  Polarization-sensitive optical coherence tomography (PS-OCT) is a promising
biomedical imaging tool for differentiation of various tissue properties.
However, the presence of multiple-scattering (MS) signals can degrade the
quantitative polarization measurement accuracy. We demonstrate a method to
reduce MS signals and increase the measurement accuracy of Jones matrix PS-OCT.
This method suppresses MS signals by averaging of multiple Jones matrix volumes
measured using different focal positions. The MS signals are decorrelated among
the volumes by focus position modulation and are thus reduced by averaging.
However, the single scattering signals are kept consistent among the
focus-modulated volumes by computational refocusing. We validated the proposed
method using a scattering phantom and a postmortem medaka fish. The results
showed reduced artifacts in birefringence and degree-of-polarization uniformity
measurements, particularly in deeper regions in the samples. This method offers
a practical solution to mitigate MS-induced artifacts in PS-OCT imaging and
improves quantitative polarization measurement accuracy.
