  The main types of negative internal and external influences on complex
network systems (NS) and intersystem interactions in monoflow partially
overlapped multilayer network systems (MLNS) are analyzed. Among such
influences, targeted attacks on real complex systems and their non-targeted
damages of various nature are primarily singled out. On the basis of structural
and flow models of NS and MLNS, sequential and simultaneous local, group and
system-wide damages to the structure and operation process of complex network
systems and intersystem interactions are considered. The existing structural
and functional scenarios of consecutive attacks on the most important
components of the system and the need to neutralize the sources of such attacks
as one of the means of system protection are analyzed. The peculiarities of
application of such scenarios for the protection of NS and MLNS from
system-wide non-target lesions are considered. Approaches to evaluation and
overcoming the consequences of negative impacts on the structure and operation
process of complex network systems and intersystem interactions are proposed.
