  Dosage schedule of the Proton Pump Inhibitors (PPIs) is critical for gastric
acid disorder treatment. In this paper, we develop a constrained optimization
based approach for scheduling the PPIs dosage. In particular, we exploit a
mathematical prediction model describing the gastric acid secretion, and use it
within the optimization algorithm to predict the acid level. The dosage of the
PPIs which is used to enforce acid level constraints is computed by solving a
constrained optimization problem. Simulation results show that the proposed
approach can successfully suppress the gastric acid level with less PPIs intake
compared with the conventional fixed PPIs dosage regimen, which may reduce the
long-term side effects of the PPIs.
