  We use a recently developed coarse-grained model to simulate the
overstretching of duplex DNA. Overstretching at 23C occurs at 74 pN in the
model, about 6-7 pN higher than the experimental value at equivalent salt
conditions. Furthermore, the model reproduces the temperature dependence of the
overstretching force well. The mechanism of overstretching is always
force-induced melting by unpeeling from the free ends. That we never see S-DNA
(overstretched duplex DNA), even though there is clear experimental evidence
for this mode of overstretching under certain conditions, suggests that S-DNA
is not simply an unstacked but hydrogen-bonded duplex, but instead probably has
a more exotic structure.
