  Motivated by the flavor anomalies in $b \to s$ transitions, we embed minimal
models with a $Z'$ gauge boson, vector-like fermions, and a singlet scalar in
the framework of trans-Planckian asymptotic safety. The presence of a fixed
point in the renormalization group flow of the models' parameters leads to
predictions for the $\gamma/Z'$ kinetic mixing, the New Physics Yukawa
couplings, and the quartic couplings of the scalar potential. We derive the
constraint on the kinetic mixing from the most recent high-mass dilepton
resonance searches at the LHC, showing that this bound is often inescapable in
this framework, unless the U(1) charges conspire to forbid the radiative
generation of kinetic mixing. In the latter case, the parameter space
consistent with the flavor anomalies can still be probed in depth by direct LHC
searches for heavy vector-like quarks and leptons. We derive the current
exclusion bounds and projections for future high-luminosity runs.
