  Nanoparticle (NP)-based applications are becoming increasingly important in
the biomedical field. However, understanding the interactions of NPs with
biofluids and cells is a major issue in order to develop novel approaches aimed
at boosting their internalization and, therefore, their translation into the
clinic. To this end, we put forward a transport mathematical model to describe
the spatio-temporal dynamics of iron oxide NPs and their interaction with cells
under moderate centrifugation. Our numerical simulations allowed us to quantify
the relevance of the flux density as one of the unavoidable key features
driving NPs interaction with the media as well as for cell internalization
processes. These findings will help to increase the efficiency of cell
labelling for biomedical applications.
