  Recent experiment has observed Feshbach resonances between alkaline and
alkaline-earth atoms. These Feshbach resonances are insensitive to the nuclear
spin of alkaline-earth atoms. Ultilizing this feature, we propose to take this
system as a candidate to perform quantum simulation of the Kondo effect. An
alkaline atom can form a molecule with an alkaline-earth atom with different
nuclear spins, which plays the role of spin-exchange scattering responsible for
the Kondo effect. Furthermore, we point out that the existence of three-body
bound state and atom-molecule resonance due to the Efimov effect can enhance
this spin-exchange scattering, and therefore enhance the Kondo effect. We
discuss this mechanism first with a three-body problem in free space, and then
demonstrate that the same mechanism still holds when the alkaline atom is
localized by an external trap and becomes an impurity embedded in the
alkaline-earth atomic gases.
