  We describe a framework for designing novel materials, combining modern
first-principles electronic structure tools, materials databases, and
evolutionary algorithms capable of exploring large configurational spaces.
Guided by the chemical principles introduced by Antipov, \emph{et. al.}, for
the design and synthesis of the Hg-based high-temperature superconductors, we
apply our framework to design a new layered copper oxysulfide,
Hg(CaS)$_2$CuO$_2$. We evaluate the prospects of superconductivity in this
oxysulfide using theories based on charge-transfer energies, orbital
distillation and uniaxial strain.
