  We consider open quantum systems weakly coupled to a heat reservoir and
driven by arbitrary time-dependent parameters. We derive exact microscopic
expressions for the nonequilibrium entropy production and entropy production
rate, valid arbitrarily far from equilibrium. By using the two-point energy
measurement statistics for system and reservoir, we further obtain a quantum
generalization of the integrated fluctuation theorem put forward by Seifert
[PRL 95, 040602 (2005)].
