  We consider the Nelson model on some static space-times and investigate the
problem of absence of a ground state. Nelson models with variable coefficients
arise when one replaces in the usual Nelson model the flat Minkowski metric by
a static metric, allowing also the boson mass to depend on position. We
investigate the absence of a ground state of the Hamiltonian in the presence of
the infrared problem, i.e. assuming that the boson mass $m(x)$ tends to $0$ at
spatial infinity. Using path space techniques, we show that if $m(x)\leq C
|x|^{-\mu}$ at infinity for some $C>0$ and $\mu>1$ then the Nelson Hamiltonian
has no ground state.
