  Single molecule imaging is one of the main target areas of X-ray free
electron lasers. It relies on the possibility of orienting the large number of
low counting statistics 2D diffraction patterns taken at random orientations of
identical replicas of the sample. This is a difficult process and the low
statistics limits the usability of orientation methods and ultimately it could
prevent single molecule imaging. We suggest a new approach, which avoids the
orientation process from the diffraction patterns. In our schema one measures
the orientation of the sample together with the diffraction pattern by
detecting some fragments of the Coulomb explosion. We show by molecular
dynamics simulations that from the angular distribution of the fragments one
can obtain the orientation of the samples.
