  We propose a flexible change-point model for inhomogeneous Poisson Processes,
which arise naturally from next-generation DNA sequencing, and derive score and
generalized likelihood statistics for shifts in intensity functions. We
construct a modified Bayesian information criterion (mBIC) to guide model
selection, and point-wise approximate Bayesian confidence intervals for
assessing the confidence in the segmentation. The model is applied to DNA Copy
Number profiling with sequencing data and evaluated on simulated spike-in and
real data sets.
