  We propose a multiscale chemo-mechanical model of cancer tumour development
in an epithelial tissue. The model is based on transformation of normal cells
into the cancerous state triggered by a local failure of spatial
synchronisation of the circadian rhythm. The model includes mechanical
interactions and chemical signal exchange between neighbouring cells, as well
as division of cells and intercalation, and allows for modification of the
respective parameters following transformation into the cancerous state. The
numerical simulations reproduce different dephasing patterns - spiral waves and
quasistationary clustering, with the latter being conducive to cancer
formation. Modification of mechanical properties reproduces distinct behaviour
of invasive and localised carcinoma.
