  The two-Higgs-doublet with additional scalar (2HDM$+S$) model is one proposed
to account for several anomalies that have persisted and increased in
significance over runs 1 and 2 at the Large Hadron Collider (LHC). In addition
to this, 2HDM+$S$ also supplies a potential Dark Matter (DM) candidate coupling
to the Standard Model via the $S$ boson. So far, this model has been difficult
to constrain by indirect means. Here we will explore the potential of Omega
Centauri, a nearby globular cluster to constrain this interesting DM model.
Although such structures are generally considered to be lacking in DM,
arguments have been made that this cluster is in fact the relic of a tidally
stripped dwarf galaxy. In such a scenario, the DM content would be significant.
Combined with its nearness, this would suggest a potential for powerful
indirect dark matter signals. We employ both Fermi-LAT gamma-ray data, as well
as MeerKAT telescope sensitivities to determine the current status of Omega
Centauri as a source of indirect constraints on Weakly Interacting Massive
Particles (WIMPs) in a 2HDM+$S$ scenario and for general annihilation channels.
