  The DisProt database is a significant resource containing manually curated
data on experimentally validated intrinsically disordered proteins (IDPs) and
regions (IDRs) from the literature. Developed in 2005, its primary goal was to
collect structural and functional information into proteins that lack a fixed
three-dimensional (3D) structure. Today, DisProt has evolved into a major
repository that not only collects experimental data but also contributes
significantly to our understanding of the IDPs/IDRs roles in various biological
processes, such as autophagy or the life cycle mechanisms in viruses, or their
involvement in diseases (such as cancer and neurodevelopmental disorders).
DisProt offers detailed information on the structural states of IDPs/IDRs,
including state transitions, interactions, and their functions, all provided as
curated annotations. One of the central activities of DisProt is the meticulous
curation of experimental data from the literature. For this reason, to ensure
that every expert and volunteer curator possesses the requisite knowledge for
data evaluation, collection, and integration, training courses and curation
materials are available. However, biocuration guidelines concur on the
importance of developing robust guidelines that not only provide critical
information about data consistency but also ensure data acquisition.This
guideline aims to provide both biocurators and external users with best
practices for manually curating IDPs and IDRs in DisProt. It describes every
step of the literature curation process and provides use cases of IDP curation
within DisProt.
  Database URL: https://disprot.org/
