  The cluster 1ES0657-556 is an ideal astrophysical laboratory to study the
distribution and the nature of Dark Matter because this last component is
spatially separated from the intracluster gas. We show that microwave
observations can provide crucial probes of Dark Matter in this system. We
calculate the expected SZ effect from Dark Matter annihilation in the main mass
concentrations of the cluster 1ES0657-556, and we estimate the sources of
contamination, confusion and bias to asses its significance. We find that SZ
observations at a frequency of 223 GHz can resolve both spatially and
spectrally the SZ_DM signal and isolate it from the other SZ signals, and
mainly from the thermal SZ effect which is null at frequencies 220-223 GHz for
the case of 1ES0657-556. We conclude that SZ observations with sub-arcmin
resolution and micro-K sensitivity of 1ES0657-556 are crucial, and maybe
unique, to find direct astrophysical probes of the existence and of the nature
of Dark Matter, or to set strong experimental limits.
