  A molecular dynamics (MD) simulation is used to quantitatively analyze the
induced membrane potential for an applied external field varied between 0.4
V/nm to 2.0 V/nm. The change in the electrostatic potential in the DPPC is
directly correlated to the membrane permeability. The effect of the decrease in
external conductivity on the DPPC is also evaluated and the analytical results
are compared with the simulation. The correlation between the electrostatic
potential of the DPPC and the total dipole are compared, and a positive
correlation is identified until saturation. This is because the membrane
permeability factor plays a dominant role to control reversible and
irreversible electroporation. The obtained dipole parameters through simulation
for various electric field allows for an accurate determination of the
quantitative changes in the membrane and external conductivity during the
process of electroporation.
