  Electroporation is a very useful tool for drug delivery into various diseased
tissues of the human body. This technique helps to improve the clinical
treatment by transferring drugs into the targeted cells rapidly. In
electroporation, drug particles enter easily into the intracellular compartment
through the temporarily permeabilized cell membrane due to the applied electric
field. In this work, a mathematical model of drug delivery focusing on
reversible tissue electroporation is presented. In addition, the thermal
effects on the tissue, which is an outcome of Joule heating, are also
considered. This model introduces a time-dependent mass transfer coefficient,
which is significant to drug transport. Multiple pulses with low voltage are
applied to reach sufficient drugs into the targeted cells. According to the
physical circumstances, a set of differential equations are considered and
solved. The changes in drug concentration with different parameters (e.g.,
diffusion coefficient, drug permeability, pulse length, and pulse number) are
analyzed. The model optimizes the electroporation parameters to uptake drugs
sufficiently into the cells with no thermal damage. This model can be used in
clinical experiments to predict drug uptake into the infected cells by
controlling the model parameters according to the nature of infections.
