  Organogenesis is a tightly regulated process that has been studied
experimentally for decades. We are developing mechanistic models for the
morphogenesis of limbs, lungs, and kidneys with a view to integrate available
knowledge and to better understand the underlying regulatory logic. In our
previous paper on simulating organogenesis in COMSOL (German et al COMSOL Conf
Procedings 2011) we discussed methods to efficiently solve such models,
predominantly on a static domain. Organ size, however, changes dramatically
during development, and tissues are composed of several layers that may expand
both together or independently. Moreover, the developing organ are typically
embedded in an environment, and diffusional exchange with this environment can
affect the patterning process. Here we discuss methods to build and efficiently
solve models involving large deformation of composite domains in COMSOL
Multiphysics.
