  In this study, we conduct a study on magnetic hyperthermia treatment when a
vessel is located near the tumor. The holistic framework is established to
solve the process of tumor treatment. The interstitial tissue fluid, MNP
distribution, temperature profile, and nanofluids are involved in the
simulation. The study evaluates the cancer treatment efficacy by
cumulative-equivalent-minutes-at-43 centigrade (CEM43), a widely accepted
thermal dose. The influence of the nearby blood vessel is investigated, and
parameter studies about the distance to the tumor, the width of the blood
vessel, and the vessel direction are also conducted. After that, the effects of
the fluid-structure interaction of moving vessel boundaries and blood rheology
are discussed. The results demonstrate the cooling effect of a nearby blood
vessel, and such effect reduces with the augment of the distance between the
tumor and blood vessel. The combination of downward gravity and the cool effect
from the lower horizontal vessel leads to the best performance with 97.77%
ablation in the tumor and 0.87% injury in healthy tissue at distance d = 4 mm,
but the cases of the vertical vessel are relatively poor. The vessel width and
blood rheology affect the treatment by velocity gradient near the vessel wall.
Additionally, the moving boundary almost has no impact on treatment efficacy.
The simulation tool has been well-validated and the outcomes can provide a
useful reference to magnetic hyperthermia treatment.
