  In this work, we deal with a mathematical model describing the dissolution
process of irregularly shaped particles. In particular, we consider a complete
dissolution model accounting for both surface kinetics and convective
diffusion, for three drugs with different solubility and wettability:
theophylline, griseofulvin, and nimesulide. The possible subsequent
recrystallization process in the bulk fluid is also considered. The governing
differential equations are revisited in the context of the level-set method and
Hamilton-Jacobi equations, then they are solved numerically. This choice allows
us to deal with the simultaneous dissolution of hundreds of different
polydisperse particles. We show the results of many computer simulations which
investigate the impact of the particle size, shape, area/volume ratio, and the
dependence of the interfacial mass transport coefficient on the surface
curvature.
