  Monte Carlo simulations of protein folding show the emergence of a strong
correlation between the relative contact order parameter, CO, and the folding
time, t, of two-state folding proteins for longer chains with number of amino
acids, N>=54, and higher contact order, CO > 0.17. The correlation is
particularly strong for N=80 corresponding to slow and more complex folding
kinetics. These results are qualitatively compatible with experimental data
where a general trend towards increasing t with CO is indeed observed in a set
of proteins with chain length ranging from 41 to 154 amino acids.
