  In this letter we present a predictive SO(10) SUSY GUT with flavor symmetry
U(2) \times U(1) which has several nice features. We are able to fit fermion
masses and mixing angles, including recent neutrino data, with 9 parameters in
the charged fermion sector and 4 in the neutrino sector. The flavor symmetry
plays a preeminent role -- (i) The model is "natural" -- we include all terms
allowed by the symmetry. It restricts the number of arbitrary parameters and
enforces many zeros in the effective mass matrices. (ii) Flavor symmetry
breaking from U(2) \times U(1) \to U(1) \to nothing generates the family
hierarchy. It also constrains squark and slepton mass matrices, thus
ameliorating flavor violation resulting from squark and slepton loop
contributions. (iii) Finally, it naturally gives large angle $\nu_\mu -
\nu_\tau$ mixing describing atmospheric neutrino oscillation data and small
angle $\nu_e - \nu_{s}$ mixing consistent with the small mixing angle MSW
solution to solar neutrino data.
