  We construct tilting modules over Jacobian algebras arising from knots. To a
two-bridge knot $L[a_1,\ldots,a_n]$, we associate a quiver $Q$ with potential
and its Jacobian algebra $A$. We construct a family of canonical indecomposable
$A$-modules $M(i)$, each supported on a different specific subquiver $Q(i)$ of
$Q$. Each of the $M(i)$ is expected to parametrize the Jones polynomial of the
knot. We study the direct sum $M=\oplus_iM(i)$ of these indecomposables inside
the module category of $A$ as well as in the cluster category.
  In this paper we consider the special case where the two-bridge knot is given
by two parameters $a_1,a_2$. We show that the module $M$ is rigid and
$\tau$-rigid, and we construct a completion of $M$ to a tilting (and
$\tau$-tilting) $A$-module $T$. We show that the endomorphism algebra
$\operatorname{End}_AT$ of $T$ is isomorphic to $A$, and that the mapping
$T\mapsto A[1]$ induces a cluster automorphism of the cluster algebra
$\mathcal{A}(Q)$. This automorphism is of order two. Moreover, we give a
mutation sequence that realizes the cluster automorphism. In particular, we
show that the quiver $Q$ is mutation equivalent to an acyclic quiver of type
$T_{p,q,r}$ (a tree with three branches). This quiver is of finite type if
$(a_1,a_2)=(a_1,2), (1,a_2),$ or $(2,3)$, it is tame for $(a_1,a_2)=(2,4)$ or
$(3,3)$, and wild otherwise.
