  We discuss SU(5) Grand Unified Theories in the context of orientifold
compactifications. Specifically, we investigate two and three D-brane stack
realizations of the Georgi-Glashow and the flipped SU(5) model and analyze them
with respect to their Yukawa couplings. As pointed out in arXiv:0909.0271 the
most economical Georgi-Glashow realization based on two stacks generically
suffers from a disastrous large proton decay rate. We show that allowing for an
additional U(1) D-brane stack this as well as other phenomenological problems
can be resolved. We exemplify with globally consistent Georgi-Glashow models
based on RCFT that these D-brane quivers can be indeed embedded in a global
setting. These globally consistent realizations admit rigid O(1) instantons
inducing the perturbatively missing coupling 10105^H. Finally we show that
flipped SU(5) D-brane realizations even with multiple U(1) D-brane stacks are
plagued by severe phenomenological drawbacks which generically cannot be
overcome.
