  We consider generalized self-duality equations for U(2r) Yang-Mills theory on
R^{4k} with quaternionic structure and self-dual Moyal deformation. We employ
the extended ADHM method in 4k dimensions to construct new noncommutative
generalizations of the 't Hooft as well as of the BPST instantons. It is shown
that in the commutative limit the BPST-type configurations coincide with the
standard instantons on HP^n written in local coordinates.
