  A computational framework is presented to numerically simulate the effects of
antihypertensive drugs, in particular calcium channel blockers, on the
mechanical response of arterial walls. A stretch-dependent smooth muscle model
by Uhlmann and Balzani is modified to describe the interaction of
pharmacological drugs and the inhibition of smooth muscle activation. The
coupled deformation-diffusion problem is then solved using the finite element
software FEDDLib and overlapping Schwarz preconditioners from the Trilinos
package FROSch. These preconditioners include highly scalable parallel GDSW
(generalized Dryja-Smith-Widlund) and RDSW (reduced GDSW) preconditioners.
Simulation results show the expected increase in the lumen diameter of an
idealized artery due to the drug-induced reduction of smooth muscle
contraction, as well as a decrease in the rate of arterial contraction in the
presence of calcium channel blockers. Strong and weak parallel scalability of
the resulting computational implementation are also analyzed.
