  In this paper we present our study of carbamazepine solubility in
supercritical carbon dioxide. We have calculated the solubility values along
two isochores corresponding to the CO$_2$ densities $\rho = 1.1\rho_{cr}(CO_2)$
and $\rho= 1.3\rho_{cr}(CO_2)$, where $\rho_{cr}(CO_2)$ is the critical density
of CO$_2$, in the temperature range from $313$ to $383~K$, as well as along
three isotherms at $T=318$, $328$ and $348~K$ by an approach based on the
classical density functional theory. The solubility values were also obtained
using in situ IR spectroscopy and molecular dynamics simulations along the
mentioned isochores and isotherms, respectively. Because the density functional
theory only takes into account the Lennard-Jones interactions, it can be
expected to underestimate the solubility values when compared to the
experimental ones. However, we have shown that the data calculated within the
classical density functional theory qualitatively reproduce the solubility
trends obtained by IR spectroscopy and molecular dynamics simulation. Moreover,
the obtained position of the upper crossover pressure is in good agreement with
the experimental literature results.
