  An integrated microscope that combines different optical techniques for
simultaneous imaging is demonstrated. The microscope enables spectral-domain
optical coherence microscopy based on optical backscatter, and multi-photon
microscopy for the detection of two-photon fluorescence and second harmonic
generation signals. The unique configuration of this integrated microscope
allows for the simultaneous acquisition of both anatomical (structural) and
functional imaging information with particular emphasis for applications in the
fields of tissue engineering and cell biology. In addition, the contemporary
analysis of the spectroscopic features can enhance contrast by differentiating
among different tissue components.
