  We develop an efficient, sensitive, accurate, cost effective, and greener
liquid chromatography method for the determination of a quantification method
concerning Captopril in pharmaceutical dosage forms by using ultra high
performance liquid chromatography (UHPLC) equipment. Satisfactory resolution
was able to be achieved using a Water Aquity UHPLC BEH C18 1.7 $\mu$m $\times$
2.1 mm $\times$ 50 mm column and an isocratic mobile phase composition of
Methanol, Milli-Q water and Trifluoroacetic acid in the ratio of 55:45:0.05
v/v/v respectively at a flow rate of 0.1mL/min and a wavelength detection of
220nm. The retention time for Captopril was found to be 1.744 minutes while for
Captopril disulfide it was found to be 2.657 minutes. The method was validated
based on the ICH and USP guidelines.
