  It is well-known that thermal leptogenesis through the decays of the lightest
right-handed neutrinos encounters serious difficulties when SO(10)-inspired
mass conditions are imposed on the Dirac neutrino mass matrix and light
neutrino masses are generated through the type I see-saw mechanism. We show
that these can be circumvented when the production from the next-to-lightest
right-handed neutrinos and flavor effects are properly taken into account. Some
conditions on the low energy parameters have to be satisfied in order for
inverse processes involving the lightest right-handed neutrino not to wash-out
the asymmetry. In particular we find m_1 \gtrsim 0.001 eV, where m_1 is the
mass of the lightest left-handed neutrino and that non-vanishing values of the
mixing angle theta_13 are preferred in the case of a normal fully hierarchical
spectrum of light neutrinos.
