  Whole slide imaging (WSI) has become the primary modality for digital
pathology data. However, due to the size and high-resolution nature of these
images, they are generally only accessed in smaller sections or tiles via
specialized platforms, most of which require extensive setup and/or costly
infrastructure. These platforms typically also need a copy of the images to be
locally available to them, potentially causing issues with data governance and
provenance. To address these concerns, we developed ImageBox3, an in-browser
tiling mechanism to enable zero-footprint traversal of remote WSI data. All
computation is performed client-side without compromising user governance,
operating public and private images alike as long as the storage service
supports HTTP range requests (standard in Cloud storage and most web servers).
ImageBox3 thus removes significant hurdles to WSI operation and effective
collaboration, allowing for the sort of democratized analytical tools needed to
establish participative, FAIR digital pathology data commons.
  Availability:
  code - https://github.com/episphere/imagebox3;
  fig1 (live) - https://episphere.github.io/imagebox3/demo/scriptTag ;
  fig2 (live) - https://episphere.github.io/imagebox3/demo/serviceWorker ;
  fig 3 (live) - https://observablehq.com/@prafulb/imagebox3-in-observable .
