  We discuss various aspects of inclusive top-quark pair production based on
TOPIXS, a new, flexible program that computes the production cross section at
the Tevatron and LHC at next-to-next-to-leading logarithmic accuracy in soft
and Coulomb resummation, including bound-state effects and the complete
next-to-next-to-leading order result in the q-qbar channel, which has recently
become available. We present the calculation of the top-pair cross section in
pp collisions at 8 TeV centre-of-mass energy, as well as the cross sections for
hypothetical heavy quarks in extensions of the standard model. The dependence
on the parton distribution input is studied. Further we investigate the impact
of LHC top cross section measurements at sqrt(s)=7 TeV on global fits of the
gluon distribution using the NNPDF re-weighting method.
