  In this paper we study dominant rational maps $f$ from a very general
hypersurface $X$ of degree at least $n+3$ in the projective $(n+1)$-space
${\mathbb P}^{n+1}$ to smooth projective $n$-folds $Y$. Based on Lefschetz
theory, Hodge theory, and Cayley-Bacharach property, we prove that there is no
dominant rational map from $X$ to $Y$ unless $Y$ is rationally connected, if
the degree of the map is a prime number.
