  Single molecule localization microscopy relies on the precise quantification
of the position of single dye emitters in a sample. This precision is improved
by the number of photons that can be detected from each molecule. It is
therefore recommendable to increase illumination times for the recording
process. Particularly recording at cryogenic temperatures dramatically reduces
photobleaching and thereby allows a massive increase in illumination times to
several seconds. As a downside, microscope instabilities may well introduce
jitter during such long illuminations, deteriorating the localization
precision. In this paper, we theoretically demonstrate that a parallel
recording of fiducial marker beads together with a novel fitting approach
accounting for the full drift trajectory allows for largely eliminating drift
effects for drift magnitudes of several hundred nanometers per frame.
