  In this paper, we investigate the global well-posedness of 3-D incompressible
inhomogeneous Navier-Stokes equations with ill-prepared large initial data
which are slowly varying in one space variable, that is, initial data of the
form $\bigl(1+\e^{\be}a_0(x_{\rm h},\e x_3),(\ve^{1-\al} v^{\rm h}_0,
\ve^{-\al}v_0^3)(x_{\rm h},\e x_3)\bigr)$ for any $\al\in ]0,1/3[,$
  $\be>2\al,$ and $\ve$ being sufficiently small. We remark that initial data
of this type do not satisfy the smallness conditions in \cite{c-p-z,HPZ3} no
matter how small $\e$ is. In particular, this result greatly improves the
global well-posedness result in \cite{PZZ3} with the so-called well-prepared
initial data.
