  We investigated a new optical approach for the detection of the coagulation
dynamic process by means of the information on the optical vortex. In our
study, laser speckle was captured using a high-speed CMOS camera, and the
statistical information of the optical vortex characterized the change in
coagulation properties with time. Similar to the scattering particles, the
motion of the optical vortex is restricted during coagulation, as a result, the
whole process of coagulation can be detected by calculating the mean square
displacement(MSD) of the optical vortex. The results demonstrate a close
correlation between coagulation parameters measured using the optical vortex
method and thrombelastography(TEG), creating a powerful opportunity for
self-testing and real-time detection of coagulation.
