  We study the effects of solute interactions on osmotic transport through
pores. By extending single-file, single-species kinetic models to include
entrance of solute into membrane pores, we model the statistical mechanics of
competitive transport of two species across membrane pores. The results have
direct applications to water transport across biomembrane pores and particle
movement in zeolites, and can be extended to study ion channel transport.
Reflection coefficients, the reduction of osmotic fluxes measured using
different solutes, are computed in terms of the microscopic kinetic parameters.
We find that a reduction in solvent flow due to solute-pore interactions can be
modelled by a Langmuir adsorption isotherm. Osmosis experiments are discussed
and proposed. Special cases and Onsager relations are presented in the
Appendices.
