  We combine the standard 1992 20x20 substitution matrix based on block
alignment, BLOSUM62, with the standard 1982 amino acid hydropathicity scale KD
as well as the modern 2007 hydropathicity scale MZ, and compare the results.
The 20-parameter KD and MZ hydropathicity scales have different thermodynamic
character, corresponding to first and second order transitions. The KD and MZ
comparisons show that the mutation rates reflect quantitative iteration of
qualitative amino acid phobic and philic binary 2x10 properties that define
quaternary 4x5 subgroups (but not quinary 5x4 subgroups), with the modern MZ
bioinformatic scale giving much better results. The quaternary 5 mer MZ 4x5
subgroups are called mutons (Mu5).
