  We have measured the current-voltage characteristics of small-capacitance
single Josephson junctions at low temperatures (T < 0.04 K), where the strength
of the coupling between the single junction and the electromagnetic environment
was controlled with one-dimensional arrays of dc SQUIDs. We have clearly
observed Coulomb blockade of Cooper-pair tunneling and even a region of
negative differential resistance, when the zero-bias resistance of the SQUID
arrays is much higher than the quantum resistance h/e^2 = 26 kohm. The negative
differential resistance is evidence of coherent single-Cooper-pair tunneling in
the single Josephson junction.
