  Neuromodulation techniques have emerged as promising approaches for treating
a wide range of neurological disorders, precisely delivering electrical
stimulation to modulate abnormal neuronal activity. While leveraging the unique
capabilities of artificial intelligence (AI) holds immense potential for
responsive neurostimulation, it appears as an extremely challenging proposition
where real-time (low-latency) processing, low power consumption, and heat
constraints are limiting factors. The use of sophisticated AI-driven models for
personalized neurostimulation depends on back-telemetry of data to external
systems (e.g. cloud-based medical mesosystems and ecosystems). While this can
be a solution, integrating continuous learning within implantable
neuromodulation devices for several applications, such as seizure prediction in
epilepsy, is an open question. We believe neuromorphic architectures hold an
outstanding potential to open new avenues for sophisticated on-chip analysis of
neural signals and AI-driven personalized treatments. With more than three
orders of magnitude reduction in the total data required for data processing
and feature extraction, the high power- and memory-efficiency of neuromorphic
computing to hardware-firmware co-design can be considered as the
solution-in-the-making to resource-constraint implantable neuromodulation
systems. This perspective introduces the concept of Neuromorphic
Neuromodulation, a new breed of closed-loop responsive feedback system. It
highlights its potential to revolutionize implantable brain-machine
microsystems for patient-specific treatment
