  We present the results obtained from exploratory Chandra observations of nine
high-redshift (z=4.09-4.51) quasars, selected from among the optically
brightest Palomar Digital Sky Survey quasars known. Their broad-band spectral
energy distributions are characterized, on average, by steeper alpha_ox values
(<alpha_ox>=-1.81+/-0.03) than those of lower-redshift, lower-luminosity
samples of quasars. We find a significant correlation between AB1450(1+z)
magnitude and soft X-ray flux, suggesting that the engine powering the UV and
X-ray emission is the same. The joint 2-30 keV rest-frame X-ray spectrum is
well parameterized by a Gamma=2.0+/-0.2 power-law model with no evidence for
intrinsic absorption (N_H<8.8 10^{21} cm^-2).
