  We report on OVRO, WISE, Swift and Fermi-LAT observations of the high
redshift blazar CGRaBS J0733+0456, from which significant flux variations in
radio, infrared (IR) as well as $\gamma$-ray domains are detected.
Particularly, the amplitude of long-term IR variation is over one order of
magnitude and the IR variability timescale can be constrained as short as a few
hours in the source frame. The IR and $\gamma$-ray light curves are found to be
rather similar, and the strong quasi-simultaneous infrared and $\gamma$-ray
flares are proved to be unique among the nearby $\gamma$-ray sources. This is
the first time to identify a $\gamma-$ray blazar at redshift $z\geq 3$ with
multi-wavelength flux variations (flares). Broadband spectral energy
distributions in different flux states are constructed and theoretically
described. The $\gamma-$ray flares from some blazars as distant as redshift
$\sim$ 5 are expected to be detectable for Fermi-LAT.
