  With the ongoing global pandemic of coronavirus disease 2019 (COVID-19),
there is an increasing quest for more accessible, easy-to-use, rapid,
inexpensive, and high accuracy diagnostic tools. Traditional disease diagnostic
methods such as qRT-PCR (quantitative reverse transcription-PCR) and ELISA
(enzyme-linked immunosorbent assay) require multiple steps, trained
technicians, and long turnaround time that may worsen the disease surveillance
and pandemic control. In sight of this situation, a rapid, one-step,
easy-to-use, and high accuracy diagnostic platform will be valuable for future
epidemic control especially for regions with scarce medical resources. Herein,
we report a magnetic particle spectroscopy (MPS) platform for detection of
SARS-CoV-2 biomarkers: spike and nucleocapsid proteins.
