  We present InvMSAFold, a method for generating a diverse set of protein
sequences that fold into a single structure. For a given structure, InvMSAFold
defines a probability distribution over the space of sequences, capturing the
amino acid covariances observed in Multiple Sequence Alignments (MSA) of
homologous proteins. This allows for the generation of highly diverse protein
sequences while preserving structural and functional integrity. We show that
the higher diversity of sampled sequences translates into higher diversity in
biochemical properties, pointing to exciting prospects for the applicability of
our method in fields like protein design by providing diverse starting points.
