  In this work, we investigate the effects of stent indentation on hemodynamic
indicators in stented coronary arteries. Our aim is to assess in-silico risk
factors for in-stent restenosis (ISR) and thrombosis after stent implantation.
The proposed model is applied to an idealized artery with Xience V stent for
four indentation percentages and three mesh refinements. We analyze the
patterns of hemodynamic indicators arising from different stent indentations
and propose an empirical frequency analysis of time-averaged WSS (TAWSS),
oscillatory shear index (OSI), and relative residence time (RRT). We observe
that higher indentations display higher frequency of critically low TAWSS and
non-physiological OSI and RRT. Furthermore, an appropriate mesh refinement is
needed for accurate representation of hemodynamics in the stent vicinity. The
results provide physics-based evidence for the correlation between high
indentation and ISR.
