  This paper presents a generative model for super-resolution in routine
clinical magnetic resonance images (MRI), of arbitrary orientation and
contrast. The model recasts the recovery of high resolution images as an
inverse problem, in which a forward model simulates the slice-select profile of
the MR scanner. The paper introduces a prior based on multi-channel total
variation for MRI super-resolution. Bias-variance trade-off is handled by
estimating hyper-parameters from the low resolution input scans. The model was
validated on a large database of brain images. The validation showed that the
model can improve brain segmentation, that it can recover anatomical
information between images of different MR contrasts, and that it generalises
well to the large variability present in MR images of different subjects. The
implementation is freely available at https://github.com/brudfors/spm_superres
