  For an algebraic number field $K$ with ring of integers $\mathcal{O}_{K}$, an
important subgroup of the ideal class group $Cl_{K}$ is the {\it P\'{o}lya
group}, denoted by $Po(K)$, which measures the failure of the
$\mathcal{O}_{K}$-module $Int(\mathcal{O}_{K})$ of integer-valued polynomials
on $\mathcal{O}_{K}$ from admitting a regular basis. In this paper, we prove
that for any integer $n \geq 2$, there are infinitely many totally real
bi-quadratic fields $K$ with $|Po(K)| = 2^{n}$. In fact, we explicitly
construct such an infinite family of number fields. This extends an infinite
family of bi-quadratic fields with P\'{o}lya group $\mathbb{Z}/2\mathbb{Z}$
given by the authors in \cite{self-ja}. This also provides an infinite family
of bi-quadratic fields with class numbers divisible by $2^{n}$.
