  The study of synchronization among genetic oscillators is essential for the
understanding of the rhythmic phenomena of living organisms at both molecular
and cellular levels. Genetic networks are intrinsically noisy due to natural
random intra- and inter-cellular fluctuations. Therefore, it is important to
study the effects of noise perturbation on the synchronous dynamics of genetic
oscillators. From the synthetic biology viewpoint, it is also important to
implement biological systems that minimizing the negative influence of the
perturbations. In this paper, based on systems biology approach, we provide a
general theoretical result on the synchronization of genetic oscillators with
stochastic perturbations. By exploiting the specific properties of many genetic
oscillator models, we provide an easy-verified sufficient condition for the
stochastic synchronization of coupled genetic oscillators, based on the Lur'e
system approach in control theory. A design principle for minimizing the
influence of noise is also presented. To demonstrate the effectiveness of our
theoretical results, a population of coupled repressillators is adopted as a
numerical example. In summary, we present an efficient theoretical method for
analyzing the synchronization of genetic oscillator networks, which is helpful
for understanding and testing the synchronization phenomena in biological
organisms. Besides, the results are actually applicable to general oscillator
networks.
