  While most neuromorphic systems are based on nanoscale electronic devices,
nature relies on ions for energy-efficient information processing. Therefore,
finding memristive nanofluidic devices is a milestone toward realizing
electrolytic computers mimicking the brain down to its basic principles of
operation. Here, we present a nanofluidic device designed for circuit scale
in-memory processing that combines single-digit nanometric confinement and
large entrance asymmetry. Our fabrication process is scalable while the device
operates at the second timescale with a conductance ratio in the range 10-60.
In-operando optical microscopy unveils the origin of memory, arising from the
reversible formation of liquid blisters modulating the device conductance. The
combination of features of these mechano-ionic memristive switches permits
assembling logic circuits composed of two interactive devices and an ohmic
resistor. These results open the way to design multi-component ionic machinery,
such as nanofluidic neural networks, and implementing brain-inspired ionic
computations.
