  Nanotube patterning may occur naturally upon the spontaneous self-assembly of
biomolecules onto the surface of single-walled carbon nanotubes (SWNTs). It
results in periodically alternating bands of surface properties, ranging from
relatively hydrophilic to hydrophobic, along the axis of the nanotube. Single
Chain Mean Field (SCMF) theory has been used to estimate the free energy of
systems in which a surface patterned nanotube penetrates a phospholipid
bilayer. In contrast to un-patterned nanotubes with uniform surface properties,
certain patterned nanotubes have been identified that display a relatively low
and approximately constant system free energy (10 kT) as the nanotube traverses
through the bilayer. These observations support the hypothesis that the
spontaneous self-assembly of bio-molecules on the surface of SWNTs may
facilitate nanotube transduction through cell membranes.
