  We report the discovery of gamma-ray detection from the Large Magellanic
Cloud (LMC) B0443-6657 using the Large Area Telescope (LAT) on board the
\textit{Fermi Gamma-ray Space Telescope}. LMC B0443-6657 is a flat spectrum
radio source, possibly associated with a supernova remnant in the Large
Magellanic Cloud (LMC N4). Employing the LAT data of 8 years, our results show
a significant excess ($>9.4\sigma$) of gamma-ray in the range of 0.2--100\,GeV
above the gamma-ray background. A power-law function is found to be adequate to
describe the $0.2-100$ GeV $\gamma$-ray spectrum, which yields a photon flux of
$3.27\pm0.53\ \mathrm{photon\ \,cm}^2\ \mathrm{s}^{-1}$ with a photon index of
$2.35\pm0.11$, corresponding to an isotropic gamma-ray luminosity of
$5.3\times10^{40}\ \mathrm{erg\ \,s}^{-1}$. The hadronic model predicts a low
X-ray and TeV flux while the leptonic model predicts an observable flux in
these two energy bands. The follow-up observations of the LMC B0443-6657 in
X-ray or TeV band would distinguish the radiation models of gamma-rays from
this region.
