  Electroporation method is a useful tool for delivering drugs into various
diseased tissues in the human body. As a result of an applied electric field,
drug particles enter the intracellular compartment through the temporarily
permeabilized cell membrane. Consequently, electroporation method allows better
penetration of the drug into the diseased tissue and improves treatment
clinically. In this study, a more generalized model of drug transport in a
single-cell is proposed. The model is able to capture non-homogeneous drug
transport in the cell due to non-uniform cell membrane permeabilization.
Several numerical experiments are conducted to understand the effects of
electric field and drug permeability on drug uptake into the cell. Through
investigation, the appropriate electric field and drug permeability are
identified that lead to sufficient drug uptake into the cell. This model can be
used by experimentalists to get information prior to conduct any experiment,
and it may help reduce the number of actual experiments that might be conducted
otherwise.
