  We present the QCD simulation of the first gauge ensemble of two degenerate
light quarks, a strange and a charm quark with all quark masses tuned to their
physical values within the twisted mass fermion formulation. Results for the
pseudoscalar masses and decay constants confirm that the produced ensemble is
indeed at the physical parameters of the theory. This conclusion is
corroborated by a complementary analysis in the baryon sector. We examine
cutoff and isospin breaking effects and demonstrate that they are suppressed
through the presence of a clover term in the action.
