  We propose a suite of technologies for analyzing the interaction between
anisotropic arterial walls and blood flow for subject-specific geometries.
Utilizing an established lumen modeling strategy, we present a comprehensive
pipeline for generating the thick-walled artery models. Through a specialized
mesh generation procedure, we obtain the meshes for the arterial lumen and wall
with mesh continuity across the interface ensured. Exploiting the centerline
information, a series of procedures is introduced for generating local basis
vectors within the arterial wall. The procedures are tailored to handle
thick-walled and, in particular, aneurysmatic tissues in which the basis
vectors may exhibit transmural variations. Additionally, we propose methods to
accurately identify the centerline in multi-branched vessels and bifurcating
regions. The developed fiber generation method is evaluated against the
strategy using linear elastic analysis, demonstrating that the proposed
approach yields satisfactory fiber definitions in the considered benchmark.
Finally, we examine the impact of anisotropic arterial wall models on the
vascular fluid-structure interaction analysis through numerical examples. For
comparison purposes, the neo-Hookean model is considered. The first case
involves an idealized curved geometry, while the second case studies an
image-based abdominal aorta model. The numerical results reveal that the
deformation and stress distribution are critically related to the constitutive
model of the wall, while the hemodynamic factors are less sensitive to the wall
model. This work paves the way for more accurate image-based vascular modeling
and enhances the prediction of arterial behavior under physiologically
realistic conditions.
