  We introduce a global nuclear mass formula which is based on the
macroscopic-microscopic method, the Skyrme energy-density functional and the
isospin symmetry in nuclear physics. The rms deviation with respect to 2149
known nuclear masses falls to 336 keV, and the rms deviations from 1988 neutron
separation energies and \alpha-decay energies of 46 super-heavy nuclei are
significantly reduced to 286 and 248 keV, respectively. The predictive power of
the mass formula for describing new measured masses in GSI and those in AME2011
is excellent. In addition, we introduce an efficient and powerful systematic
method, radial basis function approach, for further improving the accuracy and
predictive power of global nuclear mass models.
