  The genesis, growth and rupture of intracranial aneurysm (IA) are open
questions in neurovascular medicine until the present moment. The complexity of
aneurysm mechanobiology and pathobiology staggeringly combine intertwining
biological and physical processes that are tightly connected. Recently,
transition to turbulence in IA blood flow is thought to play a central role in
IA growth and rupture as it can be directly linked to endothelial dysfunction.
However, the problem of turbulence brings unprecedented complications to the
topic. We found turbulence in IA to be of non-Kolmogorov type. For the first
time, we detected inverse kinetic energy cascade in blood flow and in
non-Kolmogorov turbulence. Here, we hypothesize that the near-wall turbulence
undergoing inverse energy cascade have scales that could affect the
mechano-signaling of endothelial cells. Our findings could be a paradigm shift
in the contemporary theory of aneurysm hemodynamics.
