  We report a search for an anomalous excess of inclusive charged-current (CC)
$\nu_e$ interactions using the Wire-Cell event reconstruction package in the
MicroBooNE experiment, which is motivated by the previous observation of a
low-energy excess (LEE) of electromagnetic events from the MiniBooNE
experiment. With a single liquid argon time projection chamber detector, the
measurements of $\nu_{\mu}$ CC interactions as well as $\pi^0$ interactions are
used to constrain signal and background predictions of $\nu_e$ CC interactions.
A data set collected from February 2016 to July 2018 corresponding to an
exposure of 6.369 $\times$ 10$^{20}$ protons on target from the Booster
Neutrino Beam at FNAL is analyzed. With $x$ representing an overall
normalization factor and referred to as the LEE strength parameter, we select
56 fully contained $\nu_e$ CC candidates while expecting 69.6 $\pm$ 8.0 (stat.)
$\pm$ 5.0 (sys.) and 103.8 $\pm$ 9.0 (stat.) $\pm$ 7.4 (sys.) candidates after
constraints for the absence (eLEE$_{x=0}$) of the median signal strength
derived from the MiniBooNE observation and the presence (eLEE$_{x=1}$) of that
signal strength, respectively. Under a nested hypothesis test using both rate
and shape information in all available channels, the best-fit $x$ is determined
to be 0 (eLEE$_{x=0}$) with a 95.5% confidence level upper limit of $x$ at
0.502. Under a simple-vs-simple hypotheses test, the eLEE$_{x=1}$ hypothesis is
rejected at 3.75$\sigma$, while the eLEE$_{x=0}$ hypothesis is shown to be
consistent with the observation at 0.45$\sigma$. In the context of the eLEE
model, the estimated 68.3% confidence interval of the $\nu_e$ hypothesis to
explain the LEE observed in the MiniBooNE experiment is disfavored at a
significance level of more than 2.6$\sigma$ (3.0$\sigma$) considering
MiniBooNE's full (statistical) uncertainties.
