  The 19-dimensional TP06 cardiac muscle cell model is reduced to a
17-dimensional version, which satisfies the required conditions for performing
an analysis of its dynamics by means of bifurcation theory. The reformulated
model is shown to be a good approximation of the original one. As a
consequence, one can extract fairly precise predictions of the behaviour of the
original model from the bifurcation analysis of the modified model. Thus, the
findings of bifurcations linked to complex dynamics in the modified model -
like early afterdepolarisations (EADs), which can be precursors to cardiac
death - predicts the occurrence of the same dynamics in the original model. It
is shown that bifurcations linked to EADs in the modified model accurately
predicts EADs in the original model at the single cell level. Finally, these
bifurcations are linked to cardiac death at the tissue level by example.
