  We review the origin of the physical consistency of the Lorentz- Poincar\'e
symmetry. We outline seemingly catastrophic physical inconsistencies recently
identified for noncanonical-nonunitary generalized theories defined on
conventional spaces over conventional fields. We review Santilli's isotopic
lifting of the Lorentz-Poincar\'e symmetry, by proving its invariant resolution
of said inconsistencies, and universality for the representation of all
possible spacetimes with a symmetric metric. The explicit isosymmetry
transforms are identified. Particular care is devoted to the recent discovery
of the 11-th dimensionality of the conventional Poincar\'e symmetry and the
consequential emergence of an axiomatically consistent grand unification of
electroweak and gravitational interactions. The article closes with an outline
of the broader geno- and hyper-symmetries and their isodual for the description
of single-valued irreversible systems, multivalued irreversible systems and
antimatter systems, respectively.
