  The essential role played by differentiable structures in physics is reviewed
in light of recent mathematical discoveries that topologically trivial
space-time models, especially the simplest one, ${\bf R^4}$, possess a rich
multiplicity of such structures, no two of which are diffeomorphic to each
other and thus to the standard one. This means that physics has available to it
a new panoply of structures available for space-time models. These can be
thought of as source of new global, but not properly topological, features.
This paper reviews some background differential topology together with a
discussion of the role which a differentiable structure necessarily plays in
the statement of any physical theory, recalling that diffeomorphisms are at the
heart of the principle of general relativity. Some of the history of the
discovery of exotic, i.e., non-standard, differentiable structures is reviewed.
Some new results suggesting the spatial localization of such exotic structures
are described and speculations are made on the possible opportunities that such
structures present for the further development of physical theories.
