The crew will now have to wait
The seven crew members aboard Discovery had been preparing for their re-entry into Earth's atmosphere.
Low-lying cloud which could obscure the landing strip forced flight controllers to scrub Monday's two landing windows at Nasa's Kennedy Space Center.
Discovery's mission is the first flight for the shuttle since Columbia broke up on re-entry in February 2003.
The shuttle was originally due to land at 0946 BST (0446 EST; 0846 GMT). The crew were told to circle the planet again in the hope that weather problems would clear.
GUIDE TO RE-ENTRY
How the space shuttle returns
But a persistent cloud deck at low altitude finally forced mission controllers to give up on bringing the shuttle down for 1121 BST (0621 EST; 1021 GMT).
The shuttle's first landing opportunity on Tuesday is at 1007 BST (0507 EST; 0907 GMT) at Kennedy Space Center.
Back-up strips are scheduled at Edwards Air Force Base in California and White Sands in New Mexico.
While the forecast for Kennedy is similar for tomorrow, the outlook at Edwards Air Force Base is favourable all week.
Homeward bound
The US space agency's administrator Dr Mike Griffin said there was "no agony" over the delay.
"We're going to land one way or another, one place or another, and all we're talking about is where," said Dr Griffin.
Discovery's crew were woken on Monday at 0130 BST (2030 EST; 0030 GMT). The seven astronauts immediately began preparing for landing.
"We're getting ready here and we're looking forward to coming home," Discovery commander Eileen Collins told mission control in Houston, Texas, earlier on Monday.
SHUTTLE LANDING SITES Kennedy Space Center - the shuttle's "home" and preferred site for landing Edwards Air Force Base - has been used numerous times for shuttle landings White Sands - back-up known as Northrup Strip lies 45 miles north of US Army missile range
When mission control finally gives its approval, Discovery will fire its engines for three minutes nine seconds at an altitude of about 340km (220 miles), to slow it down enough to begin the descent.
The shuttle will pitch up as it starts to experience the burning effects of the atmosphere at an altitude of 129km (80 miles) and a speed of about 27,360km/h (17,000mph).
After Discovery has banked from side to side in order to dissipate speed, Commander Collins will take manual control to pilot the vehicle to touchdown.
Anxious wait
Space shuttle Columbia's external tank shed a suitcase-sized piece of insulating foam during launch that punched a hole in the ship's wing, allowing super-heated gases to pierce the airframe during re-entry and pull it apart.
Clouds settle in over Nasa's Vehicle Assembly Building in Florida
But onboard cameras captured multiple pieces of foam being shed from the tank - one of which was only slightly smaller than the one that doomed Columbia.
Nasa has grounded the fleet until it has made changes, so Discovery's visit to the International Space Station (ISS) may be the last shuttle mission for some time. On Saturday, Discovery undocked from the station before flying around the space lab to check it for wear and tear.
Safety concerns
Because of safety measures put in place after Columbia, Discovery has been videotaped, photographed and laser-inspected.
Experts are now investigating items seen to fall around the orbiter
The astronaut removed two loose cloth strips, which were protruding from the shuttle's belly.
The US space agency ruled out another spacewalk to fix a thermal blanket, which has billowed out under a cockpit window.
There had been some concern that part of it could tear off during re-entry and hit the orbiter.
Wahadłowiec DiscoveryProm kosmiczny Discovery wróci na ziemię 24 godziny później niż początkowo zakładano. Wszystkiemu winna jest pochmurna i mglista pogoda, która utrzymuje się nad Przylądkiem Canaveral, gdzie lądować będzie wahadłowiec. Siedmioosobowa załoga promu przygotowuje się w tej chwili do ponownej próby wejścia w ziemską atmosferę.

Misja Discovery to pierwszy lot amerykańskiego promu kosmicznego od lutego 2003, kiedy awaria w poszyciu promu Columbia spowodowała jego katastrofę podczas lądowania na Ziemi.

Discovery początkowo miał lądować dzisiaj w godzinach przedpołudniowych. Jednak lądowanie wstrzymano i załoga wahadłowca została poproszona o wykonanie pełnego przelotu wokół ziemi w nadziei, że w tym czasie znikną chmury, które nie pozwalały na bezpieczne lądowanie promu.

W rezultacie jednak zachmurzenie nie zmieniło się i kontrolerzy lotu zadecydowali o odłożeniu lądowania do jutra. Gdyby jutro sytuacja pogodowa nad Florydą nie zmieniła się NASA nie wyklucza lądowania wahadłowca w bazach lotniczych: Edwards w Kaliforni lub White Sands w Nowym Meksyku. Taka operacja byłaby jednak bardzo kosztowna, zmusiłaby NASA do niezwykle drogiego i trudnego logistycznie transportu wahadłowca przez większość część Stanów Zjednoczonych.

Discovery już wcześniej miał dość duże problemy podczas wykonywania misji. Najpierw zawiodły czujniki paliwa, przez co przełożono start wahadłowca. Później podczas startu oderwał się fragment pianki izolacyjnej, co zmusiło członków załogi do pierwszej w historii naprawy zewnętrznego uszkodzenia promu kosmicznego w Kosmosie.