  With tangent angle perturbation approach the axial symmetry deformation of a
spherical vesicle in large under the pressure changes is studied by the
elasticity theory of Helfrich spontaneous curvature model.Three main results in
axial symmetry shape: biconcave shape, peanut shape, and one type of myelin are
obtained. These axial symmetry morphology deformations are in agreement with
those observed in lipsome experiments by dark-field light microscopy [Hotani,
J. Mol. Biol. 178, (1984) 113] and in the red blood cell with two thin
filaments (myelin) observed in living state (see, Bessis, Living Blood Cells
and Their Ultrastructure, Springer-Verlag, 1973). Furthermore, the biconcave
shape and peanut shape can be simulated with the help of a powerful software,
Surface Evolver [Brakke, Exp. Math. 1, 141 (1992) 141], in which the
spontaneous curvature can be easy taken into account.
