  Heterogeneous high-performance computing (HPC) systems offer novel
architectures which accelerate specific workloads through judicious use of
specialized coprocessors. A promising architectural approach for future
scientific computations is provided by heterogeneous HPC systems integrating
quantum processing units (QPUs). To this end, we present XACC (eXtreme-scale
ACCelerator) --- a programming model and software framework that enables
quantum acceleration within standard or HPC software workflows. XACC follows a
coprocessor machine model that is independent of the underlying quantum
computing hardware, thereby enabling quantum programs to be defined and
executed on a variety of QPUs types through a unified application programming
interface. Moreover, XACC defines a polymorphic low-level intermediate
representation, and an extensible compiler frontend that enables language
independent quantum programming, thus promoting integration and
interoperability across the quantum programming landscape. In this work we
define the software architecture enabling our hardware and language independent
approach, and demonstrate its usefulness across a range of quantum computing
models through illustrative examples involving the compilation and execution of
gate and annealing-based quantum programs.
