  From the perspective of coronary heart disease, the development of stents has
come significantly far in reducing the associated mortality rate, drug-eluting
stents being the epitome of innovative and effective solutions. Within this
work, the intricate process of in-stent restenosis is modelled considering one
of the significant growth factors and its effect on constituents of the
arterial wall. A multiphysical modelling approach is adopted in this regard.
Experimental investigations from the literature have been used to hypothesize
the governing equations and the corresponding parameters. A staggered solution
strategy is utilised to capture the transport phenomena as well as the growth
and remodeling that follows stent implantation. The model herein developed
serves as a tool to predict in-stent restenosis depending on the endothelial
injury sustained and the protuberance of stents into the lumen of the arteries.
Keywords: in-stent restenosis, smooth mucsle cells, platelet-derived growth
factor, extracellular matrix, growth
