  The control of electromechanical responses within bonding regions is
essential to face frontier challenges in nanotechnologies, such as molecular
electronics and biotechnology. Here, we present I\b{eta}-nanocellulose as a
potentially new orthotropic 2D piezoelectric crystal. The predicted in-layer
piezoelectricity is originated on a sui-generis hydrogen bonds pattern. Upon
this fact and by using a combination of ab-initio and ad-hoc models, we
introduce a description of electrical profiles along chemical bonds. Such
developments lead to obtain a rationale for modelling the extended
piezoelectric effect originated within bond scales. The order of magnitude
estimated for the 2D I\b{eta}-nanocellulose piezoelectric response, ~pm V-1,
ranks this material at the level of currently used piezoelectric energy
generators and new artificial 2D designs. Such finding would be crucial for
developing alternative materials to drive emerging nanotechnologies.
