As we get older we have a greater risk of developing impairments in areas of cognitive function – such as memory, reasoning and verbal ability. We also have a greater risk of dementia, which is what we call cognitive decline that interferes with daily life. The trajectory of this cognitive decline can vary considerably from one person to the next.

Despite these varying trajectories, one thing is for sure: even cognitively normal people experience pathological changes in their brain, including degeneration and atrophy, as they age. By the time a person reaches the age of 70 to 80, these changes closely resemble those seen in the brains of people with Alzheimer’s Disease.

Even so, many people are able to function normally in the presence of significant brain damage and pathology. So why do some experience symptoms of Alzheimer’s and dementia, while others remain sharp of mind?

It comes down to something called cognitive reserve. This is a concept used to explain a person’s capacity to maintain normal cognitive function in the presence of brain pathology. To put it simply, some people have better cognitive reserve than others.

Evidence shows the extent of someone’s cognitive decline doesn’t occur in line with the amount of biological damage in their brain as it ages. Rather, certain life experiences determine someone’s cognitive reserve and, therefore, their ability to avoid dementia or memory loss.

How do we know?

Being educated, having higher levels of social interaction or working in cognitively demanding occupations (managerial or professional roles, for instance) increases resilience to cognitive decline and dementia. Many studies have shown this. These studies followed people over a number of years and looked for signs of them developing cognitive decline or dementia in that period.

As we get older we have a greater risk of developing impairments in cognitive function, such as memory.from shutterstock.com

Cognitive reserve is traditionally measured and quantified based on self reports of life experience such as education level, occupational complexity and social engagement. While these measures provide an indication of reserve, they’re only of limited use if we want to identify those at risk of cognitive decline. Genetic influences obviously play a part in our brain development and will influence resilience.

Brain plasticity

The fundamental brain mechanisms that underpin cognitive reserve are still unclear.
The brain consists of complex, richly interconnected networks that are responsible for our cognitive ability. These networks have the capacity to change and adapt to task demands or brain damage. And this capacity is essential not only for normal brain function, but also for maintaining cognitive performance in later life.

This adaptation is governed by brain plasticity. This is the brain’s ability to continuously modulate its structure and function throughout life in response to different experiences. So, plasticity and flexibility in brain networks likely contribute in a major way to cognitive reserve and these processes are influenced by both genetic profiles and life experiences.

A major focus of our research is examining how brain connectivity and plasticity relate to reserve and cognitive function. We hope this will help identify a measure of reserve that reliably identifies individuals at risk of cognitive decline.

Strengthening your brain

While there is little we can do about our genetic profile, adapting our lifestyles to include certain types of behaviours offers a significant opportunity to improve our cognitive reserve.

Activities that engage your brain, such as learning a new language and completing crosswords, as well as having high levels of social interaction, increase reserve and can reduce your risk of developing dementia.

Regular physical activity also improves cognitive function and reduces the risk of dementia. Unfortunately, little evidence is available to suggest what type of physical activity, as well as intensity and amount, is required to best increase reserve and protect against cognitive impairment.

There is also mounting evidence that being sedentary for long periods of the day is bad for health. This might even undo any benefits gained from periods of physical activity. So, it is important to understand how the composition of physical activity across the day impacts brain health and reserve, and this is an aim of our work.

Our ongoing studies should contribute to the development of evidence-based guidelines that provide clear advice on physical activity patterns for optimising brain health and resilience.

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Quite a number of years ago I went on a road trip of sorts with some friends through a number of NSW national parks, including Guy Fawkes River National Park, Oxley Wild Rivers National Park and Cathedral Rocks National Park. If memory serves, there were three cars on the trip.

I do have something of a plan for when (or rather if) I have a million dollars. I would like to start a diabetes foundation in memory of a friend who died. My friend had diabetes and this would be a great way to remember her I think.

Obviously, there would be other things I would do with some of the money, but the establishment of a foundation would be very important to me.

My best friend is not around anymore. I would probably have not written about her tonight, except I have been thinking about her throughout the day. I have just felt a need to write something about her tonight.

My friend Rebecca died over two years ago now, but the memory of her continues fresh in my mind and in my heart. I miss her so, so much. I think of her often – there may be a smile, sometimes a quiet laugh, often there will be tears. Her place has never been taken by another & her place will always be her place.

I think this far down the track I am yet to say goodbye… I don’t want to say goodbye. I still hope that she is just around the corner and that we can continue where we left off. One more conversation, one more embrace, one more look – one more so much. But that would still not be enough.

I knew her – she knew me. We could talk with openness. We just went together so well. Her thoughtfulness, her heart, her being – Rebecca. That is why she was my best friend. She was Rebecca – she is Rebecca. There is no one like Rebecca to me.

Summer is a great time of the year – I love it. Summer has generally been the best time for getting into the Great Outdoors and exploring Australia. Summer has brought me many great memories – so many that it is hard to place one as being THE favorite summer memory. However, there is one summer memory that means more to me now than a lot of others, for one particular reason. It was in a November (summer in Australia) a few years ago now, that I traveled to Gloucester Tops with Bec and we enjoyed the bush, the river and the waterfalls together. It was a special time. It is even more special to me now because Bec died 2 years ago (June 25) and this is one of the greatest memories I have and times I spent with her. It was a great day I will never forget.

More than a year after a sudden outburst of persecution drove them from their village, a group of 14 Christians in West Bengal, India, still can’t go home, reports Gospel for Asia.

In July 2008, the Christians agreed to meet with a group of other villagers for what they thought was a routine gathering. However, the villagers turned out to be violent anti-Christians who immediately attacked the believers, threatening to murder them if they didn’t leave.

The beaten-up men and women made it to safety in a nearby village, where they found shelter with two Gospel for Asia–supported missionaries. Since then, the missionaries and their GFA leaders have been trying to work out the situation with village leaders and police. A local political party tried to help negotiate for the displaced believers to be allowed to return home.

Finally, on December 20, the Christians thought it was safe to return. So they cautiously went back, only to be called that very night for another village meeting. The memory of their last meeting was vivid, and the Christians approached hoping that this time, it would be different.

But just as before, the villagers waited to harm them. They beat the Christians mercilessly, forcing them to run once more for their lives.

Currently, the political party that tried to help the persecuted group is providing shelter for them and trying to find a permanent solution.

The GFA-supported missionaries and the believers urgently ask for prayer that God will work in this situation, and that His love will soften the hearts of the anti-Christians.

More than a thousand attendees are expected to gather for a four-day conference to celebrate John Calvin’s 500th birthday, reports Michael Ireland, chief correspondent, ASSIST News Service.

As America prepares to celebrate Independence Day this July 4, Vision Forum Ministries will be hosting the national celebration to honor the 500th birthday of John Calvin, a man who many scholars recognize as America’s “Founding Father.”

The event — The Reformation 500 Celebration — will take place July 1-4 at the Park Plaza Hotel in downtown Boston, according to a media release about the event.

“Long before America declared its independence, John Calvin declared and defended principles that birthed liberty in the modern world,” noted Doug Phillips, president of Vision Forum Ministries.

“Scholars both critical and sympathetic of the life and theology of Calvin agree on one thing: that this reformer from Geneva was the father of modern liberty as well as the intellectual founding father of America,” he said.

Phillips pointed out: “Jean Jacques Rousseau, a fellow Genevan who was no friend to Christianity, observed: ‘Those who consider Calvin only as a theologian fail to recognize the breadth of his genius. The editing of our wise laws, in which he had a large share, does him as much credit as his Institutes. . . . [S]o long as the love of country and liberty is not extinct amongst us, the memory of this great man will be held in reverence.'”

He continued: “German historian Leopold von Ranke observed that ‘Calvin was virtually the founder of America.’ Harvard historian George Bancroft was no less direct with this remark: ‘He who will not honor the memory and respect the influence of Calvin knows but little of the origin of American liberty.’

“John Adams, America’s second president, agreed with this sentiment and issued this pointed charge: ‘Let not Geneva be forgotten or despised. Religious liberty owes it much respect.’

“As we celebrate America’s Independence this July 4, we would do well to heed John Adams’ admonition and show due respect to the memory of John Calvin whose 500th birthday fall six days later,” Phillips stated.

Calvin, a convert to Reformation Christianity born in Noyon, France, on July 10, 1509, is best known for his influence on the city of Geneva, the media release explains.

“It was there that he modeled many of the principles of liberty later embraced by America’s Founders, including anti-statism, the belief in transcendent principles of law as the foundation of an ethical legal system, free market economics, decentralized authority, an educated citizenry as a safeguard against tyranny, and republican representative government which was accountable to the people and a higher law,” the release states.

The Reformation 500 Celebration will honor Calvin’s legacy, along with other key Protestant reformers, and will feature more than thirty history messages on the impact of the Reformation, Faith & Freedom mini-tours of historic Boston, and a Children’s Parade.

The festivities will climax on America’s Independence Day as attendees join thousands of others for the world-renowned music and fireworks celebration on the Esplanade with the Boston Pops Orchestra.