  A basically new Hierarchic theory, general for solids and liquids
(Kaivarainen, 2001, 2000, 1995, 1992), has been briefly described and
illustrated by computer simulations on examples of water and ice. Full
description of theory and its numerous applications are presented in series of
articles at the arXiv of Los-Alamos (see http://arXiv.org/abs/physics/0102086).
New clusterphilic interactions, intermediate between hydrophilic and
hydrphobic, are introduced. They can be subdivided into: intramolecular - when
water cluster is localized in the ''open'' states of big interdomain or
intersubunit cavities and intermolecular clusterphilic interactions.
Intermolecular clusterphilic interactions can be induced by very different
macromolecules. The latter displays themselves in bordering of water cluster by
macromolecules and forming so-called ''clustrons''. Clusterphilic interactions
can play an important role in self-organization of biosystems, especially
multiglobular allosteric enzymes, microtubules and the actin filaments. The
selected review of literature, devoted to antifreeze proteins (AFP) and
ice-nucleation proteins (INP) interaction with water is presented.
Corresponding experimental results were analyzed on the base of Hierarchic
theory. The possible mechanism of cryoproteins influence on water, changing its
freezing point has been proposed. The consequences of new model of AFP action
and ways of its experimental verification are described also.
