  We test the validity of a possible schematization of DNA structure and
dynamics based on the Chern-Simons theory, that is a topological field theory
mostly considered in the context of effective gravity theories. By means of the
expectation value of the Wilson Loop, derived from this analogue gravity
approach, we find the point-like curvature of genomic strings in KRAS human
gene and COVID-19 sequences, correlating this curvature with the genetic
mutations. The point-like curvature profile, obtained by means of the
Chern-Simons currents, can be used to infer the position of the given mutations
within the genetic string. Generally, mutations take place in the highest
Chern-Simons current gradient locations and subsequent mutated sequences appear
to have a smoother curvature than the initial ones, in agreement with a free
energy minimization argument.
