  Recently, there has been extensive research interest in training deep
networks to denoise images without clean reference. However, the representative
approaches such as Noise2Noise, Noise2Void, Stein's unbiased risk estimator
(SURE), etc. seem to differ from one another and it is difficult to find the
coherent mathematical structure. To address this, here we present a novel
approach, called Noise2Score, which reveals a missing link in order to unite
these seemingly different approaches. Specifically, we show that image
denoising problems without clean images can be addressed by finding the mode of
the posterior distribution and that the Tweedie's formula offers an explicit
solution through the score function (i.e. the gradient of log likelihood). Our
method then uses the recent finding that the score function can be stably
estimated from the noisy images using the amortized residual denoising
autoencoder, the method of which is closely related to Noise2Noise or
Nose2Void. Our Noise2Score approach is so universal that the same network
training can be used to remove noises from images that are corrupted by any
exponential family distributions and noise parameters. Using extensive
experiments with Gaussian, Poisson, and Gamma noises, we show that Noise2Score
significantly outperforms the state-of-the-art self-supervised denoising
methods in the benchmark data set such as (C)BSD68, Set12, and Kodak, etc.
