  Here we review how environmental context can be used to interpret whether O2
is a biosignature in extrasolar planetary observations. This paper builds on
the overview of current biosignature research discussed in Schwieterman et al.
(2017), and provides an in-depth, interdisciplinary example of biosignature
identification and observation that serves as a basis for the development of
the general framework for biosignature assessment described in Catling et al.,
(2017). O2 is a potentially strong biosignature that was originally thought to
be an unambiguous indicator for life at high-abundance. We describe the
coevolution of life with the early Earth's environment, and how the interplay
of sources and sinks in the planetary environment may have resulted in
suppression of O2 release into the atmosphere for several billion years, a
false negative for biologically generated O2. False positives may also be
possible, with recent research showing potential mechanisms in exoplanet
environments that may generate relatively high abundances of atmospheric O2
without a biosphere being present. These studies suggest that planetary
characteristics that may enhance false negatives should be considered when
selecting targets for biosignature searches. Similarly our ability to interpret
O2 observed in an exoplanetary atmosphere is also crucially dependent on
environmental context to rule out false positive mechanisms. We describe future
photometric, spectroscopic and time-dependent observations of O2 and the
planetary environment that could increase our confidence that any observed O2
is a biosignature, and help discriminate it from potential false positives. By
observing and understanding O2 in its planetary context we can increase our
confidence in the remote detection of life, and provide a model for
biosignature development for other proposed biosignatures.
