  Digital holographic microcopy is a thriving imaging modality that attracts
considerable research interest due to its ability to not only create excellent
label-free contrast, but also supply valuable physical information regarding
the density and dimensions of the sample with nanometer-scale axial
sensitivity. Three basic holographic recording geometries currently exist,
including on-axis, off-axis and slightly off-axis holography, each of them
enabling a variety of architectures in terms of bandwidth use and compression
capacity. Specifically, off-axis holography and slightly off-axis holography
allow spatial hologram multiplexing, enabling compressing more information into
the same digital hologram. In this paper, we define an efficiency score used to
analyze the various possible architectures, and compare the signal-to-noise
ratio and mean squared error obtained using each of them, determining the
optimal holographic method.
