  Multi-modal image registration is a challenging task that is vital to fuse
complementary signals for subsequent analyses. Despite much research into cost
functions addressing this challenge, there exist cases in which these are
ineffective. In this work, we show that (1) this is true for the registration
of in-vivo Drosophila brain volumes visualizing genetically encoded calcium
indicators to an nc82 atlas and (2) that machine learning based contrast
synthesis can yield improvements. More specifically, the number of subjects for
which the registration outright failed was greatly reduced (from 40% to 15%) by
using a synthesized image.
