  Developing successful scaffolds requires clinicians to adopt a
multidisciplinary approach in order to understand and stimulate the natural
bone regeneration process. A variety of natural and synthetic biomaterials,
including naturally extracted, chemically functionalised collagen and synthetic
Poly(epsilon-caprolactone) (PCL), can be manufactured into fibres, enabling the
formation of nonwoven scaffolds. Many different nonwoven architectures and
structural features can then be introduced, depending on the manufacturing
parameters. This chapter introduces methods for producing scaffolds with
appropriate pore sizes by means of electrospinning, and it outlines the
opportunities that exist for other nonwoven manufacturing technologies in the
development of biomimetic products.
