  Despite recent advances in the length and the accuracy of long-read data,
building haplotype-resolved genome assemblies from telomere to telomere still
requires considerable computational resources. In this study, we present an
efficient de novo assembly algorithm that combines multiple sequencing
technologies to scale up population-wide telomere-to-telomere assemblies. By
utilizing twenty-two human and two plant genomes, we demonstrate that our
algorithm is around an order of magnitude cheaper than existing methods, while
producing better diploid and haploid assemblies. Notably, our algorithm is the
only feasible solution to the haplotype-resolved assembly of polyploid genomes.
