  The effects of off-stoichiometry and elemental substitution on electronic
properties of iron-based ladder compound BaFe$_{2}$S$_{3}$ are investigated.
Resistivity and magnetization are revealed to be quite sensitive to the
stoichiometry of Fe atoms, and 10 \% deficiency at Fe sites reduces the
antiferromagnetic transition temperature by 40 K. The antiferromagnetic
transition temperature decreases even faster and collapse to zero with hole
doping through 10 \% K substitution at Ba site, while the antiferromagnetic
ordering phase remains with electron doping through 20 \% Co substitution at Fe
site. Such electron-hole asymmetry is opposite to two-dimensional iron-based
superconductors, and can be explained on the basis of both itinerant and
localized electronic pictures.
