  The influence of the daily prolonged administration of silver nanoparticles
on cognitive functions of model mammals was studied. The accumulation of silver
in whole brain, hippocampus, cerebellum, cortex and residual part of mice brain
was investigated by highly precise and representative Neutron Activation
Analysis and the histological studies were conducted in the present research.
Some of the main results of the comprehensive study are the description of the
biokinetics of silver in the hippocampus, cerebellum and cortex, the finding of
the jump increase of silver in the hippocampus and cerebellum after the period
of administration of 120 days. Accumulation of silver in the mice brain and
hippocampus itself as well as the integrity violation of the CA2 subregion
caused long-term contextual memory impairment at 180 days of silver
nanoparticle exposure. However, destruction of CA2 had started 60 days before
the visible changes in behavior appeared. Complex of the three types of the
approach let us find the cognitive impairment and understand the reasons of it.
