  Weight gain is a well-established side effect of both conventional and newer
anti-psychotic drugs, but the cause is not well understood. Recent studies
correlate obesity with the presence or absence of particular genetic sequences
in the gut microbiota. We identified strong associations between protein
targets of antipsychotics and microbiota sequences directly related to weight
regulation in human body, leading to a potential metagenomic mechanism of
action. Further experimental study is recommended.
