  Compressive Raman is a recent framework that allows for large data
compression of microspectroscopy during its measurement. Because of its
inherent multiplexing architecture, it has shown imaging speeds considerably
higher than conventional Raman microspectroscopy. Nevertheless, the low
signal-to-noise (SNR) of Raman scattering still poses challenges for
high-sensitivity bio-imaging exploiting compressive Raman: (i) the idle solvent
acts as a background noise upon imaging small biological organelles, (ii)
current compressive spectrometers are lossy precluding high-sensitivity
imaging. We present inexpensive high-throughput spectrometer layouts for
high-sensitivity compressive hyperspectroscopy. We exploit various modalities
of compressive Raman allowing for up to 80X reduction of data storage and 2X
microspectroscopy speed up at a 230-nm spatial resolution. Such achievements
allowed us to chemically image sub-diffraction-limited biological specimens
(lipid bilayers) in few seconds.
