  The idea of this project is to study the protein structure and sequence
relationship using the hidden markov model and artificial neural network. In
this context we have assumed two hidden markov models. In first model we have
taken protein secondary structures as hidden and protein sequences as observed.
In second model we have taken protein sequences as hidden and protein
structures as observed. The efficiencies for both the hidden markov models have
been calculated. The results show that the efficiencies of first model is
greater that the second one .These efficiencies are cross validated using
artificial neural network. This signifies the importance of protein secondary
structures as the main hidden controlling factors due to which we observe a
particular amino acid sequence. This also signifies that protein secondary
structure is more conserved in comparison to amino acid sequence.
