  We prove multi-parameter Leibniz rules corresponding to flag paraproducts of
arbitrary complexity in mixed-norm spaces, including endpoint estimates. The
proof relies on multi-linear harmonic analysis techniques and a quantitative
treatment of the commutators introduced by Bourgain and Li. The argument is
robust and applicable to a generic class of multipliers, including (symmetric)
Mikhlin multipliers of positive order and asymmetric variants of partial
differential operators and Mikhlin multipliers of positive order.
