  This is initial study of a gene signatures responsible for adapting
microscopic life to the life in extreme Earth environments. We present a
results on ID of the clusters of COGs common to several hyperthermophiles and
exclusion of those common to a mesophile: E.coli.K12, will yield a group of
proteins possibly involved in adaptation to life under extreme T. Methanogens
stand out as the only group of organisms that have species capable of growth at
0C (M.frigidum and M.burtonii) and 110C (M.kandleri). Not all the components of
heat adaptation can be attributed to novel genes, the chaperones known as heat
shock proteins stabilize the enzymes under elevated temperature. Highly
conserved chaperons found in bacteria and eukaryots are not present in
hyperthermophilic Archea, rather, they have a unique chaperone TF55. Our aim is
to use software which we specifically developed for extremophile genome
comparative analyses in order to search for additional novel genes involved in
hyperthermophile adaptation. The following hyperthermophile genomes
incorporated in our software were used for these studies: M.jannaschii,
M.kandleri, A.fulgidus and 3 species of Pyrococcus. Common genes were annotated
and grouped according to their roles in cellular processes when information was
available and proteins not previously implicated in the heat-adaptation of
hyperthermophiles were identified. Additional experimental data is needed in
order to learn more about these proteins. To address a non-gene based
components of thermal adaptation, all sequenced extremophiles were analysed for
their GC contents and aminoacid hydrophobicity. We develop a prediction model
for optimal growth temperature.
