  We explore how nuclear modifications to the free nucleon structure functions
(also known as shadowing) affect heavy quark production in collisions at
different impact parameters. We assume that the nuclear modifications arise
from a density dependent effect such as gluon recombination and are thus
proportional to the local density. We calculate the dependence of charm and
bottom quark production on impact parameter and show that density dependent
modifications can lead to significant reductions in the heavy quark production
cross sections in central relative to peripheral interactions.
