  In this work, we explore the relation between the tropicalization of a real
semi-algebraic set $S = \{ f_1 < 0, \dots , f_k < 0\}$ defined in the positive
orthant and the combinatorial properties of the defining polynomials $f_1,
\dots, f_k$. We describe a cone that depends only on the face structure of the
Newton polytopes of $f_1, \dots ,f_k$ and the signs attained by these
polynomials. This cone provides an inner approximation of the real
tropicalization, and it coincides with the real tropicalization if $S = \{ f <
0\}$ and the polynomial $f$ has generic coefficients. Furthermore, we show that
for a maximally sparse polynomial $f$ the real tropicalization of $S = \{ f <
0\}$ is determined by the outer normal cones of the Newton polytope of $f$ and
the signs of its coefficients. Our arguments are valid also for signomials,
that is, polynomials with real exponents defined in the positive orthant.
