  We find exact multi-instanton solutions to the selfdual Yang-Mills equation
on a large class of curved spaces with $SO(3)$ isometry, generalizing the
results previously found on $\mathbb{R}^4$. The solutions are featured with
explicit multi-centered expressions and topological properties. As examples, we
demonstrate the approach on several different curved spaces, including the
Einstein static universe and $\mathbb{R} \times$ dS$_3^E$, and show that the
exact multi-instanton solutions exist on these curved backgrounds.
