  Generative models hold promise for revolutionizing medical education,
robot-assisted surgery, and data augmentation for machine learning. Despite
progress in generating 2D medical images, the complex domain of clinical video
generation has largely remained untapped.This paper introduces \model, an
innovative approach to generate medical videos that simulate clinical endoscopy
scenes. We present a novel generative model design that integrates a
meticulously crafted spatial-temporal video transformer with advanced 2D vision
foundation model priors, explicitly modeling spatial-temporal dynamics during
video generation. We also pioneer the first public benchmark for endoscopy
simulation with video generation models, adapting existing state-of-the-art
methods for this endeavor.Endora demonstrates exceptional visual quality in
generating endoscopy videos, surpassing state-of-the-art methods in extensive
testing. Moreover, we explore how this endoscopy simulator can empower
downstream video analysis tasks and even generate 3D medical scenes with
multi-view consistency. In a nutshell, Endora marks a notable breakthrough in
the deployment of generative AI for clinical endoscopy research, setting a
substantial stage for further advances in medical content generation. For more
details, please visit our project page: https://endora-medvidgen.github.io/.
