  Various approaches to increase efficiency of antitumor therapy by a
combination of vaccinotherapy, chemotherapy and surgical excision of primary
tumor nodes, and also the comparative analyses of therapeutic and preventive
application of antitumoral vaccines were carried out in melanoma experimental
model. It was postulated that preventive vaccination is able to prevent tumor
incidence by 70 %. The combination of vaccinotherapy and surgical treatment of
melanoma increases antimetastatic activity of vaccination by 43 %. We conclude
the combined therapy would lead to more effective antitumor response.
