  We calculate all the branching ratios and direct CP violations of $B \to PV$
decays in a most general two-Higgs-doublet model with spontaneous CP violation.
As the model has rich CP-violating sources, it is shown that the new physics
effects to direct CP violations and branching ratios in some channels can be
significant when adopting the generalized factorization approach to evaluate
the hadronic matrix elements, which provides good signals for probing new
physics beyond the SM in the future B experiments.
