  Immunological systems have been an abundant inspiration to contemporary
computer scientists. Problem solving strategies, stemming from known immune
system phenomena, have been successfully applied to challenging problems of
modern computing (MONROY, SAAB, GODINEZ, 2004). Simulation systems and
mathematical modeling are also beginning use to answer more complex
immunological questions as immune memory process and duration of vaccines,
where the regulation mechanisms are not still known sufficiently (LundegaarD,
Lund, Kesmir, Brunak, Nielsen, 2007).In this article we studied in machina a
approach to simulate the process of antigenic mutation and its implications for
the process of memory. Our results have suggested that the durability of the
immune memory is affected by the process of antigenic mutation and by
populations of soluble antibodies in the blood. The results also strongly
suggest that the decrease of the production of antibodies favors the global
maintenance of immune memory.
