  The difference between the chronological and biological brain age of a
subject can be an important biomarker for neurodegenerative diseases, thus
brain age estimation can be crucial in clinical settings. One way to
incorporate multimodal information into this estimation is through population
graphs, which combine various types of imaging data and capture the
associations among individuals within a population. In medical imaging,
population graphs have demonstrated promising results, mostly for
classification tasks. In most cases, the graph structure is pre-defined and
remains static during training. However, extracting population graphs is a
non-trivial task and can significantly impact the performance of Graph Neural
Networks (GNNs), which are sensitive to the graph structure. In this work, we
highlight the importance of a meaningful graph construction and experiment with
different population-graph construction methods and their effect on GNN
performance on brain age estimation. We use the homophily metric and graph
visualizations to gain valuable quantitative and qualitative insights on the
extracted graph structures. For the experimental evaluation, we leverage the UK
Biobank dataset, which offers many imaging and non-imaging phenotypes. Our
results indicate that architectures highly sensitive to the graph structure,
such as Graph Convolutional Network (GCN) and Graph Attention Network (GAT),
struggle with low homophily graphs, while other architectures, such as
GraphSage and Chebyshev, are more robust across different homophily ratios. We
conclude that static graph construction approaches are potentially insufficient
for the task of brain age estimation and make recommendations for alternative
research directions.
