  In the past several years, we have taken advantage of a number of
opportunities to advance the intersection of next generation high-performance
computing AI and big data technologies through partnerships in precision
medicine. Today we are in the throes of piecing together what is likely the
most unique convergence of medical data and computer technologies. But more
deeply, we observe that the traditional paradigm of computer simulation and
prediction needs fundamental revision. This is the time for a number of
reasons. We will review what the drivers are, why now, how this has been
approached over the past several years, and where we are heading.
