  Adversarial attacks pose a challenge to the deployment of deep neural
networks (DNNs), while previous defense models overlook the generalization to
various attacks. Inspired by targeted therapies for cancer, we view adversarial
samples as local lesions of natural benign samples, because a key finding is
that salient attack in an adversarial sample dominates the attacking process,
while trivial attack unexpectedly provides trustworthy evidence for obtaining
generalizable robustness. Based on this finding, a Pixel Surgery and Semantic
Regeneration (PSSR) model following the targeted therapy mechanism is
developed, which has three merits: 1) To remove the salient attack, a
score-based Pixel Surgery module is proposed, which retains the trivial attack
as a kind of invariance information. 2) To restore the discriminative content,
a Semantic Regeneration module based on a conditional alignment extrapolator is
proposed, which achieves pixel and semantic consistency. 3) To further
harmonize robustness and accuracy, an intractable problem, a self-augmentation
regularizer with adversarial R-drop is designed. Experiments on numerous
benchmarks show the superiority of PSSR.
