  We present the development process of Bioblox2-5D, an educational biology
game aimed at teenagers. The game content refers to protein docking and aims to
improve learning about molecular shape complexity, the roles of charges in
molecular docking and the scoring function to calculate binding affinity. We
developed the game as part of a collaboration between the Computing Department
at Goldsmiths, University of London, and the Structural Bioinformatics group at
Imperial College London. The team at Imperial provided the content requirements
and validated the technical solution adopted in the game. The team at
Goldsmiths designed and implemented the content requirements into a fun and
stimulating educational puzzle game that supports teaching and motivates
students to engage with biology. We illustrate the game design choices, the
compromises and solutions that we applied to accomplish the desired learning
outcomes. This paper aims to illustrate useful insights and inspirations in the
context of educational game development for biology students.
