  SPAD cameras offer single photon detection sensitivity, high frame rates and
zero readout noise. They are a core technology for widefield FLIM, but have
further potential in ultra-fast imaging applications. However, in practice
sensitivity falls behind that of EMCCD and sCMOS devices due to the lower
photon detection efficiency of SPAD arrays. This paper considers the
application of a binary SPAD camera to the capture of blinking molecules as
part of a superresolution (dSTORM/PALM) experiment. Simulation and experimental
studies demonstrate that the effective sensitivity of the camera can be
improved significantly by aggregation of signal only binary frames. The
simulations also indicate that with future advances in SPAD camera technology,
SPAD devices could in time outperform existing scientific cameras when
capturing fast temporal dynamics.
