  We present high spatial resolution (~ 35 parsec) 5-38 um spectra of the
central region of M82, taken with the Spitzer Infrared Spectrograph. From these
spectra we determined the fluxes and equivalent widths of key diagnostic
features, such as the [NeII]12.8um, [NeIII]15.5um, and H_2 S(1)17.03um lines,
and the broad mid-IR polycyclic aromatic hydrocarbon (PAH) emission features in
six representative regions and analysed the spatial distribution of these lines
and their ratios across the central region. We find a good correlation of the
dust extinction with the CO 1-0 emission. The PAH emission follows closely the
ionization structure along the galactic disk. The observed variations of the
diagnostic PAH ratios across M82 can be explained by extinction effects, within
systematic uncertainties. The 16-18um PAH complex is very prominent, and its
equivalent width is enhanced outwards from the galactic plane. We interpret
this as a consequence of the variation of the UV radiation field. The EWs of
the 11.3um PAH feature and the H_2 S(1) line correlate closely, and we conclude
that shocks in the outflow regions have no measurable influence on the H_2
emission. The [NeIII]/[NeII] ratio is on average low at ~0.18, and shows little
variations across the plane, indicating that the dominant stellar population is
evolved (5 - 6 Myr) and well distributed. There is a slight increase of the
ratio with distance from the galactic plane of M82 which we attribute to a
decrease in gas density. Our observations indicate that the star formation rate
has decreased significantly in the last 5 Myr. The quantities of dust and
molecular gas in the central area of the galaxy argue against starvation and
for negative feedback processes, observable through the strong extra-planar
outflows.
