  Dynamic instability in the cytoskeleton underlies a great many vital cellular
processes. In neurons, it is thought to play a role in information processing
and the establishment of synaptic connections. It is from this interneuronal
connectivity that the large-scale organization and function of the brain
ultimately emerges. While brain networks above the cellular scale have been
extensively investigated with medical imaging, no research has yet examined the
contribution of the dynamic architecture subserving the components of these
networks to their functionality. Simultaneous functional imaging at molecular
and whole-brain scales may yield more comprehensive knowledge of this
entailment. Procedures of statistical analysis based on a recently developed
nonlinear model of microtubule dynamics are proposed to verify predictions
about the spatiotemporal relationships between various microtubule-associated
protein activities and functional connectivity. Known effects of brain cancer
on functional connectivity and peritumoral complexity serve as the basis for a
comparative study of these phenomena in regions of interest with particularly
high and low complexity.
