  We develop a new model, to our knowledge, for the many-body hydrodynamics of
amphiphilic Janus particles suspended in a viscous background flow. The Janus
particles interact through a hydrophobic attraction potential that leads to
self-assembly into bilayer structures. We adopt an efficient integral equation
method for solving the screened Laplace equation for hydrophobic attraction and
for solving the mobility problem for hydrodynamic interactions. The integral
equation formulation accurately captures both interactions for near touched
boundaries. Under a linear shear flow, we observe the tank-treading deformation
in a two-dimensional vesicle made of Janus particles. The results yield
measurements of inter-monolayer friction, membrane permeability, and at large
shear rates, membrane rupture. The simulations studies include a vesicle in
parabolic flow and vesicle-vesicle interactions in shear and extensional flows.
The hydrodynamics of the Janus particles vesicle replicate the behaviour of an
inextensible elastic vesicle membrane.
