  A topological index of a graph $G$ is a numerical quantity that describes its
topology. Reverse degree-based topological indices play an important role in
finding topological descriptors. Azacitidine, Decitabine, and Guadecitabine are
hypomethylating agents which are used for the treatment of patients with
higher-risk myelodysplastic syndromes, acute myeloid leukemia, and chronic
myelomonocytic leukemia which are not suitable for in-depth treatments such as
induction chemotherapy. In this article, some reverse degree-based topological
indices of the three said drugs are computed. Furthermore, QSPR analysis of the
said topological indices is discussed and it is shown that these topological
indices are highly correlated with the physical properties of the three cancer
drugs. These findings may help chemists and people working in the
pharmaceutical industry to predict the properties of cancer drugs without
experimenting.
