  A previous report claimed no evidence of transgenerational epigenetic
inheritance in a mouse model of in utero environmental exposure, based on the
observation that gene expression changes observed in the germ cells of G1 and
G2 male fetus were not in the same direction. A subsequent data reanalysis
however showed a statistically significant overlap between G1 and G2 genes
irrespective of direction, leading to the suggestion that, as phenotypic
variability in epigenetic transmission has been observed in several other
examples also, the above report provided evidence in favor of, not against,
transgenerational inheritance. This criticism has recently been questioned.
Here, it is shown that the questions raised are based not only on incorrect
statistical calculations but also on wrong premise that gene expression changes
do not constitute a phenotype.
