David Silva celebrates scoring Valencia's second equaliser
Esteban Cambiaso headed Inter in front as he followed up Zlatan Ibrahimovic's blocked shot from Luis Figo's cross.
Hernan Crespo wasted two good chances to stretch the lead before David Villa's stunning second-half free-kick round the wall drew Valencia level.
Maicon linked up with Julio Cruz to put Inter ahead but David Silva's shot after a poor clearance secured a draw.
Inter Milan: Julio Cesar, Maicon, Cordoba, Materazzi, Burdisso, Stankovic, Cambiasso (Dacourt 31), Figo (Solari 89), Zanetti, Crespo (Cruz 68), Ibrahimovic.
Subs Not Used: Toldo, Maxwell, Adriano, Samuel.
Booked: Burdisso, Zanetti.
Goals: Cambiasso 29, Maicon 76.
Valencia: Canizares, Miguel, Ayala, Albiol, Moretti, Angulo (Joaquin 83), Marchena, Albelda, Silva (Jorge Lopez 90), Morientes (Hugo Viana 77), Villa.
Subs Not Used: Butelle, Navarro, Curro Torres, Pallardo.
Booked: Albelda, Marchena.
Goals: Villa 64, Silva 87.
Att: 65,000
Ref: Martin Hansson (Sweden).
The first leg of the round of sixteen in the  was completed on Wednesday, with at least one controversial result, and a bag full of ties.  The leg began on Tuesday with four games, and the other four were played the next day, including reigning champions FC Barcelona of Spain.

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