  Recent writings on "innate immune memory" or "trained immunity," and on
"hormetic responses," herald reinvigoration of an important research area with
early 20th century roots. However, it is questionable that the thesis of a
"major importance of the sensed dose of pathogen for the development of innate
immune system-mediated responses," should be labelled a "paradigm shift." The
works of Almroth Wright (1861-1947) should be taken into account.
