  Within cells, vesicles and proteins are actively transported several
micrometers along the cytoskeletal filaments. The transport along microtubules
is propelled by dynein and kinesin motors, which carry the cargo in opposite
directions. Bidirectional intracellular transport is performed with great
efficiency, even under strong confinement, as for example in the axon. For this
kind of transport system, one would expect generically cluster formation. In
this work, we discuss the effect of the recently observed self-enhanced
binding-affinity along the kinesin trajectories on the MT. We introduce a
stochastic lattice-gas model, where the enhanced binding affinity is realized
via a floor-field. From Monte Carlo simulations and a mean-field analysis we
show that this mechanism can lead to self-organized symmetry-breaking and
lane-formation which indeed leads to efficient bidirectional transport in
narrow environments.
