  For $n\geq 2$, we establish the smooth effects for the solutions of the
linear fourth order Shr\"{o}dinger equation in anisotropic Lebesgue spaces with
$\Box_k$-decomposition. Using these estimates, we study the Cauchy problem for
the fourth order nonlinear Schr\"{o}dinger equations with three order
derivatives and obtain the global well posedness for this problem with small
data in modulation space $M^{9/2}_{2,1}({\Real^{n}})$.
