  Thermodynamic effects of local structure fluctuations in glassformers are
analyzed in terms of energy basins and inter-basin hopping. Depending on the
time-scale of measurement, one observes short-time thermodynamic properties
related to a narrow set of basins, or equilibrium properties that include
structural relaxation. The inter-basin hopping is manifested by the
fluctuations of the pressure, internal energy, and other thermodynamic short
time characteristics. Formulas relating the inter-basin fluctuations of
pressure and internal energy to the differences between the long- and
short-time susceptibilities are found. Based on obtained relations, we discuss
the relative sensitivity of the structure to temperature and pressure.
