  Deciphering the complex interactions between neurotransmission and astrocytic
$Ca^{2+}$ elevations is a target promising a comprehensive understanding of
brain function. While the astrocytic response to excitatory synaptic activity
has been extensively studied, how inhibitory activity results to intracellular
$Ca^{2+}$ waves remains elusive. In this study, we developed a compartmental
astrocytic model that exhibits distinct levels of responsiveness to inhibitory
activity. Our model suggested that the astrocytic coverage of inhibitory
terminals defines the spatial and temporal scale of their $Ca^{2+}$ elevations.
Understanding the interplay between the synaptic pathways and the astrocytic
responses will help us identify how astrocytes work independently and
cooperatively with neurons, in health and disease.
