  In genetic diseases with variable age of onset, an accurate estimation of the
survival function for the mutation carriers and also modifying factors effects
estimations are important for the management of asymptomatic gene carriers
across life. Among the modifying factors, the gender of the parent transmitting
the mutation (i.e. the parent-of-origin effect) has been shown to have a
significant effect on survival curve estimation on transthyretin familial
amyloid polyneuropathy (ATTRv) families. However, as most genotypes are
unknown, the parent-of-origin must be calculated through a probability
estimated from the pedigree. We propose in this article to extend the method
providing mutation carrier survival estimates in order to estimate the
parent-of-origin effect. The method is both validated on simulated data and
applied to familly samples with ATTRv.
