  Tumor angiogenesis concerns the development of new blood vessels supplying
the necessary nutrients for the further development of existing tumor cells.
The entire process is complex, involving the production and consumption of
chemicals, endothelial cell transitions as well as cell interactions,
divisions, and migrations. Microfluidic cell culture platform has been used to
study angiogenesis of endothelial cells derived from human induced pluripotent
stem cells (iPSC-ECs) for a physiological relevant micro-environment. In this
paper, we elaborate on how to define a pipeline for simulating the
transformation and process that an iPSC-derived endothelial cell goes through
in this biological scenario. We leverage the robustness and simplicity of Petri
nets for modeling the cell transformation and associated constraints. The
environmental and spacial factors are added using custom 2-dimensional grids.
Although the pipeline does not capture the entire complexity of tumor
angiogenesis, we are able to capture the essence of endothelial cell
transitions in tumor angiogenesis using this conceptually simplified solution.
