  Qualitative attributes of the region between order and disorder are examined
to explore models of genetic and protein networks. Results show how the
connectivity of vertices and the strength of their connections are related and
how their stability is related to their geometry. It has been possible to
relate the interaction energies and chemical potentials of general lattices
with the coordination numbers of such lattice models. The results seem to agree
with some of those obtained by means of other methods, e.g., those of Barabasi,
Strognatz, Dorogovtsev, and Kauffman (BSDK). This can yield new perspectives to
the cause, treatment and remedies of disease other than the present mode of
drug discovery prevalent: the docking of a single ligand on to a target
molecule. In order to utilize such results more efficiently, the pathway of
biological processes need be elucidated. A method is available for determining
biochemical-reaction or metabolic pathways through its systematic synthesis. It
is based on a rigorous graph-theoretic method for identifying pathways of
catalytic reactions. It synthesizes networks of metabolic pathways using a
highly exacting combinatorial method. It generates not only all feasible,
independent reaction networks but also those combinations of independent
pathways. This method can determine the mechanisms of complex chemical
reactions and is applicable to biochemical reactions. It is important to
combine this result with the mechanisms existent in gene regulatory networks.
Training Genetic Regulatory Networks for feasible biochemical reaction networks
or pathways and incorporating such knowledge into DNA would be a superb
technique for vanquishing complex diseases.
