  Dynamic nuclear polarization (DNP) has revolutionized the field of NMR
spectroscopy, expanding its reach and capabilities to investigate diverse
materials, biomolecules, and complex dynamic processes. Bringing
high-efficiency DNP to the nanometer scale would open new avenues for studying
nanoscale nuclear spin ensembles, such as single biomolecules, virus particles,
and condensed matter systems. Combining pulsed DNP with nanoscale
force-detected magnetic resonance measurements, we demonstrated a 100-fold
enhancement in the Boltzmann polarization of proton spins in nanoscale sugar
droplets at 6 K and 0.33 T. Crucially, this enhancement corresponds to a factor
of 200 reduction in the averaging time compared to measurements that rely on
the detection of statistical fluctuations in nanoscale nuclear spin ensembles.
These results significantly advance the capabilities of force-detected magnetic
resonance detection as a practical tool for nanoscale imaging.
