  The regulating mechanism of miRNA on p53 dynamics in p53-MDM2-miRNA model
network incorporating reactive oxygen species (ROS) is studied. The study shows
that miRNA drives p53 dynamics at various states, namely, stabilized states and
oscillating states (damped and sustain oscillation). We found the co-existence
of these states within certain range of the concentartion level of miRNA in the
system. This co-existence in p53 dynamics is the signature of the system's
survival at various states, normal, activated and apoptosis driven by a
constant concentration of miRNA.
