  The purpose of this article is to infer patient level outcomes from
population level randomized control trials (RCTs). In this pursuit, we utilize
the recently proposed synthetic nearest neighbors (SNN) estimator. At its core,
SNN leverages information across patients to impute missing data associated
with each patient of interest. We focus on two types of missing data: (i)
unrecorded outcomes from discontinuing the assigned treatments and (ii)
unobserved outcomes associated with unassigned treatments. Data imputation in
the former powers and de-biases RCTs, while data imputation in the latter
simulates "synthetic RCTs" to predict the outcomes for each patient under every
treatment. The SNN estimator is interpretable, transparent, and causally
justified under a broad class of missing data scenarios. Relative to several
standard methods, we empirically find that SNN performs well for the above two
applications using Phase 3 clinical trial data on patients with Alzheimer's
Disease. Our findings directly suggest that SNN can tackle a current pain point
within the clinical trial workflow on patient dropouts and serve as a new tool
towards the development of precision medicine. Building on our insights, we
discuss how SNN can further generalize to real-world applications.
