  Semantic communication (SemCom) has been a transformative paradigm,
emphasizing the precise exchange of meaningful information over traditional
bit-level transmissions. However, existing SemCom research, primarily centered
on simplified scenarios like single-pair transmissions with direct wireless
links, faces significant challenges when applied to real-world radio access
networks (RANs). This article introduces a Semantic-aware Radio Access Network
(S-RAN), offering a holistic systematic view of SemCom beyond single-pair
transmissions. We begin by outlining the S-RAN architecture, introducing new
physical components and logical functions along with key design challenges. We
then present transceiver design for end-to-end transmission to overcome
conventional SemCom transceiver limitations, including static channel
conditions, oversimplified background knowledge models, and hardware
constraints. Later, we delve into the discussion on radio resource management
for multiple users, covering semantic channel modeling, performance metrics,
resource management algorithms, and a case study, to elaborate distinctions
from resource management for legacy RANs. Finally, we highlight open research
challenges and potential solutions. The objective of this article is to serve
as a basis for advancing SemCom research into practical wireless systems.
