Utilizing new ingredients, and backed by new clinical research, Natural Science has formulated a long term, 100% natural, Muscle Growth formula that is safe for both men and women, and also has many benefits for the elderly as well!

Korean Mistletoe Extract:

Korean mistletoe (Viscum album coloratum) is a semi-parasitic plant that grows on various trees and has a diverse range of effects on biological functions, being implicated in having anti-tumor, immunostimulatory, anti-diabetic, and anti-obesity properties. It’s inclusion in Natural Muscle Growth Complex, however, is due to it’s ability to increase muscle mass and strength when combined with resistance training†. Korean Mistletoe Extract induced the mRNA expression of SREBP-1c, PGC-1α, and GLUT4, known positive regulators of muscle hypertrophy, in C2C12 cells. On the contrary, KME reduced the expression of Atrogin-1, which is directly involved in the induction of muscle atrophy†. In a 12 weeks study involving Middle Age and Elderly subjects, taking 2000mg of KME per day (the same dose found in Natural Muscle Growth Complex) exhibited a body composition that was significantly changed in the the intervention period, showing increased skeletal muscle, fat-free mass, and a decrease in body fat percent. Knee strength was measured by Cybex, demonstrating a significant effect in the KME groups compared to the placebo group† 1. Jeong J, Park CH, Kim I, et al. Korean mistletoe (Viscum album coloratum) extract regulates gene expression related to muscle atrophy and muscle hypertrophy. BMC Complement Altern Med. 2017;17(1):68. Published 2017 Jan 21. doi:10.1186/s12906-017-1575-9 2. Lim NJ, Shin JH, Kim HJ, et al. A combination of Korean mistletoe extract and resistance exercise retarded the decline in muscle mass and strength in the elderly: A randomized controlled trial. Exp Gerontol. 2017;87(Pt A):48–56. doi:10.1016/j.exger.2016.11.003

Rehmanniae Radix Extract 20:1

Rehmanniae contains more than 140 distinct compounds that have healing effects on all kinds of diseases. The most powerful of these plant chemicals are called iridoid glycosides, which can act as powerful repair kits. These special compounds deliver a wide range of curative properties, such as anti-inflammatory, immune-modulating, antioxidant, neuroprotective, anti-aging, and regenerative actions. Two of these Iridoid Glycosides that have great effect for this formula are Catalpol and Loganin.

Catalpol:

High levels of Catalpol leads to sharp increases† in production of EPO, VEGF, IGF1, and Beta endorphins. Increasing these anabolic and performance enhancing signals can lead to powerful increases in muscle mass, athletic performance and fat loss. Catalpol itself acts as natural performance enhancer!

Loganin:

A fantastic anabolic agent in its own right, Loganin is being studied currently as a treatment for skeletal muscle atrophy. In addition, Loganin seems to possess anti inflammatory, antioxidant, glucose lowering and muscle protective effects. Loganin upregulates the Atk/mTOR pathway and increases IGF1 leading to increased muscle tissue. Loganin has also been shown to increase skeletal muscle strength in animal studies and inhibits Atrogin-1 which prevents skeletal muscle atrophy. Further anabolic potential lies in its suppression of SMAD2/3 and increased expression of SMAD7†. In animals studies Loganin increased muscle mass, overall bodyweight, strength and protein synthesis making it a powerhouse anabolic! 1. Yuan XP, Liu LS, Fu Q, Wang CX. Effects of ligustrazine on ureteral obstruction-induced renal tubulointerstitial fibrosis. Phytother Res. 2012;26(5):697–703. doi:10.1002/ptr.3630

Quercetin/Sinomenine

Any product is only as good as it’s absorption, and the human body has many built-in mechanism’s to prevent full absorption of certain compounds into the cells, the main protection agent is known as P-Glycoprotein Efflux. Efflux, as in the opposite of Influx, actually pumps out and away foreign agents from the cells, even when they are beneficial. To combat this, we have added in two polyphenols that have been proven to inhibit the Efflux pump†. With this addition, we can vastly increase the absorption and usage of the compounds, allowing for a massive increase in gains products that don’t contain this solution! 1. Nabekura T, Kawasaki T, Furuta M, Kaneko T, Uwai Y. Effects of Natural Polyphenols on the Expression of Drug Efflux Transporter P-Glycoprotein in Human Intestinal Cells. ACS Omega. 2018;3(2):1621–1626. doi:10.1021/acsomega.7b01679

HPBC-Osthole

Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. Osthole enhances bone fracture healing through activation of BMP2 signaling†. Working in tandem with the BMP2 signaling is the ability to increase the muscle building natural androgens in your system†. This leads to more muscle gains, as well as the enhanced ability to repair damaged bone structures. This is combined with Hydroxy Propyl Beta Cyclodextrin, which vastly increases the ability to be absorbed into the body. 1. Wang P, Ying J, Luo C, et al. Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes. Int J Biol Sci. 2017;13(8):996–1007. Published 2017 Jul 18. doi:10.7150/ijbs.19986 2. Yuan J, Xie J, Li A, Zhou F. Zhong Yao Cai. 2004;27(7):504–506.

HPBC-Kaempferol

Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L., which is used in traditional medicine in Asia. Kaempeferol has been highly studies for its ability to prevent Estrogen deficient bone loss (osteoperosis)†. It’s inclusion in this formula is for its ability to prevent the resorption of bone material, rather increasing bone anabolism (our goal with increasing BMP signaling. Kaemperol has low oral bioavailability, so we mixed into Hydroxy Propyl Beta-CycloDextrin, allowing for far greater absorption into the body. 1. Wattel A, Kamel S, Mentaverri R, Lorget F, Prouillet C, Petit J-P, et al. Potent inhibitory effect of naturally occurring flavonoids quercetin and kaempferol on in vitro osteoclastic bone resorption. Biochem Pharmacol. 2003 Jan;65(1):35–42.

Ligustrazine HCL

Ligustrazine (LIG) is a purified and chemically identified component of the Chinese herb Ligusticum wallichii Franchat. It is a potent blocker of vasoconstriction and has strong scavenger of oxygen free radicals. Studies have also shown a significant increase in hepatocyte growth factor and bone morphogenetic protein-7 (BMP7), allowing for both increased blood flow and nutrient distribution as well as increased BMP signaling.