  Biased Brownian motion of point-size particles in a three-dimensional tube
with smoothly varying cross-section is investigated. In the fashion of our
recent work [Martens et al., PRE 83,051135] we employ an asymptotic analysis to
the stationary probability density in a geometric parameter of the tube
geometry. We demonstrate that the leading order term is equivalent to the
Fick-Jacobs approximation. Expression for the higher order corrections to the
probability density are derived. Using this expansion orders we obtain that in
the diffusion dominated regime the average particle current equals the
zeroth-order Fick-Jacobs result corrected by a factor including the corrugation
of the tube geometry. In particular we demonstrate that this estimate is more
accurate for extreme corrugated geometries compared to the common applied
method using the spatially dependent diffusion coefficient D(x,f). The analytic
findings are corroborated with the finite element calculation of a
sinusoidal-shaped tube.
