  Context: Difference imaging has proven to be a powerful technique for
detecting and monitoring the variability of unresolved stellar sources in M 31.
Using this technique in surveys of galaxies outside the Local Group could have
many interesting applications. Aims: The goal of this paper is to test
difference imaging photometry on Centaurus A, the nearest giant elliptical
galaxy, at a distance of 4 Mpc. Methods: We obtained deep photometric data with
the Wide Field Imager at the ESO/MPG 2.2m at La Silla spread over almost two
months. Applying the difference imaging photometry package DIFIMPHOT, we
produced high-quality difference images and detected variable sources. The
sensitivity of the current observational setup was determined through
artificial residual tests. Results: In the resulting high-quality difference
images, we detect 271 variable stars. We find a difference flux detection limit
corresponding to m_R~24.5. Based on a simple model of the halo of Centaurus A,
we estimate that a ground-based microlensing survey would detect in the order
of 4 microlensing events per year due to lenses in the halo. Conclusions:
Difference imaging photometry works very well at the distance of Centaurus A
and promises to be a useful tool for detecting and studying variable stars in
galaxies outside the local group. For microlensing surveys, a higher
sensitivity is needed than achieved here, which would be possible with a large
ground-based telescope or space observatory with wide-field imaging
capabilities.
