  In this study, we analyze discordance between the transcriptome and proteome
using paired scRNA-Seq and multiplexed spatial proteomics data from HuBMAP. Our
findings highlight persistent transcripts in key immune markers, including
CD45-RO, Ki67, CD45, CD20, and HLA-DR. CD45-RO is consistently expressed in
memory T cells, while Ki67, associated with cell proliferation, also displays
sustained expression. Furthermore, HLA-DR, part of the MHC class II molecules,
demonstrates continuous expression, possibly crucial for APCs to trigger an
effective immune response. This investigation provides novel insights into the
complexity of gene expression regulation and protein function.
