  Weakly interacting massive particles (WIMPs) may interact with a virtual pion
that is exchanged between nucleons. This interaction channel is important to
consider in models where the spin-independent isoscalar channel is suppressed.
Using data from the first science run of the LUX-ZEPLIN dark matter experiment,
containing 60 live days of data in a 5.5~tonne fiducial mass of liquid xenon,
we report the results on a search for WIMP-pion interactions. We observe no
significant excess and set an upper limit of $1.5\times10^{-46}$~cm$^2$ at a
90\% confidence level for a WIMP mass of 33~GeV/c$^2$ for this interaction.
