  Our evolving understanding of the heterocellular cardiac environment demands
innovative tools for its study. While murine models are lauded for their
versatility and accessibility, they are constrained by scale; tools designed
for larger subjects are unsuitable in mice. Advanced techniques, such as
optical trans-membrane potential mapping and three-dimensional microscopy may
fill this void. To enhance the utility of these methods, we developed a novel
cross-correlation technique grounded in quaternion mathematics. The successful
integration of multimodal observations represents a significant advancement in
our ability to study cardiac electrophysiology in murine models, providing
insight into mechanisms previously unexplored due to technical constraints.
