  Understanding and modelling the complexity of the immune system is a
challenge that is shared by the ImmunoComplexiT$^1$ thematic network from the
RNSC. The immune system is a complex biological, adaptive, highly diversified,
self-organized and degenerative cognitive network of entities, allowing for a
robust and resilient system with emergent properties such as anamnestic
responses and regulation. The adaptive immune system has evolved into a complex
system of billions of highly diversified lymphocytes all interacting as a
connective dynamic, multi-scale organised and distributed system, in order to
collectively insure body and species preservation. The immune system is
characterized by complexity at different levels: network organisation through
fluid cell populations with inter-and intra-cell signalling, lymphocyte
receptor diversity, cell clonotype selection and competition at cell level,
migration and interaction inside the immunological tissues and fluid
dissemination through the organism, homeostatic regulation while rapid
adaptation to a changing environment.
