  We investigate magnetic reconnection in systems simultaneously containing
asymmetric (anti-parallel) magnetic fields, asymmetric plasma densities and
temperatures, and arbitrary in-plane bulk flow of plasma in the upstream
regions. Such configurations are common in the high-latitudes of Earth's
magnetopause and in tokamaks. We investigate the convection speed of the
X-line, the scaling of the reconnection rate, and the condition for which the
flow suppresses reconnection as a function of upstream flow speeds. We use
two-dimensional particle-in-cell simulations to capture the mixing of plasma in
the outflow regions better than is possible in fluid modeling. We perform
simulations with asymmetric magnetic fields, simulations with asymmetric
densities, and simulations with magnetopause-like parameters where both are
asymmetric. For flow speeds below the predicted cutoff velocity, we find good
scaling agreement with the theory presented in Doss et al., J.~Geophys.~Res.,
120, 7748 (2015). Applications to planetary magnetospheres, tokamaks, and the
solar wind are discussed.
