  Accurate characterization of suspicious microcalcifications is critical to
determine whether these calcifications are associated with invasive disease.
Our overarching objective is to enable the joint characterization of
microcalcifications and surrounding breast tissue using mammography images and
digital histopathology images. Towards this goal, we investigate a template
matching-based approach that utilizes microcalcifications as landmarks to match
radiographs taken of biopsy core specimens to groups of calcifications that are
visible on mammography. Our approach achieved a high negative predictive value
(0.98) but modest precision (0.66) and recall (0.58) in identifying the
mammographic region where microcalcifications were taken during a core needle
biopsy.
