  We prove that the Riemannian Penrose Inequality holds for Asymptotically Flat
$3$-manifolds with nonnegative scalar curvature and a connected horizon
boundary, provided the optimal decay assumptions are met, which result in the
$\mathrm{ADM}$ mass being a well-defined geometric invariant. Our proof builds
on new asymptotic comparison arguments involving Huisken's Isoperimetric mass
and the Hawking mass, as well as a novel interplay between the Hawking mass and
a potential-theoretic version of it, recently introduced by Agostiniani,
Oronzio and the third named author. As a crucial step in our argument, we
establish a Riemannian Penrose Inequality in terms of the Isoperimetric mass,
on any $3$-manifold with nonnegative scalar curvature and connected horizon
boundary, on which a well posed notion of weak Inverse Mean Curvature Flow is
available. In particular, such an Isoperimetric Riemannian Penrose Inequality
does not require the asymptotic flatness of the manifold.
