  The formation of a hot deconfined medium (Quark-Gluon Plasma) in high-energy
nuclear collisions affects heavy-flavor observables. In the low/moderate-pT
range transport calculations allow one to simulate the propagation of heavy
quarks in the plasma and to evaluate the effect of the medium on the final
hadronic spectra: results obtained with transport coefficients arising from
different theoretical approaches can be compared to experimental data. Finally,
a discussion of possible effects on heavy-flavor observables due to the
possible formation of a hot-medium in small systems (like in p-A collisions) is
presented.
