  The effect of the microscopic structure of a pore on polymer translocation is
studied using Langevin dynamics simulation, and the consequence of introducing
patterned stickiness inside the pore is investigated. It is found that the
translocation process is extremely sensitive to the detailed structure of such
patterns with faster than exponential dependence of translocation times on the
stickiness of the pore. The stochastic nature of the translocation process
leads to discernable differences between how polymers with different sequences
go through specifically patterned pores. This notion is utilized to propose a
stochastic sensing protocol for polynucleotides, and it is demonstrated that
the method, which would be significantly faster than the existing methods,
could be made arbitrarily robust.
