  We present a web interface for the BioFET-SIM program. The web interface
allows to conveniently setup calculations based on the BioFET-SIM multiple
charges model. As an illustration, two case studies are presented. In the first
case, a generic peptide with opposite charges on both ends is inverted in
orientation on a semiconducting nanowire surface leading to a corresponding
change in sign of the computed sensitivity of the device. In the second case,
the binding of an antibody/antigen complex on the nanowire surface is studied
in terms of orientation and analyte/nanowire surface distance. We demonstrate
how the BioFET-SIM web interface can aid in the understanding of experimental
data and postulate alternative ways of antibody/antigen orientation on the
nanowire surface.
