A loss of $29 billion in airline revenue. China auto sales down by 92 percent. Interruptions for Procter & Gamble’s 387 suppliers in China.

As the coronavirus outbreak rattles the global economy and disrupts supply chains, international companies across nearly every industry are confronting a stark reality: Business will not go on as usual.

And investors have taken notice. U.S. stocks fell for the second-straight day on Friday. Shares of energy, airline and technology companies led the broader market lower on Wall Street, as the S&P closed more than 1 percent lower, putting it on pace for its worst day of the month. Oil and gas prices also fell, with the price of a barrel of benchmark American crude slipping nearly 1 percent. The markets have become more volatile since the outbreak, but American investors have largely shrugged off the threat. Since Jan. 7, when Chinese officials identified the virus, the S&P 500 remains up more than 3 percent, even after this morning’s sell-off. — Matt Philips