  A review of recent investigations into pathogenesis of psoriasis summarizing
data on the relationship between the presence beta-streptococci in the organism
and the cutaneous immune reaction. Results of the studies on gastrointestinal
pathology in psoriatic patients are presented. The authors propose a hypothesis
that advocates the primary origin of psoriatic gastrointestinal pathology and
secondary nature of skin manifestations. A chronic plaque psoriasis model is
developed on the basis of the assumption on the key role of two psorafactors,
i.e. hyperpermeability of intestinal walls for certain proteins and
incorporation of beta-streptococci in the microbiocenosis of intestinal mucosa.
The validity of the model is confirmed by the results of practical clinical
work.
