  Breast cancers is the second leading cause of cancer mortality in women;
early diagnosis increase the probability of a successful therapy; any marginal
improvement in this direction helps sparing lives. In this context functional
imaging techniques such as Molecular Breast Imaging (MBI) represents an
important supplemental screening, especially in the more questionable cases. In
order to further extend the MBI performances an innovative asymmetric dual
detector device, with mixed optics has been recently proposed and prototyped;
the sensors are highly segmented with a correspondingly large number of
independent, configurable, electronic readout channels with self-triggering
capability.
  This flexible electronics architecture has different advantages in addition
to those related to the adopted asymmetric dual detector geometry: real-time
event selection based on the adjustable gain and discriminator threshold at
single channel (or group of channels) level; repeatable, quick hardware and
software channel response equalization; configurable list mode acquisition for
versatile offline image processing.
  These benefits come at the expenses of more complex calibration methods and
optimization procedures, which are detailed in the present paper.
