  Context. The knowledge of abundance distributions is central to understanding
the formation and evolution of galaxies. Most of the relations employed for the
derivation of gas abundances have so far been derived from observations of
outer disk HII regions, despite the known differences between inner and outer
regions. Aims. Using integral field spectroscopy (IFS) observations we aim to
perform a systematic study and comparison of two inner and outer HII regions
samples. The spatial resolution of the IFS, the number of objects and the
homogeneity and coherence of the observations allow a complete characterization
of the main observational properties and differences of the regions. Methods.
We analyzed a sample of 725 inner HII regions and a sample of 671 outer HII
regions, all of them detected and extracted from the observations of a sample
of 263 nearby, isolated, spiral galaxies observed by the CALIFA survey.
Results. We find that inner HII regions show smaller equivalent widths, greater
extinction and luminosities, along with greater values of
[NII]{\lambda}6583/H{\alpha} and [OII]{\lambda}3727/[OIII]{\lambda}5007
emission-line ratios, indicating higher metallicites and lower ionization
parameters. Inner regions have also redder colors and higher photometric and
ionizing masses, although Mion/Mphot is slighty higher for the outer regions.
Conclusions. This work shows important observational differences between inner
and outer HII regions in star forming galaxies not previously studied in
detail. These differences indicate that inner regions have more evolved stellar
populations and are in a later evolution state with respect to outer regions,
which goes in line with the inside-out galaxy formation paradigm.
