  In this work, we present a computing platform named digital twin brain (DTB)
that can simulate spiking neuronal networks of the whole human brain scale and
more importantly, a personalized biological brain structure. In comparison to
most brain simulations with a homogeneous global structure, we highlight that
the sparseness, couplingness and heterogeneity in the sMRI, DTI and PET data of
the brain has an essential impact on the efficiency of brain simulation, which
is proved from the scaling experiments that the DTB of human brain simulation
is communication-intensive and memory-access intensive computing systems rather
than computation-intensive. We utilize a number of optimization techniques to
balance and integrate the computation loads and communication traffics from the
heterogeneous biological structure to the general GPU-based HPC and achieve
leading simulation performance for the whole human brain-scaled spiking
neuronal networks. On the other hand, the biological structure, equipped with a
mesoscopic data assimilation, enables the DTB to investigate brain cognitive
function by a reverse-engineering method, which is demonstrated by a digital
experiment of visual evaluation on the DTB. Furthermore, we believe that the
developing DTB will be a promising powerful platform for a large of research
orients including brain-inspiredintelligence, rain disease medicine and
brain-machine interface.
