  We review a microscopic model of the nuclear parton distribution functions,
which accounts for a number of nuclear effects including Fermi motion and
nuclear binding, nuclear meson-exchange currents, off-shell corrections to
bound nucleon distributions and nuclear shadowing. We also discuss applications
of this model to a number of processes including lepton-nucleus deep inelastic
scattering, proton-nucleus Drell-Yan lepton pair production at Fermilab, as
well as W+- and Z0 boson production in proton-lead collisions at the LHC.
