  We present a stochastic computational model of avascular tumors, emphasizing
the detailed implementation of the first four so-called hallmarks of cancer:
self-sufficiency in growth factors, resistance to growth inhibitors, avoidance
of apoptosis, and unlimited growth potential. Our goal is to provide a
foundational understanding of the first steps of cancer malignancy while
addressing modeling uncertainties, thus bringing us closer to a
first-principles grasp of this process. Preliminary numerical simulations
illustrate the comprehensiveness of our perspective.
