  We derive strong observational limits on any possible large-scale spatial
variation in the values of physical 'constants' whose space-time evolution is
driven by a scalar field. The limits are imposed by the isotropy of the
microwave background on large angular scales in theories which describe space
and time variations in the fine structure constant, the electron-proton mass
ratio, and the Newtonian gravitational constant, G. Large-scale spatial
fluctuations in the fine structure constant are bounded by 2x10^-9 and
1.2x10^-8 in the BSBM and VSL theories respectively, fluctuations in the
electron-proton mass ratio by 9x10^-5 in the BM theory and fluctuations in G by
3.6x10^-10 in Brans-Dicke theory. These derived bounds are significantly
stronger than any obtainable by direct observations of astrophysical objects at
the present time.
