  In this work, we virtually study the intra-arterial targeted drug delivery.
Specifically, this work models and quantifies the uncertainties associated with
catheter steerability limitations. We classify catheter's limited steerability
into two types, i.e., zero steerability, and wall pressing steerability.
Further, we investigate the effects of steerability limitations on uncertainty
of causing systemic toxicity levels, i.e., percentage of drug particles missing
target. Proposed method quantifies the uncertainty of causing systemic toxicity
in terms of probability. With this calculation approach, we look at the effects
of upstream vasculature and catheter tip size. Results indicate the existence
of a 'transition toxicity' level. Beyond transition toxicity level, larger
catheters should be preferred over smaller catheters. Furthermore, we found
that it is relatively easier to decide preferrable catheter size in
zero-steerability than wall-pressing steerability conditions.
