  Aggregation of amphiphiles through the action of hydrophobic interactions is
a common feature in soft condensed matter systems and is of particular
importance in the context of biophysics as it underlies both the generation of
functional biological machinery as well as the formation of pathological
misassembled states of proteins. Here we explore the aggregation behaviour of
amphiphilic polymers using lattice Monte-Carlo calculations and show that the
distribution of hydrophobic residues within the polymer sequence determines the
facility with which dry/wet interfaces can be created and that such interfaces
drive the aggregation process.
