  Background: The objective of this study is to evaluate the impact of COVID-19
inactivated vaccine administration on the outcomes of in vitro fertilization
(IVF) and intracytoplasmic sperm injection (ICSI) cycles in infertile couples
in China. Methods: We collected data from the CYART prospective cohort, which
included couples undergoing IVF treatment from January 2021 to September 2022
at Sichuan Jinxin Xinan Women & Children's Hospital. Based on whether they
received vaccination before ovarian stimulation, the couples were divided into
the vaccination group and the non-vaccination group. We compared the laboratory
parameters and pregnancy outcomes between the two groups. Findings: After
performing propensity score matching (PSM), the analysis demonstrated similar
clinical pregnancy rates, biochemical pregnancy and ongoing pregnancy rates
between vaccinated and unvaccinated women. No significant disparities were
found in terms of embryo development and laboratory parameters among the
groups. Moreover, male vaccination had no impact on patient performance or
pregnancy outcomes in assisted reproductive technology treatments.
Additionally, there were no significant differences observed in the effects of
vaccination on embryo development and pregnancy outcomes among couples
undergoing ART. Interpretation: The findings suggest that COVID-19 vaccination
did not have a significant effect on patients undergoing IVF/ICSI with fresh
embryo transfer. Therefore, it is recommended that couples should receive
COVID-19 vaccination as scheduled to help mitigate the COVID-19 pandemic.
