  Computational models have great potential to accelerate bioscience,
bioengineering, and medicine. However, it remains challenging to reproduce and
reuse simulations, in part, because the numerous formats and methods for
simulating various subsystems and scales remain siloed by different software
tools. For example, each tool must be executed through a distinct interface. To
help investigators find and use simulation tools, we developed BioSimulators
(https://biosimulators.org), a central registry of the capabilities of
simulation tools and consistent Python, command-line, and containerized
interfaces to each version of each tool. The foundation of BioSimulators is
standards, such as CellML, SBML, SED-ML, and the COMBINE archive format, and
validation tools for simulation projects and simulation tools that ensure these
standards are used consistently. To help modelers find tools for particular
projects, we have also used the registry to develop recommendation services. We
anticipate that BioSimulators will help modelers exchange, reproduce, and
combine simulations.
