  The thermodynamic aspects of the polymorphic phase transition from
{\alpha}-indomethacin to {\gamma}-indomethacin are the fundamental key to find
the most bioavailable phase of indomethacin. In the present work, varying the
temperature and solvent permittivity changes the polymorphic transitions.
Hence, the thermodynamic properties such as enthalpy, Gibbs free energy, and
entropy of both indomethacin polymorphs are determined in terms of the solvent
permittivity as functions of indomethacin's temperature in a vacuum, which are
crucially related to the stability, spontaneity, and reversibility of the
polymorphic transformation.
