  Left atrial (LA) segmentation from late gadolinium enhanced magnetic
resonance imaging (LGE MRI) is a crucial step needed for planning the treatment
of atrial fibrillation. However, automatic LA segmentation from LGE MRI is
still challenging, due to the poor image quality, high variability in LA
shapes, and unclear LA boundary. Though deep learning-based methods can provide
promising LA segmentation results, they often generalize poorly to unseen
domains, such as data from different scanners and/or sites. In this work, we
collect 210 LGE MRIs from different centers with different levels of image
quality. To evaluate the domain generalization ability of models on the LA
segmentation task, we employ four commonly used semantic segmentation networks
for the LA segmentation from multi-center LGE MRIs. Besides, we investigate
three domain generalization strategies, i.e., histogram matching, mutual
information based disentangled representation, and random style transfer, where
a simple histogram matching is proved to be most effective.
