  This paper is concerned with the statistical development of our
spatial-temporal data mining procedure, LASR (pronounced ``laser''). LASR is
the abbreviation for Longitudinal Analysis with Self-Registration of
large-$p$-small-$n$ data. It was motivated by a study of ``Neuromuscular
Electrical Stimulation'' experiments, where the data are noisy and
heterogeneous, might not align from one session to another, and involve a large
number of multiple comparisons. The three main components of LASR are: (1) data
segmentation for separating heterogeneous data and for distinguishing outliers,
(2) automatic approaches for spatial and temporal data registration, and (3)
statistical smoothing mapping for identifying ``activated'' regions based on
false-discovery-rate controlled $p$-maps and movies. Each of the components is
of interest in its own right. As a statistical ensemble, the idea of LASR is
applicable to other types of spatial-temporal data sets beyond those from the
NMES experiments.
