  We calculate the new physics contributions to the rare semileptonic decay $B
\to X_s l^+ l^-$ $(l=e,\mu)$ induced by the charged-Higgs loop diagrams
appeared in the top quark two-Higgs doublet model (T2HDM). Within the
considered parameter space, we found that (a) the effective Wilson coefficients
$\widetilde{C}_{i}^{eff}(m_b)$ ($i =7\gamma, 9V$ and $10A$) in the T2HDM are
always standard model like; (b) the new physics contributions to
$\widetilde{C}_{7\gamma}^{eff}$ and $\widetilde{C}_{9V}^{eff}$ can be
significant, but they tend to cancel each other; and (c) the T2HDM predictions
for $Br(B \to X_s l^+ l^-)$ agree well with the measured value within one
standard deviation.
