  It is widely accepted that the immune system undergoes age-related changes
correlating with increased disease in the elderly. T cell subsets have been
implicated. The aim of this work is firstly to implement and validate a
simulation of T regulatory cell (Treg) dynamics throughout the lifetime, based
on a model by Baltcheva. We show that our initial simulation produces an
inversion between precursor and mature Treys at around 20 years of age, though
the output differs significantly from the original laboratory dataset.
Secondly, this report discusses development of the model to incorporate new
data from a cross-sectional study of healthy blood donors addressing balance
between Treys and Th17 cells with novel markers for Treg. The potential for
simulation to add insight into immune aging is discussed.
