  Monte Carlo simulations of a Miyazawa-Jernigan lattice-polymer model indicate
that, depending on the native's structure geometry, the model exhibits two
broad classes of folding mechanisms for two-state folders. Folding to native
structures of low contact order is driven by contact range and is characterised
by progressive accumulation of structure towards the native fold. By contrast,
folding to high contact order targets is largely dominated by intermediate
stage contacts which are not present in the native fold, yielding a more
cooperative folding process.
