  We metaphorically call "Grammar of Biology" a small field of genomic
research, whose main objective is to search for intrinsic DNA sequence
properties. Erwin Chargaff inaugurated it back in 50s, but since then little
progress has been made. It remained almost neglected until early 90s, when
Vinayakumar V. Prabhu made a major contribution determining the Symmetry
Principle. Remarkably, different sciences have contributed for its development,
for instance, Chargaff used his Chemistry background to discover the so-called
Chargaff's rules; taking advantage of several publicly available genomic
sequences, and through Computational and Statistical analyses, Prabhu
identified the Symmetry Principle and, recently, using a Mathematical approach,
we have discovered four new Generalized Chargaff's rules. Our work has expanded
the "Grammar of Biology", and created the conceptual and theoretical framework
necessary to further developments.
