  Time delay cosmography uses the arrival time delays between images in strong
gravitational lenses to measure cosmological parameters, in particular the
Hubble constant $H_0$. The lens models used in time delay cosmography omit dark
matter subhalos and line-of-sight halos because their effects are assumed to be
negligible. We explicitly quantify this assumption by analyzing mock lens
systems that include full populations of dark matter subhalos and line-of-sight
halos, applying the same modeling assumptions used in the literature to infer
$H_0$. We base the mock lenses on six quadruply-imaged quasars that have
delivered measurements of the Hubble constant, and quantify the additional
uncertainties and/or bias on a lens-by-lens basis. We show that omitting dark
substructure does not bias inferences of $H_0$. However, perturbations from
substructure contribute an additional source of random uncertainty in the
inferred value of $H_0$ that scales as the square root of the lensing volume
divided by the longest time delay. This additional source of uncertainty, for
which we provide a fitting function, ranges from $0.7 - 2.4\%$. It may need to
be incorporated in the error budget as the precision of cosmographic inferences
from single lenses improves, and sets a precision limit on inferences from
single lenses.
