  One of the frontiers of nanotechnology is advancing beyond the periodic
self-assembly of materials. Icosahedral quasicrystals, aperiodic in all
directions, represent one of the most challenging targets that have yet to be
experimentally realized at the colloidal scale. Previous attempts have required
meticulous human-designed building blocks and often resulted in interactions
beyond current experimental capabilities. In this work, we introduce a
framework for generating experimentally accessible designs that self-assemble
into quasicrystalline arrangements. We present a design for icosahedral
DNA-origami building blocks and demonstrate, through molecular simulations,
their successful assembly into the target quasicrystalline structure. Our
results highlight the feasibility of using automated design protocols to
achieve complex quasicrystalline patterns, paving the way for new applications
in material science and nanotechnology.
