  Routine single-sample haplotype-resolved assembly remains an unresolved
problem. Here we describe a new algorithm that combines PacBio HiFi reads and
Hi-C chromatin interaction data to produce a haplotype-resolved assembly
without the sequencing of parents. Applied to human and other vertebrate
samples, our algorithm consistently outperforms existing single-sample assembly
pipelines and generates assemblies of comparable quality to the best
pedigree-based assemblies.
