  There are two fundamental problems in applying deep learning/machine learning
methods to disease classification tasks, one is the insufficient number and
poor quality of training samples; another one is how to effectively fuse
multiple source features and thus train robust classification models. To
address these problems, inspired by the process of human learning knowledge, we
propose the Feature-aware Fusion Correlation Neural Network (FaFCNN), which
introduces a feature-aware interaction module and a feature alignment module
based on domain adversarial learning. This is a general framework for disease
classification, and FaFCNN improves the way existing methods obtain sample
correlation features. The experimental results show that training using
augmented features obtained by pre-training gradient boosting decision tree
yields more performance gains than random-forest based methods. On the
low-quality dataset with a large amount of missing data in our setup, FaFCNN
obtains a consistently optimal performance compared to competitive baselines.
In addition, extensive experiments demonstrate the robustness of the proposed
method and the effectiveness of each component of the model\footnote{Accepted
in IEEE SMC2023}.
