  Hypertension is the leading global cause of cardiovascular disease and
premature death. Distinct hypertension subtypes may vary in their prognoses and
require different treatments. An individual's risk for hypertension is
determined by genetic and environmental factors as well as their interactions.
In this work, we studied 911 African Americans and 1,171 European Americans in
the Hypertension Genetic Epidemiology Network (HyperGEN) cohort. We built
hypertension subtype classification models using both environmental variables
and sets of genetic features selected based on different criteria. The fitted
prediction models provided insights into the genetic landscape of hypertension
subtypes, which may aid personalized diagnosis and treatment of hypertension in
the future.
