission boasted the largest native population in Alta California, with over 1,400 neophytes living in and around the mission proper. Mission San Diego was the southern anchor in California of the historic mission trail El Camino Real. Both the Presidio and the Mission are National Historic Landmarks.
What was developed on a hill by the San Francisco River?