  We construct quasiequilibrium sequences of black hole-neutron star binaries
in general relativity. We solve Einstein's constraint equations in the
conformal thin-sandwich formalism, subject to black hole boundary conditions
imposed on the surface of an excised sphere, together with the relativistic
equations of hydrostatic equilibrium. In contrast to our previous calculations
we adopt a flat spatial background geometry and do not assume extreme mass
ratios. We adopt a Gamma=2 polytropic equation of state and focus on
irrotational neutron star configurations as well as approximately nonspinning
black holes. We present numerical results for ratios of the black hole's
irreducible mass to the neutron star's ADM mass in isolation of
M_{irr}^{BH}/M_{ADM,0}^{NS} = 1, 2, 3, 5, and 10. We consider neutron stars of
baryon rest mass M_B^{NS}/M_B^{max} = 83% and 56%, where M_B^{max} is the
maximum allowed rest mass of a spherical star in isolation for our equation of
state. For these sequences, we locate the onset of tidal disruption and, in
cases with sufficiently large mass ratios and neutron star compactions, the
innermost stable circular orbit. We compare with previous results for black
hole-neutron star binaries and find excellent agreement with third-order
post-Newtonian results, especially for large binary separations. We also use
our results to estimate the energy spectrum of the outgoing gravitational
radiation emitted during the inspiral phase for these binaries.
