  Theoretical concepts in condensed matter physics are typically verified and
also developed by exploiting computer simulations mostly in simple models.
Predictions based on these usually isotropic models are often at odds with
measurement results obtained for real materials. On the other hand, all-atom
simulations are complex and time-consuming. In this paper, we formulate a new
strategy for effective molecular modelling, which properly reflects properties
of real particles by using quasi-real molecules of simple but anisotropic
architecture and identifying the applicable range of intermolecular
interactions for a given physical process or quantity. As a demonstration of
our method capabilities, we solve an intriguing problem within the density
scaling idea that has attracted attention in recent decades due to its
hallmarks of universality. It demonstrates that the new strategy for molecular
modelling opens broad perspectives for simulation and theoretical research, for
example, into unifying concepts in the glass transition physics.
