  A highly-efficient method for optical detection and separation of left- and
right-handed chiral molecules is presented. The method utilizes a closed-loop
three-state system in which the population dynamics depends on the phases of
the three couplings. Due to the different signs of the coupling between two of
the states for the opposite chiralities and the phase sensitivity of the
scheme, the population dynamics is chirality-dependent. By using concepts from
the `shortcuts to adiabaticity' approach, one can achieve 100\% contrast in
state population transfer between the two enantiomers, which can be probed by
light-induced fluorescence in the case of large ensembles or through
resonantly-enhanced multiphoton ionization at the single molecular level.
