  Nanopore based sequencing has demonstrated significant potential for the
development of fast, accurate, and cost-efficient fingerprinting techniques for
next generation molecular detection and sequencing. We propose a specific
multi-layered graphene-based nanopore device architecture for the recognition
of single DNA bases. Molecular detection and analysis can be accomplished
through the detection of transverse currents as the molecule or DNA base
translocates through the nanopore. To increase the overall signal-to-noise
ratio and the accuracy, we implement a new "multi-point cross-correlation"
technique for identification of DNA bases or other molecules on the molecular
level. We demonstrate that the cross-correlations between each nanopore will
greatly enhance the transverse current signal for each molecule. We implement
first-principles transport calculations for DNA bases surveyed across a
multi-layered graphene nanopore system to illustrate the advantages of proposed
geometry. A time-series analysis of the cross-correlation functions illustrates
the potential of this method for enhancing the signal-to-noise ratio. This work
constitutes a significant step forward in facilitating fingerprinting of single
biomolecules using solid state technology.
