  Overcoming chemoresistance is a challenge for multiple chemotherapeutics
agents like cisplatin. ABC transporters such as MDR1 or MRPs and PI3K/AKT
pathway have been proposed as actors of chemoresistance in several cancers. In
this review we describe two downstream targets of Akt: c-myc and p53 in the
chemoresistance. We suggest a potential link between p53, c-myc and ABC
transporters expression. Consequently a link between Akt and ABC
transporters-mediated chemoresistance may exist. Finally we show that Akt
activation may be Orai-dependent and/or TRPC-dependent, suggesting that these
ion channels could constitute a therapeutic target in cancer.
