  This paper proposes an extension of the Multi-Index Stochastic Collocation
(MISC) method for forward uncertainty quantification (UQ) problems in
computational domains of shape other than a square or cube, by exploiting
isogeometric analysis (IGA) techniques. Introducing IGA solvers to the MISC
algorithm is very natural since they are tensor-based PDE solvers, which are
precisely what is required by the MISC machinery. Moreover, the
combination-technique formulation of MISC allows the straight-forward reuse of
existing implementations of IGA solvers. We present numerical results to
showcase the effectiveness of the proposed approach.
