  Microfluidics have emerged as a vital tool in various scientific and
engineering applications, ranging from biomedical diagnostics to chemical
analysis. However, conventional fabrication methods often necessitate costly
equipment and limiting accessibility, thereby hindering widespread adoption. In
response, this note presents a cost-effective approach for fabricating
microfluidic channels using photolithographic methods, which circumvents the
need for expensive instruments. The procedure commences with the preparation of
a suitable substrate, followed by the application of a photoresist layer. A
photomask, containing the desired microfluidic pattern, is then used to define
the layout on the photoresist-coated substrate. Upon exposure to ultraviolet
(UV) light, the photoresist undergoes a chemical transformation, allowing for
selective removal of either exposed or unexposed regions. Consequently, the
patterned microfluidic channels are unveiled on the substrate. The versatility
of this photolithographic method allows for the fabrication of intricate and
customizable microchannels with relative ease and precision. Further processing
steps, such as etching or surface treatment, optimize the substrate's
properties for specific applications. This low cost approach not only empowers
researchers and engineers to develop microfluidic devices at a fraction of the
cost but also fosters broader access to photolithography related research and
development. The enhanced accessibility opens doors to a myriad of
applications, ranging from advanced diagnostics and drug delivery systems to
portable point-of-care devices. Overall, this paper showcases a promising
avenue for expanding the reach of microfluidics, fostering innovation, and
driving impactful advancements in diverse scientific disciplines.
