  The presence of metamorphism in the protein's native state is not yet fully
understood. In an attempt to throw light on this issue here we present an
assessment, in terms of the amide hydrogen exchange protection factor, that
aims to determine the likely existence of structural fluctuations in the
native-state consistent with both the upper bound marginal stability of
proteins and the metamorphism presence. The preliminary results enable us to
conclude that the native-state metamorphism is, indeed, more probable than
thought.
