  Accessible machine learning algorithms, software, and diagnostic tools for
energy-efficient devices and systems are extremely valuable across a broad
range of application domains. In scientific domains, real-time near-sensor
processing can drastically improve experimental design and accelerate
scientific discoveries. To support domain scientists, we have developed hls4ml,
an open-source software-hardware codesign workflow to interpret and translate
machine learning algorithms for implementation with both FPGA and ASIC
technologies. We expand on previous hls4ml work by extending capabilities and
techniques towards low-power implementations and increased usability: new
Python APIs, quantization-aware pruning, end-to-end FPGA workflows, long
pipeline kernels for low power, and new device backends include an ASIC
workflow. Taken together, these and continued efforts in hls4ml will arm a new
generation of domain scientists with accessible, efficient, and powerful tools
for machine-learning-accelerated discovery.
