  "If it could be demonstrated that any complex organ existed, which could not
possibly have been formed by numerous successive, slight modifications, my
theory would absolutely break down". Can Darwinian random mutations and
selection generate biological complexity and holism? In this paper we argue
that the "wonderful but not enough" tools of linear reductionism cannot lead to
chaos and hence to complexity and holism, but with ChaNoXity this seems indeed
plausible, even likely. Based on the Pump-Engine realism of mutually
interacting supply and demand --- demand institutes supply that fuels demand
--- we demonstrate that the "supply" of symmetry breaking Darwinian genetic
variation, in direct conflict with the symmetry inducing "demand" of natural
selection, defines the antagonistic arrows of the real and negative worlds.
Working in this competitively collaborating nonlinear mode, these opposites
generate the homeostasy of holistic life. Protein folding, mitosis, meiosis,
hydrophobicity and other ingredients have their respective expressions in this
paradigm; nucleotide substitution, gene duplication-divergence, HGT,
stress-induced mutations, antibiotic resistance, Lamarckism would appear to fit
in naturally in this complexity paradigm defined through emergence of novelty
and self-organization.
  With obvious departures from current reductionism, this can have far reaching
implications in the Darwinian and nano medicine of genetic diseases and
disorders.
  Our goal is to chart a roadmap of adventure beyond (neo)-Darwinian
reductionism.
