  Driven by the development goal of network paradigm and demand for various
functions in the sixth-generation (6G) mission-critical Internet-of-Things
(MC-IoT), we foresee a goal-oriented integration of sensing, communication,
computing, and control (GIS3C) in this paper. We first provide an overview of
the tasks, requirements, and challenges of MC-IoT. Then we introduce an
end-to-end GIS3C architecture, in which goal-oriented communication is
leveraged to bridge and empower sensing, communication, control, and computing
functionalities. By revealing the interplay among multiple subsystems in terms
of key performance indicators and parameters, this paper introduces unified
metrics, i.e., task completion effectiveness and cost, to facilitate S3C
co-design in MC-IoT. The preliminary results demonstrate the benefits of GIS3C
in improving task completion effectiveness while reducing costs. We also
identify and highlight the gaps and challenges in applying GIS3C in the future
6G networks.
