  Knowledge of thermal history in biological tissues during laser based
hyperthermia is essential to achieve necrosis of tumour orcarcinoma cells. A
semi analytical model to predict sub surface thermal history in translucent,
soft, bio tissue mimics has been proposed. The model can accurately predict the
spatio temporal temperature variations along depth and the anomalous thermal
behaviour in such media, viz. occurrence of sub surface temperature peaks.
Based on opto thermal properties, the augmented temperature and shift of the
peak positions in case of gold nanostructure mediated tissue phantom
hyperthermia can be predicted. Employing inverse approach, the absorbance
coefficient of nano graphene infused tissue mimics is determined from the peak
temperature and found to provide appreciably accurate predictions along depth.
Furthermore, a simplistic, dimensionally consistent correlation to
theoretically determine the position of the peak in such media is proposed and
found to be consistent with experiments and computations. The model shows
promise in predicting thermal history in optically active soft matter and
deduction of therapeutic hyperthermia parameters, thereby providing a priori
estimates for clinical trials.
