  Background: Insomnia makes people more physically unable of doing daily
duties, which results in a lack of strength, leads to lacking in strength.
However, the effects of insomnia on muscle function have not yet been
thoroughly investigated. So, the objectives of this study were to clarify how
insomnia contributes to the decrease of muscular function and to investigate
the mechanisms behind this phenomenon. Methods: To understand how insomnia
influence muscle function, we analyzed the expression level of factors
associated with muscle protein degradation, muscle protein synthesis , protein
synthesis and degradation pathways and muscle clock. Results: The results
showed that lower BMI and grip strength were observed in insomnia patients. The
mice in the sleep deprivation(SD) group saw a 7.01 g loss in body mass. The SD
group's tibialis anterior and gastrocnemius muscle mass decreased after 96 h of
SD). The grip strength reduced in SD group. Using the RT-PCR approaches, we
found a significant increase in muscle degradation factors expression in SD
group versus normal control group. Conclusions: Insomnia can impair muscle
function. The mechanism may be associated with the increased expression of
muscle degradation related factors , as well as the abnormal expression of
Clock gene.
