  High-content biological microscopy targets high-resolution imaging across
large fields-of-view (FOVs). Recent works have demonstrated that computational
imaging can provide efficient solutions for high-content microscopy. Here, we
use speckle structured illumination microscopy (SIM) as a robust and
cost-effective solution for high-content fluorescence microscopy with
simultaneous high-content quantitative phase (QP). This multi-modal
compatibility is essential for studies requiring cross-correlative biological
analysis. Our method uses laterally-translated Scotch tape to generate
high-resolution speckle illumination patterns across a large FOV. Custom
optimization algorithms then jointly reconstruct the sample's super-resolution
fluorescent (incoherent) and QP (coherent) distributions, while digitally
correcting for system imperfections such as unknown speckle illumination
patterns, system aberrations and pattern translations. Beyond previous linear
SIM works, we achieve resolution gains of 4x the objective's
diffraction-limited native resolution, resulting in 700 nm fluorescence and 1.2
um QP resolution, across a FOV of 2x2.7 mm^2, giving a space-bandwidth product
(SBP) of 60 megapixels.
