  Structure and reaction studies with a method of antisymmetrized molecular
dynamics (AMD) were reviewed. Applications of time-independent and
time-dependent versions of the AMD were described. In applications of
time-independent AMD to nuclear structure studies, structures of neutron-rich
nuclei such as Be, C, Ne, and Mg isotopes were described focusing on cluster
aspects. Important roles of valence neutrons were discussed. The results
suggested a variety of cluster structures appear also in unstable nuclei as
well as in stable nuclei. Deformation and cluster phenomena in $Z\sim N$ nuclei
in $p$- and $sd$- shell regions were also discussed. Applications of
time-dependent AMD contain various topics such as fragmentation in heavy-ion
collisions as well as nuclear responses. The AMD calculations successfully
describe multifragmentation which is one of the remarkable phenomena in
heavy-ion collisions. The approach is able to link reactions and nuclear matter
properties. The studies suggested the important balance between single-particle
motions and correlations to form clusters and fragments.
