  Graphical Markov models combine conditional independence constraints with
graphical representations of stepwise data generating processes.The models
started to be formulated about 40 years ago and vigorous development is
ongoing. Longitudinal observational studies as well as intervention studies are
best modeled via a subclass called regression graph models and, especially
traceable regressions. Regression graphs include two types of undirected graph
and directed acyclic graphs in ordered sequences of joint responses. Response
components may correspond to discrete or continuous random variables and may
depend exclusively on variables which have been generated earlier. These
aspects are essential when causal hypothesis are the motivation for the
planning of empirical studies.
  To turn the graphs into useful tools for tracing developmental pathways and
for predicting structure in alternative models, the generated distributions
have to mimic some properties of joint Gaussian distributions. Here, relevant
results concerning these aspects are spelled out and illustrated by examples.
With regression graph models, it becomes feasible, for the first time, to
derive structural effects of (1) ignoring some of the variables, of (2)
selecting subpopulations via fixed levels of some other variables or of (3)
changing the order in which the variables might get generated. Thus, the most
important future applications of these models will aim at the best possible
integration of knowledge from related studies.
