  We have witnessed some flavor anomalies appeared in the past years, and
explanations based on extended gauge sectors are among the most popular
solutions. These beyond the Standard Model (SM) theories often assume flavor
changing interactions mediated by new vector bosons, but at the same time they
could yield deviations from the SM in the $K^{0}-\bar{K}^{0}$,
$D^{0}-\bar{D}^{0}$, $B^0_d-\bar{B^0}_d$ and $B^0_s-\bar{B^0}_s$ meson systems.
Using up-to-date data on the mass difference of these meson systems, we derive
lower mass bounds on vector mediators for two different parametrizations of the
quark mixing matrices. Focusing on a well-motivated model, based on the
fundamental representation of the weak SU(3) gauge group, we put our findings
into perspective with current and future hadron colliders to conclude that
meson mass systems can give rise to bounds much more stringent than those from
high-energy colliders and that recent new physics interpretations of the
$b\rightarrow s$ and $R(D^{\ast})$ anomalies are disfavored.
