  Background: Gliomas are the most common brain tumors, which vary from low to
high-grade. Despite the improvements in imaging techniques in the last decade,
all parts of the tumor are not visible in these images, due to having a
threshold of detection often lower than most of the tumor. Method: We simulated
a brain domain to model heterogeneous growth plus gross total resection
following concurrent chemo- and radiation therapy and adjuvant chemotherapy
using temozolomide for a patient, diagnosed with glioblastoma, for different
radiobiological alpha parameter as high, medium, and low sensitivity. The
extent of difference in the result of treatment, area of the tumor, and
survival time relating to those sensitivity parameters were shown. Moreover,
based on the threshold of detection of MRI (T1Gd), the area of the tumor
visible to this imaging technique was simulated. Furthermore, the extent of
difference in the result of treatment for both conventional and
hyperfractionated radiotherapy was investigated. Conclusion: The survival time
of patient was increased by 2 months and more than 3 months at the lowest and
highest sensitivity of radiation therapy, respectively.The result showed
hyperfractionated radiotherapy was more effective than conventional
radiotherapy in reducing the concentration of cancerous cells,as
hyperfractionated method allows administration of higher total dose.
