  Sonogenetics can be used as a new alternative for treating arrhythmia due to
its advantages of noninvasive, high safety and strong penetration. In the
treatment of arrhythmias by sonogenetics, cardiac myocytes are deformed by
ultrasonic radiation force. We quantitatively calculated the shape variation of
cardiomyocytes under ultrasonic radiation force, and the deformation of
cardiomyocytes caused the change of membrane tension. Membrane tension consists
of two parts, plasma membrane tension and cortical tension between the cell
membrane and cytoskeleton. Since plasma membrane tension was mainly considered
in existing experiments, we proposed a quantitative model of the relationship
between ultrasonic radiation force and plasma membrane tension. The Boltzmann
relationship between plasma membrane tension and ion channel opening
probability is presented based on the experimental results of ion channel
activation by stretching. Finally, a quantitative model was obtained for
ultrasonic radiation force to regulate the opening probability of ion channel
activated by stretching. Based on this quantitative model, we proposed the
regulation mechanism of ultrasonic radiation force under hypercompression and
hyperstretching, and verified that this mechanism can eliminate arrhythmias by
sonogenetics.
