  Several clinical methods had been utilized for diagnosis of COVID-19 for
instance, real-time reverse transcription-polymerase chain reaction (rRT-PCR),
hematology examination, polymerase chain reaction (PCR), diagnostic guidelines
based on clinical features, and Chest CT scans. However, the accurate current
methods are time-consuming and expensive and other methods are inaccurate. To
solve these drawbacks, nanozyme-based sensors have been developed for the
reliable, accurate, and rapid detection of SARS-CoV-2. The main basis of these
sensors is the detection of color variation of a nanozyme-mediated oxidation
reaction in the presence and the absence of antigens of COVID-19. Besides, some
of methods are based on probing the fluorescence of these systems as the
clinical signal toward detection of SARS-CoV-2. This mini review focused on
overviewing the nanozymes-based methods toward COVID-19 diagnosis. The
historical background of COVID-19 was reviewed. Thereafter, the biomedical
applications of nanozymes was discussed and finally, the recent progress of
early diagnosis of COVID-19 based on nanozymatic systems was briefly reviewed.
