  Prion diseases caused by the conversion from a soluble normal cellular prion
protein into insoluble abnormally folded infectious prions, are invariably
fatal and highly infectious degenerative diseases that affect a wide variety of
mammalian species. The palindrome and the Glycine-rich conserved segment in the
hydrophobic region 109-136 control the conversion from normal prion protein to
form into diseased prions. This paper gives detailed reviews on the 109-136
region and presents the studies of its 3D structures and structural dynamics.
