  Motion during image acquisition can cause image degradation in all medical
imaging modalities. This is particularly relevant in 2-D ultrasound imaging,
since out-of-plane motion can only be compensated for movements smaller than
elevational beamwidth of the transducer. Localization based super-resolution
imaging creates even a more challenging motion correction task due to the
requirement of a high number of acquisitions to form a single super-resolved
frame.
  In this study, an extension of two-stage motion correction method is proposed
for 3-D motion correction. Motion estimation was performed on high volumetric
rate ultrasound acquisitions with a handheld probe. The capability of the
proposed method was demonstrated with a 3-D microvascular flow simulation to
compensate for handheld probe motion. Results showed that two-stage motion
correction method reduced the average localization error from 136 to 18
micrometres.
