  Dozens of layered V$_2$IV$_2$VI$_6$ (V=P, As, Sb, Bi, IV=Si, Ge, Sn, Pb,
VI=S, Se, Te) materials are investigated, several of which have been
successfully synthesized in experiment. Among them, we predict nine strong
topological insulators (TIs), two strong topological metals (TMs) and nearly
twenty trivial insulators at their equilibrium structures. The TIs are in the
(1;111) topological class, with energy gaps ranging from 0.04 to 0.2 eV. The
strong TMs and the trivial insulators belong to the (1;111) and (0;000)
topological classes, respectively. Small compressive strains easily turn some
of the trivial insulators into strong TIs. This study enriches not only the
family of topological materials but also the family of van der Waals layered
materials, providing promising candidates for the future spintronic devices.
