  This paper addresses a design procedure of pulse-modulated feedback control
solving a dosing problem defined for implementation in a manual mode. Discrete
dosing, as a control strategy, is characterized by exerting control action on
the plant in impulsive manner at certain time instants. Dosing applications
appear primarily in chemical industry and medicine where the control signal
constitutes a sequence of (chemically or pharmacologically) active substance
quantities (doses) administered to achieve a desired result. When the doses and
the instants of their administration are adjusted as functions of some measured
variable, a feedback control loop exhibiting nonlinear dynamics arises. The
impulsive character of the interaction between the controller and the plant
makes the resulting closed-loop system non-smooth. Limitations of the control
law with respect to control goals are discussed. An application of the approach
at hand to neuromuscular blockade in closed-loop anesthesia is considered in a
numerical example.
