  The revolutionary progress in development of next-generation sequencing (NGS)
technologies has made it possible to deliver accurate genomic information in a
timely manner. Over the past several years, NGS has transformed biomedical and
clinical research and found its application in the field of personalized
medicine. Here we discuss the rise of personalized medicine and the history of
NGS. We discuss current applications and uses of NGS in medicine, including
infectious diseases, oncology, genomic medicine, and dermatology. We provide a
brief discussion of selected studies where NGS was used to respond to wide
variety of questions in biomedical research and clinical medicine. Finally, we
discuss the challenges of implementing NGS into routine clinical use.
