  Mathematical Modelling has a long history in developmental biology. Advances
in experimental techniques and computational algorithms now permit the
development of increasingly more realistic models of organogenesis. In
particular, 3D geometries of developing organs have recently become available.
In this paper, we show how to use image-based data for simulations of
organogenesis in COMSOL Multiphysics. As an example, we use limb bud
development, a classical model system in mouse developmental biology. We
discuss how embryonic geometries with several subdomains can be read into
COMSOL using the Matlab LiveLink, and how these can be used to simulate models
on growing embryonic domains. The ALE method is used to solve signaling models
even on strongly deforming domains.
