  We show that any two-dimensional system with a non-zero \textit{symmetric}
off-diagonal component of the resistance matrix, $R_{xy}=R_{yx} \neq 0$, must
have the in-plane rotational symmetry broken down to $C_2$. Such a resistance
response is Ohmic, and is different from the Hall response which is the
\textit{anti-symmetric} part of the resistance tensor, $R_{xy}=-R_{yx}$, is
rotationally symmetric in the 2D plane, and requires broken time-reversal
symmetry. We show how a minute amount of strain due to lattice mismatch - less
than $1 \%$ - can produce a vastly exaggerated symmetric off-diagonal response
- $\frac{R_{xy}}{R_{xx}} \sim 20\%$ - because of the momentum matching
constraints in a Moire system. Our results help explain an important new
transport experiment on graphene-WSe$_2$ heterostructures, as well as are
relevant for other experimental systems with rotational symmetry breaking, such
as nematic systems and Kagome charge density waves. Additionally, our work
predicts an example of a `magic' angle, $\theta\sim 27^0$, in a Moire system
which is a significant fraction of $\pi$. Our prediction that the anomalous
resistance anisotropy occurs at a large value of magic angle, in contrast to
known examples of magic angle transport anomalies that are small fractions of
$\pi$, can be experimentally tested in graphene-WSe$_2$ heterostructures.
