  Aggregation of protein into bundles is responsible for many neurodegenerative
diseases. In this work, we show how two-patch colloidal particles self assemble
into chains and a sudden transition to bundles takes place by tuning the patch
size and solvent condition. We study the kinetics of formation of chains,
bundles and network like structures using Patchy Brownian cluster dynamics. We
also analyse the ways to inhibit and accelerate the formation of these bundles.
We show that in presence of inert immobile obstacles, the kinetics of formation
of bundles slows down. Whereas, in presence of mobile aggregating particles
which exhibit inter-particle attraction and intra-particle repulsion, the
kinetics of bundle formation accelerates slightly. We also show that if we
introduce mobile obstacles which exhibit intra-particle attraction and
inter-particle hard sphere repulsion, the kinetics of formation of bundles is
inhibited. This is similar to the inhibitory effect of peptide P4 on the
formation of insulin fibres. We are providing a model of mobile obstacles
undergoing directional interactions to inhibit the formation of bundles.
