  Manipulating point defects for tailored macroscopic properties remains a
formidable challenge in materials science. This study demonstrates a
proof-of-principle for a universal law involving element Mn, significantly
enhancing vacancy diffusion through an unprecedented anomalous Friedel
Oscillations phenomenon, across most metals in the periodic table. The
correlation between Mn-induced point-defect dynamic changes and intrinsic
macro-properties is robustly validated through the first-principles theory and
well-designed experiments. The physical origin stems from Mn's exceptionally
large effective intra-elemental 3d electron interactions, surpassing the
Coulomb attraction induced by vacancy and disrupting the electron screening
effect. Given the ubiquitous nature of vacancies and their recognition as the
most crucial defects influencing nearly all physical and mechanical properties
of crystalline materials, this outcome may drive advances in a broad domain.
