  Drug delivery through electroporation could be highly beneficial for the
treatment of different types of diseased tissues within the human body. In this
work, a mathematical model of reversible tissue electroporation is presented
for injecting drug into the diseased cells. The model emphasizes the tissue
boundary where the drug is injected as a point source. Drug loss from the
tissue boundaries through extracellular space is studied. Multiple pulses are
applied to deliver a sufficient amount of drug into the targeted cells. The set
of differential equations that model the physical circumstances are solved
numerically. This model obtains a mass transfer coefficient in terms of pore
fraction coefficient and drug permeability. It controls the drug transport from
extracellular to intracellular space. The drug penetration throughout the
tissue is captured for the application of different pulses. The boundary
effects on drug concentration are highlighted in this study. The advocated
model is able to perform homogeneous drug transport into the cells so that the
affected tissue is treated completely. This model can be applied to optimize
clinical experiments by avoiding the lengthy and costly in vivo and in vitro
experiments.
