  Variously stained histology slices are routinely used by pathologists to
assess extracted tissue samples from various anatomical sites and determine the
presence or extent of a disease. Evaluation of sequential slides is expected to
enable a better understanding of the spatial arrangement and growth patterns of
cells and vessels. In this paper we present a practical two-step approach based
on diffeomorphic registration to align digitized sequential histopathology
stained slides to each other, starting with an initial affine step followed by
the estimation of a detailed deformation field.
