  I report on investigations of physics beyond the Standard Model using
experiments designed to investigate $b$ quark and $c$ quark interactions.
Generalized searches involving loop diagrams using heavy meson mixing and CP
violation experiments imply limits on New Physics (NP) at large scales from
100-100,000 TeV. There are ways of avoiding these limits, but satisfying their
requirements puts severe restrictions on NP properties. Specific constraints on
NP models are discussed from individual measurements including b-> s gamma,
Bs->mu+ mu-, B0 -> K* l+ l-, and CP violation in the B0 and Bs systems. Hints
of deviations from Standard Model predictions from other decays including B- ->
tau- nu, and B->D(*)tau- nu$\ are investigated. Finally, searches for dark
matter and Majorana neutrinos are reviewed.
