  Intensity Modulated Radiation Therapy is an effective cancer treatment.
Models based on the Generalized Equivalent Uniform Dose (gEUD) provide
radiation plans with excellent planning target volume coverage and low
radiation for organs at risk. However, manual adjustment of the parameters
involved in gEUD is required to ensure that the plans meet patient-specific
physical restrictions. This paper proposes a radiotherapy planning methodology
based on bi-level optimization. We evaluated the proposed scheme in a real
patient and compared the resulting irradiation plans with those prepared by
clinical planners in hospital devices. The results in terms of efficiency and
effectiveness are promising.
