  Systems of D3-branes at orientifold singularities can receive
non-perturbative D-brane instanton corrections, inducing field theory operators
in the 4d effective theory. In certain non-chiral examples, these systems have
been realized as the infrared endpoint of a Seiberg duality cascade, in which
the D-brane instanton effects arise from strong gauge theory dynamics. We
present the first UV duality cascade completion of chiral D3-brane theories, in
which the D-brane instantons arise from gauge theory dynamics. Chiral examples
are interesting because the instanton fermion zero mode sector is topologically
protected, and therefore lead to more robust setups. As an application of our
results, we provide a UV completion of certain D-brane orientifold systems
recently claimed to produce conformal field theories with conformal invariance
broken only by D-brane instantons.
