  Based on the canonical quantization of $d>2$ dimensional general relativity
(GR) via the Dirac constraint formalism (also termed as `constraint
quantization'), we propose the loss of covariance as a fundamental property of
the theory. This breakdown occurs for the first-order Einstein Hilbert action,
whereby loss of diffeomorphism invariance, besides first class constraints,
second class constriants also exist leading to non-standard ghost fields which
render the path integral non-covariant. We also attempt, for the first time,
the canonical quantization via calculation of the path integral for the
equivalent Hamiltonian formulation of GR for which only first class constraints
exist. However, loss of covariance still occurs in this action due to loss of
diffeomorphism invariance and structures arising from non-covariant constraints
in the path integral. In contrast, we find that covariance as a symmetry is
restored and quantization with perturbative calculations is possible in the
weak limit of the gravitational field of these actions. Hence, we firstly
establish, for the first time, that the breakdown in space-time is a property
of GR itself as its limitation, indicating it to be an Effective Field Theory
(EFT). We further propose that the breakdown of space-time occurs as a
non-perturbative feature of GR in the strong field limit of the theory. Besides
GR, we also note that covariance is preserved when constraint quantization is
conducted for non-Abelian gauge theories, such as the Yang-Mills theory. These
findings are novel from a canonical gravity formalism and EFT approach, and are
consistent with GR singularity theorems, yet are general and extend them, as
the singularity theorems indicate breakdown at a strong field limit of GR in
black holes.
