  Background: This study aims to investigate whether maternal SARS-CoV-2 status
affect placental pathology. Methods: A retrospective case-control study was
conducted by reviewing charts and slides of placentas between April 1 to July
24, 2020. Clinical history of COVID-19 were searched in Pathology Database
(CoPath). Controls were matched with SARS-CoV-2-negative women with singleton
deliveries in the 3rd-trimester. Individual and group, pathological features
were extracted from placental pathology reports. Results: Twenty-one
3rd-trimester, placentas from SARS-CoV-2-positive women were identified and
compared to 20 placentas from SARS-CoV-2-negative women. There were no
significant differences in individual or group gross or microscopic
pathological features between the groups. Within the SARS-CoV-2+ group, there
are no differences between symptomatic and asymptomatic women. Conclusion:
Placentas from SARS-CoV-2-positive women do not demonstrate a specific
pathological pattern. Pregnancy complicated with COVID-19 during the 3rd
trimester does not have a demonstrable effect on placental structure and
pathology.
