  In this paper, we study the recent 750 GeV diphoton excess in the Hill Model
with vector-like fermions, in which the singlet-like Higgs boson is chosen as
750 GeV resonance and is mainly produced by the gluon fusion through
vector-like top and bottom quarks. Meanwhile its diphoton decay rate is greatly
enhanced by the vector-like lepton. Under the current experimental and
theoretical constraints, we present the viable parameter space that fits the
750 GeV diphoton signal strength at 13 TeV LHC. We find that the heavier
vector-like fermion masses are, the smaller mixing angle $\theta$ is required.
The mixing angle of singlet and doublet Higgs bosons is constrained within
$|\sin\theta| \lesssim 0.15$ in the condition of the perturbative Yukawa
couplings. In the allowed parameter space, the 750 GeV diphoton cross section
can be maximally enhanced to about 6 fb at 13 TeV LHC.
