  Starting from kinetic transport equations and subcellular dynamics we deduce
a multiscale model for glioma invasion relying on the go-or-grow dichotomy and
the influence of vasculature, acidity, and brain tissue anisotropy. Numerical
simulations are performed for this model with multiple taxis, in order to
assess the solution behavior under several scenarios of taxis and growth for
tumor and endothelial cells. An extension of the model to incorporate the
macroscopic evolution of normal tissue and necrotic matter allows us to perform
tumor grading.
