  Native horse mucus is characterized with micro- and macrorheology and
compared to hydroxyethylcellulose (HEC) gel as a model. Both systems show
comparable viscoelastic properties on the microscale and for the HEC the
macrorheology is in good agreement with the microrheology. For the mucus, the
viscoelastic moduli on the macroscale are several orders of magnitude larger
than on the microscale. Large amplitude oscillatory shear experiments show that
the mucus responds nonlinearly at much smaller deformations than HEC. This
behavior fosters the assumption that the mucus has a foam like structure on the
microscale compared to the typical mesh like structure of the HEC, a model that
is supported by cryogenic-scanning-electron-microscopy (CSEM) images. These
images allow also to determine the relative amount of volume that is occupied
by the pores and the scaffold. Consequently, we can estimate the elastic
modulus of the scaffold. We conclude that this particular foam like
microstructure should be considered as a key factor for the transport of
particulate matter which plays a central role in mucus function with respect to
particle penetration. The mesh properties composed of very different components
are responsible for macroscopic and microscopic behavior being part of
particles fate after landing.
