  The study's objective is to explore the distinctions in the functional brain
network connectivity between Alzheimer's Disease (AD) patients and normal
controls using Functional Magnetic Resonance Imaging (fMRI). The study included
590 individuals, with 175 having AD dementia and 415 age-, gender-, and
handedness-matched normal controls. The connectivity of functional brain
networks was measured using ROI-to-ROI and ROI-to-Voxel connectivity analyses.
The findings reveal a general decrease in functional connectivity among the AD
group in comparison to the normal control group. These results advance our
comprehension of AD pathophysiology and could assist in identifying AD
biomarkers.
