  Consistency of trans-unification RG evolution is used to discuss the domain
of definition of the New Minimal Supersymmetric SO(10) GUT (NMSGUT). We compute
the 1-loop RGE $\beta$ functions, simplifying generic formulae using
constraints of gauge invariance and superpotential structure. We also calculate
the 2 loop contributions to the gauge coupling and gaugino mass and indicate
how to get full 2 loop results for all couplings. Our method overcomes
combinatorial barriers that frustrate computer algebra based attempts to
calculate SO(10) $\beta$ functions involving large irreps. Use of the RGEs
identifies a perturbative domain $Q < M_E$, where $M_E <M_{Planck}$ is the
\emph{scale of emergence} where the NMSGUT, with GUT compatible soft
supersymmetry breaking terms emerges from the strong UV dynamics associated
with the Landau poles in gauge and Yukawa couplings. Due to the strength of the
RG flows the Landau poles for gauge and Yukawa couplings lie near a cutoff
scale $\Lambda_E $ for the perturbative dynamics of the NMSGUT which just above
$M_E$. SO(10) RG flows into the IR are shown to facilitate small gaugino masses
and generation of negative Non Universal Higgs masses squared needed by
realistic NMSGUT fits of low energy data. Running the simple canonical theory
emergent at $M_E$ through $M_X$ down to the electroweak scale enables tests of
candidate scenarios such as supergravity based NMSGUT with canonical kinetic
terms and NMSGUT based dynamical Yukawa unification.
