  Majorana zero bound mode exists in the vortex core of a chiral $p+ip$
superconductor or superfluid, which can be driven from an s-wave pairing state
by two-dimensional (2D) spin-orbit (SO) coupling. We propose here a novel
scheme based on realistic cold atom platforms to generate 2D SO interactions in
a blue-detuned square optical lattice, and predict both the quantum anomalous
Hall effect and chiral topological superfluid phase in the experimentally
accessible parameter regimes. This work opens a new direction with experimental
feasibility to observe non-Abelian topological orders in cold atom systems.
