Introduction {#section1-1536012118776068}
============

Most deaths related to prostate cancer (PC) are due to advanced disease, which results from any combination of lymphatic, blood, or contiguous local spread. Targeted radionuclide therapy is an attractive and quickly developing therapy option for a variety of cancers, such as lymphoma, melanoma, and neuroendocrine tumor.^[@bibr1-1536012118776068][@bibr2-1536012118776068][@bibr3-1536012118776068]-[@bibr4-1536012118776068]^ Prostate-specific membrane antigen (PSMA), also known as folate hydrolase I or glutamate carboxypeptidase II, is a type II, 750-amino acid transmembrane protein (100-120 kDa), which is anchored in the cell membrane of prostate epithelial cells. The PSMA is highly expressed on prostate epithelial cells and strongly upregulated in PC. The PSMA expression seems correlated to androgen independence, the presence of metastases, and PC progression.^[@bibr5-1536012118776068]^ Despite its name, PSMA is not specific to the prostate gland and is expressed in other normal (eg, salivary glands, duodenal mucosa, subset of proximal renal tubular cells, and subpopulation of neuroendocrine cells in the colonic crypts) and neoplastic (eg, subtypes of transitional cell carcinoma, renal cell carcinoma, colon carcinoma, and peritumoral and endotumoral endothelial cell of neovasculature) tissues.^[@bibr6-1536012118776068][@bibr7-1536012118776068]-[@bibr8-1536012118776068]^ There is no known natural ligand for PSMA, and the reasons for its upregulation in PC remains unknown. The PSMA ligands undergo constitutive cell internalization by PSMA, which, therefore, represents an appealing molecular target for theranostics in metastatic PC.^[@bibr9-1536012118776068]^

PSMA-Based Imaging {#section2-1536012118776068}
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Anti-PSMA Antibodies {#section3-1536012118776068}
--------------------

The first commercialized anti-PSMA antibody was ^111^In-capromab-pendetide (ProstaScint, AYTU Bioscience, Englewood, USA),^[@bibr10-1536012118776068]^ which was approved by the US Food and Drug Administration in 1996. However, ProstaScint was only able to bind to the intracellular epitope of PSMA and was therefore not capable of visualizing viable PC cells leading to poor clinical performance.^[@bibr11-1536012118776068]^

In contrast to ^111^In-capromab-pendetide, J591 binds to the extracellular domain of PSMA. Labeled with ^111^In, J591 can be used for scintigraphy^[@bibr12-1536012118776068]^ and when labeled with ^89^Zr for positron emission tomography (PET).^[@bibr13-1536012118776068],[@bibr14-1536012118776068]^ Recently, ^89^Zr-Df-IAB2M was introduced as an anti-PSMA minibody.^[@bibr15-1536012118776068]^ Despite good tumor detection rates and contrast in scintigraphy,^[@bibr16-1536012118776068]^ J591 as well as other radiolabeled antibodies present with limitations such as low tumor penetrability, long delay between injection and imaging, nonspecific accumulation associated with inflammation, and high radiation exposure due to the necessity of radionuclides with long half-lives due to the long plasma half-life of antibodies.

Small-Molecule PSMA Inhibitors {#section4-1536012118776068}
------------------------------

Small-molecule inhibitors have been developed over the past 2 decades.^[@bibr17-1536012118776068][@bibr18-1536012118776068][@bibr19-1536012118776068][@bibr20-1536012118776068][@bibr21-1536012118776068][@bibr22-1536012118776068][@bibr23-1536012118776068][@bibr24-1536012118776068][@bibr25-1536012118776068][@bibr26-1536012118776068]-[@bibr27-1536012118776068]^ The basic chemical structure of the majority of small-molecule PSMA ligands consists of glutamate--urea--lysine dimers. This structure derives from hydroxyphosphinyl derivatives described by Jackson et al in 1996.^[@bibr17-1536012118776068]^ Another significant step forward was the development of urea-based inhibitors by Kozikowski et al^[@bibr21-1536012118776068],[@bibr23-1536012118776068]^ as well as the inhibition of PSMA by phosphonamidothionate derivatives of glutamic acid.^[@bibr28-1536012118776068]^ One attribute of small-molecule inhibitors that has a significant impact on imaging and therapy is the feature that these ligands are internalized into the cells after binding to PSMA.

Small-Molecule PSMA Inhibitors for Scintigraphy {#section5-1536012118776068}
-----------------------------------------------

^123^I- (MIP)-1072 and ^123^I-MIP-1095 were the first small-molecule PSMA inhibitors that were introduced into the clinic in 2008 by Molecular Insight Pharmaceuticals, Inc (MIP, now a subsidiary of Progenics Pharmaceuticals Inc, Cambridge, Massachusetts, USA).^[@bibr24-1536012118776068],[@bibr29-1536012118776068]^ These ligands demonstrated for the first time the enormous potential of PSMA ligands for imaging and therapy of PC.^[@bibr25-1536012118776068],[@bibr30-1536012118776068]^ The subsequent replacement of ^123^I by ^131^I led to the first human therapy with PSMA ligands.^[@bibr31-1536012118776068],[@bibr32-1536012118776068]^ However, the widespread availability and use of ^99m^Tc made the development of ^99m^Tc-labeled PSMA ligands a desirable pursuit. MIP-1404 and MIP-1405 were the first ^99m^Tc-labeled PSMA ligands, which were introduced into the clinic in 2010.^[@bibr26-1536012118776068],[@bibr33-1536012118776068]^ Although both ligands presented with promising results,^[@bibr25-1536012118776068]^ ^99m^Tc-MIP-1404 was chosen to enter further clinical studies due to its lower urinary excretion.^[@bibr34-1536012118776068],[@bibr35-1536012118776068]^ Currently, ^99m^Tc-MIP-1404 is the subject of a phase 3 clinical trial designed to evaluate its sensitivity and specificity to detect PC compared to histopathology (ClinicalTrials.gov Identifier: NCT02615067).

PSMA Ligands for PET Imaging {#section6-1536012118776068}
----------------------------

The development of PSMA ligands for PET imaging dates back to as early as 2002. The first tracer published was ^11^C-MCG which was used in animal studies.^[@bibr22-1536012118776068]^ The clinical breakthrough of PET imaging with PSMA ligands was achieved with the invention of ^68^Ga-PSMA-11 (also called HBED-CC, HBED, PSMA-HBED, or Prostamedix), which demonstrated excellent characteristics.^[@bibr36-1536012118776068][@bibr37-1536012118776068]-[@bibr38-1536012118776068]^ Since its clinical introduction in May 2011, PET imaging with ^68^Ga-PSMA-11 has spread rapidly worldwide and is regarded as a significant step forward in the diagnosis of recurrent PC.^[@bibr38-1536012118776068][@bibr39-1536012118776068][@bibr40-1536012118776068][@bibr41-1536012118776068][@bibr42-1536012118776068][@bibr43-1536012118776068]-[@bibr44-1536012118776068]^ The first publications indicated that this novel method is significantly superior compared to alternative methods used for the detection of recurrent PC.^[@bibr36-1536012118776068],[@bibr38-1536012118776068]^ Later publications confirmed the high sensitivity and specificity of ^68^Ga-PSMA-11 PET/computed tomography (CT).^[@bibr38-1536012118776068][@bibr39-1536012118776068][@bibr40-1536012118776068][@bibr41-1536012118776068][@bibr42-1536012118776068][@bibr43-1536012118776068]-[@bibr44-1536012118776068]^ ^68^Ga-PSMA-11 PET/CT is usually conducted at 1 hour post injection (p.i.) according to its first described clinical setup.^[@bibr37-1536012118776068]^ However, experience showed that most PC lesions present with increased uptake and contrast at later imaging timings (3 hours p.i.), despite the relatively short half-life of ^68^ Ga.^[@bibr37-1536012118776068]^ Later publications confirmed these findings.^[@bibr45-1536012118776068][@bibr46-1536012118776068]-[@bibr47-1536012118776068]^ Alternative PSMA ligands such as ^18^F-DCFPyL, ^68^Ga-PSMA-617, ^68^Ga-PSMA I&T, or ^124^I-MIP-1095 demonstrated similar characteristics.^[@bibr31-1536012118776068],[@bibr48-1536012118776068][@bibr49-1536012118776068]-[@bibr50-1536012118776068]^

Several studies with large patient cohorts have analyzed the sensitivity of ^68^Ga-PSMA-11 PET/CT as well as possibly interacting factors such as prostate specific antigen (PSA), injected amount of tracer, androgen deprivation therapy (ADT), or Gleason Score (GS).^[@bibr39-1536012118776068][@bibr40-1536012118776068]-[@bibr41-1536012118776068]^ As expected, the probability to detect tumor lesions (sensitivity) increased with the PSA value. At PSA values less than 0.5 ng/mL, the reported detection probability was about 50%. This rate is assumed to be the highest among all methods for imaging recurrent PC. However, as shown in [Figure 1](#fig1-1536012118776068){ref-type="fig"}, a continuous increase in PSA level does not always correlate with an increase in tumor detection. Even in the subcohort of patients with PSA levels above 10 ng/mL, not all patients presented with a pathologic ^68^Ga-PSMA-11 PET/CT. Absent or low PSMA expression as well as small tumor size could be possible reasons for this observation. No association was found between the probability of a pathologic scan and either of age, injected tracer activity, faster PSA doubling times, or faster PSA velocity. No significant association but only a tendency was found between higher GS and a higher probability of a pathologic scan.^[@bibr39-1536012118776068],[@bibr40-1536012118776068]^ In contrast to GS, an ongoing ADT at the time of the scans was significantly associated with a pathologic ^68^Ga-PSMA-11 PET/CT^[@bibr39-1536012118776068],[@bibr40-1536012118776068]^ although such a therapy can cause a reduction in tumor size as well as PSA values. Both of these effects usually entail a negative impact on tumor detection. It is known from preclinical literature that ADT can increase the PSMA expression in PC cells.^[@bibr51-1536012118776068],[@bibr52-1536012118776068]^ On the other hand, another reason for the fact that patients with ADT more often showed pathological findings in the ^68^Ga-PSMA-11-PET/CT could be that ADT is often started in cases of advanced tumor stages. According to the current knowledge, there is no need to pause an ADT prior to a PSMA ligand scan.

![Probability of a pathologic ^68^Ga-PSMA-11 PET/CT as histogram (A) and plot of the rates of pathologic scans with confidence intervals (B) depending on PSA (ng/mL) in a cohort of 971 patients. Reprinted from Afshar-Oromieh et al^[@bibr40-1536012118776068]^ with the permission of the authors. Ct indicates computed tomography; PET, positron emission tomography; PSMA, prostate-specific membrane antigen.](10.1177_1536012118776068-fig1){#fig1-1536012118776068}

The PSMA is not specific for PC. Since the late 1990s, it is also well-known that the neovasculature of many solid tumors may express PSMA as well.^[@bibr53-1536012118776068]^ This is reflected by multiple case reports describing PET-positive nonprostatic tissues.^[@bibr8-1536012118776068]^ However, in case of recurrent PC, ^68^Ga-PSMA-11 PET/CT has showed an excellent specificity.^[@bibr39-1536012118776068],[@bibr54-1536012118776068],[@bibr55-1536012118776068]^

Recently, ^18^F-labeled PSMA-ligands were clinically introduced with promising results such as DCFBC, DCFPyL, or PSMA-1007.^[@bibr48-1536012118776068],[@bibr56-1536012118776068][@bibr57-1536012118776068]-[@bibr58-1536012118776068]^ They all show promising first results. In theory, ^18^F-labeled tracers present with advantages such as higher physical resolution and high amounts of ^18^F deriving from cyclotrons. However, future studies will show whether these theoretical advantages can outweigh the faster pharmacokinetics and excellent tumor contrast of ^68^Ga-PSMA-11.

PSMA-Targeted Therapy {#section7-1536012118776068}
=====================

After rather unsuccessful therapy with ^90^Y-CYT-356 monoclonal antibody (mAb) that binds to the intracellular domain of PSMA,^[@bibr59-1536012118776068]^ the phase 1 and 2 clinical trials utilizing radiolabeled (^177^Lu or ^90^Y) PSMA mAb J591, which targets the extracellular domain and then gets internalized through endocytosis, have shown promising results,^[@bibr16-1536012118776068],[@bibr60-1536012118776068][@bibr61-1536012118776068]-[@bibr62-1536012118776068]^ however, with higher ratio of irreversible hematological toxicity. Tagawa et al^[@bibr60-1536012118776068]^ treated 47 patients with ^177^Lu-PSMA mAb J591. They reported grade 4 thrombocytopenia in 46.8% of patients (29.8% received platelet transfusions), and a total of 25.5% patients experienced grade 4 neutropenia. Monoclonal antibodies are large molecules and therefore show poor permeability in solid tumors and slow clearance from the circulation, which is probably the cause of grade 4 hematotoxicity. Instead of mAb, Maresca et al described the design and synthesis of a series of small-molecule inhibitors of PSMA.^[@bibr24-1536012118776068]^ First clinical experiences with PSMA-based radionuclide treatment using ^131^I-labeled PSMA ligands showed promising results with mild hematotoxicity and a PSA decrease \>50% in 60% of treated patients with PC.^[@bibr31-1536012118776068],[@bibr32-1536012118776068]^ The ^131^I has a long half-life of 8.02 days and with maximum β-particle range of 2.4 mm in soft tissue. Due to the γ-emitting properties and long half-life, ^131^I is less attractive from a radiation safety point of view. The ^177^Lu has a half-life of 6.7 days and low-energy β-particles emission with a mean range of 0.7 mm and maximum range of 2.1 mm in soft tissue.^[@bibr63-1536012118776068]^

Current Status of PSMA-Targeted Radioligand Therapy {#section8-1536012118776068}
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[Table 1](#table1-1536012118776068){ref-type="table"} shows a list of current therapy molecules already administered in humans. In the first cohort of 10 patients, mild side effects and considerable rates of PSA response were reported after 1 cycle of radioligand therapy (RLT) with ^177^Lu PSMA-617.^[@bibr64-1536012118776068]^ A decline in PSA was observed in 70% of patients, with more than 50% decline in a few patients. Another recently published study showed the safety and favorable therapy response in a larger cohort of 24 patients who received up to 2 cycles of ^177^Lu PSMA-617. Twenty-two patients received 2 cycles of RLT. Eight weeks after the second cycle of ^177^Lu PSMA-617 therapy, 15 (68.2%) of 22 patients experienced a PSA decline compared to the baseline PSA value, of who 15 experienced a decline of more than 30% and 13 a decline of more than 50%.^[@bibr65-1536012118776068]^ Relevant hematotoxicity (grade 3) occurred during the observation period (within 2 months after the last cycle) in 2 patients only. Apart from minor grade 1 or 2 hematotoxicity, the majority of patients did not have any hematotoxicity during the observation period. No relevant nephrotoxicity or hepatotoxicity was observed. The overall survival benefit of RLT in comparison to a historical control group could be demonstrated in another investigation.^[@bibr66-1536012118776068]^ The estimated median survival was 29.4 weeks in the group treated with ^177^Lu PSMA-617, which was noticeably longer than survival in a historical control group with 19.7 weeks (hazard ratio: 0.44; 95% confidence interval: 0.20-0.95; *P* = .031).

###### 

PSMA Ligands for Therapy.

![](10.1177_1536012118776068-table1)

  Ligand     Radionuclide   Status^a^
  ---------- -------------- ----------------------------
  MIP-1095   Iodine-131     Compassionate use
  PSMA-I&T   Lutetium-177   Compassionate use
  J591       Lutetium-177   Phase I
  PSMA-617   Lutetium-177   Phase I/phase II/phase III

Abbreviations: MIP, Molecular Insight Pharmaceuticals; PSMA, prostate-specific membrane antigen.

^a^ Status of use according clinicaltrials.gov.

Baum et al presented similar results using ^177^Lu PSMA-I&T^[@bibr67-1536012118776068]^ treating 56 patients with metastasized PC at an early stage of castration resistance. Any PSA decline and a decline of ≥50% were reported in 80% and a median overall survival of 13.7 months. In this cohort, prior chemotherapy was performed in 25% of patients. Prior therapy with abiraterone was performed in 21% and prior enzalutamide was given in 11% of patients, whereas in the prior study mentioned earlier, pretreatments with chemotherapy, abiraterone, and enzalutamide were administered in 78%, 75%, and 86% of patients, respectively.^[@bibr66-1536012118776068]^

Results of the abovementioned studies were confirmed by the findings of the German multicenter study including 145 patients with metastatic castration-resistant PC. Biochemical response was defined by the PC work group as a PSA decline ≥50%.^[@bibr68-1536012118776068]^ A PSA decline ≥50% and any PSA decline were reported in 45% and 60% of the patients.^[@bibr69-1536012118776068]^ The presence of visceral metastases and an alkaline phosphatase ≥220 U/L were negative predictors of therapy response. Adverse events were analyzed according to common toxicity criteria. Grade 3 to 4 toxicities such as anemia, leukopenia, and thrombocytopenia were reported in 10%, 3%, and 4% of patients treated with ^177^Lu PSMA-617. Mild or transient xerostomia were reported in 8% of the patients. Repeated cycles of ^177^Lu PSMA-617 RLT can be performed after radionuclide therapy using ^223^Ra dichloride, without a higher probability of hematotoxicity.^[@bibr69-1536012118776068]^ These results about the safety and toxicity were confirmed by another study including 49 patients who were treated with 3 cycles of ^177^Lu-PSMA-617. The patients were separated into 2 groups subjected to a history of prior therapy with ^223^Ra. Group 1 included 20 patients who had received therapy with ^223^Ra prior to ^177^Lu-PSMA-617 therapy. Group 2, which was the control group, comprised 29 patients without any history of a bone-targeted radionuclide therapy. No grade 4 hematotoxicity was observed in the entire study population. There were no significant differences between the 2 groups regarding leukopenia and thrombocytopenia.^[@bibr70-1536012118776068]^ [Figure 2A and B](#fig2-1536012118776068){ref-type="fig"} shows a case of a 66-year-old patient with metastasized castration-resistant PC with an excellent response to ^177^Lu PSMA-617 RLT with history of prior ^223^Ra dichloride therapy.

![A, ^68^Ga-PSMA11-PET images of a 66-year-old patient with castration-resistant prostate cancer pretreated with docetaxel, abiraterone, and 6 cycles of ^223^Radium. Maximum intensity projection (MIP) on the left side shows multiple bone and lymph node lesions. Patient was treated with 3 cycles of ^177^Lu-PSMA-617 radioligand therapy with a cumulative activity of 13.5 GBq (reduced activity because of single kidney). The MIP images on the right side show significant reduction in prostate-specific membrane antigen (PSMA)-positive lesions in correlation with a PSA decline of 99%. B, Fused images of ^68^Ga-PSMA11-positron emission tomography/computed tomography (PET/CT) images in the upper row show a significant reduction in PSMA-positive lesions. Low-dose CT images (lower row) show a significant volume reduction in soft tissue lesions (especially in the right pelvis).](10.1177_1536012118776068-fig2){#fig2-1536012118776068}

Although there is a specific renal binding of PSMA-ligands, no grade 3 to 4 toxicities were reported after the RLT. Only low-grade renal toxicity has been reported so far.^[@bibr71-1536012118776068]^ [Table 2](#table2-1536012118776068){ref-type="table"} presents reported toxicities of ^177^Lu-PSMA RLT.

###### 

Safety of ^177^Lu-PSMA radioligand therapy in the literature.

![](10.1177_1536012118776068-table2)

                                                           Hematotoxicity CTCAE grade 3/4                   
  -------------------------------------------------- ----- -------------------------------- --- ----- ----- ------------------------
  Ahmadzadehfar et al.^[@bibr64-1536012118776068]^   10    10                               0   0     0     mild nausea, fatigue
  Rahbar et al.^[@bibr66-1536012118776068]^          28    11                               0   0     14    mild nausea
  Ahmadzadehfar et al.^[@bibr65-1536012118776068]^   24    9                                0   0     8.7   mild nausea
  Baum et al.^[@bibr67-1536012118776068]^            56    0                                0   0     3.5   na
  Kratochwil et al.^[@bibr72-1536012118776068]^      30    3.3                              0   3.3   6.7   mild nausea, fatigue
  Rahbar et al.^[@bibr73-1536012118776068]^          82    2.8                              0   0     8.5   mild nausea
  Heck et al.^[@bibr74-1536012118776068]^            22    0                                0   0     37    fatigue, appetite loss
  Rahbar et al.^[@bibr69-1536012118776068]^          145   10                               3   4     8     mild nausea
  Bräuer et al.^[@bibr75-1536012118776068]^          59    18                               3   3     25    nausea, fatigue

Abbreviations: CTCAE: common toxicity criteria of adverse events, Hb: haemoglobin, WBC: white blood cells, Plt: platlets.

Yordanova et al analyzed changes in creatinine, cyctatin C, glomerular filtration rate, and tubular function assessed by ^99m^Tc-MAG3 renal scintigraphy in 55 patients receiving at least 3 (range 3-6) consecutive cycles of ^177^Lu PSMA-617 every 8 weeks. Significant negative predictor for renal function were age (\>65 years), arterial hypertension, and prior renal failure.

Two recently published studies^[@bibr75-1536012118776068],[@bibr76-1536012118776068]^ analyzed overall survival in patients receiving up to 8 cycles of ^177^Lu PSMA-617 RLT. Any PSA decline after the first cycle was a significant prognosticator of survival in both studies (68 vs 33 weeks reported by the first mentioned study and 59 vs 28 weeks reported by the second-listed study). These results could be confirmed by a larger 2-center study in patients pretreated with at least 1 line of chemotherapy and abiraterone and/or enzalutamide.^[@bibr77-1536012118776068]^ The PSA decline of at least 20.87% was the optimal parameter in predicting improved overall survival in the multivariate analysis. The same study group also showed that in patients who do not respond to the first cycle, further therapy cycles should be performed, because nearly one-third of the patients showed a delayed response after additional therapy cycles.^[@bibr78-1536012118776068]^

According to currently available results, ^177^Lu PSMA-617 is a new and promising therapy option for patients with metastatic PC, but it has not yet reached clinical approval. It should therefore mostly be offered to patients as a salvage therapy; however, a more upfront role of RLT with PSMA ligands leading to regulatory approval would seem prudent.

In the following, we summarize the current therapy protocol most widely used.

Indications for RLT With ^177^Lu-PSMA-617 {#section9-1536012118776068}
-----------------------------------------

metastatic castrate-resistant PC with PSMA-positive metastatic disease upon PSMA-PET or single-photon emission computed tomography (SPECT) imaging;after initial hormone therapy (luteinizing hormone-releasing hormone agonists/antagonists):progressive disease, despite newly developed hormone therapies (abiraterone / enzalutamide)progressive disease, despite (first line or second line) chemotherapy (docetaxel and cabazitaxel) or patient not suitable for chemotherapynot suitable for ^223^Ra-dichloride due to visceral metastases or diffuse bone marrow metastases; anddecision for salvage PSMA therapy at the institutional interdisciplinary tumor board.

Preparation Prior to RLT {#section10-1536012118776068}
------------------------

PSMA-PET or SPECT imaging to verify PSMA positive lesions.Renal scintigraphy to evaluate renal function and rule out obstructive dysfunction, which should be treated prior to the RLT

Prerequisites for RLT {#section11-1536012118776068}
---------------------

White blood cells ≥ 2 tsd/µL.Hb ≥ 8 g/dL, in the case of symptomatic anemia a red blood cell transfusion should precede the therapy. The RLT with ^177^Lu-PSMA-617 may have a positive effect on bone marrow depression because of tumor regression in bone marrow.^[@bibr79-1536012118776068]^Platelets ≥ 75 × 10^9^/L.Creatinine \< 2 mg/dL.Eastern Cooperative Oncology Group ≤2.

Proposed Protocol {#section12-1536012118776068}
-----------------

Cooling the salivary glands from 30 minutes before and up to 4 hours after the ^177^Lu-PSMA-617 injection for reducing the risk of salivary glands radiation injuries.Using urinary catheter in incontinent patients in the first 48 hours for avoiding any contamination.A dose of 6 to 7.4 GBq ^177^Lu-PSMA-617.Injection intravenously as a slow bolus (over about 30 seconds) followed by 1000 mL Ringer or NaCl.Four to 6 cycles of the RLT every 6 to 8 weeks.

Follow-Up After RLT {#section13-1536012118776068}
-------------------

The PSMA-PET or SPECT imaging before first cycle to confirm PSMA-positive metastatic disease and after the last cycle (interim imaging should also be performed if needed).Laboratory test after RLT should be performed every 2 weeks: blood cell counts, creatinine, and liver panel.Decision to pursue the RLT depending on the imaging and clinical situation.

Future Perspectives and Remaining Issues {#section14-1536012118776068}
========================================

The PSMA-based imaging and RLT is a theranostic approach, which is currently applied in metastatic castration--resistant PC. Radioligand therapy with ^177^Lu-PSMA-617 seems to be a promising treatment for metastatic patients with PC. Despite very encouraging early results, several issues will need to be resolved to clarify and establish the exact role of PSMA-based theranostics in PC. With regard to imaging, currently a number of different agents are available, and the most suitable agent from the point of view of optimal imaging characteristics, availability, access, and cost will need to be identified. Similar notion holds for RLT with β- or α-particles and the specific clinical situations, which may be best amenable for either type of particles or both. Using this therapy, as a combination with newer antiandrogenic drugs such as abiraterone and enzalutamide, at earlier stages of the therapy must be evaluated in future studies. Larger prospective multicenter studies are needed to evaluate the potential of RLT among and with other available therapy options. Moreover, the long-term results and toxicities must be analyzed after longer follow-up periods. We have to point out that while preliminary protocols have been devised, both the imaging and the therapy protocols will evolve in time as experience with PSMA theranostics grows. An expanded understanding of the effects of various treatments on PSMA expression will be needed to facilitate therapy response assessment. It has been recognized that ADT increases PSMA expression which is not only relevant in recognition of posttreatment PSMA PET imaging changes but also suggests the possibility of synergistic therapeutic effect of androgen deprivation and PSMA-based RLT. Determination of the impact of PSMA theranostics on various outcome measures and comparative cost--benefit analysis will need investigations.

**Declaration of Conflicting Interests:** The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: The University of Muenster received consulting fees from ABX Advanced Biochemical Compounds, Radeberg, Germany for K.R.

**Funding:** The author(s) received no financial support for the research, authorship, and/or publication of this article.

**ORCID iD:** Kambiz Rahbar, MD ![](10.1177_1536012118776068-img1.jpg) <http://orcid.org/0000-0002-4591-4055>
