  To perform precision medicine in realtime at home, a device capable of long
distance continuously monitoring target biomolecules in unprocessed blood under
dynamic situations is essential. In this study, an integrative buffer free
wireless device is developed to measure drug concentrations in patients blood
in real time for remote clinical healthcare. To demonstrate its capability, the
drug molecules (i.e., small molecule drug doxorubicin, DOX) are continuously
measured in the unprocessed whole blood of live animals (e.g., rats). The
dynamic changes of drug concentrations with sub minute temporal resolution are
recorded for an extended period of time (8 hours). As an advance in remote
diagnosis, this device would benefit the public by enabling long-distance
precision medicine to prevent pandemics in advance.
