  The confinement mechanism in the nonperturbative QCD is studied in terms of
topological excitation as QCD-monopoles and instantons. In the 't Hooft abelian
gauge, QCD is reduced into an abelian gauge theory with monopoles, and the QCD
vacuum can be regarded as the dual superconductor with monopole condensation,
which leads to the dual Higgs mechanism. The monopole-current theory extracted
from QCD is found to have essential features of confinement. We find also close
relation between monopoles and instantons using the lattice QCD. In this
framework, the lowest $0^{++}$ glueball (1.5 $\sim$ 1.7GeV) can be identified
as the QCD-monopole or the dual Higgs particle.
