  The recent zoonotic coronavirus virus outbreak of a novel type [COVID 19] has
necessitated the adequate understanding of the evolutionary pathway of zoonotic
viruses which adversely affects human populations for therapeutic constructs to
combat the pandemic now and in the future. We analyzed conserved domains of the
severe acute respiratory coronavirus 2 [SARS-CoV2] for possible targets of
viral entry inhibition in host cells, evolutionary relationship of human
coronavirus [229E] and zoonotic coronaviruses with SAR-CoV2 as well as
evolutionary relationship between selected SARS-CoV 2 genomic data. Conserved
domains with antagonistic action on host innate antiviral cellular mechanisms
in SARS-CoV 2 include nsp 11, nsp 13 etc. Also, multiple sequence alignments of
the spike [S] gene protein of selected candidate zoonotic coronaviruses
alongside the S gene protein of the SARs-CoV2 revealed closest evolutionary
relationship [95.6%] with pangolin coronaviruses [S] gene. Clades formed
between Wuhan SARS-CoV2 phylogeny data and five others suggests viral entry
trajectory while revealing genomic and protein SARS CoV 2 data from Philippines
as early ancestors. Therefore, phylogeny of SARS-CoV 2 genomic data suggests
profiling in diverse populations with and without the outbreak alongside
migration history and racial background for mutation tracking and dating of
viral subtype divergence which is essential for effective management of present
and future zoonotic coronavirus outbreaks.
