  The non-equilibrium fluctuation dissipation theorem is applied to predict how
critically ill patients respond to treatment, based upon data currently
collected by standard hospital monitoring devices. This framework is
demonstrated on a common procedure in critical care: the spontaneous breathing
trial. It is shown that the responses of groups of similar patients to the
spontaneous breathing trial can be predicted by the non-equilibrium fluctuation
dissipation approach. This mathematical framework, when fully formed and
applied to other clinical interventions, may serve as part of the basis for
personalized critical care.
