  Recent studies of AzoTAB activity in excitable cell cultures have shown that
this substance is able to control excitability depending on isomer, cis or
trans, predominating in the cellular membrane. Control of isomerization can be
performed noninvasively by UV-visual radiation. At the same time it is
well-known that azobenezenes can be effectively transformed from one isomer
into another by two-photon absorption. Current work is devoted to the study of
trans-AzoTAB two-photon transformation in aqueous solution and inside primal
neonatal contractive rat cardiomyocytes. In accordance with results obtained
Azo-TAB can be used as a probe for two-photon optical control of cardiac
excitability.
