  Here we demonstrate that a term in the nuclear spin Hamiltonian, the
antisymmetric \textit{J}-coupling, is fundamentally connected to molecular
chirality. We propose and simulate a nuclear magnetic resonance (NMR)
experiment to observe this interaction and differentiate between enantiomers
without adding any additional chiral agent to the sample. The antisymmetric
\textit{J}-coupling may be observed in the presence of molecular orientation by
an external electric field. The opposite parity of the antisymmetric coupling
tensor and the molecular electric dipole moment yields a sign change of the
observed coupling between enantiomers. We show how this sign change influences
the phase of the NMR spectrum and may be used to discriminate between
enantiomers.
