  The MISE Project (Mediation Information System Engineering) aims at providing
collaborating organizations with a Mediation Information System (MIS) in charge
of supporting interoperability of a collaborative network. MISE proposes an
overall MIS design method according to a model-driven approach, based on model
transformations. This MIS is in charge of managing (i) information, (ii)
functions and (iii) processes among the information systems (IS) of partner
organizations involved in the network. Semantic issues are accompanying this
triple objective: How to deal with information reconciliation? How to ensure
the matching between business functions and technical services? How to identify
workflows among business processes? This article aims first, at presenting the
MISE approach, second at defining the semantic gaps along the MISE approach and
third at describing some past, current and future research works that deal with
these issues. Finally and as a conclusion, the very "design-oriented" previous
considerations are confronted with "run-time" requirements.
