  The purpose of this paper is to show that it is possible to replace Monod's
type model of a chemostat by a constraint based model of bacteria at the genome
scale. This new model is an extension of the RBA model of bacteria developed in
a batch mode to the chemostat. This new model, and the associated framework,
leads to a dramatic improvement in the prediction capacities of the chemostat
behaviour. Indeed, for example, the internal states of the bacteria are now
part of the prediction outputs and the chemostat behaviour can now be predicted
for any limiting source. Finally, the first interests of this new predictive
method are illustrated on a set of classic situations where predictions are
already close of the well-known biological observations about chemostat.
  This paper is an extended version of [8] that includes a discussion on the
modeling assumptions.
