  The NIKA2 Sunyaev-Zel'dovich Large Program (SZLP) is focused on mapping the
thermal SZ signal of a representative sample of selected Planck and ACT
clusters spanning the redshift range 0.5<$z$<0.9. Hydrodynamical N-body
simulations prove to be a powerful tool to endorse NIKA2 capabilities for
estimating the impact of IntraCluster Medium (ICM) disturbances when recovering
the pressure radial profiles. For this goal we employ a subsample of objects,
carefully extracted from the catalog "Marenostrum MUltidark SImulations of
galaxy Clusters" (MUSIC), spanning equivalent redshift and mass ranges as the
LPSZ. The joint analysis of real observations of the tSZ with NIKA2 and Planck
enables to validate the NIKA2 pipeline and to estimate the ICM pressure
profiles. Moreover, the possibility to identify "a priori" the dynamical state
of the selected synthetic clusters allows us to verify the impact on the
recovered ICM profile shapes and their scatters. Morphological analysis of maps
of the Compton parameter seems to be a way to observationally segregate the
sample based on the dynamical state in relaxed and disturbed synthetic
clusters.
