  Neuropeptide SF (NPSF) is a member of RFamide neuropeptides that play diverse
roles in central nervous system. Little is know about the effects of NPSF on
brain functions. Antidepressant-like effect of NPSF was studied in modified
mice FST. NPSF showed the antidepressant-like effects by decreasing the
immobility time and increasing the climbing and swimming time. Furthermore, the
involvement of the adrenergic, serotonergic, cholinergic or dopaminergic
receptors in the antidepressant-like effect of NPSF was studied in modified
mice FST. Mice were pretreated with a non-selective {\alpha}-adrenergic
receptor antagonist phenoxybenzamine, a \b{eta}-adrenergic receptor antagonist,
propranolol, a non-selective 5-HT2 serotonergic receptor antagonist,
cyproheptadine, nonselective muscarinic acetylcholine receptor antagonist,
atropine, or D2, D3, D4 dopamine receptor antagonist, haloperidol. The present
results confirmed that the antidepressant-like effect of NPSF is mediated, at
least in part, by an interaction of the {\alpha}-adrenergic, 5-HT2
serotonergic, muscarinic acetylcholine receptors and D2, D3, D4 dopamine
receptor in a modified mouse FST.
