Two protesters climbed up into the roof of the hall where Mr Blair was due to address the Confederation of British Industry conference.
After a 48-minute delay, Mr Blair made his speech in a smaller side-hall.
He said renewable sources could meet some but not all energy gaps and the review would examine nuclear options.
Opening his speech in a packed room in the Business Design Centre in Islington, London, Mr Blair said: "Nuclear power is of course a difficult and a challenging issue.
"Like most tough issues what we actually need is an open and democratic debate, not one conducted by protests and demonstrations to stop people having the freedom to express their views."
Amid the noise from clattering microphones and mobile phones ringing, Mr Blair joked: "This is going to be a surreal occasion... I'm going to give this speech if it's the last thing I do."
Offer refused
Greenpeace wanted to be allowed to make a 10-minute speech in return for ending the protest.
But CBI director general Digby Jones decided to move the PM's speech instead, saying: "At the end of the day I don't give in to ultimatums."
He said he had offered two "legitimate" Greenpeace delegates the chance to ask the prime minister the first question after his speech in return for ending their protest, but they had refused.
A protester balances on a girder in the hall's roof
The two protesters, wearing yellow jackets over their suits and with conference delegates' badges, appeared on girders in the roof about 20 minutes before Mr Blair was due to begin at 0930 GMT.
One unfurled a banner saying: "Nuclear: Wrong Answer." They also dropped stickers onto the delegates below them.
The men, both believed to be trained climbers, were attached by loops of rope to the roof girders.
'Disgrace'
Greenpeace named the protesters as Huw Williams and Nyls Verhauelt. They have now been arrested and taken to a London police station.
Mr Verhauelt said: "We should have a democratic right to have a voice here as well. This was the only way we could say what we wanted to say."
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CBI deputy director general John Cridland condemned the protest as "quite disgraceful".
He said the two men had posed as employees of a fictitious company, E-Lingo and had booked for the conference as delegates last week.
Mr Cridland said "it would be a sad day" if every company had to be checked out before being granted access but the CBI would be holding a full review of security.
Metal detectors and x-ray machines were used at the conference, and delegates' bags were searched on entry.
The CBI says initial investigations show the men entered the building wearing climbing harnesses, concealed beneath their clothes. These would not be detected by the security equipment.
Nuclear focus
The prime minister is believed to view nuclear power as a way to improve the security of the UK's energy supply and also help to meet UK greenhouse gas targets.
Business chiefs want a quick decision. Green groups say there are cleaner and safer alternatives to fossil fuels.
Mr Blair said the energy review would be headed by the Energy Minister Malcolm Wicks and report by the middle of next year.
The review would "include specifically the issue of whether we facilitate the development of a new generation of nuclear power stations", he said.
Two Greenpeace protestors entered the CBI conference at the Business Design Centre in Islington, London and delayed a speech being made by the Prime Minister Tony Blair, in which he was expected to announce the consideration of further nuclear power stations to offset the increasing gas prices being experienced by industry in the UK. The protestors, wearing yellow safety jackets over business suits, climbed up into the ceiling rafters and held banners saying "NUCLEAR: WRONG ANSWER", and dropped 'radioactive confetti' onto the delegates down below.

Greenpeace threatened to make noise and throw missiles at the Prime Minister should he make his speech. They requested a ten minute speech before Tony Blair's speech, but this was turned down by the conference organisers and the speech was delayed whilst delegates moved into an alternative room in the building so that the speech could continue without disruption.