  Muscular dystrophy (MD) describes generalized progressive muscular weakness
due to the wasting of muscle fibers. The progression of the disease is affected
by known immunological and mechanical factors, and possibly other unknown
mechanisms. These dynamics have begun to be elucidated in the last two decades.
This article reviews mathematical models of MD that characterize molecular and
cellular components implicated in MD progression. A biological background for
these processes is also presented. Molecular effectors that contribute to MD
include mitochondrial bioenergetics and genetic factors; both drive cellular
metabolism, communication and signaling. These molecular events leave cells
vulnerable to mechanical stress which can activate an immunological cascade
that weakens cells and surrounding tissues. This review article lays the
foundation for a systems biology approach to study MD progression.
