  Photon-induced nuclear excitation (i.e. photo-excitation) can be used for
production of nuclear isomers, which have potential applications in
astrophysics, energy storing, and medical diagnosis and treatment. This paper
presents a feasibility study on production of four nuclear isomers ({99m}^Tc,
{103m}^Rh and {113m, 115m}^In) using high-intensity {\gamma}-ray source based
on laser-electron Compton scattering (LCS), for use in the medical diagnosis
and treatment. The decay properties and the medical applications of these
nuclear isomers were reviewed. The cross-section curves, simulated yields and
activity of product of each photo-excitation process were calculated. The
cutoff energy of LCS {\gamma}-ray beam is optimized by adjusting the electron
energy in order to maximize the yields as well as the activities of
photo-excitation products. It is found that the achievable activity of
above-mentioned isomers can exceed 10 mCi for 6-hour target irradiation at an
intensity of the order of 10^{13} {\gamma}/s. Such magnitude of activity
satisfies the dose requirement of medical diagnosis. Our simulation results
suggest the prospect of producing medically interesting isomers with
photo-excitation using the state-of-art LCS {\gamma}-ray beam facility.
