  An ensemble of directed macromolecules on a lattice is considered, where the
constituting molecules are chosen as a random sequence of N different types.
The same type of molecules experiences a hard-core (exclusion) interaction. We
study the robustness of the macromolecules with respect to breaking and
substituting individual molecules, using a 1/N expansion. The properties depend
strongly on the density of macromolecules. In particular, the macromolecules
are robust against breaking and substituting at high densities.
