  Published survival data for Chinese hamster ovarian cells CHO-K1 and their
radiosensitive mutant xrs5 after irradiation by carbon ions of energies from
2.4 to 266.4 MeV/u have been analyzed using the probabilistic two-stage
radiobiological model, which enables to represent the interplay of damage
induction and repair processes. The results give support for the hypothesis
that the differences in radiation sensitivity of diverse cell lines are given
primarily by their different repair capabilities, and indicate the need for
explicitly representing the outcome of repair processes in radiobiological
models and treatment planning approaches in radiotherapy.
