  Successful epilepsy surgery depends on localising and resecting cerebral
abnormalities and networks that generate seizures. Abnormalities, however, may
be widely distributed across multiple discontiguous areas. We propose spatially
constrained clusters as candidate areas for further investigation, and
potential resection. We quantified the spatial overlap between the abnormality
cluster and subsequent resection, hypothesising a greater overlap in
seizure-free patients.
  Thirty-four individuals with refractory focal epilepsy underwent pre-surgical
resting-state interictal MEG recording. Fourteen individuals were totally
seizure free (ILAE 1) after surgery and 20 continued to have some seizures
post-operatively (ILAE 2+). Band power abnormality maps were derived using
controls as a baseline. Patient abnormalities were spatially clustered using
the k-means algorithm. The tissue within the cluster containing the most
abnormal region was compared with the resection volume using the dice score.
  The proposed abnormality cluster overlapped with the resection in 71% of ILAE
1 patients. Conversely, an overlap only occurred in 15% of ILAE 2+ patients.
This effect discriminated outcome groups well (AUC=0.82).
  Our novel approach identifies clusters of spatially similar tissue with high
abnormality. This is clinically valuable, providing (i) a data-driven framework
to validate current hypotheses of the epileptogenic zone localisation or (ii)
to guide further investigation.
