  In their work [Proc. Natl. Acad. Sci. USA 112 (2015) E5725], Bosse et al.
experimentally showed that virus capsid exhibits not only normal diffusion but
also anomalous diffusion in nucleus of a living cell. There, it was found that
the distribution of fluctuations of the diffusion exponent characterizing them
takes the Gaussian form, which is, quite remarkably, the same form for two
different types of the virus. This suggests high robustness of such
fluctuations. Here, the statistical property of local fluctuations of the
diffusion exponent of the virus capsid in the nucleus is studied. A
maximum-entropy-principle approach (originally proposed for a different virus
in a different cell) is applied for obtaining the fluctuation distribution of
the exponent. Largeness of the number of blocks identified with local areas of
interchromatin corrals is also examined based on the experimental data. It is
shown that the Gaussian distribution of the local fluctuations can be derived,
in accordance with the above form. In addition, it is quantified how the
fluctuation distribution on a long time scale is different from the Gaussian
distribution.
