  Aging is a multifactorial process and a key factor of morbidity and
mortality. Alzheimer's disease (AD) is an age-related disorder and a main cause
of worldwide disability. Both aging and AD can be characterized by metabolic
dysfunction. Metabolomics can quantify the complete set of metabolites in a
studied sample and is helpful for studying metabolic alterations in aging and
AD. In this review, we summarize the metabolomic changes regarding aging and
AD, discuss their biological functions, and highlight their potential
application as diagnostic biomarkers or therapeutic targets. Recent advances in
multi-omics approaches for understanding the metabolic mechanism of aging and
AD are also reviewed.
