  General relativity is a set of physical and geometric principles, which lead
to a set of (Einstein) field equations that determine the gravitational field,
and to the geodesic equations that describe light propagation and the motion of
particles on the background. But open questions remain, including: What is the
scale on which matter and geometry are dynamically coupled in the Einstein
equations? Are the field equations valid on small and large scales? What is the
largest scale on which matter can be coarse grained while following a geodesic
of a solution to Einstein's equations? We address these questions. If the field
equations are causal evolution equations, whose average on cosmological scales
is not an exact solution of the Einstein equations, then some simplifying
physical principle is required to explain the statistical homogeneity of the
late epoch Universe. Such a principle may have its origin in the dynamical
coupling between matter and geometry at the quantum level in the early
Universe. This possibility is hinted at by diverse approaches to quantum
gravity which find a dynamical reduction to two effective dimensions at high
energies on one hand, and by cosmological observations which are beginning to
strongly restrict the class of viable inflationary phenomenologies on the
other. We suggest that the foundational principles of general relativity will
play a central role in reformulating the theory of spacetime structure to meet
the challenges of cosmology in the 21st century.
