  In 2016, the Dutch National Health Care Institute issued new guidelines that
aggregated and updated previous recommendations on key elements for conducting
economic evaluation. However, the impact on standard practice after the
introduction of the guidelines in terms of design, methodology and reporting
choices, is still uncertain. To assess this impact, we examine and compare key
analysis components of economic evaluations conducted in the Netherlands before
(2010-2015) and after (2016-2020) the introduction of the guidelines. We
specifically focus on two aspects of the analysis that are crucial in
determining the plausibility of the results: statistical methodology and
missing data handling. Our review shows how many components of economic
evaluations have changed in accordance with the new recommendations towards
more transparent and advanced analytic approaches. However, potential
limitations are identified in terms of the statistical software and information
provided to support the choice of missing data methods.
