  Hyperthermia therapy (HT) is used to treat diseases through heating of high
temperature usually in conjunction with some other medical therapeutics like
chemotherapy and radiotherapy. In this study, we propose a promising
thermostatic hyperthermia method that uses high-intensity focused ultrasound
(HIFU) for clinical tumor treatment combined with diagnostic ultrasound image
guidance and non-invasive temperature monitoring through the speed of sound
(SOS) imaging. HIFU heating is realized by a ring ultrasound transducer array
with 256 elements. The inner structure information of thigh tissue is obtained
by B-mode ultrasound imaging. Since the relationship between the temperature
and the SOS in the different human tissue is available, the temperature
detection is converted to the SOS detection obtained by the full-wave inversion
(FWI) method. Simulation results show that our model can achieve expected
thermostatic hyperthermia on tumor target with 0.2 degree maximum temperature
fluctuation for 5 hours. This study verifies the feasibility of the proposed
thermostatic hyperthermia model. Furthermore, the temperature measurement can
share the same ultrasound transducer array for HIFU heating and B-mode
ultrasound imaging, which provides a guiding significance for clinical
application.
