  ECG interval monitoring provides key insights into the diagnosis of cardiac
diseases. The standard 12-lead ECG is generally used, however, because of the
current COVID-19 pandemic there is a strong need for a remote monitoring
solution which will reduce exposure of health care providers to coronavirus.
This article presents a disposable wireless patch biosensor (VitalPatch) and
associated platform functionalities for real-time continuous measurement of
clinically relevant ECG intervals including PR interval, QRS duration, QT
interval, corrected QT interval by Bazett (QTb), and corrected QT interval by
Fridericia (QTf). The performance of the VitalPatch is validated by comparing
its automated algorithm interval measurements to the manually annotated global
intervals of the 12-lead ECG device in 30 subjects. The accuracy of interval
monitoring (in terms of mean timing error calculated by subtracting the
VitalPatch measurements from the global intervals) is 2.7+/-15.94 ms,
-1.97+/-12.29 ms, -14.6+/-12.97 ms, - 15.33+/-14.11 ms, and -15.08+/-13.69 ms
for PR interval, QRS duration, QT interval, QTb, and QTf, respectively. These
results demonstrate that the VitalPatch is a viable solution for measuring ECG
intervals while taking advantage of its remote monitoring feature during the
pandemic.
