  In this paper, we propose a viable approach to realise two texture-zeros in
the scotogenic model with flavor dependent $U(1)_{B-2L_\alpha-L_\beta}$ gauge
symmetry. These models are extended by two right-handed singlets $N_{Ri}$ and
two inert scalar doublets $\eta_{i}$, which are odd under the dark $Z_2$
symmetry. Among all the six constructed textures, texture $A_1$ and $A_2$ are
the only two allowed by current experimental limits. Then choosing texture
$A_1$ derived from $U(1)_{B-2L_e-L_\tau}$, we perform a detail analysis on the
corresponding phenomenology such as predictions of neutrino mixing parameters,
lepton flavor violation, dark matter and collider signatures. One distinct
nature of such model is that the structure of Yukawa coupling
$\bar{L}\tilde{\eta}N_R$ is fixed by neutrino oscillation data, and can be
further tested by measuring the branching ratios of charged scalars
$\eta_{1,2}^\pm$.
