  We present a detailed study of charged-current (CC) neutrino-nucleus
reactions in a fully relativis- tic framework and comparisons with recent
experiments spanning an energy range from hundreds of MeV up to 100 GeV within
the SuperScaling Approach, which is based on the analysis of electron- nucleus
scattering data and has been recently improved with the inclusion of
Relativistic Mean Field theory effects. We also evaluate and discuss the impact
of two-particle two-hole meson-exchange currents (2p-2h MEC) on
neutrino-nucleus interactions through the analysis of two-particle two-hole
axial and vector contributions to weak response functions in a fully
relativistic Fermi gas. The results show a fairly good agreement with
experimental data over the whole range of neutrino energies.
