  We develop a multiphysics-based model to predict the response of localized
tumors to combined-hyperthermia-radiotherapy (CHR) treatment. This procedure
combines hyperthermia (tumor heating) with standard radiotherapy to improve
efficacy of the overall treatment. In addition to directly killing tumor cells,
tumor heating amends several parameters within the tumor microenvironment. This
leads to radiosensitization, which improves the performance of radiotherapy
while reducing the side-effects of excess radiation in the surrounding normal
tissue. Existing tools to model this kind of treatment consider each of the
physics separately. The model presented in this paper accounts for the synergy
between hyperthermia and radiotherapy providing a more realistic and holistic
approach to simulate CHR treatment. Our model couples radiation transport and
heat-transfer with cell population dynamics.
