  The humoral adaptive immune system, from the physical perspective, can be
regarded as a self-organized antibody binding energy landscape. In biological
terms it means the system organizes its repertoire of antigen binding molecules
so as to maintain its integrity. In this article I reason that the
super-landscape created by the fusion of binding energy landscapes can be
described by the distribution of interaction energies and a deformation
parameter of thermodynamic potentials in the system. This deformation parameter
characterizes the adaptive network of interactions in the system and the
asymmetry of generalized logistic distributions in immunoassays. Overall,
statistical thermodynamics approaches could provide a deeper theoretical
insight into the dynamical self-organization of the adaptive immune system and
into the interpretation of experimental results.
