  The metastable region of binary mixtures is examined with the PC-SAFT
equa-tion of state (EOS) and compared to molecular simulations. The studied
mixtures are Methane + Ethane, Methanol + Ethanol, Carbon Dioxide + Toluene,
Carbon Dioxide + Hydrogen Chloride and Hydrogen Chloride + Toluene. In order to
cal-culate the spinodal, the second partial derivatives with respect to the
components molarities are analytically determined for the PC-SAFT EOS. Thermal
properties as well as the spinodal points determined using PC-SAFT and
molecular simula-tion are compared. For the studied metastable gas phases the
results obtained with PC-SAFT and the molecular simulations agree well. For
liquid phases the meta-stable region calculated with the PC-SAFT EOS is
typically broader than that ob-tained from the molecular simulations. No
unphysical results were obtained with PC-SAFT for metastable states. Hence,
PC-SAFT EOS is found to be principally suitable for predicting metastable
states and spinodals of mixtures.
