  In this study, we use THz-assisted atom probe tomography (APT) to analyse
silica matrices used to encapsulate biomolecules. This technique provides the
chemical composition and 3D structure without significantly heating the
biosample, which is crucial for studying soft organic molecules such as
proteins. Our results show that THz pulses and a positive static field trigger
controlled evaporation of silica matrices, enabling 4D imaging with chemical
sensitivity comparable to UV laser-assisted APT. To support the interpretation
of these experimental results, we devise a computational model based on
time-dependent density functional theory to describe the interaction between
silica matrices and THz radiation. This model captures the nonlinear dynamics
driven by THz-pulses and the interplay between the THz source and the static
electric field in real time. This interdisciplinary approach expands the
capabilities of APT and holds promise for other THz-based analyses offering new
insights into material dynamics in complex biological environments.
