  We review the present activities related to hypernuclear production in
hadronic in-medium reactions at intermediate energies. The status of
theoretical predictions and experimental evidences for the in-medium formation
of bound superstrange matter is discussed. Heavy-ion collisions and
antiproton-induced reactions at energies close to strangeness production
thresholds create the conditions of hypermatter formation. This allows to
understand better in-medium hyperon interactions and sets constraints on the
strangeness sector of the nuclear equation of state.
