  We present a novel determination of the astrophysical uncertainties
associated to the secondary antiproton flux originating from cosmic-ray
spallation on the interstellar gas. We select a set of propagation models
compatible with the recent B/C data from PAMELA, and find those providing
minimal and maximal antiproton fluxes in different energy ranges. We use this
result to determine the most conservative bounds on relevant Dark Matter (DM)
annihilation channels: We find that the recent claim of a DM interpretation of
a gamma-ray excess in the Galactic Center region cannot be ruled out by current
antiproton data. Finally, we discuss the impact of the recently released
preliminary data from AMS-02. In particular, we provide a reference model
compatible with proton, helium and B/C spectra from this experiment.
Remarkably, the main propagation parameters of this model are in agreement with
the best fit presented in our earlier statistical analyses. We also show that
the antiproton-to-proton ratio does not exhibit any significant anomaly at high
energy with respect to our predictions.
