  Honeycomb lattice can support electronic states exhibiting Dirac energy
dispersion, with graphene as the icon. We propose to derive nontrivial topology
by grouping six neighboring sites of honeycomb lattice into hexagons and
enhancing the inter-hexagon hopping energies over the intra-hexagon ones. We
reveal that this manipulation opens a gap in the energy dispersion and drives
the system into a topological state. The nontrivial topology is characterized
by the $\mathbb{Z}_2$ index associated with a pseudo time-reversal symmetry
emerging from the $C_6$ symmetry of the Kekul\'{e} hopping texture, where the
angular momentum of orbitals accommodated on the hexagonal "artificial atoms"
behaves as the pseudospin. The size of topological gap is proportional to the
hopping-integral difference, which can be larger than typical spin-orbit
couplings by orders of magnitude and potentially renders topological electronic
transports available at high temperatures.
