  The paper addresses the quantization of minisuperspace cosmological models by
studying a possible solution to the problem of time and time asymmetries in
quantum cosmology. Since General Relativity does not have a privileged time
variable of the newtonian type, it is necessary, in order to have a dynamical
evolution, to select a physical clock. This choice yields, in the proposed
approach, to the breaking of the so called clock-reversal invariance of the
theory which is clearly distinguished from the well known motion-reversal
invariance of both classical and quantum mechanics. In the light of this new
perspective, the problem of imposing proper boundary conditions on the space of
solutions of the Wheeler-DeWitt equation is reformulated. The symmetry-breaking
formalism of previous papers is analyzed and a clarification of it is proposed
in order to satisfy the requirements of the new interpretation.
