  Objective: To develop a high-throughput biomedical relation extraction system
that takes advantage of the large language models'(LLMs) reading comprehension
ability and biomedical world knowledge in a scalable and evidential manner.
Methods: We formulate the relation extraction task as binary classifications
for large language models. Specifically, LLMs make the decision based on the
external corpus and its world knowledge, giving the reason for the judgment for
factual verification. This method is tailored for semi-structured web articles,
wherein we designate the main title as the tail entity and explicitly
incorporate it into the context, and the potential head entities are matched
based on a biomedical thesaurus. Moreover, lengthy contents are sliced into
text chunks, embedded, and retrieved with additional embedding models. Results:
Using an open-source LLM, we extracted 248659 relation triplets of three
distinct relation types from three reputable biomedical websites. To assess the
efficacy of the basic pipeline employed for biomedical relation extraction, we
curated a benchmark dataset annotated by a medical expert. Evaluation results
indicate that the pipeline exhibits performance comparable to that of GPT-4.
Case studies further illuminate challenges faced by contemporary LLMs in the
context of biomedical relation extraction for semi-structured web articles.
Conclusion: The proposed method has demonstrated its effectiveness in
leveraging the strengths of LLMs for high-throughput biomedical relation
extraction. Its adaptability is evident, as it can be seamlessly extended to
diverse semi-structured biomedical websites, facilitating the extraction of
various types of biomedical relations with ease.
