  Peptide Nucleic Acids (PNA) are non-natural oligonucleotides mimics.
{\gamma}-PNA backbone are formed by standard nucleic acids nucleobases
connected by a neutral N-(2-aminoethyl)glycine backbone linked by a peptide
bond. In this study, we use Nuclear Magnetic Resonance (NMR) and Circular
Dichroism (CD) to explore the properties of the supramolecular duplexes formed
by these species. We show that standard Watson-Crick base pair as well as
non-standard ones are formed in solution. The duplexes thus formed present
marked melting transition temperatures substantially higher than their nucleic
acid homologs. Moreover, the presence of a chiral group on the
{\gamma}-peptidic backbone increases further more this transition temperature,
leading to very stable duplexes.
