  The Quark-Meson-Coupling model, which self-consistently relates the dynamics
of the internal quark structure of a hadron to the relativistic mean fields
arising in nuclear matter, provides a natural explanation to many open
questions in low energy nuclear physics, including the origin of many-body
nuclear forces and their saturation, the spin-orbit interaction and properties
of hadronic matter at a wide range of densities up to those occurring in the
cores of neutron stars. Here we focus on four aspects of the model (i) a full
comprehensive survey of the theory, including the latest developments, (ii)
extensive application of the model to ground state properties of finite nuclei
and hypernuclei, with a discussion of similarities and differences between the
QMC and Skyrme energy density functionals, (iii) equilibrium conditions and
composition of hadronic matter in cold and warm neutron stars and their
comparison with the outcome of relativistic mean-field theories and, (iv) tests
of the fundamental idea that hadron structure changes in-medium.
