  Boron neutron capture therapy is a powerful anti-cancer treatment, the
success of which depends heavily on the boron delivery agent. Enabling the
real-time tracing of delivery agents as they move through the body is crucial
to the further development of boron neutron therapy. In this study, we
fabricate highly bio-compatible boron-10 embedded nanodiamonds using physical
ion implantation in conjunction with a two-step annealing process. The red
fluorescence of the nanodiamonds allows their use in fluorescence microscopy
and in vivo imaging systems, thereby making it possible to conduct tracking in
real time. The proposed fluorescent boron-10 embedded nanodiamonds, combining
optical visibility and boron-10 transport capability, are a promising boron
delivery agent suitable for a wide range of biomedical applications.
