  This manuscript provides a response to a recent report by Mazzone et al.
available online on arXiv that, in turn, tentatively aims at demonstrating the
inefficacy of proton boron capture in hadrotherapy. We clarify that Mazzone et
al. do not add any scientific or technical insights to the points extensively
discussed in the original manuscript by Cirrone et al., and/or in the series of
iterations had with the Referee, which ultimately lead to the publication of
our original and pioneering experimental work. Here we summarize some of the
key points of the long scientific debate we had during the review process of
paper by Cirrone et al., which are very similar to the considerations presented
by Mazzone et al.. In conclusion, no quantitative explanation of our robust
experimental achievements presented in Cirrone et al. is provided in Mazzone et
al.
