  We propose a data-dependent early completion of dose finding trials for
drug-combination. The early completion is determined when a beta-binomial
probability for dose retainment with the trial data and the number of remaining
patients is high. This paper also proposes an early completion method that a
dose retainment probability is adjusted by a bivariate isotonic regression. We
demonstrate the early completion for a virtual trial. We evaluate the
performance of early completion method through simulation studies with 12
scenarios. We confirmed the superior performance for our proposed early
completion methods. We show the number of patients for determining early
completion before a trial starts and a program code for calculating dose
retainment probability in this paper.
