  We describe Superstaq, a quantum software platform that optimizes the
execution of quantum programs by tailoring to underlying hardware primitives.
For benchmarks such as the Bernstein-Vazirani algorithm and the Qubit Coupled
Cluster chemistry method, we find that deep optimization can improve program
execution performance by at least 10x compared to prevailing state-of-the-art
compilers. To highlight the versatility of our approach, we present results
from several hardware platforms: superconducting qubits (AQT @ LBNL, IBM
Quantum, Rigetti), trapped ions (QSCOUT), and neutral atoms (Infleqtion).
Across all platforms, we demonstrate new levels of performance and new
capabilities that are enabled by deeper integration between quantum programs
and the device physics of hardware.
