  There is immense interest in how the local environment influences the
electronic structure of materials at the single layer limit. We characterize
moir\'e induced spatial variations in the electronic structure of in-situ grown
monolayer V2S3 on Au(111) by means of low temperature scanning tunneling
microscopy and spectroscopy. We observe a long-range modulation of the
integrated local density of states (LDOS), and quantify this modulation with
respect to the moir\'e superstructure for multiple orientations of the
monolayer with respect to the substrate. Scanning tunneling spectroscopy
reveals a prominent peak in the LDOS, which is shifted in energy at different
points of the moir\'e superstructure. Comparing ab initio calculations with
angle-resolved photoemission, we are able to attribute this peak to bands that
exhibit a large out-of-plane d-orbital character. This suggests that the
moir\'e driven variations in the measured density of states is driven by a
periodic modulation of the monolayer-substrate hybridization.
