  Multi-Arm, Multi-Stage (MAMS) clinical trial designs allow for multiple
therapies to be compared across a spectrum of clinical trial phases. MAMS
designs can be categorized into several overarching design groups, including
adaptive designs (AD) and multi-arm (MA) designs. Factorial clinical trials
designs represent an additional group of designs which can provide increased
efficiency relative to fixed, traditional designs. In this work, we explore
design choices associated with Factorial Adaptive Multi-Arm Multi-Stage (FAST)
designs, which represent the combination of factorial and MAMS designs. This
category of trial can potentially offer benefits similar to both MAMS and
factorial designs. This work is motivated by a proposed clinical trial under
development.
