  Can the SO(10) model with one {\bf 10} and one {\bf 126} Higgs scalars give
the observed masses and mixings of quarks and leptons without any other
additional Higgs scalars? Recently, at least, for quarks and charged leptons,
it has been demonstrated that it is possible. However, for the neutrinos, it is
usually said that parameters which are determined from the quark and charged
lepton masses cannot give the observed large neutrino mixings. This problem is
systematically investigated, and it is concluded that the present data cannot
exclude SO(10) model with two Higgs scalars although it cannot give the best
fit values of the data.
