  A library of substituted pyrimidines was synthesized and evaluated for free
radical scavenging, and in vitro cytotoxic activity in 3T3 cells. All compounds
showed good free radical scavenging activity with IC50 values in the range of
42.9 + 0.31 to 438.3 3.3 {\mu}M as compared to the standard butylated
hydroxytoluene having IC50 value of 128.83 2. 1 {\mu}M. The structure
activity-relationship was also established. Selected analogues 1, 2, 3, 5, 6,
7, 8, 9, 10, 12, 13, 15, 19, 20, 21, 24, 25, 26 and 28 were tested for
cytotoxicity in mouse fibroblast 3T3 cell line using MTT assay, and most of the
analogues showed cytotoxicity. This study has identified a number of cytotoxic
novel substituted pyrimidines having free radical scavenging activities that
can be used as inhibitory compounds for those cancer cells whose growth is
mediated by reactive oxygen species.
