  The mixing induced time dependent CP asymmetry, direct CP asymmetry, and
branching ratio in $B \to \Phi K_S$ in a model III 2HDM are calculated, in
particular, neutral Higgs boson contributions are included. It is shown that
satisfying all the relevant experimental constraints, for time dependent CP
asymmetry $S_{\phi K}$ the model III can agree with the present data, $S_{\phi
k}=-0.39\pm 0.41$, within the $1\sigma$ error, and the direct CP asymmetry
which is zero in SM can be about $ -8% \sim -20%$ in the reasonable regions of
parameters.
