  A common mechanism for intracellular transport is the use of controlled
deformations of the membrane to create spherical or tubular buds. While the
basic physical properties of homogeneous membranes are relatively well-known,
the effects of inhomogeneities within membranes are very much an active field
of study. Membrane domains enriched in certain lipids in particular are
attracting much attention, and in this Letter we investigate the effect of such
domains on the shape and fate of membrane tubes. Recent experiments have
demonstrated that forced lipid phase separation can trigger tube fission, and
we demonstrate how this can be understood purely from the difference in elastic
constants between the domains. Moreover, the proposed model predicts timescales
for fission that agree well with experimental findings.
