  We study neutrino physics in a 5D supersymmetric SO(10) GUT. We analyze
several different choices for realizing the See-Saw mechanism. We find that the
"natural" scale for the Majorana mass of right-handed neutrinos depends
critically on whether the right-handed neutrinos are located in the bulk or
localized on a brane. In the former case, the effective Majorana mass is
"naturally" of order the compactification scale, about 10^{14} GeV. Note, this
is the value necessary for obtaining a light tau neutrino mass approximately
10^{-2} eV which, within the context of hierarchical neutrino masses, is the
right order of magnitude to explain atmospheric neutrino oscillations. On the
other-hand when the right-handed neutrino is localized on the brane, the
effective Majorana mass is typically larger than the compactification scale.
Nevertheless with small parameters of order 1/10 - 1/30, an effective Majorana
mass of order 10^{14} GeV can be accommodated. We also discuss the constraints
on model building resulting from the different scenarios for locating the
right-handed neutrinos.
