  We present constraints on cosmological parameters from the Pantheon+ analysis
of 1701 light curves of 1550 distinct Type Ia supernovae (SNe Ia) ranging in
redshift from $z=0.001$ to 2.26. This work features an increased sample size,
increased redshift span, and improved treatment of systematic uncertainties in
comparison to the original Pantheon analysis and results in a factor of two
improvement in cosmological constraining power. For a Flat$\Lambda$CDM model,
we find $\Omega_M=0.334\pm0.018$ from SNe Ia alone. For a Flat$w_0$CDM model,
we measure $w_0=-0.90\pm0.14$ from SNe Ia alone, H$_0=73.5\pm1.1$ km s$^{-1}$
Mpc$^{-1}$ when including the Cepheid host distances and covariance (SH0ES),
and $w_0=-0.978^{+0.024}_{-0.031}$ when combining the SN likelihood with
constraints from the cosmic microwave background (CMB) and baryon acoustic
oscillations (BAO); both $w_0$ values are consistent with a cosmological
constant. We also present the most precise measurements to date on the
evolution of dark energy in a Flat$w_0w_a$CDM universe, and measure
$w_a=-0.1^{+0.9}_{-2.0}$ from Pantheon+ alone, H$_0=73.3\pm1.1$ km s$^{-1}$
Mpc$^{-1}$ when including SH0ES, and $w_a=-0.65^{+0.28}_{-0.32}$ when combining
Pantheon+ with CMB and BAO data. Finally, we find that systematic uncertainties
in the use of SNe Ia along the distance ladder comprise less than one third of
the total uncertainty in the measurement of H$_0$ and cannot explain the
present "Hubble tension" between local measurements and early-Universe
predictions from the cosmological model.
