  In this study, we compare the charge transport properties of multiple (double
stranded) dsRNA sequences with corresponding dsDNA sequences. Recent studies
have presented a contradictory picture of relative charge transport
efficiencies in A-form DNA:RNA hybrids and dsDNA. Using a multiscale modelling
framework, we compute conductance of dsDNA and dsRNA using Landauer formalism
in coherent limit and Marcus-Hush theory in the incoherent limit. We find that
dsDNA conducts better than dsRNA in both the charge transport regimes. Our
analysis shows that the structural differences in the twist angle and slide of
dsDNA and dsRNA are the main reasons behind the higher conductance of dsDNA in
the incoherent hopping regime. In the coherent limit however, for the same base
pair length, the conductance of dsRNA is higher than that of dsDNA for the
morphologies where dsRNA has smaller end-to-end length relative to that of
dsDNA.
