  We demonstrate Rydberg blockade due to the charge-dipole interaction between
a single Rb atom and a single RbCs molecule confined in optical tweezers. The
molecule is formed by magnetoassociation of a Rb+Cs atom pair and subsequently
transferred to the rovibrational ground state with an efficiency of 91(1)\%.
Species-specific tweezers are used to control the separation between the atom
and molecule. The charge-dipole interaction causes blockade of the transition
to the Rb(52s) Rydberg state, when the atom-molecule separation is set to
$310(40)$~nm. The observed excitation dynamics are in good agreement with
simulations using calculated interaction potentials. Our results open up the
prospect of a hybrid platform where quantum information is transferred between
individually trapped molecules using Rydberg atoms.
