  We investigate the plasma enhancement of nuclear reactions in the
intermediate coupling regime using orbital free molecular dynamics (OFMD)
simulations. Mixtures of H-Cu and H-Ag serve as prototypes of simultaneous weak
and strong couplings due to the charge asymmetry. Of particular importance is
the partial ionization of Cu and Ag and the free electron polarization captured
by OFMD simulations. By comparing a series of OFMD simulations at various
concentrations and constant pressure to multi-component hyper netted chain
(MCHNC) calculations of effective binary ionic mixtures (BIM), we set a general
procedure for computing enhancement factors. The MCHNC procedure allows
extension to very low concentrations (5% or less) and to very high temperatures
(few keV) unreachable by the simulations. Enhancement factors for nuclear
reactions rates extracted from the MCHNC approach are compared with the
Salpeter theory in the weak and strong coupling regimes, and a new
interpolation is proposed.
