  By exploiting the nonlinear responses of the fluorescent probes, the spatial
resolution of structured illumination microscopy(SIM) can be further increased.
However, due to the complex reconstruction process, the traditional
reconstruction method of nonlinear structured illumination microscopy (NL-SIM)
is relatively slow, which brings a great challenge to realizing real-time
display of super-resolution results. To address these issues, an accelerated
NL-SIM reconstruction algorithm was developed by extending a high-speed
reconstruction framework, Joint Space and Frequency Reconstruction (JSFR) to
NL-SIM. We anticipate that this algorithm will facilitate NL- SIM becoming a
routine tool in biomedical laboratories.
