  Objective: To investigate free radical scavenging potential of
thiocarbohydrazones derivatives for the discovery of antioxidant compounds of
synthetic origin. Method: Eighteen thiocarbohydrazones derivatives were
screened for antioxidant activities by using in vitro radical inhibition assay.
Cytotoxicity all derivatives were evaluated using invitro cytotoxicity assay on
mouse fibroblast cell line. Results: various compounds of the have shown
significant radical scavenging activities as compared with the standard drug
butylated hydroxytoluene. In addition in an in vitro cell cytotoxicity assay
selected analogues were found to be non-cytotoxic against fibroblast 3T3 cell
line. Conclusion: Taken together, these findings all compound this series could
be further evaluated in in vivo model of oxidative stress to develop as a
therapeutic agent against oxidative stress related disorders due to exhibiting
excellent free radical scavenging properties and having their non cytotoxic
nature against normal cells.
