  Machine learning methods play increasingly important roles in pre-procedural
planning for complex surgeries and interventions. Very often, however,
researchers find the historical records of emerging surgical techniques, such
as the transcatheter aortic valve replacement (TAVR), are highly scarce in
quantity. In this paper, we address this challenge by proposing novel
generative invertible networks (GIN) to select features and generate
high-quality virtual patients that may potentially serve as an additional data
source for machine learning. Combining a convolutional neural network (CNN) and
generative adversarial networks (GAN), GIN discovers the pathophysiologic
meaning of the feature space. Moreover, a test of predicting the surgical
outcome directly using the selected features results in a high accuracy of
81.55%, which suggests little pathophysiologic information has been lost while
conducting the feature selection. This demonstrates GIN can generate virtual
patients not only visually authentic but also pathophysiologically
interpretable.
