  George and Wilson [Acta. Cryst. D 50, 361 (1994)] looked at the distribution
of values of the second virial coefficient of globular proteins, under the
conditions at which they crystallise. They found the values to lie within a
fairly narrow range. We have defined a simple model of a generic globular
protein. We then generate a set of proteins by picking values for the
parameters of the model from a probability distribution. At fixed solubility,
this set of proteins is found to have values of the second virial coefficient
that fall within a fairly narrow range. The shape of the probability
distribution of the second virial coefficient is Gaussian because the second
virial coefficient is a sum of contributions from different patches on the
protein surface.
