  A structural relationship between the centrosome and cytoskeleton has been
recognized for many years. Centrosomes typically reside near the nucleus,
establishing and maintaining the nucleus-centrosome axis. This spatial
arrangement is critical for determining cell polarity during interphase and
ensuring the proper assembly of the spindle apparatus during mitosis.
Centrosomes also engage in physical interactions with various components of the
cytoskeleton, balancing internal cellular architecture and polarity in a manner
specific to tissue type and developmental stage. Numerous crosslinking proteins
facilitate these interactions, promoting both cytoskeletal and centrosomal
nucleation. This article provides an overview of how cytoskeletal elements and
centrosomes coordinate their actions to regulate complex cellular functions
such as cell migration, adhesion, and division. The reciprocal influence
between cytoskeletal dynamics and centrosomal positioning underscores their
integral roles in cellular organization and function.
