  Magnetic topological insulator provide a prominent material platform for
quantum anomalous Hall physics and axion electrodynamics. However, the lack of
material realizations with cleanly gapped surfaces hinders technological
utilization of these exotic quantum phenomena. Here, using the Zintl concept
and the properties of non-symmorphic space groups, we computationally engineer
magnetic topological insulators. Specifically, we explore Eu$_5M_2X_6$
($M$=metal, $X$=pnictide) Zintl compounds and find that Eu$_5$Ga$_2$Sb$_6$,
Eu$_5$Tl$_2$Sb$_6$ and Eu$_5$In$_2$Bi$_6$ form stable structures with
non-trivial $\mathbb{Z}_2$ indices. We also show that epitaxial and uniaxial
strain can be used to control the $\mathbb{Z}_2$ index and the bulk energy gap.
Finally, we discuss experimental progress towards the synthesis of the proposed
candidates and provide insights that can be used in the search for robust
magnetic topological insulators in Zintl compounds.
