  Structural biology aims at characterizing the structural and dynamic
properties of biological macromolecules at atomic details. Gaining insight into
three dimensional structures of biomolecules and their interactions is critical
for understanding the vast majority of cellular processes, with direct
applications in health and food sciences. Since 2010, the WeNMR project
(www.wenmr.eu) has implemented numerous web-based services to facilitate the
use of advanced computational tools by researchers in the field, using the high
throughput computing infrastructure provided by EGI. These services have been
further developed in subsequent initiatives under H2020 projects and are now
operating as Thematic Services in the European Open Science Cloud (EOSC) portal
(www.eosc-portal.eu), sending >12 millions of jobs and using around 4000
CPU-years per year. Here we review 10 years of successful e-infrastructure
solutions serving a large worldwide community of over 23,000 users to date,
providing them with user-friendly, web-based solutions that run complex
workflows in structural biology. The current set of active WeNMR portals are
described, together with the complex backend machinery that allows distributed
computing resources to be harvested efficiently.
