  We address interconnection challenges in limited-qubit superconducting
quantum computers (SQC), which often face crosstalk errors due to expanded
qubit interactions during operations. Existing mitigation methods carry
trade-offs, like hardware couplers or software-based gate scheduling. Our
innovation, the Context-Aware COupler REconfiguration (CA-CORE) compilation
method, aligns with application-specific design principles. It optimizes the
qubit connections for improved SQC performance, leveraging tunable couplers.
Through contextual analysis of qubit correlations, we configure an efficient
coupling map considering SQC constraints. Our method reduces depth and SWAP
operations by up to 18.84% and 42.47%, respectively. It also enhances circuit
fidelity by 40% compared to IBM and Google's topologies. Notably, our method
compiles a 33-qubit circuit in less than 1 second.
