  In this letter we study the low-energy phenomenology and cosmological
implications of supersymmetric grand unified theory with asymmetric flavor
structure, which is suggested by the recent observation of fermion masses and
mixing angles. The predictions of the scenario are rather dependent on a Yukawa
parameter fixed by group-theoretical argument. A reduced value of the parameter
gives a resolution to the sign problem of supersymmetric Higgs mass \mu, with
which the theory becomes simultaneously consistent with the experimental data
of bottom/tau mass ratio, flavor-changing rare decay of bottom quark, and the
muon anomalous magnetic moment. The relic abundance of the lightest
superparticle as cold dark matter of the universe is also investigated in light
of the three-years WMAP result. A new source of flavor violation is found in
the D-term induced scalar masses, that is a distinctive signature of the
generation asymmetry.
