  We discuss R-parity violation (RPV) in semi-local and local F-theory
constructions. We first present a detailed analysis of all possible
combinations of RPV operators arising from semi-local F-theory spectral cover
constructions, assuming an $SU(5)$ GUT. We provide a classification of all
possible allowed combinations of RPV operators originating from operators of
the form $10\cdot \bar 5\cdot \bar 5$, including the effect of $U(1)$ fluxes
with global restrictions. We then relax the global constraints and perform
explicit computations of the bottom/tau and RPV Yukawa couplings, at an
$SO(12)$ local point of enhancement in the presence of general fluxes subject
only to local flux restrictions. We compare our results to the experimental
limits on each allowed RPV operator, and show that operators such as $LLe^c$,
$LQd^c$ and $u^cd^cd^c$ may be present separately within current bounds,
possibly on the edge of observability, suggesting lepton number violation or
neutron-antineutron oscillations could constrain F-theory models.
