  It is a common belief that metamorphic proteins challenge the Anfinsen
thermodynamic hypothesis (or dogma). Here we argue against this view aims to
show that metamorphic proteins not just fulfill the Anfinsen dogma but also
exhibit marginal stability comparable to that seen on macromolecules and
macromolecular complexes. This work contributes to our general understanding of
protein classification and may spur significant progress in our effort to
analyze protein evolvability.
