  The Doplicher-Fredenhagen-Roberts (DFR) framework for noncommutative (NC)
space-times is considered as an alternative approach to describe the physics of
quantum gravity. In this formalism, the NC parameter, {\it i.e.}
$\theta^{\mu\nu}$, is promoted to a coordinate of a new extended space-time.
Consequently, we can construct a Field Theory in a space-time with spatial
extra-dimensions. This new coordinate has a canonical momentum associated,
where the effects of a new physics point of view can emerge in the fields
propagation along the extra-dimension. In this paper we have introduced the
gauge invariance in the DFR NC space-time by the composite symmetry
$U^{\star}(N)\times U^{\star}(N)$. We have constructed the non-Abelian gauge
symmetry based on DFR formalism, and we analyzed the consequences of this
symmetry in the presence of such extra-dimensions. The gauge symmetry in this
DFR scenario can reveal new gauge fields attached to $\theta$-extra-dimension.
As an application, we have accomplished the unification of Strong Interaction
with the electromagnetism and a Higgs model to give masses to the NC bosons. We
have estimated their masses by using some experimental constraints of QCD.
