  Many models of physics beyond the Standard Model (SM) contain enhanced
couplings to third generation particles. The predicted signatures include
vector-like quarks and $t\bar{t}$ resonances. We present a review of non-SUSY
based searches for new physics beyond the SM in final states with
third-generation quarks using proton-proton collision data collected with the
CMS detector at the CERN LHC. We analyze a wide range of final states, from
multi-leptonic to entirely hadronic, and many results use novel analysis
techniques to identify and reconstruct highly boosted final states that are
created in these topologies. These techniques provide increased sensitivity to
new high-mass particles over traditional search methods.
