  We show that the Galactic latitude distribution of IceCube astrophysical
neutrino events with energies above 100~TeV is inconsistent with the isotropic
model of the astrophysical neutrino flux. Namely, the Galactic latitude
distribution of the events shows an excess at low latitudes |b|<10 degrees and
a deficit at high Galactic latitude |b|> 50 degrees. We use Monte-Carlo
simulations to show that the inconsistency of the isotropic signal model with
the data is at > 3 sigma level, after the account of trial factors related to
the choice of the low-energy threshold and Galactic latitude binning in our
analysis.
