Armed thieves have raided a jewellery store in the Melbourne suburb of South Yarra, marking the second daylight robbery in as many days.

Four masked men entered the store on Toorak Road, South Yarra, about 3pm, police said.

It is the second jewellery store robbery in Melbourne in as many days. (9NEWS)

The offenders used an unknown weapon to smash cabinets and steal a quantity of jewellery.

READ MORE: Jewellery thieves filmed running to getaway car after daylight smash and raid in Melbourne

They fled the scene in an allegedly stolen vehicle.

The thieves targeted the store about 3pm. (9NEWS)

A male staff member suffered a small cut to his hand during the robbery.

Police remain at the scene.

It is unknown whether the incident is linked to yesterday’s robbery on Canterbury Road.