  The blue compact dwarf galaxy NGC 5253 hosts a very young starburst
containing twin nuclear star clusters, separated by a projected distance of 5
pc. One cluster (#5) coincides with the peak of the H-alpha emission and the
other (#11) with a massive ultracompact H II region. A recent analysis of these
clusters shows that they have a photometric age of 1+/-1 Myr, in apparent
contradiction with the age of 3-5 Myr inferred from the presence of Wolf-Rayet
features in the cluster #5 spectrum. We examine Hubble Space Telescope
ultraviolet and Very Large Telescope optical spectroscopy of #5 and show that
the stellar features arise from very massive stars (VMS), with masses greater
than 100 Msun, at an age of 1-2 Myr. We further show that the very high
ionizing flux from the nuclear clusters can only be explained if VMS are
present. We investigate the origin of the observed nitrogen enrichment in the
circum-cluster ionized gas and find that the excess N can be produced by
massive rotating stars within the first 1 Myr. We find similarities between the
NGC 5253 cluster spectrum and those of metal poor, high redshift galaxies. We
discuss the presence of VMS in young, star-forming galaxies at high redshift;
these should be detected in rest frame UV spectra to be obtained with the James
Webb Space Telescope. We emphasize that population synthesis models with upper
mass cut-offs greater than 100 Msun are crucial for future studies of young
massive star clusters at all redshifts.
