  In this paper, we give a characterization of the crystal bases
$\mathcal{B}_{x}^{+}(\lambda)$, $x \in W_{\mathrm{af}}$, of Demazure submodules
$V_{x}^{+}(\lambda)$, $x \in W_{\mathrm{af}}$, of a level-zero extremal weight
module $V(\lambda)$ over a quantum affine algebra $U_{q}$, where $\lambda$ is
an arbitrary level-zero dominant integral weight, and $W_{\mathrm{af}}$ denotes
the affine Weyl group. This characterization is given in terms of the initial
direction of a semi-infinite Lakshmibai-Seshadri path, and is established under
a suitably normalized isomorphism between the crystal basis
$\mathcal{B}(\lambda)$ of the level-zero extremal weight module $V(\lambda)$
and the crystal $\mathbb{B}^{\frac{\infty}{2}}(\lambda)$ of semi-infinite
Lakshmibai-Seshadri paths of shape $\lambda$, which is obtained in our previous
work. As an application, we obtain a formula expressing the graded character of
the Demazure submodule $V_{w_0}^{+}(\lambda)$ in terms of the specialization at
$t=0$ of the symmetric Macdonald polynomial $P_{\lambda}(x\,;\,q,\,t)$.
