  1,4-benzodiazepine-2-ones and their derivatives are prominent structures in
medicinal chemistry. These biomolecules have wide biological activities and
posses therapeutic applications. In this works, we introduce new derivatives of
1,4-benzodiazepine-2-ones which are synthesized using michael addition reaction
of 7-chloro- 1,3-dihydro-5-phenyl-2H-1,4-benzodiazepine-2-ones with fumaric
esters that matches with green chemistry protocols. The structures of all
products are confirmed by FT-IR, 1H-NMR, 13C-NMR and MASS spectroscopy. Since
the stereochemistry of 1,4-benzo diazepine-2-ones is important, we study the
most stable conformer of one of the products as a model for conformational
analysis by hyper chem soft ware and semi empirical AM1 program. Also, using
the 1H-NMR spectrum, we investigate the produced diastereomers of one of
products as a model.
