  In this paper, we investigate the noncommutative KKLMMT D3/anti-D3 brane
inflation scenario in detail. Incorporation of the brane inflation scenario and
the noncommutative inflation scenario can nicely explain the large negative
running of the spectral index as indicated by WMAP three-year data and can
significantly release the fine-tuning for the parameter $\beta$. Using the WMAP
three year results (blue-tilted spectral index with large negative running), we
explore the parameter space and give the constraints and predictions for the
inflationary parameters and cosmological observables in this scenario. We show
that this scenario predicts a quite large tensor/scalar ratio and what is more,
a too large cosmic string tension (assuming that the string coupling $g_s$ is
in its likely range from 0.1 to 1) to be compatible with the present
observational bound. A more detailed analysis reveals that this model has some
inconsistencies according to the fit to WMAP three year results.
