  Due to the non-linear ionizing and heating processes, the 21-cm signals from
epoch of reionization (EoR) are expected to have strong non-Gaussian
fluctuations. In this paper, we use the semi-numerical simulations to study the
non-Gaussian statistics i.e. skew spectrum and smoothed skewness of the 21-cm
signals from EoR. We find the 21-cm skew spectrum and smoothed skewness have
similar evolution features with the 21-cm bispectrum. All of them are sensitive
to the EoR models, while not too much to the cosmic volume applied. With the
SKA1-low telescope as reference, we find both the skew spectrum and smoothed
skewness have much higher S/N ratios than the 21-cm bispectrum.
