  Active (catalysed) and passive (intrinsic) nucleosome repositioning is known
to be a crucial event during the transcriptional activation of certain
eucaryotic genes. Here we consider theoretically the intrinsic mechanism and
study in detail the energetics and dynamics of DNA-loop-mediated nucleosome
repositioning, as previously proposed by Schiessel et al. (H. Schiessel, J.
Widom, R. F. Bruinsma, and W. M. Gelbart. 2001. {\it Phys. Rev. Lett.}
86:4414-4417). The surprising outcome of the present study is the inherent
nonlocality of nucleosome motion within this model -- being a direct physical
consequence of the loop mechanism. On long enough DNA templates the longer
jumps dominate over the previously predicted local motion, a fact that
contrasts simple diffusive mechanisms considered before. The possible
experimental outcome resulting from the considered mechanism is predicted,
discussed and compared to existing experimental findings.
