  Six thermo-activated transient receptor potential (TRP) channels are the
molecular basis of the thermosensation for mammals. But the molecular source of
their gating remains unknown. In the Letter, we suggest a physically based
model for the TRP channels and show that the temperature dependence of the
"internal friction" can be a key factor governing the ion channels gating.
Results of the computer modeling allowed us to successfully reproduce the
experimental data for the open probability Popen of the TRPV1 and TRPM8
channels at different temperatures and voltages.
