  School environments are thought to play an important role in the community
spread of airborne infections (e.g., influenza) because of the high mixing
rates of school children. The closure of schools has therefore been proposed as
efficient mitigation strategy, with however high social and economic costs:
alternative, less disruptive interventions are highly desirable. The recent
availability of high-resolution contact networks in school environments
provides an opportunity to design micro-interventions and compare the outcomes
of alternative mitigation measures. We consider mitigation measures that
involve the targeted closure of school classes or grades based on readily
available information such as the number of symptomatic infectious children in
a class. We focus on the case of a primary school for which we have
high-resolution data on the close-range interactions of children and teachers.
We simulate the spread of an influenza-like illness in this population by using
an SEIR model with asymptomatics and compare the outcomes of different
mitigation strategies. We find that targeted class closure affords strong
mitigation effects: closing a class for a fixed period of time -equal to the
sum of the average infectious and latent durations- whenever two infectious
individuals are detected in that class decreases the attack rate by almost 70%
and strongly decreases the probability of a severe outbreak. The closure of all
classes of the same grade mitigates the spread almost as much as closing the
whole school. Targeted class closure strategies based on readily available
information on symptomatic subjects and on limited information on mixing
patterns, such as the grade structure of the school, can be almost as effective
as whole-school closure, at a much lower cost. This may inform public health
policies for the management and mitigation of influenza-like outbreaks in the
community.
