  We present a calculation of the B0-B0--mixing including Next--to--Leading
Order (NLO) QCD corrections within the Two Higgs Doublet Model (2HDM). The QCD
corrections at NLO are contained in the factor denoted by eta_2 which modifies
the result obtained at the lowest order of perturbation theory. In the Standard
Model case, we confirm the results for eta_2 obtained by Buras, Jamin and
Weisz. The factor eta_2 is gauge and renormalization prescription invariant and
it does not depend on the infrared behaviour of the theory, which constitutes
an important test of the calculations. The NLO--calculations within the 2HDM
enhance the LO--result up to 18%, which affects the correlation between M_H and
V_{td}.
