  Summary: More sophisticated models are needed to address problems in
bioscience, synthetic biology, and precision medicine. To help facilitate the
collaboration needed for such models, the community developed the Simulation
Experiment Description Markup Language (SED-ML), a common format for describing
simulations. However, the utility of SED-ML has been hampered by limited
support for SED-ML among modeling software tools and by different
interpretations of SED-ML among the tools that support the format. To help
modelers debug their simulations and to push the community to use SED-ML
consistently, we developed a tool for validating SED-ML files. We have used the
validator to correct the official SED-ML example files. We plan to use the
validator to correct the files in the BioModels database so that they can be
simulated. We anticipate that the validator will be a valuable tool for
developing more predictive simulations and that the validator will help
increase the adoption and interoperability of SED-ML.
  Availability: The validator is freely available as a webform, HTTP API,
command-line program, and Python package at
https://run.biosimulations.org/utils/validate and
https://pypi.org/project/biosimulators-utils. The validator is also embedded
into interfaces to 11 simulation tools. The source code is openly available as
described in the Supplementary data.
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