  Nanobubbles and related technologies are expected to be highly utilized in
water resource-based industries such as water purification, crops,
horticulture, medicine, bio, and sterilization. Ozone, a chemical with high
sterilizing power, is known as a natural substance that is reduced to oxygen
and water after reacting with pollutants. Ozone water, which is generated by
dissolving ozone in water, has been used in various industrial sectors such as
medical care, food, and environment. Due to the unstable molecular state of
ozone, however, it is difficult to produce, use, and supply ozone at industrial
sites in a stable manner. This study proposed a method for constructing a
system that can generate high-concentration ozone water in large quantities
using low power in real time and maintaining the concentration of the generated
ozone water over the long term. Friction tubes (called 'nanotube') played a key
role to generate nanobubble ozone water with an increased half-life for virus
killing activity. In addition, the safety of ozone water during its spray into
the air was explained, and virucidal activity test cases for the influenza A
(H1N1/A/PR8) and COVID-19 (SARS-CoV-2) virus using high-concentration ozone
water as well as its technical efficacy were described.
