  Zero mode waveguide technology of next generation sequencing demonstrated
sequence-dependence of the enzymatic reaction, incorporating a base into the
genomic DNA. We show that these experimental results indicate existence of a
previously uncharacterized physical property of DNA, the incorporation reaction
chemical potential {\Delta}{\mu}. We use the combination of graph theory and
statistical thermodynamics to derive entromics - a series of results providing
the thermodynamic model of {\Delta}{\mu}. We also show that {\Delta}{\mu}i is
quantitatively characterized as incorporation entropy. We present formulae for
computing {\Delta}{\mu} from the genome DNA sequence. We then derive important
restrictions on DNA properties and genome assembly that follow from
thermodynamic properties of {\Delta}{\mu}. Finally, we show how these genome
assembly restrictions lead directly to the evolution of detectable coherences
in incorporation entropy along the entire genome. Examples of entromic
applications, demonstrating functional and biological importance are shown.
