  The manuscript focuses on the high impact science of the EIC with objective
to identify a portion of the science program for QCD precision studies that
requires or greatly benefits from high luminosity and low center-of-mass
energies. The science topics include (1) Generalized Parton Distributions, 3D
imagining and mechanical properties of the nucleon (2) mass and spin of the
nucleon (3) Momentum dependence of the nucleon in semi-inclusive deep inelastic
scattering (4) Exotic meson spectroscopy (5) Science highlights of nuclei (6)
Precision studies of Lattice QCD in the EIC era (7) Science of far-forward
particle detection (8) Radiative effects and corrections (9) Artificial
Intelligence (10) EIC interaction regions for high impact science program with
discovery potential. This paper documents the scientific basis for supporting
such a program and helps to define the path toward the realization of the
second EIC interaction region.
