  Using path integral technique, we show exactly that for a semiflexible
biopolymer in constant extension ensemble, no matter how long the polymer and
how large the external force, the effects of short range correlations in the
sequence-dependent spontaneous curvatures and torsions can be incorporated into
a model with well-defined mean spontaneous curvature and torsion as well as a
renormalized persistence length. Moreover, for a long biopolymer with large
mean persistence length, the sequence-dependent persistence lengths can be
replaced by their mean. However, for a short biopolymer or for a biopolymer
with small persistence lengths, inhomogeneity in persistence lengths tends to
make physical observables very sensitive to details and therefore less
predictable.
