  We evaluate the effectiveness of different classical potentials to predict
the thermodynamics of a number of organic solid form polymorphs relative to
experimentally reported values using the quasi-harmonic approximation. Using
the polarizable potential AMOEBA we are able to predict the correct sign of the
enthalpy difference for 71+/-12 % of the polymorphs. Alternatively, all point
charge potentials perform on par with random chance of correcting the correct
sign (50%) for enthalpy. We find that the entropy is less sensitive to the
accuracy of the potential with all force fields, excluding CGenFF, reporting
the correct sign of the entropy for 64+/-13 - 75+/-11 % of the systems.
Predicting the correct sign of the enthalpy and entropy differences can help
indicate the low and high temperature stability of the polymorphs,
unfortunately the error relative to experiment in these predicted values can be
as large as 1 - 2.5 kcal/mol at the transition temperature.
