  Identifying key agents for the transmission of diseases (ideas, technology,
etc.) across social networks has predominantly relied on measures of centrality
on a static base network or a temporally flattened graph of agent interactions.
Various measures have been proposed as the best trackers of influence, such as
degree centrality, betweenness, and $k$-shell, depending on the structure of
the connectivity. We consider SIR and SIS propagation dynamics on a
temporally-extruded network of observed interactions and measure the
conditional marginal spread as the change in the magnitude of the infection
given the removal of each agent at each time: its temporal knockout (TKO)
score. We argue that the exhaustive approach of the TKO score makes it an
effective benchmark measure for evaluating the accuracy of other, often more
practical, measures of influence. We find that none of the common network
measures applied to the induced flat graphs are accurate predictors of network
propagation influence on the systems studied; however, temporal networks and
the TKO measure provide the requisite targets for the hunt for effective
predictive measures.
