  Crosslinking mass spectrometry (Crosslinking MS) has substantially matured as
a method over the last two decades through parallel development in multiple
labs, demonstrating its applicability for protein structure determination,
conformation analysis and mapping protein interactions in complex mixtures.
Crosslinking MS has become a much-appreciated and routinely applied tool
especially in structural biology. Therefore, it is timely that the community
commits to the development of methodological and reporting standards. This
white paper builds on an open process comprising a number of events at
community conferences since 2015 and identifies aspects of Crosslinking MS for
which guidelines should be developed as part of a Crosslinking MS standards
initiative.
