  We report the demonstration of a low-power pixelated readout system designed
for three-dimensional ionization charge detection and digital readout of liquid
argon time projection chambers (LArTPCs). Unambiguous 3D charge readout was
achieved using a custom-designed system-on-a-chip ASIC (LArPix) to uniquely
instrument each pad in a pixelated array of charge-collection pads. The LArPix
ASIC, manufactured in 180 nm bulk CMOS, provides 32 channels of
charge-sensitive amplification with self-triggered digitization and multiplexed
readout at temperatures from 80 K to 300 K. Using an 832-channel LArPix-based
readout system with 3 mm spacing between pads, we demonstrated low-noise
($<$500 e$^-$ RMS equivalent noise charge) and very low-power ($<$100
$\mu$W/channel) ionization signal detection and readout. The readout was used
to successfully measure the three-dimensional ionization distributions of
cosmic rays passing through a LArTPC, free from the ambiguities of existing
projective techniques. The system design relies on standard printed circuit
board manufacturing techniques, enabling scalable and low-cost production of
large-area readout systems using common commercial facilities. This
demonstration overcomes a critical technical obstacle for operation of LArTPCs
in high-occupancy environments, such as the near detector site of the Deep
Underground Neutrino Experiment (DUNE).
