  We study the ultraviolet completion of semileptonic four-fermion operator
$O_{ledq}^{\alpha \beta 11}$ that incorporates Majorana dark matter (DM) in
both lepton-flavor-conserving (LFC) and lepton-flavor-violating (LFV) scenarios
at the one-loop level via box diagram, which effectively alleviates the lower
bounds on the new physics scale. The interplay between the model-independent
constraints on the Wilson coefficients and DM direct detection, relic density,
and collider searches in the context of fermion portal DM model with two
mediators is investigated. We find that both the projected future constraint on
the LFC Wilson coefficient $C_{ledq}^{2211}/\Lambda^2< (12.3~\text{TeV})^{-2}$
from the measurements of neutrino non-standard interaction in the
next-generation neutrino oscillation experiments, and LFV constraint
$C_{ledq}^{1211}/\Lambda^2< \left(2.2\times 10^3 ~\text{TeV} \right)^{-2}$ from
ongoing charged-lepton-flavor-violation searches, provide a complementary
exploration of the parameter space encompassing the DM mass and scalar mass.
With the colored mediator mass typically around $2~\text{TeV}$, the sensitivity
of the indirect constraints on the four-fermion operator could surpass those of
collider searches and DM direct detection, in scenarios where the masses of the
DM and scalar are close. By ensuring the correct DM relic density, however, we
obtain that the collider searches and DM direct detection are more sensitive to
the electroweak scale DM and scalar compared to the indirect constraints.
