  Polymer properties are inherently multi-scale in nature, where delicate local
interaction details play a key role in describing their global conformational
behavior. In this context, deriving coarse-grained (CG) multi-scale models for
polymeric liquids is a non-trivial task. Further complexities arise when
dealing with copolymer systems with varying microscopic sequences, especially
when they are of an amphiphilic nature. In this work, we derive a segment-based
generic CG model for amphiphilic copolymers consisting of repeat units of
hydrophobic (methylene) and hydrophilic (ethylene oxide) monomers. The system
is a simulation analogue of polyacetal copolymers [Samanta et al.,
Macromolecules 49, 1858 (2016)]. The CG model is found to be transferable over
a wide range of copolymer sequences and also to be consistent with existing
experimental data.
