  Crawling cell motility is vital to many biological processes such as wound
healing and the immune response. Using a minimal model we investigate the
effects of patterned substrate adhesiveness and biophysical cell parameters on
the direction of cell motion. We show that cells with low adhesion site
formation rates may move perpendicular to adhesive stripes while a those with
high adhesion site formation rates results in motility only parallel to the
substrate stripes. We explore the effects of varying the substrate pattern and
the strength of actin polymerization on the directionality of the crawling
cell; these results have applications in motile cell sorting and guiding on
engineered substrates.
