  We introduce a method for computation of exact conditional efficiency robust
enumeration p-values for detection of genotype--phenotype associations at a
single bi-allelic genetic locus. Our method can be based on any arbitrary
ranking test statistics, such as efficiency robust test statistics or
asymptotic p-values. The resulting p-values are exact conditional enumeration
p-values and satisfy the basic statistical validity property. Practically, the
method allows performing statistically valid significance testing in genomic
analyses with unknown modes of inheritance at individual bi-allelic genetic
loci -- the situation typical in genome-wide association studies. We provide an
open-source R code implementing the method.
