  Thermophoresis (thermodiffusion, Soret effect) moves molecules along thermal
gradients. We measure its phenomenological linear drift relation by single
particle tracking in convection-free settings. For moderate thermal gradients,
drift velocity depends linearly on the gradient. However, for strong thermal
gradients, we find a nonlinear dependence of the drift on the applied gradient
for large Soret coefficient and particle radius. Interestingly, the onset of
the nonlinearity coincides with a local disequilibrium of the particle.
Nonlinear thermophoresis resolves several fundamental contradictions between
thermophoretic experiments and theory.
