  In this paper, we consider the Cauchy problem of the isentropic compressible
Navier-Stokes equations with degenerate viscosity and vacuum in $\mathbb{R}$,
where the viscosity depends on the density in a super-linear power law(i.e.,
$\mu(\rho)=\rho^\delta, \delta>1$). We first obtain the local existence of the
regular solution, then show that the regular solution will blow-up in finite
time if initial data has an isolated mass group, no matter how small and smooth
the initial data are. It is worth mentioning that based on the transport
structure of some intrinsic variables, we obtain the $L^\infty$ bound of the
density, which helps to remove the restriction $\delta\leq \gamma$ in
Li-Pan-Zhu[21] and Huang-Wang-Zhu[13].
