  Functional Magnetic Resonance Imaging (fMRI) is commonly utilized to study
human brain activity, including abnormal functional properties related to
neurodegenerative diseases. This study aims to investigate the differences in
the topological properties of functional brain networks between individuals
with Alzheimer's Disease (AD) and normal controls. A total of 590 subjects,
consisting of 175 with AD dementia and 415 age-, gender-, and
handedness-matched controls, were included. The topological properties of the
brain network were quantified using graph-theory-based analyses. The results
indicate abnormal network integration and segregation in the AD group. These
findings enhance our understanding of AD pathophysiology from a functional
brain network structure perspective and may aid in identifying AD biomarkers.
Supplementary data to aid in the validation of this research are available at
https://github.com/YongchengYAO/AD-FunctionalBrainNetwork.
