  We study variation of the proton-to-electron mass ratio $ \mu=m_{p}/m_{e} $
by incorporating standard model (SM) of particle physics into an extended
Brans-Dicke theory. We show that the evolution of the Higgs vacuum expectation
value (VEV), with expansion of the Universe, leads to the variation of the
proton-to-electron mass ratio. This is because the electron mass is
proportional to the Higgs VEV, while the proton mass is mainly dependent on the
quantum chromodynamics (QCD) energy scale, i.e., $ \Lambda_{QCD} $. Therefore,
using the experimental and cosmological constraints on the variation of the $
\mu $ we can constrain the variation of the Higgs VEV. This study is important
in understanding the recent claims of the detection of a variation of the
proton-to-electron mass ratio in quasar absorption spectra.
