  The Southern Photometric Local Universe Survey (S-PLUS) is a project to map
$\sim9300$ sq deg of the sky using twelve bands (seven narrow and five
broadbands). Observations are performed with the T80-South telescope, a robotic
telescope located at the Cerro Tololo Observatory in Chile. The survey
footprint consists of several large contiguous areas, including fields at high
and low galactic latitudes, and towards the Magellanic Clouds. S-PLUS uses
fixed exposure times to reach point source depths of about $21$ mag in the
$griz$ and $20$ mag in the $u$ and the narrow filters. This paper describes the
S-PLUS Data Release 4 (DR4), which includes calibrated images and derived
catalogues for over 3000 sq deg, covering the aforementioned area. The
catalogues provide multi-band photometry performed with the tools
\texttt{DoPHOT} and \texttt{SExtractor} -- point spread function (\PSF) and
aperture photometry, respectively. In addition to the characterization, we also
present the scientific potential of the data. We use statistical tools to
present and compare the photometry obtained through different methods. Overall
we find good agreement between the different methods, with a slight systematic
offset of 0.05\,mag between our \PSF and aperture photometry. We show that the
astrometry accuracy is equivalent to that obtained in previous S-PLUS data
releases, even in very crowded fields where photometric extraction is
challenging. The depths of main survey (MS) photometry for a minimum
signal-to-noise ratio $S/N = 3$ reach from $\sim19.5$ for the bluer bands to
$\sim21.5$ mag on the red. The range of magnitudes over which accurate \PSF
photometry is obtained is shallower, reaching $\sim19$ to $\sim20.5$ mag
depending on the filter. Based on these photometric data, we provide
star-galaxy-quasar classification and photometric redshift for millions of
objects.
