  Precision Medicine (PM) is an emerging approach that appears with the
impression of changing the existing paradigm of medical practice. Recent
advances in technological innovations and genetics, and the growing
availability of health data have set a new pace of the research and imposes a
set of new requirements on different stakeholders. To date, some studies are
available that discuss about different aspects of PM. Nevertheless, a holistic
representation of those aspects deemed to confer the technological perspective,
in relation to applications and challenges, is mostly ignored. In this context,
this paper surveys advances in PM from informatics viewpoint and reviews the
enabling tools and techniques in a categorized manner. In addition, the study
discusses how other technological paradigms including big data, artificial
intelligence, and internet of things can be exploited to advance the potentials
of PM. Furthermore, the paper provides some guidelines for future research for
seamless implementation and wide-scale deployment of PM based on identified
open issues and associated challenges. To this end, the paper proposes an
integrated holistic framework for PM motivating informatics researchers to
design their relevant research works in an appropriate context.
