  A campaign of intermediate energy (300-450 MeV/u) proton-induced nucleon
knockout measurements in inverse kinematics has been recently undertaken at the
R 3 B/LAND setup at GSI. We present a systematic theoretical analysis of these
data with the aim of studying the quenching of the single-particle strengths
and its binding-energy dependence. For that, the measured semi-inclusive (p,
2p) and (p, pn) cross sections are compared with theoretical predictions based
on single-particle cross sections derived from a novel coupled-channels
formalism and shell-model spectroscopic factors. A systematic reduction of
about 20-30% is found, with a very limited dependence on proton-neutron
asymmetry.
