  We investigate the electron (hole) transport through short double-stranded
DNA wires in which the electrons are strongly coupled to the specific
vibrational modes (vibrons) of the DNA. We analyze the problem starting from a
tight-binding model of DNA, with parameters derived from ab-initio
calculations, and describe the dissipative transport by equation-of-motion
techniques. For homogeneous DNA sequences like Poly- (Guanine-Cytosine) we find
the transport to be quasi-ballistic with an effective density of states which
is modified by the electron-vibron coupling. At low temperatures the linear
conductance is strongly enhanced, but above the `semiconducting' gap it is
affected much less. In contrast, for inhomogeneous (`natural') sequences almost
all states are strongly localized, and transport is dominated by dissipative
processes. In this case, a non-local electron-vibron coupling influences the
conductance in a qualitative and sequence-dependent way.
