  With the introduction of the Electric Health Records, large amounts of
digital data become available for analysis and decision support. When
physicians are prescribing treatments to a patient, they need to consider a
large range of data variety and volume, making decisions increasingly complex.
Machine learning based Clinical Decision Support systems can be a solution to
the data challenges. In this work we focus on a class of decision support in
which the physicians' decision is directly predicted. Concretely, the model
would assign higher probabilities to decisions that it presumes the physician
are more likely to make. Thus the CDS system can provide physicians with
rational recommendations. We also address the problem of correlation in target
features: Often a physician is required to make multiple (sub-)decisions in a
block, and that these decisions are mutually dependent. We propose a solution
to the target correlation problem using a tensor factorization model. In order
to handle the patients' historical information as sequential data, we apply the
so-called Encoder-Decoder-Framework which is based on Recurrent Neural Networks
(RNN) as encoders and a tensor factorization model as a decoder, a combination
which is novel in machine learning. With experiments with real-world datasets
we show that the proposed model does achieve better prediction performances.
