  Design of detection strategies for multipartite entanglement stands as a
central importance on our understanding of fundamental quantum mechanics and
has had substantial impact on quantum information applications. However,
accurate and robust detection approaches are severely hindered, particularly
when the number of nodes grows rapidly like in a quantum network. Here we
present an exquisite procedure that generates novel entanglement witness for
arbitrary targeted state via a generic and operational framework. The framework
enjoys a systematic and high-efficient character and allows to substantiate
genuine multipartite entanglement for a variety of states that arise naturally
in practical situations, and to dramatically outperform currently standard
methods. With excellent noise tolerance, our framework should be broadly
applicable to witness genuine multipartite entanglement in various practically
scenarios, and to facilitate making the best use of entangled resources in the
emerging area of quantum network.
