  A new paradigm is beginning to emerge in Radiology with the advent of
increased computational capabilities and algorithms. This has led to the
ability of real time learning by computer systems of different lesion types to
help the radiologist in defining disease. For example, using a deep learning
network, we developed and tested a multiparametric deep learning (MPDL) network
for segmentation and classification using multiparametric magnetic resonance
imaging (mpMRI) radiological images. The MPDL network was constructed from
stacked sparse autoencoders with inputs from mpMRI. Evaluation of MPDL
consisted of cross-validation, sensitivity, and specificity. Dice similarity
between MPDL and post-DCE lesions were evaluated. We demonstrate high
sensitivity and specificity for differentiation of malignant from benign
lesions of 90% and 85% respectively with an AUC of 0.93. The Integrated MPDL
method accurately segmented and classified different breast tissue from
multiparametric breast MRI using deep leaning tissue signatures.
