  In this work, we provide a thorough analysis of energy extraction via
magnetic reconnection, a novel mechanism recently proposed by Comisso and
Asenjo, for a Kerr-Newman black hole immersed in a perfect fluid dark matter
(PFDM) background. Our studies focus on the impact of black hole spin $a$,
electric charge $Q$ and PFDM parameter $\lambda$ on the horizons, ecoregions
and circular geodesics at the equatorial plane of this black hole, and how they
further influence the reconnection efficiency and energy extraction rate. Our
results show that the size of ergoregion does not vary monotonically with
increasing dark matter parameters $\lambda$, but it can significantly increase
at faster spins ($a>0.8$) as the dark matter parameter $\lambda$ decreases,
given the electric charge stays within $Q\in [0.2,0.5]$. We identify the
optimal conditions for the combination of $a$, $Q$ and $\lambda$ that enable
efficient energy extraction even when the black hole is not rapidly spinning.
The Kerr-Newman black hole in PFDM allows for achieving high energy extraction
rates comparable to those of most previously studied rotating black holes,
which typically require near-extremal spin to reach similar efficiency levels.
