  The very high rates of second generation star formation detected and inferred
in high redshift objects should be accompanied by intense millimetre-wave
emission from hot core molecules. We calculate the molecular abundances likely
to arise in hot cores associated with massive star formation at high redshift,
using several independent models of metallicity in the early Universe. If the
number of hot cores exceeds that in the Milky Way Galaxy by a factor of at
least one thousand, then a wide range of molecules in high redshift hot cores
should have detectable emission. It should be possible to distinguish between
independent models for the production of metals and hence hot core molecules
should be useful probes of star formation at high redshift.
