  Subclinical leaflet thrombosis (SLT) is a potentially serious complication of
aortic valve replacement with a bioprosthetic valve in which blood clots form
on the replacement valve. SLT is associated with increased risk of transient
ischemic attacks and strokes and can progress to clinical leaflet thrombosis.
SLT following aortic valve replacement also may be related to subsequent
structural valve deterioration, which can impair the durability of the valve
replacement. Because of the difficulty in clinical imaging of SLT, models are
needed to determine the mechanisms of SLT and could eventually predict which
patients will develop SLT. To this end, we develop methods to simulate leaflet
thrombosis that combine fluid-structure interaction and a simplified thrombosis
model that allows for deposition along the moving leaflets. Additionally, this
model can be adapted to model deposition or absorption along other moving
boundaries. We present convergence results and quantify the model's ability to
realize changes in valve opening and pressures. These new approaches are an
important advancement in our tools for modeling thrombosis in which they
incorporate both adhesion to the surface of the moving leaflets and feedback to
the fluid-structure interaction.
