  We report on a joint experimental and theoretical study of photoelectron
circular dichroism (PECD) in methyloxirane. By detecting O 1s-photoelectrons in
coincidence with fragment ions, we deduce the molecule's orientation and
photoelectron emission direction in the laboratory frame. Thereby, we retrieve
a fourfold differential PECD clearly beyond 50%. This strong chiral asymmetry
is reproduced by ab initio electronic structure calculations. Providing such a
pronounced contrast makes PECD of fixed-in-space chiral molecules an even more
sensitive tool for chiral recognition in the gas phase.
