  In this paper, we study the well-posedness theory and the scattering
asymptotics for fourth-order Schr\"odinger equations (4NLS) on waveguide
manifolds (semiperiodic spaces) $\mathbb{R}^d\times \mathbb{T}^n$, $d \geq 5$,
$n=1,2,3$. The tori component $\mathbb{T}^n$ can be generalized to
$n$-dimensional compact manifolds $\mathcal{M}^n$. First, we modify Strichartz
estimates for 4NLS on waveguide manifolds, with which we establish the
well-posedness theory in proper function spaces via the standard contraction
mapping method. Moreover, we prove the scattering asymptotics based on an
interaction Morawetz-type estimate established for 4NLS on waveguides. At last,
we discuss the higher dimensional analogue, the focusing scenario and give some
further remarks on this research line. This result can be regarded as the
waveguide analogue of Pausader \cite{Pau2,Pau1,Pau3} and the 4NLS analogue of
Tzvetkov-Visciglia \cite{TV2}.
