  Inhomogeneities in the refractive index of a biological sample can introduce
phase aberrationsin microscopy systems, severely impairing the quality of
images. Adaptive optics can be employed to correct for phase aberrations and
improve image quality. However, conventional adaptive optics can only correct a
single phase aberration for the whole field of view (isoplanatic correction)
while, due to the three dimensional nature of biological tissues, sample
induced aberrations in microscopy often vary throughout the field of view
(anisoplanatic aberration), limiting significantly the effectiveness of
adaptive optics. This paper reports on a new approach for aberration correction
in laser scanning confocal microscopy, in which a spatial light modulator is
used to generate multiple excitation points in the sample to simultaneously
scan different portions of the field of view with completely independent
correction, achieving anisoplanatic compensation of sample induced aberrations.
The method was tested in 150 {\mu}m thick whole Drosophila brains, showing a
dramatic improvement in resolution and sharpness when compared to conventional
isoplanatic adaptive optics.
