  We present the first complete calculation of the history of the inhomogeneous
21-cm signal from neutral hydrogen during the era of the first stars. We use
hybrid computational methods to capture the large-scale distribution of the
first stars, whose radiation couples to the neutral hydrogen emission, and to
evaluate the 21-cm signal from z ~ 15-35. In our realistic picture large-scale
fluctuations in the 21-cm signal are sourced by the inhomogeneous density field
and by the Ly-alpha and X-ray radiative backgrounds. The star formation is
suppressed by two spatially varying effects: negative feedback provided by the
Lyman-Werner radiative background, and supersonic relative velocities between
the gas and dark matter. Our conclusions are quite promising: we find that the
fluctuations imprinted by the inhomogeneous Ly-alpha background in the 21-cm
signal at z ~ 25 should be detectable with the Square Kilometer Array.
