  It is theoretically well established that a spin-dependent electron
transmission generally appears in chiral systems, even without magnetic
components, as long as a strong spin-orbit coupling is present in some of its
elements. However, how this translates into the so-called chirality-induced
spin selectivity in experiments, where the system is taken out of equilibrium,
is still debated. Aided by non-equilibrium DFT-based quantum transport
calculations, here we show that, when spatial symmetries that forbid a finite
spin polarization in equilibrium are broken, a \textit{net} spin accumulation
appears at finite bias in an arbitrary two-terminal nanojunction. Furthermore,
when a suitably magnetized detector is introduced in the system, the net spin
accumulation, in turn, translates into a finite magneto-conductance. The
symmetry prerequisites are mostly analogous to those for the spin polarization
at any bias, with the vectorial nature given by the direction of magnetization.
