  We investigate the potential association between leucine-rich repeat kinase 2
(LRRK2) mutations and voice. Sustained phonations ('aaah' sounds) were recorded
from 7 individuals with LRRK2-associated Parkinson's disease (PD), 17
participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutation
carriers, 25 related non-carriers, and 26 controls. In distinguishing
LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean
specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers,
related non-carriers, and controls were much less discriminatory. Vocal
deficits in LRRK2-associated PD may be different than those in iPD. These
preliminary results warrant longitudinal analyses and replication in larger
cohorts
