One such variation is to artificially modify the codon-amino acids mapping, so that it is more complicated, saying, one protein mapping to more than 3 amino acids. By this means, the combination of mappings can be increased potentially, and make the brute force attacks more difficult. Another variation is to make the splicing rule more flexible, and this can enhance the confusion effects.

Since one amino acid can be represented by 3-letter sequence, and the 64 amino acids can be distinguished by 6 bits; only 2 bits are needed for each letter in the cipher text. Thus, the number of bits needed for each of the cipher text is 2 times that of the length of the cipher text.