  A sensation of fullness in the bladder is a regular experience, yet the
mechanisms that act to generate this sensation remain poorly understood. This
is an important issue because of the clinical problems that can result when
this system does not function properly. The aim of the study group activity was
to develop mathematical models that describe the mechanics of bladder filling,
and how stretch modulates the firing rate of afferent nerves. Several models
were developed, which were qualitatively consistent with experimental data
obtained from a mouse model.
