  In this paper we consider the influence of intercellular communication on the
development and progression of Glioblastoma Multiforme (GBM), a grade IV
malignant glioma which is defined by an interplay Grow i.e. self renewal and Go
i.e. invasiveness potential of multiple malignant glioma stem cells. Firstly,
we performed wet lab experiments with U87 malignant glioma cells to study the
node-stem growth pattern of GBM. Next we develop a model accounting for the
structural influence of multiple transmitter and receiver glioma stem cells
resulting in the node-stem growth structure of GBM tumour. By using information
theory we study different properties associated with this communication model
to show that the growth of GBM in a particular direction (node to stem) is
related to an increase in mutual information. We further show that information
flow between glioblastoma cells for different levels of invasiveness vary at
different points between node and stem. These findings are expected to
contribute significantly in the design of future therapeutic mechanisms for
GBM.
