  Following the recent release of various Artificial Intelligence (AI) based
Conversation Agents (CAs), adolescents are increasingly using CAs for
interactive knowledge discovery on sensitive topics, including mental and
sexual health topics. Exploring such sensitive topics through online search has
been an essential part of adolescent development, and CAs can support their
knowledge discovery on such topics through human-like dialogues. Yet,
unintended risks have been documented with adolescents' interactions with
AI-based CAs, such as being exposed to inappropriate content, false
information, and/or being given advice that is detrimental to their mental and
physical well-being (e.g., to self-harm). In this position paper, we discuss
the current landscape and opportunities for CAs to support adolescents' mental
and sexual health knowledge discovery. We also discuss some of the challenges
related to ensuring the safety of adolescents when interacting with CAs
regarding sexual and mental health topics. We call for a discourse on how to
set guardrails for the safe evolution of AI-based CAs for adolescents.
