  Background: Combining magnetic particle imaging (MPI) and magnetic fluid
hyperthermia (MFH) offers the ability to perform localized hyperthermia and
magnetic particle imaging-assisted ther-mometry of hyperthermia treatment. This
allows precise regional selective heating inside the body without invasive
interventions. In current MPI-MFH platforms, separate systems are used, which
require object transfer from one system to another. Here, we present the
design, development and evaluation process for integrable MFH platforms, which
extends a commercial MPI scanner with the functionality of MFH. Methods: The
biggest issue of integrating magnetic fluid hyperthermia platforms into a
magnetic par-ticle imaging system is the magnetic coupling of the devices,
which induces high voltage in the imaging system, and is harming its
components. In this paper we use a self-compensation approach derived from
heuristic algorithms to protect the magnetic particle imaging scanner. The
integrable platforms are evaluated regarding electrical and magnetic
characteristics, cooling capability, field strength, the magnetic coupling to a
replica of the magnetic particle imaging system's main solenoid and particle
heating. Results: The MFH platforms generate suitable magnetic fields for
magnetic heating of particles and are compatible with a commercial magnetic
particle imaging scanner. In combination with the imaging system, selective
heating with a gradient field and steerable heating positioning using the MPI
focus fields are possible. Conclusion: The proposed MFH platforms serve as a
therapeutic tool to unlock MFH functionality of a commercial magnetic particle
imaging scanner, enabling its use in future preclinical trials of MPI-guided,
spatially selective magnetic hyperthermia therapy.
