  The fate of massive stars up to 300 Msun is highly uncertain. Do these
objects produce pair-instability explosions, or normal Type Ic supernovae? In
order to address these questions, we need to know their mass-loss rates during
their lives. Here we present mass-loss predictions for very massive stars (VMS)
in the range of 60-300 Msun. We use a novel method that simultaneously predicts
the wind terminal velocities (vinf) and mass-loss rate (dM/dt) as a function of
the stellar parameters: (i) luminosity/mass Gamma, (ii) metallicity Z, and
(iii) effective temperature Teff. Using our results, we evaluate the likely
outcomes for the most massive stars.
