  It is shown that using non-abelian horizontal gauge symmetry and anomalous
U(1)_A symmetry in grand unified theories (GUTs), realistic quark and lepton
mass matrices including large neutrino mixings can be obtained, while the
differences among the scalar fermion masses are sufficiently small for
suppression of various flavor changing neutral current (FCNC) processes,
especially in E_6 GUT. Combining the Higgs sector, in which doublet-triplet
splitting is realized, a complete E_6\times SU(3)_H GUT, in which three
generations are unified into a single multiplet, Psi(27,3), is obtained.
