  A massive gap exists between current quantum computing (QC) prototypes, and
the size and scale required for many proposed QC algorithms. Current QC
implementations are prone to noise and variability which affect their
reliability, and yet with less than 80 quantum bits (qubits) total, they are
too resource-constrained to implement error correction. The term Noisy
Intermediate-Scale Quantum (NISQ) refers to these current and near-term systems
of 1000 qubits or less. Given NISQ's severe resource constraints, low
reliability, and high variability in physical characteristics such as coherence
time or error rates, it is of pressing importance to map computations onto them
in ways that use resources efficiently and maximize the likelihood of
successful runs.
  This paper proposes and evaluates backend compiler approaches to map and
optimize high-level QC programs to execute with high reliability on NISQ
systems with diverse hardware characteristics. Our techniques all start from an
LLVM intermediate representation of the quantum program (such as would be
generated from high-level QC languages like Scaffold) and generate QC
executables runnable on the IBM Q public QC machine. We then use this framework
to implement and evaluate several optimal and heuristic mapping methods. These
methods vary in how they account for the availability of dynamic machine
calibration data, the relative importance of various noise parameters, the
different possible routing strategies, and the relative importance of
compile-time scalability versus runtime success. Using real-system
measurements, we show that fine grained spatial and temporal variations in
hardware parameters can be exploited to obtain an average $2.9$x (and up to
$18$x) improvement in program success rate over the industry standard IBM
Qiskit compiler.
