  3 transmembrane and 4 transmembrane helices models are suggested for the
human vitamin K epoxide reductase (VKOR). In this study, we investigate the
stability of the human 3 transmembrane/4 transmembrane VKOR models employing a
coarse-grained normal mode analysis and molecular dynamics simulation. Based on
the analysis of the mobility of each transmembrane domain, we suggest that the
3 transmembrane human VKOR model is more stable than the 4 transmembrane human
VKOR model.
