  Physiological whole-body models are valuable tools for the development of
novel drugs where understanding the system aspects is important. This paper
presents a generalized model that encapsulates the structure and flow of
whole-body human physiology. The model contains vascular, interstitial, and
cellular subcompartments for each organ. Scaling of volumes and blood flows is
described to allow for investigation across populations or specific patient
groups. The model equations and the corresponding parameters are presented
along with a catalog of functions that can be used to define the organ
transport model and the biochemical reaction model. A simple example
illustrates the procedure.
