  We present a new method, the analytical rebridging scheme, for Monte Carlo
simulation of proline-containing, cyclic peptides. The cis/trans isomerization
is accommodated by allowing for two states of the amide bond. We apply our
method to five peptides that have been previously characterized by NMR methods.
Our simulations achieve effective equilibration and agree well with
experimental data in all cases. We discuss the importance of effective
equilibration and the role of bond flexibility and solvent effects on the
predicted equilibrium properties.
