  Originally designed to model text, topic modeling has become a powerful tool
for uncovering latent structure in domains including medicine, finance, and
vision. The goals for the model vary depending on the application: in some
cases, the discovered topics may be used for prediction or some other
downstream task. In other cases, the content of the topic itself may be of
intrinsic scientific interest.
  Unfortunately, even using modern sparse techniques, the discovered topics are
often difficult to interpret due to the high dimensionality of the underlying
space. To improve topic interpretability, we introduce Graph-Sparse LDA, a
hierarchical topic model that leverages knowledge of relationships between
words (e.g., as encoded by an ontology). In our model, topics are summarized by
a few latent concept-words from the underlying graph that explain the observed
words. Graph-Sparse LDA recovers sparse, interpretable summaries on two
real-world biomedical datasets while matching state-of-the-art prediction
performance.
