  Studies suggests that patients with deep vein thrombosis and diabetes often
have hy-per coagulable blood plasma leading to higher chances of forming
thromboembolisms by the rupture of blood clots, which may lead to stroke and
death. Despite the advances in the field of blood clot formation and lysis
research, the change in mechanical properties and its impli-cation into the
formation of thromboembolisms in platelet poor plasma is poorly understood. In
this paper, we present a new computational method to simulate fibrin clot
formation using molecular simulations. With an effective combination of
reactive molecular dynamics con-cept and coarse graining principle, we have
utilized the reactive coarse grain molecular dy-namics to predict the complex
network formation of fibrin clots and the branching of the fi-brins. The heavy
340 kDa fibrinogen is converted into a simple spring-bead coarse grain sys-tem
with 9 beads, and using our customized reactive potentials, we simulated the
formation of the fibrin clot. Thus, formed fibrin clot agrees with the
experimental results qualitatively, and to our best knowledge this is the first
kind of molecular polymerization study of fibrin clot which can lead to improve
our understanding about blood clot formation and its relation-ship with
mechanical properties.
