  A superspace model of knots and links for DNA time series data is proposed to
take into account the feedback loop from docking to undocking state of
protein-protein interactions. In particular, the direction of interactions
between the 8 hidden states of DNA is considered. It is a $E_{8}\times E_{8}$
unified spin model where the genotype, from active and inactive side of DNA
time data series, can be considered for any living organism. The mathematical
model is borrowed from loop-quantum gravity and adapted to biology. It is used
to derive equations for gene expression describing transitions from ground to
excited states, and for the 8 coupling states between geneon and anti-geneon
transposon and retrotransposon in trash DNA. Specifically, we adopt a modified
Grothendieck cohomology and a modified Khovanov cohomology for biology. The
result is a Chern-Simons current in $(8+3)$ extradimensions of a given
unoriented super manifold with ghost fields of protein structures. The $8$
dimensions come from the 8 hidden states of spinor field of genetic code. The
extradimensions come from the 3 types of principle fiber bundle in the
secondary protein.
