  The interaction energies between the different types of bases of a single
strand of DNA molecule have been calculated. Using these original values of
energies the harmonic behavior of a number of base patterns of DNA has been
studied. In view of the great interest aroused by the discovery of the role of
the telomere segment of the DNA in the replication process and its possible
link with the aging process, we have investigated, with simple models, the
harmonic behavior of the telomeric pattern of bases as well as the
thermodynamic response in the biological system. With these results a
conclusion on the probable role of the telomeric pattern on aging has also been
drawn. Here the calculated values of harmonic frequencies of the telomeric
pattern of bases and of other possible patterns show that the telomeric pattern
is associated with the highest vibrational frequency among all patterns of base
combinations at the replication end of DNA. This seems to suggest that due to
the existing telomeric pattern being closest to the frequencies of the
electromagnetic radiation coming from sunlight, resonance of the telomeric
frequency with such radiation may be responsible for damage to the reproductive
ability of the cells and consequent aging and other problems. On the other hand
in the last part of this work we have calculated the thermal vibrational
amplitudes of the telomeric pattern and other possible patterns which show that
the amplitude for the telomeric pattern is the least, and this suggests that
the telomeric pattern is more mechanically and thermally stable than other
possible patterns in the biological environment against damage from ordinary
heat and mechanical effects.
