  Summary: We develop TaSer (TabAnno and SeqMiner), a toolkit for annotating
and querying next generation sequence (NGS) dataset in tab-delimited files.
TabAnno is a powerful and efficient command-line tool designed to pre-process
sequence data, annotate variations and generate an indexed feature-enriched
project file that can integrate multiple sources of information. Using the
project file generated by TabAnno, complex queries to the sequence dataset can
be performed using SeqMiner, an R-package designed to efficiently access large
datasets. Extracted information can be conveniently viewed and analyzed by
tools in R. TaSer is optimized and computationally more efficient than software
using database systems. It enables annotating and querying NGS dataset using
moderate computing resource. Availability and implementation: TabAnno can be
downloaded from github (zhanxw.github.io/anno/). SeqMiner is distributed on
CRAN (cran.r-project.org/web/packages/seqminer). Contact: X.Z.
<EMAIL_ADDRESS>D.J.L<EMAIL_ADDRESS>