  An accurate approximate formula of the die-out probability in a SIS epidemic
process on a network is proposed. The formula contains only three essential
parameters: the largest eigenvalue of the adjacency matrix of the network, the
effective infection rate of the virus, and the initial number of infected nodes
in the network. The die-out probability formula is compared with the exact
die-out probability in complete graphs, Erd\H{o}s-R\'enyi graphs, and a
power-law graph. Furthermore, as an example, the formula is applied to the
$N$-Intertwined Mean-Field Approximation, to explicitly incorporate the
die-out.
