  We present Infrared Space Observatory (ISO) observations of several OH, CH
and H2O rotational lines toward the bright infrared galaxies NGC253 and
NGC1068. As found in the Galactic clouds in SgrB2 and Orion, the extragalactic
far-IR OH lines change from absorption to emission depending on the physical
conditions and distribution of gas and dust along the line of sight. As a
result, most of the OH rotational lines that appear in absorption toward NGC253
are observed in emission toward NGC1068. We show that the far-IR spectrum of OH
can be used as a powerful diagnostic to derive the physical conditions of
extragalactic neutral gas. In particular, we find that a warm (Tk~150 K, n(H2)<
5 10^4 cm^-3) component of molecular gas with an OH abundance of 10^{-7} from
the inner <15'' can qualitatively reproduce the OH lines toward NGC253. Similar
temperatures but higher densities (5 10^5 cm^-3) are required to explain the OH
emission in NGC1068.
