  Magnetic resonance image (MRI) in high spatial resolution provides detailed
anatomical information and is often necessary for accurate quantitative
analysis. However, high spatial resolution typically comes at the expense of
longer scan time, less spatial coverage, and lower signal to noise ratio (SNR).
Single Image Super-Resolution (SISR), a technique aimed to restore
high-resolution (HR) details from one single low-resolution (LR) input image,
has been improved dramatically by recent breakthroughs in deep learning. In
this paper, we introduce a new neural network architecture, 3D Densely
Connected Super-Resolution Networks (DCSRN) to restore HR features of
structural brain MR images. Through experiments on a dataset with 1,113
subjects, we demonstrate that our network outperforms bicubic interpolation as
well as other deep learning methods in restoring 4x resolution-reduced images.
