  We present results from molecular dynamics simulations of a spherically
confined neutral polymer in the presence of crowding agents, studying polymer
shapes and conformations as a function of the confining potential, solvent
quality and the density of crowders. The conformations of the polymer under
good solvent conditions are largely independent of crowder density, even when
the polymer is strongly confined. However, for poor solvents and attractive
walls, the polymer shows a transition between an adsorbed extended state to a
globular conformation on the surface as a function of crowder particle density.
This state differs from both the desorbed globular conformation in the absence
of any wall interactions and the adsorbed globular conformation at low values
of the attractive wall interactions. We revisit the earlier understanding of
the adsorption of confined polymers on curved, attractive surfaces in the light
of these results.
