  Particles that can be trapped in optical tweezers range from tens of microns
down to tens of nanometres in size. Interestingly, this size range includes
large macromolecules. We show experimentally, in agreement with theoretical
expectations, that optical tweezers can be used to manipulate single molecules
of polyethylene oxide suspended in water. The trapped molecules accumulate
without aggregating, so this provides optical control of the concentration of
macromolecules in solution. Apart from possible applications such as the
micromanipulation of nanoparticles, nanoassembly, microchemistry, and the study
of biological macromolecules, our results also provide insight into the
thermodynamics of optical tweezers.
