  The paper by Malek Mansour and Garcia [Phys. Rev. E 101, 052135 (2020)] is
shown to be based on misconceptions in the stochastic formulation of chemical
thermodynamics in reactive systems. Their erroneous claims, asserting that
entropy production cannot be correctly evaluated using path probabilities
whenever the reactive system involves more than one elementary reaction leading
to the same composition changes, are refuted.
