  A charge-symmetry-breaking nucleon-nucleon force due to the up-down quark
mass difference is evaluated in the quark cluster model. It is applied to the
shell-model calculation for the isovector mass shifts of isospin multiplets and
the isospin-mixing matrix elements in 1s0d-shell nuclei. We find that the
contribution of the quark mass difference effect is large and agrees with
experiment. This contribution may explain the Okamoto-Nolen-Schiffer anomaly,
alternatively to the meson-mixing contribution, which is recently predicted to
be reduced by the large off-shell correction.
