(CNN) -- Rescue teams on Friday found the wreckage of a plane that crashed Thursday night in the mountains of Venezuela, but none of the 46 people aboard survived, a searcher said.
Relatives of passengers on board the flight wait for news Thursday at the desk of Santa Barbara Airlines.
"The impact was direct. The aircraft is practically pulverized," firefighter Jhonny Paz told Globovision, a privately owned Venezuelan television station. "There are no survivors."
There was no word on the cause of the crash.
Witnesses saw the Santa Barbara Airlines plane go down, according to Antonio Rivero, Venezuela's national director of civil protection.
Harsh weather and rough terrain in the Andes Mountains likely will make the job of emergency workers difficult, Rivero said on a state-run television station.
The plane went missing while flying from Merida to the international airport near Caracas, an official said.
The pilot did not check in with controllers 20 minutes into the flight, as scheduled, suggesting the plane encountered problems shortly after takeoff.
Nelson Marquez, chief of civil defense for Merida, said the plane was carrying 43 passengers and three crew members.
Media reports said the Santa Barbara Airlines plane was supposed to land about 7 p.m. local time Thursday. E-mail to a friend
CNN's Guillermo Arduino and Adrian Criscaut contributed to this report.
All About Venezuela • Air Disasters
A Venezuelan plane with 46 passengers onboard has been reported missing in western Venezuela, officials say.

The Santa Barbara Airlines plane took off just before dusk from the city of Mérida en route to Simón Bolívar International Airport outside the capital city of Caracas.

Noel Marquez, director of Venezuela's emergency management agency in Mérida, said the plane has failed to contact control towers. Civil Defense chief General Antonio Rivero told reporters that it is unknown whether or not the plane crashed or is simply missing.

Mérida a town roughly 680 kilometers (422 miles) from Caracas is a popular tourist location.