  The measurement of Higgs self-coupling is one of the most crucial physics
goals at the future colliders. At the LHC, the di-Higgs production is a main
way to measure the Higgs trilinear coupling. As a complementary to the di-Higgs
production, $t \bar{t} hh$ process may open a new avenue to measure di-Higgs
physics at the LHC and a future 100 TeV $pp$ collider or a high energy $e^+e^-$
collider since the extra $t\bar t$ in the final states may efficiently suppress
the backgrounds. However, such a kind of process is also controlled by the
top-Higgs coupling. In this work, we investigate the impact of CP-violating
top-Higgs coupling on $t\bar{t}hh$ production at the LHC, ILC and a 100 TeV
hadron collider under the current Higgs data. Within 2$\sigma$ Higgs data
allowed parameter region, we find that the cross section of $t\bar{t}hh$ at the
LHC-14 TeV, ILC-1 TeV and VHE-LHC/SPPC-100 TeV can be enhanced up to 2.1 times
the SM predictions. The future precise measurement of Higgs coupling will
reveal the nature of top-Higgs interaction and improve the sensitivity of the
determination of Higgs self-coupling through $t\bar{t}hh$ production.
