  I present a discussion of some open issues in the philosophy of space-time
theories. Emphasis is put on the ontological nature of space and time, the
relation between determinism and predictability, the origin of irreversible
processes in an expanding Universe, and the compatibility of relativity and
quantum mechanics. In particular, I argue for a Parmenidean view of time and
change, I make clear the difference between ontological determinism and
predictability, propose that the origin of the asymmetry observed in physical
processes is related to the existence of cosmological horizons, and present a
non-local concept of causality that can accommodate both special relativity and
quantum entanglement.
