  We investigate, via Brownian dynamics simulations, the reaction dynamics of a
simple, non-linear chemical network (the Willamowski-Rossler network) under
spatial confinement and crowding conditions. Our results show that the presence
of inert crowders has a non-nontrivial effect on the dynamics of the network
and, consequently, that effective modeling efforts aiming at a general
understanding of the behavior of biochemical networks in vivo should be
stochastic in nature and based on an explicit representation of both spatial
confinement and macromolecular crowding.
