  While most studies emphasize on certain aspects of Pathogen-Host Interactions
(PHI), such as the preferential attachment of bacteria or virus to its human
receptor homolog, studies have attempted to methodically classify interactions
among pathogenic proteins and their host proteins. Here we have analyzed 182
pathogens from The Pathogen-Host Interaction Search Tool (PHISTO) and could
identify the proteins/protein coding genes that act on both virus and bacteria.
Importantly there were few proteins viz. P53 (Tumor protein p53), NFKB1
(Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1), GBLP
(Guanine nucleotide-binding protein subunit beta-2-like-1), TOX4 (TOX high
mobility group box family member 4), PDIA1 (Protein disulfide-isomerase
precursor), MHY9 (Myosin 9), RAC1 (Ras-related C3 botulinum toxin substrate 1),
CCAR2 (Cell cycle and apoptosis regulator protein 2) and ILF3 (Interleukin
enhancer binding factor 3) that were more susceptible to both bacterial and
viral pathogens. Identification of such important interacting proteins (IIPs)
can elicit significant insights for better understanding the molecular
mechanisms of such pathogens that interact with the human host.
