  Interpreting 21cm measurements from current and upcoming experiments like
HERA and the SKA will provide new scientific insights and exciting implications
for astrophysics and cosmology regarding the Epoch of Reionization (EoR).
Several recent works have proposed using machine learning methods, such as
convolutions neural networks (CNNs), to analyze images of reionization
generated by these experiments since they could take full advantage of
information contained in the image. Generally, these studies have used only a
single semi-numeric method to generate the input 21cm data. In this work, we
investigate the extent to which training CNNs for reionization applications
depends on the underlying semi-numeric models. Working in the context of
predicting CMB optical depth from 21cm images, we compare networks trained on
similar datasets from 21cmfast and zreion, two widely used semi-numeric
reionization methods. We show that neural networks trained on input data from
only one model produce poor predictions on data from the other model.
Satisfactory results are only achieved when both models are included in the
training data. This finding has important implications for future analyses on
observation data, and encourages the use of multiple models to produce images
that capture the full complexity of the EoR.
