  We proposed a deconvolution optical-resolution photoacoustic microscope for
high -resolution imaging of brain. The focal spot of the photoacoustic
microscopy is measured to obtain the lateral PSF (point spread function) of the
system. Making the measured PSF as the initial system PSF to perform Lucy-
Richardson (LR) deconvolution. The image resolution of cerebral vasculature
obtained by this method is higher. The full width at half maximum (FWHM) of the
width of blood vessel before and after deconvolution are 7 micrometers and 3.6
micrometers, respectively, and the image definition is increased by about 1.9
times. Experiments show that this method can further improve the clarity of
photoacoustic images of cerebral vasculature, which lays the foundation for
further research on brain imaging.
