  Intrinsically disordered proteins are fascinating the community of protein
science since the last decade, at least. There is a well-established line of
research that intends to reveal the crucial role played by intrinsically
disordered proteins (IDPs) in the development of human diseases. The main
argument is that IDPs are differentially more present in groups of
disease-related proteins. In this note we compare the frequency of disorder in
human proteins, both disease-related and not. The frequency of disorder is
comparable in the two sub-groups of proteins. Disorder is widespread in human
proteins, but it is not a specific pre-requisite of proteins involved in the
development of cancer, cardiovascular diseases, diabetes and neurodegenerative
diseases. A tendency of cancer-related proteins to be statistically more
disordered than the rest of human proteins is confirmed.
