  Control of an inflammatory immune response is still an ongoing research.
Here, a strategy consisting of manipulating a pro and anti-inflammatory
mediator is considered. Already existing and promising model-based techniques
suffer unfortunately from a most difficult calibration. This is due to the
different types of inflammations and to the strong parameter variation between
patients. This communication explores another route via the new model-free
control and its corresponding "intelligent" controllers. A "virtual" patient,
i.e., a mathematical model, is only employed for digital simulations. A most
interesting feature of our control strategy is the fact that the two outputs
which must be driven are sensorless. This difficulty is overcome by assigning
suitable reference trajectories to two other outputs with sensors. Several most
encouraging computer simulations, corresponding to different drug treatment
strategies, are displayed and discussed.
