  With the escalating complexity and volume of genomic data, the capacity of
biology institutions' HPC faces limitations. While the Cloud presents a viable
solution for short-term elasticity, its intricacies pose challenges for
bioinformatics users. Alternatively, serverless computing allows for workload
scalability with minimal developer burden. However, porting a scientific
application to serverless is not a straightforward process. In this article, we
present a Variant Calling genomics pipeline migrated from single-node HPC to a
serverless architecture. We describe the inherent challenges of this approach
and the engineering efforts required to achieve scalability. We contribute by
open-sourcing the pipeline for future systems research and as a scalable
user-friendly tool for the bioinformatics community.
