  Symmetry lies at the heart of 2D bioelectronics, determining material
properties at the fundamental level. Breaking the symmetry allows emergent
functionalities and effects. However, symmetry modulation in 2D bioelectronics
and the resultant applications have been largely overlooked. Here we devise an
oxidized architectural MXene, referred as OXene, that couples orbit symmetric
breaking with inverse symmetric breaking to entitle the optimized interfacial
impedance and Schottky-induced piezoelectric effects. The resulting OXene
validates applications ranging from microelectrode arrays, gait analysis,
active transistor matrix, and wireless signaling transmission, which enables
highly-fidelity signal transmission and reconfigurable logic gates. Further
OXene interfaces are investigated in both rodent and porcine myocardium,
featuring high-quality and spatiotemporally resolved physiological recordings,
while accurate differentiated predictions, enabled via various machine learning
pipelines.
