  Glaucoma remains among the leading causes of blindness despite many treatment
options available today. Effective treatment requires early diagnosis, which is
difficult to achieve with existing imaging technologies that detect the already
inflicted irreversible posterior eye damage. One improved approach could be to
detect the changes in trabecular meshwork of the anterior eye that precede the
intraocular pressure buildup and vision loss. Here we report a device that
enables in vivo exploration of trabecular meshwork at cell resolution. The
instrument combines two orthogonal views: en face view of time-domain
full-field OCT for high-resolution and cross-sectional view of spectral-domain
OCT for aligning to the meshwork. The device resolves micron-level
corneoscleral and uveal pores, meshwork beams and internal elastic fibers,
ciliary body tendons and trabecular cell nuclei. Capable of detecting blockage
of trabecular pores, orthogonal view OCT presents a promising solution to the
long-standing problem of early glaucoma diagnosis. Future clinical adoption of
the device is facilitated by the compact footprint and broad functionality that
includes corneal imaging in healthy subjects and patients (with keratoconus,
Fuchs endothelial dystrophy) using the same design.
