  Based on a data sample of 60 pb$^{-1}$ collected at the $\psi(3770)$
resonance with the CLEO-c detector at CESR, we present improved measurements of
absolute branching fractions for exclusive $D^0$ semileptonic decays into
$K^-e^+\nu$, $\pi^-e^+\nu$ and $K^{*-}e^+\nu$, and the first observation and
measurement of $D^0 \to \rho^-e^+\nu$. The determinations of the CKM matrix
elements $V_{cs}$ and $V_{cd}$ are reviewed.
