  By deploying myelofibrosis as the disease context, I wish to propose that
increased availability of Tmp21 (an NFAT gene target) induces aberrant protein
secretion from the ER contributing to pathological consequences, which has not
been elucidated before. Primary myelofibrosis is now mainly considered as an
advanced stage of BCR-ABL1 negative myeloproliferative neoplasms (MPN), which
otherwise include polycythemia vera and essential thrombocythemia.
Myelofibrosis is defined by an increased insoluble collagen fiber deposition in
the bone marrow2 and harbors chronic inflammation as an important component in
disease progression.
