  Alterations in structural brain laterality are reported in
attention-deficit/hyperactivity disorder (ADHD). However, few studies examined
differences within presentations of ADHD. We investigate asymmetry index (AI)
across 13 subcortical and 33 cortical regions from anatomical metrics of
volume, surface area, and thickness. Structural T1-weighted MRI data were
obtained from youths with inattentive (n = 64) and combined (n = 51)
presentations, and aged-matched controls (n = 298). We used a linear mixed
effect model that accounts for data site heterogeneity, while studying
associations between AI and covariates of presentation and age. Our paper
contributes to the functional results seen among ADHD presentations evidencing
disrupted connectivity in motor networks from ADHD-C and cingulo-frontal
networks from ADHD-I, as well as new findings in the temporal cortex and
default mode subnetworks. Age patterns of structural asymmetries vary with
presentation type. Linear mixed effects model is a practical tool for
characterizing associations between brain asymmetries, diagnosis, and
neurodevelopment.
