  In the attention-deficit hyperactivity disorder (ADHD) study, children are
prescribed different stimulant medications. The height measurements are
recorded longitudinally along with the medication time. Differences among the
patients are captured by the parameters suggested the Superimposition by
Translation and Rotation (SITAR) model using three subject-specific parameters
to estimate their deviation from the mean growth curve. In this paper, we
generalize the SITAR model in a Bayesian way with time-invariant covariates.
The time-invariant model allows us to predict latent growth factors. Since
patients suffer from a common disease, they usually exhibit a similar pattern,
and it is natural to build a nonlinear model that is shaped invariant. The
model is semi-parametric, where the population time curve is modeled with a
natural cubic spline. The original shape invariant growth curve model,
motivated by epidemiological research on the evolution of pubertal heights over
time, fits the underlying shape function for height over age and estimates
subject-specific deviations from this curve in terms of size, tempo, and
velocity using maximum likelihood. The usefulness of the model is illustrated
in the attention deficit hyperactivity disorder (ADHD) study. Further, we
demonstrated the effect of stimulant medications on pubertal growth by gender.
