  In vivo and in vitro lipid bilayers are commonly supported by subcellular
structures, particles, and artificial substrates. Deformation of the underlying
structure can lead to large, localized deformations as the bilayer deforms to
avoid stretching. In this work, we consider the effect of defects within the
underlying substrate by simulating different bilayers supported by continuous
and nanoporous substrates. We show that the bilayer behavior greatly depends on
strain rate, and that substrate defects may contribute to the formation of
nanotubes for compressed substrate.
