  Metal-organic skeleton materials have been widely used in catalysis with
their porous structure and adsorption properties. Precious metal nanoparticles
have good catalytic properties. If the noble metal nanoparticles are adsorbed
on the MOFs surface, the active sites can be increased and the catalytic effect
of the materials can be greatly improved. We successfully synthesized Pt@ZIF-8
in two steps, the average particle size of Pt nanoparticles is about 3 nm.
Pt@ZIF-8 possesses peroxidase activity and can oxidize colorless TMB to oxTMB
in the presence of hydrogen peroxide. The peroxide-like nature of Pt@ZIF-8 is
consistent with Michaelis-Menten kinetics. Glutathione is a reducing substance
that reduces blue oxTMB to colorless oxTMB. This colorimetric method achieves a
simple, sensitive and intuitive detection of glutathione. The detection limit
of this experiment is low, which is promising in biomolecular detection.
