  One well-known way to constrain the hydrogen neutral fraction, x_H, of the
high-redshift intergalactic medium (IGM) is through the shape of the red
damping wing of the Lya absorption line. We examine this method's effectiveness
in light of recent models showing that the IGM neutral fraction is highly
inhomogeneous on large scales during reionization. Using both analytic models
and "semi-numeric" simulations, we show that the "picket-fence" absorption
typical in reionization models introduces both scatter and a systematic bias to
the measurement of x_H. In particular, we show that simple fits to the damping
wing tend to overestimate the true neutral fraction in a partially ionized
universe, with a fractional error of ~ 30% near the middle of reionization.
This bias is generic to any inhomogeneous model. However, the bias is reduced
and can even underestimate x_H if the observational sample only probes a subset
of the entire halo population, such as quasars with large HII regions. We also
find that the damping wing absorption profile is generally steeper than one
would naively expect in a homogeneously ionized universe. The profile steepens
and the sightline-to-sightline scatter increases as reionization progresses. Of
course, the bias and scatter also depend on x_H and so can, at least in
principle, be used to constrain it. Damping wing constraints must therefore be
interpreted by comparison to theoretical models of inhomogeneous reionization.
