  In tissue engineering, 3D scaffolds and chemical treatments are often used
for providing a cell-friendly surface for improving cell adhesion and tissue
growth. Indeed, the cell adhesion degree can be controlled by physical-chemical
changes in the surface of substrates, such as wettability, surface charges and
roughness. In this work, we describe the synthesis, characterization and
cytocompatibility of photoresins useful for construction of cell scaffolds via
two-photon polymerization. Additionally, we have demonstrated a simple surface
treatment method that promotes cell adhesion. This method alters the surface
charge of the polymer and enhances the adhesion of epithelial cells. Our
results indicate an efficient approach for modifying the surface of
biocompatible polymer scaffolds with the purpose of enhances the performance of
cell functions suitable for tissue engineering and regenerative medicine.
