  We present the first measurement of the proton-$\Omega$ correlation function
in heavy-ion collisions for central (0-40$\%$) and peripheral (40-80$\%$) Au+Au
collisions at \sqrtsNN\,\,=200 GeV by the STAR experiment at the Relativistic
Heavy-Ion Collider (RHIC). Predictions for the ratio of peripheral collisions
to central collisions for the proton-$\Omega$ correlation function are
sensitive to the presence of a nucleon-$\Omega$ bound state. These predictions
are based on the proton-$\Omega$ interaction extracted from (2+1)-flavor
lattice QCD calculations at the physical point. The measured ratio of
proton-$\Omega$ correlation function from peripheral (small system) to central
(large system) collisions is less than unity for relative momentum smaller than
40 MeV/c. Comparison of our measured correlation ratio with the theoretical
calculation slightly favors a proton-$\Omega$ bound system with a binding
energy of $\sim$ 27~MeV.
