  In ab-initio electronic structure simulations, fermion-to-qubit mappings
represent the initial encoding step of the fermionic problem into qubits. This
work introduces a physically-inspired method for constructing mappings that
significantly simplify entanglement requirements when simulating states of
interest. The presence of electronic excitations drives the construction of our
mappings, reducing correlations for target states in the qubit space. To
benchmark our method, we simulate ground states of small molecules and observe
an enhanced performance when compared to classical and quantum variational
approaches from prior research employing conventional mappings. In particular,
on the quantum side, our mappings require a reduced number of entangling layers
to achieve chemical accuracy for the $LiH$, $H_2$, $(H_2)_2$ and $H_4$
molecules using the RY hardware efficient ansatz. In addition, our mappings
also provide an enhanced ground state simulation performance in the density
matrix renormalization group algorithm for the $N_2$ molecule.
