  An extensive rewiring of cell metabolism supports enhanced proliferation in
cancer cells. We propose a systems level approach to describe this phenomenon
based on Flux Balance Analysis (FBA). The approach does not explicit a cell
biomass formation reaction to be maximized, but takes into account an ensemble
of alternative flux distributions that match the cancer metabolic rewiring
(CMR) phenotype description. The underlying concept is that the analysis the
common/distinguishing properties of the ensemble can provide indications on how
CMR is achieved and sustained and thus on how it can be controlled.
