  Background: Quantitative prediction of the adolescents' spherical equivalent
based on their variable-length historical vision records.
  Methods: From October 2019 to March 2022, we examined binocular uncorrected
visual acuity, axial length, corneal curvature, and axial of 75,172 eyes from
37,586 adolescents aged 6-20 years in Chengdu, China. 80\% samples consist of
the training set and the remaining 20\% form the testing set. Time-Aware Long
Short-Term Memory was used to quantitatively predict the adolescents' spherical
equivalent within two and a half years.
  Result: The mean absolute prediction error on the testing set was 0.273-0.257
for spherical equivalent, ranging from 0.189-0.160 to 0.596-0.473 if we
consider different lengths of historical records and different prediction
durations.
  Conclusions: Time-Aware Long Short-Term Memory was applied to captured the
temporal features in irregularly sampled time series, which is more in line
with the characteristics of real data and thus has higher applicability, and
helps to identify the progression of myopia earlier. The overall error 0.273 is
much smaller than the criterion for clinically acceptable prediction, say 0.75.
