  Clinicians benefit from online treatment planning systems, through off-site
accessibility, data sharing and professional interaction. As well as enhancing
clinical value, incorporation of simulation tools affords innovative avenues
for open-ended, multi-disciplinary research collaboration. An extensible system
for clinicians, technicians, manufacturers and researchers to build on a
simulation framework is presented. This is achieved using a domain model that
relates entities from theoretical, engineering and clinical domains, allowing
algorithmic generation of simulation configuration for several open source
solvers.
  The platform is applied to Minimally Invasive Cancer Treatments (MICTs),
allowing interventional radiologists to upload patient data, segment patient
images and validate simulated treatments of radiofrequency ablation,
cryoablation, microwave ablation and irreversible electroporation. A
traditional radiology software layout is provided in-browser for clinical use,
with simple, guided simulation, primarily for training and research. Developers
and manufacturers access a web-based system to manage their own simulation
components (equipment, numerical models and clinical protocols) and related
parameters.
  This system is tested by interventional radiologists at four centres, using
pseudonymized patient data, as part of the Go-Smart Project
(http://gosmart-project.eu). The simulation technology is released as a set of
open source components http://github.com/go-smart.
