  Flexible dosing and ease of swallowing are key factors when designing oral
drug delivery systems for paediatric and geriatric populations.
Multi-particulate oral dosage forms can offer significant benefits over
conventional capsules and tablets. This study proposes the use of an in vitro
model to quantitatively investigate the swallowing dynamics in presence of
multi-particulates. In vitro results were compared against sensory tests that
considered the attributes of ease of swallowing and post-swallow residues.
Water and hydrocolloids were considered as suspending vehicles, while the
suspended phase consisted of cellulose pellets of two different average sizes.
Both in vivo and in vitro tests reported easier swallow for smaller
multi-particulates. Besides, water thin liquids appeared not optimal for
complete oral clearance of the solids. The sensory study did not highlight
significant differences between the levels of thickness of the hydrocolloids.
Conversely, more discriminant results were obtained from in vitro tests,
suggesting that a minimum critical viscosity is necessary to enable a smooth
swallow, but increasing too much the carrier concentration affects swallowing
negatively. These results highlight the important interplay of particle size
and suspending vehicle rheology and the meaningful contribution that in vitro
methods can provide to pre-screening multi-particulate oral drug delivery
systems before sensory evaluation.
