  We outline a strategy of how to search for QCD instantons of invariant mass
20 -- 60 GeV in diffractive events in low luminosity runs at the LHC. We show
that by imposing appropriate selection criteria on the final states, one can
select the kinematic regime where the instanton signal exceeds the background
by a factor of at least 8. In spite of the relatively strong cuts that we
impose on the total transverse energy and the number of charged tracks, $\sum_i
E_{T,i}>15$ GeV, $N_{\rm ch}>20$ measured within the $0<\eta<2$ interval and
excluding events with high $p_{T}$ particles, the expected cross-section is
sufficiently large to study the instanton production in the events with Large
Rapidity Gaps at low luminosities, thus avoiding problems with pile-up. The
paper also includes an updated computation of instanton cross-sections and
other parameters relevant for the ongoing studies.
