  Although nanodiamonds have long being considered as a potential tool for
biomedical research, the practical in vivo application of nanodiamonds remains
relatively unexplored. In this paper, we present the first application of in
vivo MRI contrast enhancement using only iron embedded magnetic nanodiamonds.
MR image enhancement was clearly demonstrated in the rendering of T2-weighted
images of mice obtained using an unmodified commercial MRI scanner. The
excellent contrast obtained using these nanodiamonds opens the door to the
non-invasive in vivo tracking of NDs and image enhancement. In the future, one
can apply these magnetic nanodiamonds together with surface modifications to
facilitate drug delivery, targeted therapy, localized thermal treatment, and
diagnostic imaging.
