  Parkinson's disease (PD) is a progressive neurodegenerative disease, and it
is caused by the loss of dopaminergic neurons in the basal ganglia (BG).
Currently, there is no definite cure for PD, and available treatments mainly
aim to alleviate its symptoms. Due to impaired neurotransmitter-based
information transmission in PD, molecular communication-based approaches can be
employed as potential solutions to address this issue. Molecular Communications
(MC) is a bio-inspired communication method utilizing molecules for carrying
information. This mode of communication stands out for developing
bio-compatible nanomachines for diagnosing and treating, particularly in
addressing neurodegenerative diseases like PD, due to its compatibility with
biological systems. This study presents a novel treatment method that
introduces an Intelligent Dopamine Rate Modulator (IDRM), which is located in
the synaptic gap between the substantia nigra pars compacta (SNc) and striatum
to compensate for insufficiency dopamine release in BG caused by PD. For
storing dopamine in the IDRM, dopamine compound (DAC) is swallowed and crossed
through the digestive system, blood circulatory system, blood-brain barrier
(BBB), and brain extracellular matrix uptakes with IDRMs. Here, the DAC
concentration is calculated in these regions, revealing that the required
exogenous dopamine consistently reaches IDRM. Therefore, the perpetual dopamine
insufficiency in BG associated with PD can be compensated. This method reduces
drug side effects because dopamine is not released in other brain regions.
Unlike other treatments, this approach targets the root cause of PD rather than
just reducing symptoms.
