  We consider tissue P systems working on vesicles of multisets with the very
simple operations of insertion, deletion, and substitution of single objects.
With the whole multiset being enclosed in a vesicle, sending it to a target
cell can be indicated in those simple rules working on the multiset. As
derivation modes we consider the sequential mode, where exactly one rule is
applied in a derivation step, and the set maximal mode, where in each
derivation step a non-extendable set of rules is applied. With the set maximal
mode, computational completeness can already be obtained with tissue P systems
having a tree structure, whereas tissue P systems even with an arbitrary
communication structure are not computationally complete when working in the
sequential mode. Adding polarizations (-1, 0, 1 are sufficient) allows for
obtaining computational completeness even for tissue P systems working in the
sequential mode.
