  We propose an integrated surface enhanced Raman scattering (SERS) chip based
on liquid-core waveguide with total reflection, through which the depression of
leaky mode enable a long propagating distance. An Raman enhancement factor for
rhodamine 6G of 2.5*105 is obtained, and a excellent repeatability is shown.
The peaks in the SERS spectrum of DNA of silkworm clearly illustrate the
information of the molecule structure. The integration of the SERS substrate,
micro-fluid, and liquid-core waveguide make such a SERS chip attractive for
biochemical detection with high performance.
