  Objective: This study takes further step on understanding personality
structure in order to cope with the mental health during the COVID-19 global
pandemic situation. Methods: Categorized the independent variables into
biological, family and cultural predictors according to the datasets of the
Big-5 personality survey online. And established multiple regression prediction
models and exhaustive CHAID decision tree model of each personality trait.
Results: Females are different from males in personality. The personality
changes when growing. One-handed dominants are less agreeable and open than
those who use both hands. Different sexual orientation does have variety
personality. Native language used and education attainment is significantly
related to personality accordingly. Marriage did help shaping personality to be
more extroverted, less neurotic or agreeable and more conscientious and open.
People raised in urban are more agreeable and open. Neurotic and open people
often come from small families. person participated in voting are more
extroverted, conscientious and open but less neurotic and agreeable. Different
religions and races have different characteristics in each dimension of
personality and there is no clear pattern have been found. Conclusion:
Personality traits are indeed affected by multiple confounding factors. but the
exploration on multiple cultures predictors still needed more details
