  We study D-brane inspired models with U(3) x U(2) x U(1)^N gauge symmetry in
the context of split supersymmetry. We consider configurations with one, two
and three (N=1,2,3) abelian branes and derive all hypercharge embeddings which
imply a realistic particle content. Then, we analyze the implications of split
supersymmetry on the magnitude of the string scale, the gauge coupling
evolution, the third family fermion mass relations and the gaugino masses. We
consider gauge coupling relations which may arise in parallel as well as
intersecting brane scenarios and classify the various models according to their
predictions for the magnitude of the string scale and the low energy
implications. In the parallel brane scenario where the U(1) branes are
superposed to U(2) or U(3) brane stacks, varying the split susy scale in a wide
range, we find three distinct cases of models predicting a high, intermediate
and low string scale, M_S ~ 10^{16} GeV, M_S ~ 10^7 GeV and M_S ~ 10^4 GeV
respectively. We further find that in the intermediate string scale model the
low energy ratio m_b / m_\tau is compatible with b-\tau Yukawa unification at
the string scale. Furthermore, we perform a similar analysis for arbitrary
abelian gauge coupling relations at M_S corresponding to possible intersecting
brane models. We find cases which predict a string scale of the order M_S \ge
10^{14} GeV that accommodate a right-handed neutrino mass of the same order so
that a see-saw type light left-handed neutrino component is obtained in the
sub-eV range as required by experimental and cosmological data. Finally, a
short discussion is devoted for the gaugino masses and the life-time of the
gluino.
