  Two models are presented for the description of the electron screening
effects that appear in laboratory nuclear reactions at astrophysical energies.
The two-electron screening energy of the first model agrees very well with the
recent LUNA experimental result for the break-up reaction $%
He3(He3,2p)He^{4}$, which so far defies all available theoretical models.
Moreover, multi-electron effects that enhance laboratory reactions of the CNO
cycle and other advanced nuclear burning stages, are also studied by means of
the Thomas-Fermi model, deriving analytical formulae that establish a lower and
upper limit for the associated screening energy. The results of the second
model, which show a very satisfactory compatibility with the adiabatic
approximation ones, are expected to be particularly useful in future
experiments for a more accurate determination of the CNO astrophysical factors.
