  Nuclear structure and reaction theory is undergoing a major renaissance with
advances in many-body methods, strong interactions with greatly improved links
to Quantum Chromodynamics (QCD), the advent of high performance computing, and
improved computational algorithms. Predictive power, with well-quantified
uncertainty, is emerging from non-perturbative approaches along with the
potential for guiding experiments to new discoveries. We present an overview of
some of our recent developments and discuss challenges that lie ahead. Our foci
include: (1) strong interactions derived from chiral effective field theory;
(2) advances in solving the large sparse matrix eigenvalue problem on
leadership-class supercomputers; (3) selected observables in light nuclei with
the JISP16 interaction; (4) effective electroweak operators consistent with the
Hamiltonian; and, (5) discussion of A=48 system as an opportunity for the
no-core approach with the reintroduction of the core.
