  We calculate IR divergent graviton one-loop corrections to scalar correlators
in de Sitter space, and show that the leading IR contribution may be reproduced
via simple semiclassical consistency relations. One can likewise use such
semiclassical relations to calculate leading IR corrections to correlators in
slow-roll inflation. The regulated corrections shift the tensor/scalar ratio
and consistency relation of single field inflation, and non-gaussianity
parameters averaged over very large distances. For inflation of sufficient
duration, for example arising from a chaotic inflationary scenario, these
corrections become of order unity. First-order corrections of this size
indicate a breakdown of the perturbative expansion, and suggest the need for a
non-perturbative description of the corresponding regime. This is analogous to
a situation argued to arise in black hole evolution, and to interfere with a
sharp perturbative calculation of "missing information" in Hawking radiation.
