  The computer-aided diagnosis (CAD) systems can highly improve the reliability
and efficiency of melanoma recognition. As a crucial step of CAD, skin lesion
segmentation has the unsatisfactory accuracy in existing methods due to large
variability in lesion appearance and artifacts. In this work, we propose a
framework employing multi-stage UNets (MS-UNet) in the auto-context scheme to
segment skin lesion accurately end-to-end. We apply two approaches to boost the
performance of MS-UNet. First, UNet is coupled with a context information
fusion structure (CIFS) to integrate the low-level and context information in
the multi-scale feature space. Second, to alleviate the gradient vanishing
problem, we use deep supervision mechanism through supervising MS-UNet by
minimizing a weighted Jaccard distance loss function. Four out of five commonly
used performance metrics, including Jaccard index and Dice coefficient, show
that our approach outperforms the state-ofthe-art deep learning based methods
on the ISBI 2016 Skin Lesion Challenge dataset.
