  The aim of this paper is to further develop mathematical models for bleb
formation in cells, including cell-membrane interactions with linker proteins.
This leads to nonlinear reaction-diffusion equations on a surface coupled to
fluid dynamics in the bulk. We provide a detailed mathematical analysis and
investigate some singular limits of the model, connecting it to previous
literature. Moreover, we provide numerical simulations in different scenarios,
confirming that the model can reproduce experimental results on bleb initation.
