  Let $K$ be a totally real number field and consider a Fermat-type equation
$Aa^p+Bb^q=Cc^r$ over $K$. We call the triple of exponents $(p,q,r)$ the
signature of the equation. We prove various results concerning the solutions to
the Fermat equation with signature $(p,p,2)$ and $(p,p,3)$ using a method
involving modularity, level lowering and image of inertia comparison. These
generalize and extend the recent work of I\c{s}ik, Kara and Ozman. For example,
consider $K$ a totally real field of degree $n$ with $2 \nmid h_K^+$ and $2$
inert. Moreover, suppose there is a prime $q\geq 5$ which totally ramifies in
$K$ and satisfies $\gcd(n,q-1)=1$, then we know that the equation $a^p+b^p=c^2$
has no primitive, non-trivial solutions $(a,b,c) \in \mathcal{O}_K^3$ with $2 |
b$ for $p$ sufficiently large.
