  We propose a scheme to investigate the interplay between Kondo-exchange
interaction and quantum spin Hall effect with ultracold fermionic
alkaline-earth atoms trapped in two-dimensional optical lattices using
ultracold collision and laser-assisted tunneling. In the strong Kondo-coupling
regime, though the loop trajectory of the mobile atom disappears, collective
dynamics of an atom pair in two clock states can exhibit an unexpected
spin-dependent cyclotron orbit in a plaquette, realizing the quantum spin Hall
effect of the Kondo singlet. We demonstrate that the collective cyclotron
dynamics of the spin-zero Kondo singlet is governed by an effective
Harper-Hofstadter model in addition to second-order diagonal tunneling.
