  PHF5A is a member of the zinc-finger proteins. To advance knowledge on their
role in carcinogenesis, data from experimental studies, animal models and
clinical studies in different tumorigenesis have been reviewed. Furthermore,
PHF5A as an oncogenic function, is frequently expressed in tumor cells and a
potential prognostic marker for different cancers. PHF5A is implicated in the
regulation of cancer cell proliferation, invasion, migration and metastasis.
Knockdown of PHF5A prevented the invasion and metastasis of tumor cells. Here,
the role of PHF5A in different cancers and their possible mechanism in relation
to recent literature is reviewed and discussed. However, there is an open
promising perspective to their therapeutic management for different cancer
types.
