  The associated production of top-antitop-bottom-antibottom quarks is a
relevant irreducible background for Higgs boson analyses in the
top-antitop-Higgs production channel, with Higgs decaying into a
bottom-antibottom quark pair. We implement this process in the PowHel event
generator, considering the bottom quarks as massive in all steps of the
computation which involves hard-scattering matrix-elements in the 4-flavour
number scheme combined with 4-flavour Parton Distribution Functions.
Predictions with NLO QCD + Parton Shower accuracy, as obtained by PowHel +
PYTHIA, are compared to those which resulted from a previous PowHel
implementation with hard-scattering matrix-elements in the 5-flavour number
scheme, considering as a baseline the example of a realistic analysis of
top-antitop hadroproduction with additional $b$-jet activity, performed by the
CMS collaboration at the Large Hadron Collider.
