  A holistic simulation framework is established on magnetic hyperthermia
modeling to solve the treatment process of tumor, which is surrounded by a
healthy tissue block. The interstitial tissue fluid, MNP distribution,
temperature profile, and nanofluids are involved in the simulation. Study
evaluates the cancer treatment efficacy by cumulative-equivalent-minutes-at-43
centigrade (CEM43), a widely accepted thermal dose coming from the cell death
curve. Results are separated into the conditions of with or without gravity
effect in the computational domain, where two baseline case are investigated
and compared. An optimal treatment time 46.55 min happens in the baseline case
without gravity, but the situation deteriorates with gravity effect where the
time for totally killing tumor cells prolongs 36.11% and meanwhile causing
21.32% ablation in healthy tissue. For the cases without gravity, parameter
study of Lewis number and Heat source number are conducted and the variation of
optimal treatment time are both fitting to the inverse functions. For the case
considering the gravity, parameters Buoyancy ratio and Darcy ratio are
investigated and their influence on totally killing tumor cells and the injury
on healthy tissue are matching with the parabolic functions. The results are
beneficial to the prediction of various conditions, and provides useful guide
to the magnetic hyperthermia treatment.
