  The analysis of biological networks is characterized by the definition of
precise linear constraints used to cumulatively reduce the solution space of
the computed states of a multi-omic (for instance metabolic, transcriptomic and
proteomic) model. In this paper, we attempt, for the first time, to combine
metabolic modelling and networked Cox regression, using the metabolic model of
the bacterium Helicobacter Pylori. This enables a platform both for
quantitative analysis of networked regression, but also testing the findings
from network regression (a list of significant vectors and their networked
relationships) on in vivo transcriptomic data. Data generated from the model,
using flux balance analysis to construct a Pareto front, specifically, a
trade-off of Oxygen exchange and growth rate and a trade-off of Carbon Dioxide
exchange and growth rate, is analysed and then the model is used to quantify
the success of the analysis. It was found that using the analysis,
reconstruction of the initial data was considerably more successful than a pure
noise alternative. Our methodological approach is quite general and it could be
of interest for the wider community of complex networks researchers; it is
implemented in a software tool, MoNeRe, which is freely available through the
Github platform.
