  Bacterial quorum sensing can be engineered with a view to the design of
biotechnological applications based on their intrinsic role as a means of
communication. We propose the creation of a positive feedback loop that will
promote the emission of a superfolded green fluorescence protein from a
bacterial population that will flow through hydrogel, which is used to
encapsulate the cells. These engineered cells are heretofore referred to as
bio-nanomachine transmitters and we show that for lower values of diffusion
coefficient, a higher molecular output signal power can be produced, which
supports the use of engineered bacteria contained within hydrogels for
molecular communications systems. In addition, our wet lab results show the
propagation of the molecular output signal, proving the feasibility of
engineering a positive feedback loop to create a bio-nanomachine transmitter
that can be used for biosensing applications.
