  The focus of the present review is the production of the heaviest elements in
nature via the r-process. A correct understanding and modeling requires the
knowledge of nuclear properties far from stability and a detailed prescription
of the astrophysical environment. Experiments at CERN/ISOLDE have played a
pioneering role in exploring the characteristics of nuclear structure in terms
of masses and beta-decay properties. Initial examinations paid attention to far
unstable nuclei with magic neutron numbers related to r-process peaks, while
present activities are centered on the evolution of shell effects with the
distance from the valley of stability. We first show in site-independent
applications the effect of both types of nuclear properties on r-process
abundances. Then, we explore the results of calculations related to two
different `realistic' astrophysical sites, (i) the supernova neutrino wind and
(ii) neutron star mergers. We close with a list of remaining theoretical and
experimental challenges needed to overcome for a full understanding of the
nature of the r-process, and the role CERN/ISOLDE can play in this process.
