  Context: Machine Learning (ML) has been at the heart of many innovations over
the past years. However, including it in so-called 'safety-critical' systems
such as automotive or aeronautic has proven to be very challenging, since the
shift in paradigm that ML brings completely changes traditional certification
approaches.
  Objective: This paper aims to elucidate challenges related to the
certification of ML-based safety-critical systems, as well as the solutions
that are proposed in the literature to tackle them, answering the question 'How
to Certify Machine Learning Based Safety-critical Systems?'.
  Method: We conduct a Systematic Literature Review (SLR) of research papers
published between 2015 to 2020, covering topics related to the certification of
ML systems. In total, we identified 217 papers covering topics considered to be
the main pillars of ML certification: Robustness, Uncertainty, Explainability,
Verification, Safe Reinforcement Learning, and Direct Certification. We
analyzed the main trends and problems of each sub-field and provided summaries
of the papers extracted.
  Results: The SLR results highlighted the enthusiasm of the community for this
subject, as well as the lack of diversity in terms of datasets and type of
models. It also emphasized the need to further develop connections between
academia and industries to deepen the domain study. Finally, it also
illustrated the necessity to build connections between the above mention main
pillars that are for now mainly studied separately.
  Conclusion: We highlighted current efforts deployed to enable the
certification of ML based software systems, and discuss some future research
directions.
