  We present Molecular Dynamics simulations of Chymotrypsin inhibitor II and
PEO in presence of compatible solutes. Our results indicate that the the native
compact state of the studied macromolecules is stabilized in presence of
hydroxyectoine. We are able to explain the corresponding mechanism by a
variation of the solvent properties for higher hydroxyectoine concentrations.
Our results are validated by detailed free energy calculations.
