  Fruit of the relationship of our research group with the team coordinated by
the biologist Miguel Morales (http://spineup.es), we have applied different
topo-geometric techniques for neuronal image processing. The images, captured
with a powerful confocal microscope, allow to study the evolution of synaptic
density under the influence of various substances, with the aim of studying
neurodegenerative diseases like Alzheimer.
  In the paper we make a brief review of the techniques that appear in our
bioinformatic problems, including the calculation of ordinary and persistent
homology (for which one can use the program Kenzo for symbolic computation in
algebraic topology ) and classical problems of digital topology as skeleton
location and path tracking. We focus on some particular cases of recent
application, with which we will illustrate the previous techniques.
