  The Comment's author argues that a correct description of reactive systems
should incorporate the explicit interaction with reservoirs, leading to a
unified system-reservoirs entity. However, this proposition has two major
flaws. Firstly, as we will emphasize, this entity inherently follows a
thermodynamic equilibrium distribution. In the Comment, no indication is
provided on how to maintain such a system-reservoirs entity in a
non-equilibrium state. Secondly, contrary to the author's claim, the inclusion
of system-reservoir interaction in traditional stochastic modeling of reactive
systems does not automatically alter the limited applicability of path
thermodynamics to problematic reactive systems. We will provide a simple
demonstration to illustrate that certain elementary reactions may not involve
any changes in reservoir components, which seems to have been overlooked by the
author.
