  In this review we make the statement that hybrid models in oncology are
required as a mean for enhanced data integration. In the context of systems
oncology, experimental and clinical data need to be at the heart of the models
developments from conception to validation to ensure a relevant use of the
models in the clinical context. The main applications pursued are to improve
diagnosis and to optimize therapies.We first present the Successes achieved
thanks to hybrid modelling approaches to advance knowledge, treatments or drug
discovery. Then we present the Challenges than need to be addressed to allow
for a better integration of the model parts and of the data into the models.
And Finally, the Hopes with a focus towards making personalised medicine a
reality. Mathematics Subject Classification. 35Q92, 68U20, 68T05, 92-08, 92B05.
