  In contrast to extensively studied defects in traditional materials, we
report here for the first time a systematic investigation of the formation
mechanism of intrinsic defects in self-assembled peptide nanostructures. The
Monte Carlo simulations with our simplified dynamic hierarchical model revealed
that the symmetry breaking of layer bending mode at the two ends during
morphological transformation is responsible for intrinsic defect formation,
whose microscopic origin is the mismatch between layer stacking along the
side-chain direction and layer growth along the hydrogen bond direction.
Moreover, defect formation does not affect the chirality of the self-assembled
structure, which is determined by the initial steps of the peptide
self-assembly process.
