  Investigating the interplay of dualities, generalized symmetries, and
topological defects beyond theoretical models is an important challenge in
condensed matter physics and quantum materials. A simple model exhibiting this
physics is the transverse-field Ising model, which can host a noninvertible
topological defect that performs the Kramers-Wannier duality transformation.
When acting on one point in space, this duality defect imposes the duality
twisted boundary condition and binds a single Majorana zero mode. This Majorana
zero mode is unusual as it lacks localized partners and has an infinite
lifetime, even in finite systems. Using Floquet driving of a closed Ising chain
with a duality defect, we generate this Majorana zero mode in a digital quantum
computer. We detect the mode by measuring its associated persistent
autocorrelation function using an efficient sampling protocol and a compound
strategy for error mitigation. We also show that the Majorana zero mode resides
at the domain wall between two regions related by a Kramers-Wannier duality.
Finally, we highlight the robustness of the isolated Majorana zero mode to
integrability and symmetry-breaking perturbations. Our findings offer an
approach to investigating exotic topological defects in digitized quantum
devices.
