  Raoul Gatto and Bruno Touschek's collaboration in the establishment of
electron positron colliders as a fundamental discovery tool in particle physics
will be illustrated. In particular, we will tell the little-known story of how
Gatto and Touschek's pioneering vision combined to provide the theoretical
foundations for AdA, the first matter-antimatter collider, and how their
friendship with Wolfgang Pauli and Gerhard L\"uders was crucial to their
understanding of the CPT theorem, the basis for AdA's success. We will see how
these two exceptional scientists shaped physics between Rome and Frascati, from
the proposal to build AdA and, soon after in 1961, the larger machine ADONE, to
the discovery of the $J/\Psi$ particle in 1974. We will also highlight Gatto
and Touschek's contribution in mentoring an extraordinary cohort of students
and collaborators whose work contributed to the renaissance of Italian
theoretical physics after the Second World War and to the establishment of the
Standard Model of particle physics.
