  Diffuse correlation spectroscopy (DCS) is an emerging noninvasive technique
that measures the tissue blood flow, by using near-infrared coherent
point-source illumination to detect spectral changes. While machine learning
has demonstrated significant potential for measuring blood flow index (BFi), an
open question concerning the success of this approach pertains to its
robustness in scenarios involving deviations between datasets with varying
Signal-to-Noise Ratios (SNRs) originating from diverse clinical applications
and various setups. This study proposes a transfer learning approach, aims to
assess the influence of SNRs on the generalization ability of learned features,
and demonstrate the robustness for transfer learning. A synthetic dataset with
varying levels of added noise is utilized to simulate different SNRs. The
proposed network takes a 1x64 autocorrelation curve as input and generates BFi
and the correlation parameter beta. The proposed model demonstrates excellent
performance across different SNRs, exhibiting enhanced fitting accuracy,
particularly for low SNR datasets when compared with other fitting methods.
This highlights its potential for clinical diagnosis and treatment across
various scenarios under different clinical setups.
