  Recent observations using several different telescopes and sky surveys showed
patterns of asymmetry in the distribution of galaxies by their spin directions
as observed from Earth. These studies were done with data imaged from the
Northern hemisphere, showing excellent agreement between different telescopes
and different analysis methods. Here, data from the DESI Legacy Survey was
used. The initial dataset contains $\sim2.2\cdot10^7$ galaxy images, reduced to
$\sim8.1\cdot10^5$ galaxies annotated by their spin direction using a symmetric
algorithm. That makes it not just the first analysis of its kind in which the
majority of the galaxies are in the Southern hemisphere, but also by far the
largest dataset used for this purpose to date. The results show strong
agreement between opposite parts of the sky, such that the asymmetry in one
part of the sky is similar to the inverse asymmetry in the corresponding part
of the sky in the opposite hemisphere. Fitting the distribution of galaxy spin
directions to cosine dependence shows a dipole axis with probability of
4.66$\sigma$. Interestingly, the location of the most likely axis is within
close proximity to the CMB Cold Spot. The profile of the distribution is nearly
identical to the asymmetry profile of the distribution identified in
Pan-STARRS, and it is within 1$\sigma$ difference from the distribution profile
in SDSS and HST. All four telescopes show similar large-scale profile of
asymmetry.
