  We propose a new framework to generate the Standard Model (SM) quark flavor
hierarchies in the context of two Higgs doublet models (2HDM). The `flavorful'
2HDM couples the SM-like Higgs doublet exclusively to the third quark
generation, while the first two generations couple exclusively to an additional
source of electroweak symmetry breaking, potentially generating striking
collider signatures. We synthesize the flavorful 2HDM with the `flavor-locking'
mechanism, that dynamically generates large quark mass hierarchies through a
flavor-blind portal to distinct flavon and hierarchon sectors: Dynamical
alignment of the flavons allows a unique hierarchon to control the respective
quark masses. We further develop the theoretical construction of this
mechanism, and show that in the context of a flavorful 2HDM-type setup, it can
automatically achieve realistic flavor structures: The CKM matrix is
automatically hierarchical with $|V_{cb}|$ and $|V_{ub}|$ generically of the
observed size. Exotic contributions to meson oscillation observables may also
be generated, that may accommodate current data mildly better than the SM
itself.
