  Multiple light scattering in tissue limits the penetration of optical
coherence tomography (OCT) imaging. Here, we present in-vivo OCT imaging of a
live mouse using wavefront shaping to enhance the penetration depth. A digital
micro-mirror device (DMD) was used in a spectral-domain OCT system for complex
wavefront shaping of an incident beam which resulted in the optimal delivery of
light energy into deep tissue. Ex-vivo imaging of chicken breasts and mouse ear
tissues showed enhancements in the strength of the image signals and the
penetration depth, and in-vivo imaging of the tail of a live mouse provided a
multilayered structure inside the tissue, otherwise invisible in conventional
OCT imaging. Signal enhancements by a factor of 3-7 were acquired for various
experimental conditions and samples.
