  Currently, CyberPhysical Systems (CPS) represents a great challenge for
automatic control and smart systems engineering on both theoretical and
practical levels. Designing CPS requires approaches involving multidisciplinary
competences. However they are designed to be autonomous, the CPS present a part
of uncertainty, which requires interaction with human for engineering,
monitoring, controlling, performing operational maintenance, etc. This
human-CPS interaction led naturally to the human in-the-loop (HITL) concept.
Nevertheless, this HITL concept , which stems from a reductionist point of
view, exhibits limitations due to the different natures of the systems
involved. As opposed to this classical approach, we propose, in this paper, a
model of Bio-CPS (i.e. systems based on an integration of computational
elements within biological systems) grounded on theoretical biology, physics
and computer sciences and based on the key concept of human systems
integration.
