  Multicellular tissues are the building blocks of many biological systems and
organs. These tissues are not static, but dynamically change over time. Even if
the overall structure remains the same there is a turnover of cells within the
tissue. This dynamic homeostasis is maintained by numerous governing mechanisms
which are finely tuned in such a way that the tissue remains in a homeostatic
state, even across large timescales. Some of these governing mechanisms include
cell motion, and cell fate selection through inter cellular signalling.
However, it is not yet clear how to link these two processes, or how they may
affect one another across the tissue. In this paper, we present a
multicellular, multiscale model, which brings together the two phenomena of
cell motility, and inter cellular signalling, to describe cell fate selection
on a dynamic tissue. We find that the affinity for cellular signalling to occur
greatly influences a cells ability to differentiate. We also find that our
results support claims that cell differentiation is a finely tuned process
within dynamic tissues at homeostasis, with excessive cell turnover rates
leading to unhealthy (undifferentiated and unpatterned) tissues.
