  We present a computational tool, TweedleDEE, for empirically modeling diffuse
gamma-ray background emission in a 1 degree region of the sky, using publicly
available gamma-ray data slightly off-axis from this region. This background
model allows a user to perform a purely data-driven search for anomalous
localized sources of gamma-ray emission, including new physics. As an
application, we use TweedleDEE and the MADHATv2 package to perform the first
search for dark matter annihilation in the newly discovered Leo VI dwarf
spheroidal galaxy, and present model constraints for a variety of choices of
the annihilation channel and velocity dependence of the cross section.
