  In some patients of myeloproliferative neoplasm, two genetic mutations can be
found: JAK2 V617F and TET2. When one mutation is present or not, the other
mutation has different effects on regulating gene expressions. Besides, when
both mutations are present, the order of occurrence might make a difference. In
this paper, we build nonlinear ordinary differential equation models and Markov
chain models to explain such phenomena.
