  Medical non-adherence increasingly is recognized as a major medical health
problem. Approximately 50% of patients do not take their medications as
prescribed and such poor adherence has been shown to result in complications,
death, and increased health care costs. This problem becomes even more
significant for patients with chronic illness and those who need to take
medications lifetime, like transplant patients. Studies show that one-half of
rejection episodes and 15% of graft losses happen due to immunosuppression
medications non-adherence. This article explores factors that have an impact on
non-compliant behavior among transplant patients: patient factors, illness
factor, therapeutic regimen factors. Using user-centered design thinking
approach a set of hypotheses are defined and discussed strategies to enhance
adherence by using mobile technology and gamification techniques.
