  The analysis of quantitative hemodynamics and luminal pressure may add
valuable information to aid treatment strategies and prognosis for aortic
dissections. This work directly compared in vitro 4D-flow magnetic resonance
imaging (MRI), catheter-based pressure measurements, and computational fluid
dynamics that integrated fluid-structure interaction (CFD FSI). Experimental
data was acquired with a compliant 3D-printed model of a type-B aortic
dissection (TBAD) that was embedded into a physiologically tuned flow circuit.
In vitro flow and pressure information were used to tune the CFD FSI Windkessel
boundary conditions. Results showed very good overall agreement of complex flow
patterns, true to false lumen flow splits, and pressure distribution. This work
demonstrates feasibility of a tunable experimental setup that integrates a
patient-specific compliant model and provides a test bed for exploring critical
imaging and modeling parameters that ultimately may improve the prognosis for
patients with aortic dissections.
