  In this letter, we present anti-cancer drug delivery strategies using
knowledges obtained from our recent studies. We have conducted inverse analyses
of "density distributions of colloidal particles near a focused surface" and
"pair potentials between the surface and the colloidal particle" using data
measured by optical tweezers (OT) and atomic force microscopy (AFM).
Non-additive Asakura-Oosawa (NAO) theory and a lattice theory in statistical
mechanics of simple polymers have been also our research topics. Summarizing
the knowledges, we propose two strategies to increase the delivery rate of
capsule shaped anti-cancer drugs to cancer cells. We consider that enhanced
repulsion between the normal cell and the drug accelerates the attraction
between the cancer cell and the drug, which can be named enhanced repulsion and
accelerated adsorption (ERAA) effect. To realize the ERAA effect, we propose a
supporting method for measuring the interactions using OT and AFM. In the
second strategy, dose of water-soluble polymers is considered to realize
adsorptions of the drugs and cancer cell derived exosomes onto the cancer
cells, which we call non-specific and selective adsorption (NSSA) effect. In
the main text, we explain the NSSA effect using the NAO theory. Moreover, we
explain that structural stabilities of normal dispersed proteins around the
cancer cells are not largely destroyed by the dosed polymers from the viewpoint
of the lattice theory.
