  Motivated by the diphoton excess at 750 GeV reported by the ATLAS and CMS
experiments, we present an F-theory inspired flipped $SO(10)$ model embedded in
an $E_6$ GUT. The low energy spectrum includes the three MSSM chiral families,
vectorlike color triplets, several pairs of charged $SU(2)_L$ singlet fields
$(E^c, \bar E^c)$, as well as MSSM singlets, one or more of which can
contribute to the resonance. Total decay width in the multi-GeV range can arise
from couplings involving the singlet and MSSM fields
