  The $\gamma$-ray and neutrino emissions from dark matter (DM) annihilation in
galaxy clusters are studied. After about one year operation of Fermi-LAT,
several nearby clusters are reported with stringent upper limits of GeV
$\gamma$-ray emission. We use the Fermi-LAT upper limits of these clusters to
constrain the DM model parameters. We find that the DM model distributed with
substructures predicted in cold DM (CDM) scenario is strongly constrained by
Fermi-LAT $\gamma$-ray data. Especially for the leptonic annihilation scenario
which may account for the $e^{\pm}$ excesses discovered by
PAMELA/Fermi-LAT/HESS, the constraint on the minimum mass of substructures is
of the level $10^2-10^3$ M$_{\odot}$, which is much larger than that expected
in CDM picture, but is consistent with a warm DM scenario. We further
investigate the sensitivity of neutrino detections of the clusters by IceCube.
It is found that neutrino detection is much more difficult than $\gamma$-rays.
Only for very heavy DM ($\sim 10$ TeV) together with a considerable branching
ratio to line neutrinos the neutrino sensitivity is comparable with that of
$\gamma$-rays.
