  Background: Anti-Mullerian hormone (AMH) is a product of growing ovarian
follicles. The concentration of AMH in blood may also reflect the non-growing
follicle (NGF) population, i.e. the ovarian reserve, and be of value in
predicting reproductive lifespan. A full description of AMH production up to
the menopause has not been reported. Methodology/Principal Findings: By
searching the published literature for AMH concentrations in healthy
pre-menopausal females, and using our own data (combined n = 3,260) we have
generated and robustly validated the first model of AMH concentration from
conception to menopause. This model shows that 34% of the variation in AMH is
due to age alone. We have shown that AMH peaks at age 24.5 years, followed by a
decline to the menopause. We have also shown that there is a neonatal peak and
a potential pre-pubertal peak. Our model allows us to generate normative data
at all ages. Conclusions/Significance: These data highlight key inflection
points in ovarian follicle dynamics. This first validated model of circulating
AMH in healthy females describes a transition period in early adulthood, after
which AMH reflects the progressive loss of the NGF pool. The existence of a
neonatal increase in gonadal activity is confirmed for females. An improved
understanding of the relationship between circulating AMH and age will lead
more accurate assessment of ovarian reserve for the individual woman.
