  We present moderately-high resolution echelle observations of the nucleus of
NGC 5195, the line of sight to which samples intervening interstellar material
associated with the outer spiral arm of M51. Our spectra reveal absorption from
interstellar Na I, K I, Ca II, and CH+, and from a number of diffuse
interstellar bands (DIBs), at a velocity close to that exhibited by H I 21 cm
emission from M51 at the position of NGC 5195. The H I column density implied
by the equivalent width of the 5780.5 DIB, based on the relationship between
W(5780.5) and N(H I) derived for sight lines in the local Galactic interstellar
medium, is consistent with the column density obtained from the integrated H I
emission. The H2 column density predicted from the observed column density of K
I, using the Galactic relationship between N(K I) and N(H2), is comparable to
N(H I), suggesting a high molecular fraction (~0.65) for the M51 gas toward NGC
5195. The DIBs toward NGC 5195 are, on average, ~40% weaker than would be
expected based on the K I column density, a further indication that the gas in
this direction has a high molecular content. The M51 material is characterized
also by a high N(Na I)/N(Ca II) ratio (>11), indicative of a high degree of Ca
depletion, and a high W(5797.1)/W(5780.5) ratio (~1.6), suggestive of either a
very weak ambient radiation field or a significantly shielded environment. A
high N(CH+)/N(CH) ratio (>2.3) for the M51 material toward NGC 5195 may be the
result of enhanced turbulence due to interactions between M51 and its
companion.
