  From multi-photon imaging penetrating millimeters deep through scattering
biological tissue, to super-resolution imaging conquering the diffraction
limit, optical imaging techniques have greatly advanced in recent years.
Notwithstanding, a key unmet challenge in all these imaging techniques is to
perform rapid wide-field imaging through a turbid medium. Strategies such as
active wave-front correction and multi-photon excitation, both used for deep
tissue imaging; or wide-field total-internal-refection illumination, used for
super-resolution imaging; can generate arbitrary excitation patterns over a
large field-of-view through or under turbid media. In these cases, throughput
advantage gained by wide-field excitation is lost due to the use of point
detection. To address this challenge, here we introduce a novel technique
called De-scattering with Excitation Patterning, or 'DEEP', which uses
patterned excitation followed by wide-field detection with computational
imaging. We use two-photon temporal focusing (TFM) to demonstrate our approach
at multiple scattering lengths deep in tissue. Our results suggest that
millions of point-scanning measurements could be substituted with tens to
hundreds of DEEP measurements with no compromise in image quality.
