  The integration of magnetic nanoparticles within fibrillar structures
represents an interesting avenue for the remotely controlled release of
therapeutic agents. This work presents a novel drug release platform based on
electrospun magnetic fibers (EMFs) combining drugs, magnetic nanoparticles
(MNPs) and mesoporous silica nanoparticles (MSNs) for controlled drug delivery
via alternating magnetic fields (AMF). The platform was demonstrated to be
versatile and effective for hydrophilic ketorolac (KET) and hydrophobic
curcumin (CUR) encapsulation and the major response observed for AMF-triggered
release was reached using drug-loaded MSNs within the fibers, providing fine
control over drug release patterns. The EMFs exhibited excellent inductive
heating capabilities, showing a temperature increase up to 8 {\deg}C within a 5
min AMF pulse. The system is shown to be promising for applications like
transdermal pain management, oncological drug delivery, tissue engineering, and
wound healing, enabling precise control over drug release in both spatial and
temporal dimensions. The findings of this study offer valuable insights into
the development of the next generation of smart drug delivery systems, based in
multifunctional materials that can be remotely regulated and potentially
revolutionize the field of nanomedicine.
