People can be exposed to asphalt in the workplace by breathing in fumes or skin absorption. The National Institute for Occupational Safety and Health (NIOSH) has set a Recommended exposure limit (REL) of 5 mg/m3 over a 15-minute period. Asphalt is basically an inert material that must be heated or diluted to a point where it becomes workable for the production of materials for paving, roofing, and other applications. In examining the potential health hazards associated with asphalt, the International Agency for Research on Cancer (IARC) determined that it is the application parameters, predominantly temperature, that effect occupational exposure and the potential bioavailable carcinogenic hazard/risk of the asphalt emissions. In particular, temperatures greater than 199 °C (390 °F), were shown to produce a greater exposure risk than when asphalt was heated to lower temperatures, such as those typically used in asphalt pavement mix production and placement.
Temperatures higher than 300 degrees Celsius where shown to do what?