  In the recent paper by Mu et al (J. Phys. Chem. Lett. 2021, 12, 2900) the
maximal cooperativity of human glucokinase is explained by the "kinetic
resonance" effect derived from a minimal three-state model. However, a closer
inspection of the latter shows that this effect seems to be rather a particular
quantitative coincidence than a general phenomenon that reflects a physical
mechanism of conformational regulation.
