  Inspired by the string landscape and the unified gauge coupling relation in
the F-theory Grand Unified Theories (GUTs) and GUTs with suitable
high-dimensional operators, we study the canonical gauge coupling unification
and Higgs boson mass in the Standard Model (SM) with high-scale supersymmetry
breaking. In the SM with GUT-scale supersymmetry breaking, we achieve the gauge
coupling unification at about 5.3 x 10^{13} GeV, and the Higgs boson mass is
predicted to range from 130 GeV to 147 GeV. In the SM with supersymmetry
breaking scale from 10^4 GeV to 5.3 x 10^{13} GeV, gauge coupling unification
can always be realized and the corresponding GUT scale M_U is from 10^{16} GeV
to 5.3 x 10^{13} GeV, respectively. Also, we obtain the Higgs boson mass from
114.4 GeV to 147 GeV. Moreover, the discrepancies among the SM gauge couplings
at the GUT scale are less than about 4-6%. Furthermore, we present the SU(5)
and SO(10) models from the F-theory model building and orbifold constructions,
and show that we do not have the dimension-five and dimension-six proton decay
problems even if M_U \le 5 x 10^{15} GeV.
