  The aim of this work is to revisit the phenomenological theory of the
interaction between membrane inclusions, mediated by the membrane fluctuations.
We consider the case where the inclusions are separated by distances larger
than their characteristic size. Within our macroscopic approach a physical
nature of such inclusions is not essential, however we have always in mind two
prototypes of such inclusions: proteins and RNA macromolecules. Because the
interaction is driven by the membrane fluctuations, and the coupling between
inclusions and the membrane, it is possible to change the interaction potential
by external actions affecting these factors. As an example of such external
action we consider an electric field. Under external electric field (both dc or
ac), we propose a new coupling mechanism between inclusions possessing dipole
moments (as it is the case for most protein macromolecules) and the membrane.
We found, quite unexpected and presumably for the first time, that the new
coupling mechanism yields to giant enhancement of the pairwise potential of the
inclusions. This result opens up a way to handle purposefully the interaction
energy, and as well to test of the theory set forth in our article.
