  The distinguishing index $D'(G)$ of a graph $G$ is the least number of colors
necessary to obtain an edge coloring of $G$ that is preserved only by the
trivial automorphism. We show that if $G$ is a connected $\alpha$-regular graph
for some infinite cardinal $\alpha$ then $D'(G) \le 2$, proving a conjecture of
Lehner, Pil\'{s}niak, and Stawiski. We also show that if $G$ is a graph with
infinite minimum degree and at most $2^\alpha$ vertices of degree $\alpha$ for
every infinite cardinal $\alpha$, then $D'(G) \le 3$. In particular, $D'(G) \le
3$ if $G$ has infinite minimum degree and order at most $2^{\aleph_0}$.
