  Self-assembly dynamics in binary surfactant mixtures and structure changes of
lipid vesicles induced by detergent solution are studied using coarse-grained
molecular simulations. Disk-shaped micelles, the bicelles, are stabilized by
detergents surrounding the rim of a bilayer disk of lipids. The self-assembled
bicelles are considerably smaller than bicelles formed from vesicle rupture,
and their size is determined by the concentrations of lipids and detergents and
the interactions between the two species. The detergent-adsorption induces
spontaneous curvature of the vesicle bilayer and results in vesicle division
into two vesicles or vesicle rupture into worm-like micelles. The division
occurs mainly via the inverse pathway of the modified stalk model. For large
spontaneous curvature of the monolayers of the detergents, a pore is often
opened, thereby leading to vesicle division or worm-like micelle formation.
