  In this paper, we search for conditions that the mass matrix of light
neutrinos $m_{\nu}$ is not a result of large cancellations for the type-I
seesaw mechanism with four-zero texture. For the Yukawa matrix of neutrinos
$Y_{\nu}$ and heavy Majorana mass matrix $M_{R}$, these conditions are written
as $(Y_{\nu})_{i2} \propto (m_{\nu})_{i2} \, \Rightarrow \, (Y_{\nu})_{i2}
\propto (M_{R})_{i2}$. We call them {\it alignment} conditions because they
align the certain rows or columns of the three neutrino mass matrices. If these
conditions do not hold, the large mixing in $m_{\nu}$ is a result of
fine-tuning due to the cancellation of several terms. Then they are required
from a viewpoint of naturalness.
  They give an explanation of the seesaw-invariance of four-zero texture, and
place rough restrictions on flavor structures of neutrinos. Under these
conditions, $Y_{\nu}$ must have a cascade hierarchy. For $M_{R}$, the 12
submatrix has a similar hierarchy as $Y_{\nu}$ and $m_{\nu}$. However, the 23
submatrix has a waterfall hierarchy without some fine-tuning. Therefore, it is
likely that $Y_{\nu}$ and $M_{R}$ have qualitatively different flavor
structures. Furthermore, since the conditions restrict CP phases of the matrix
elements, they imply existence of a universal generalized CP symmetry in the
neutrino sector.
