  Despite on great success with artificial implant for human body, the modern
implants could not solve major health problems. The reason is an immune
reaction of organism on artificial implant known as foreign body reaction. We
have found a way to avoid or decrease the foreign body reaction. The surface of
artificial implant is modified with condensed aromatic structures containing
free radicals, which provide a covalent attachment of host proteins in native
conformation. The total protein coverage prevents direct contact of immune
cells with the implant surface and the immune cells are not activated. As
result the immune respond of organism is not generated and the artificial
implant is not isolated from the tissue: no collagen capsule, low activity of
macrophages, low cell proliferation, low inflammatory activity.
