  In the impulse approximation regime the nuclear response to a weakly
interacting probe can be written in terms of the measured nucleon structure
fuctions and the target spectral function, yielding the energy and momentum
distribution of the constituent nucleons. We discuss a calculation of charged
current neutrino-oxygen interactions in the quasielastic channel, carried out
within nuclear many body theory. The proposed approach, extensively and
successfully employed in the analysys of electron-nucleus scattering data,
allows for a parameter free prediction of the neutrino-nucleus cross section,
whose quantitative understanding will be critical to the analysis of the next
genaration of high precision neutrino oscillation experiments.
