  A multiscale model for glioma spread in brain tissue under the influence of
vascularization and vascular endothelial growth factors is proposed. It
accounts for the interplay between the different components of the neoplasm and
the healthy tissue and it investigates and compares various therapy approaches.
Precisely, these involve radio- and chemotherapy in a concurrent or adjuvant
manner together with anti-angiogenic therapy affecting the vascular component
of the system. We assess tumor growth and spread on the basis of DTI data,
which allows us to reconstruct a realistic brain geometry and tissue structure,
and we apply our model to real glioma patient data. In this latter case, a
space-dependent radiotherapy description is considered using data about the
corresponding isodose curves.
