  Hyperpolarization methods in magnetic resonance overcome sensitivity
limitations, especially for low-{\gamma} nuclei such as 13C and 15N. Signal
Amplification By Reversible Exchange (SABRE) and extended SABRE (X-SABRE) are
efficient and low-cost methods for generating large polarizations on a variety
of nuclei, but they most commonly use low magnetic fields ({\mu}T-mT). High
field approaches, where hyperpolarization is generated directly in the
spectrometer, are potentially much more convenient but have been limited to
selectively hyperpolarize single targets. Here we introduce a new pulse
sequence-based approach that affords broadband excitation of SABRE
hyperpolarization at high magnetic fields without having to tailor pulse
sequence parameters to specific targets. This permits simultaneous
hyperpolarization of multiple targets for the first time at high field and
offers a direct approach to integration of high-field SABRE hyperpolarization
into routine NMR applications, such as NMR-based metabonomics and biomolecular
NMR.
