  We combined the genetic crossover, which is one of the operations of genetic
algorithm, and replica-exchange method in parallel molecular dynamics
simulations. The genetic crossover and replica-exchange method can search the
global conformational space by exchanging the corresponding parts between a
pair of conformations of a protein. In this study, we applied this method to an
$\alpha$-helical protein, Trp-cage mini protein, which has 20 amino-acid
residues. The conformations obtained from the simulations are in good agreement
with the experimental results.
