  We have simulated 10-residue polyalanine chain by multicanonical method to
visualize the 3D topographic picture of the free energy landscape over the
whole range of temperatures, hence to show the funnel along the folding pathway
exhaustively. We have simulated and compared the system in vacuo and in
solvent, and examined the changes in the free energy landscape due to the
solvent effects, which are taken into account by commonly used model Accessible
Surface Area.
