  We consider the possibility to explain the recent $R_K$ and $R_{K ^*}$
anomalies in a 2-Higgs Doublet Model, known as Aligned, combined with a low
scale seesaw mechanism generating light neutrino masses and mixings. In this
class of models, a large Yukawa coupling allows for significant non-universal
leptonic contributions, through box diagrams mediated by charged Higgs bosons
and right-handed neutrinos, to the $b \to s \ell^+ \ell^-$ transition that can
then account for both $R_K$ and $R_{K^*}$ anomalies.
