  Hemostasis and thrombosis are often thought as two sides of the same clotting
mechanism whereas hemostasis is a natural protective mechanism to prevent
bleeding and thrombosis is a blood clot abnormally formulated inside a blood
vessel, blocking the normal blood flow. The evidence to date suggests that at
least arterial thrombosis results from the same critical pathways of
hemostasis. Analysis of these complex processes and pathways using quantitative
systems pharmacological model-based approach can facilitate the delineation of
the causal pathways that lead to the emergence of thrombosis. In this paper, we
provide an overview of the main molecular and physiological mechanisms
associated with hemostasis and thrombosis, and review the models and
quantitative system pharmacological modeling approaches that are relevant in
characterizing the interplay among the multiple factors and pathways of
thrombosis. An emphasis is given to computational models for drug development.
Future trends are discussed.
