  Significance: The depolarization of circularly polarized light caused by
scattering in turbid media reveals structural information about the dispersed
particles, such as their size, density, and distribution, which is useful for
investigating the state of biological tissue. However, the correlation between
depolarization strength and tissue parameters is unclear. Aim: We aimed to
examine the generalized correlations of depolarization strength with the
particle size and wavelength, yielding depolarization diagrams. Approach: The
correlation between depolarization intensity and size parameter were examined
for single and multiple scattering using the Monte Carlo simulation method.
Expanding the wavelength width allows us to obtain depolarization distribution
diagrams as functions of wavelength and particle diameter for reflection and
transparent geometries. Results: Circularly polarized light suffers intensive
depolarization in a single scattering against particles of various specific
sizes for its wavelength, which becomes more noticeable in the multiple
scattering regime. Conclusions: The depolarization diagrams with particle size
and wavelength as independent variables were obtained, which are particularly
helpful for investigating the feasibility of various particle-monitoring
methods. Based on the obtained diagrams, several applications have been
proposed, including blood cell monitoring, early embryogenesis, and
antigen-antibody interactions.
