  We explore how Deep Learning (DL) can be utilized to predict prognosis of
acute myeloid leukemia (AML). Out of TCGA (The Cancer Genome Atlas) database,
94 AML cases are used in this study. Input data include age, 10 common
cytogenetic and 23 most common mutation results; output is the prognosis
(diagnosis to death, DTD). In our DL network, autoencoders are stacked to form
a hierarchical DL model from which raw data are compressed and organized and
high-level features are extracted. The network is written in R language and is
designed to predict prognosis of AML for a given case (DTD of more than or less
than 730 days). The DL network achieves an excellent accuracy of 83% in
predicting prognosis. As a proof-of-concept study, our preliminary results
demonstrate a practical application of DL in future practice of prognostic
prediction using next-gen sequencing (NGS) data.
