  Low-dose ionizing radiation may induce far-reaching consequences in human,
especially regarding intrauterine development. Many studies have documented
that the risks of in utero irradiation remain controversial and no effect is
reported at doses below 50 mGy. Animal models are often used to clarify the
non-fully understood impact of intrauterine irradiation and allow the
manipulation of several experimental setups, making possible the analysis of a
wide range of end points. We investigated the impact of in utero low-dose X-ray
irradiation on postnatal development in rat offspring through a set of
well-established behavioral parameters and weight gain. To investigate the
hypothesis of postnatal behavioral and physiological alterations due to
prenatal low-dose ionizing radiation we exposed pregnant Wistar to 15 mGy of
X-rays on gestational days 8 and 15 and control mothers. This low-dose value
into diagnostic range can be achieved in a single radiological exam. Four male
animals were select from each litter. At infant age, eye-opening test and
negative geotaxis tests were performed. Animals were tested at postnatal ages
30 and 70 days in open field, elevated plus-maze, and hole board tests. We
evaluated the weight gain of all animals throughout the experiment. The results
presented differences between irradiated and non-irradiated animals. Exposed
animals presented lower weight gain in adult life, impairment in central
nervous system since infant phase, behavioral alterations persisting into later
life, and motor coordination impairment. Effects at doses under 100 mGy have
not been reported, however, the present study demonstrate that 15 mGy
intrauterine exposure was able to generate deleterious effects.
