  In carbon-therapy, the interaction of the incoming beam with human tissues
may lead to the production of a large amount of nuclear fragments and secondary
light particles. An accurate estimation of the biological dose deposited into
the tumor and the surrounding healthy tissues thus requires sophisticated
simulation tools based on nuclear reaction models. The validity of such models
requires intensive comparisons with as many sets of experimental data as
possible. Up to now, a rather limited set of double di erential carbon
fragmentation cross sections have been measured in the energy range used in
hadrontherapy (up to 400 MeV/A). However, new data have been recently obtained
at intermediate energy (95 MeV/A). The aim of this work is to compare the
reaction models embedded in the GEANT4 Monte Carlo toolkit with these new data.
The strengths and weaknesses of each tested model, i.e.
G4BinaryLightIonReaction, G4QMDReaction and INCL++, coupled to two di fferent
de-excitation models, i.e. the generalized evaporation model and the Fermi
break-up are discussed.
