  In 2014, Wang and Cai established the following harmonic congruence for any
odd prime $p$ and positive integer $r$, \begin{equation*}
Z(p^{r})\equiv-2p^{r-1}B_{p-3} ~(\bmod ~ p^{r}), \end{equation*} where $
Z(n)=\sum\limits_{i+j+k=n\atop{i,j,k\in\mathcal{P}_{n}}}\frac{1}{ijk}$ and
$\mathcal{P}_{n}$ denote the set of positive integers which are prime to $n$.
In this note, we obtain a congruence for distinct odd primes $p,~q$ and
positive integers $\alpha,~\beta$, \begin{equation*}
Z(p^{\alpha}q^{\beta})\equiv
2(2-q)(1-\frac{1}{q^{3}})p^{\alpha-1}q^{\beta-1}B_{p-3}\pmod{p^{\alpha}}
\end{equation*} and the necessary and sufficient condition for
\begin{equation*} Z(p^{\alpha}q^{\beta})\equiv 0\pmod{p^{\alpha}q^{\beta}}.
\end{equation*} Finally, we raise a conjecture that for $n>1$ and odd prime
power $p^{\alpha}||n$, $\alpha\geq1$, \begin{eqnarray} \nonumber Z(n)\equiv
\prod\limits_{q|n\atop{q\neq
p}}(1-\frac{2}{q})(1-\frac{1}{q^{3}})(-\frac{2n}{p})B_{p-3}\pmod{p^{\alpha}}.
\end{eqnarray}
