  Effects of sequence disorder on looping and cyclization of the
double-stranded DNA are studied theoretically. Both random intrinsic curvature
and inhomogeneous bending rigidity are found to result in a remarkably wide
distribution of cyclization probabilities. For short DNA segments, the range of
the distribution reaches several orders of magnitude for even completely random
sequences. The ensemble averaged values of the cyclization probability are also
calculated, and the connection to the recent experiments is discussed.
