  EEG slowing is reported in various neurological disorders including
Alzheimer's, Parkinson's and Epilepsy. Here, we investigate alpha rhythm
slowing in individuals with refractory temporal lobe epilepsy (TLE), compared
to healthy controls, using scalp electroencephalography (EEG) and
magnetoencephalography (MEG).
  We retrospectively analysed data from 17,(46) healthy controls and 22,(24)
individuals with TLE who underwent scalp EEG and (MEG) recordings as part of
presurgical evaluation. Resting-state, eyes-closed recordings were source
reconstructed using the standardized low-resolution brain electrographic
tomography (sLORETA) method. We extracted low (slow) 6-9 Hz and high (fast)
10-11 Hz alpha relative band power and calculated the alpha power ratio by
dividing low (slow) alpha by high (fast) alpha. This ratio was computed for all
brain regions in all individuals.
  Alpha oscillations were slower in individuals with TLE than controls
(p<0.05). This effect was present in both the ipsilateral and contralateral
hemispheres, and across widespread brain regions.
  Alpha slowing in TLE was found in both EEG and MEG recordings. We interpret
greater low (slow)-alpha as greater deviation from health.
