  This paper presents a novel optical processing approach for exploring genome
sequences built upon optical correlator for global alignment and extended
DV-curve method for local alignment. To overcome the problem of traditional
DV-curve method for presenting an accurate and simplified output, we propose
HAWPOD, built upon DV- curve method, to analyze genome sequences in five steps:
DNA coding, alignment, noise cancellation, simplification, and modification.
Moreover, all-optical implementation of the HAWPOD method is developed, while
its accuracy is validated through numerical simulations in LUMERICAL FDTD. The
results express the proposed method is much faster than its electrical
counterparts, such as Basic Local Alignment Search Tools.
