  Recent statistical evaluations for High-Energy Physics measurements, in
particular those at the Large Hadron Collider, require careful evaluation of
many sources of systematic uncertainties at the same time. While the
fundamental aspects of the statistical treatment are now consolidated, both
using a frequentist or a Bayesian approach, the management of many sources of
uncertainties and their corresponding nuisance parameters in analyses that
combine multiple control regions and decay channels, in practice, may pose
challenging implementation issues, that make the analysis infrastructure
complex and hard to manage, eventually resulting in simplifications in the
treatment of systematics, and in limitations to the result interpretation.
Typical cases will be discussed, having in mind the most popular implementation
tool, RooStats, with possible ideas about improving the management of such
cases in future software implementations.
