  Dynamic nuclear polarization (DNP) has become a very important
hyperpolarization method because it can dramatically increase the sensitivity
of nuclear magnetic resonance (NMR) of various molecules. Liquid-state DNP
based on Overhauser effect is capable of directly enhancing polarizations of
all kinds of nuclei in the system. The combination of simultaneous Overhauser
multi-nuclei enhancements with the multi-nuclei parallel acquisitions provides
a variety of important applications in both MR spectroscopy (MRS) and image
(MRI). Here we present two simple illustrative examples for simultaneously
enhanced multi-nuclear spectra and images to demonstrate the principle and
superiority. We have observed very large simultaneous DNP enhancements for
different nuclei, such as 1H and 23Na, 1H and 31P, 19F and 31P, especially for
the first time to report sodium ion enhancement in liquid. We have also
obtained the simultaneous imaging of 19H and 31P at low field by solution-state
DNP for the first time. This method can obtain considerably complementary
structure-determination information of miscellaneous biomolecules from a single
measurement. It can also be used in combination with the fast acquisition
schemes and quantitative analysis with reduced scan time.
