The blast on Tuesday occurred in a market, close to the house of Zulfiqar Khosa, an adviser to the chief minister of Pakistan's Punjab province.
At least 33 people have been killed and 70 injured in a car bomb blast in the town of Dera Ghazi Khan in Pakistan's Punjab province, local officials have said.
The house was damaged in the blast but he was not among the injured, officials said.
No group has yet claimed responsibility for the attack.
"There are many people trapped in the rubble after the powerful blast demolished some 10 shops ... The rescue work is under way and we fear the toll may go up," Hassan Iqbal, the town commissioner, said.
"It was a terrorist activity, similar to those being carried out in other parts of the country."
'Direct attack'
Raza Khan, a local resident, told The Associated Press: "The whole market has collapsed.
"There is smoke and people running here and there.''
Pervez Haider Altaf, a district health officer, told AFP news agency that people were frantically searching for survivors.
"The hospital in the town has been crowded by people looking for their relatives. Rescue efforts are still going on," he said.
An emergency has been declared at all local hospitals.
Zulfiqar Khosa's son, Dost Mohammad Khosa, told The Associated Press that the bombing was "a direct attack on us" and that two of his cousins were among the wounded.
But Imran Khan, Al Jazeera's correspondent in Islamabad, the Pakistani capital, said that it was unclear whether Khosa was the target of the bombing.
"Zulfikar Khosa is a close confidante of Nawaz Sharif, the former prime minister of Pakistan and the PML-N leader. It is the Islamic holy of Muharram right now, and Dera Ghazi Khan has seen violence take place [during that time]," he said.
"Muharram is a very holy month for the Shia community here in Pakistan. Ever since Muharram started, Shia community leaders have been saying that [they] need to have more security around holy sites.
"Shia leaders had said that Dera Ghazi Khan was one of the targeted areas and should be more secure."
More than 500 people have been killed in bomb blasts in Pakistan since October, in violence blamed on pro-Taliban fighters who are battling an army offensive in the country's northwest.
The US government has called on Islamabad to step up its efforts against Taliban- and al-Qaeda-linked fighters who cross over into Afghanistan.
However, Pakistan has said that it has to focus on a rising domestic insurgency which has killed more than 2,680 people in the last two-and-a-half years.
Local officials in the town of Dera Ghazi Khan in Pakistan said on Tuesday that at least twenty people were killed after a suicide car bomber attacked the house of a provincial governor. The Al Jazeera news agency reports that seventy people were injured from the blast.

According to Siddiq-ul-Farooq, a spokesman for the Pakistan Muslim League, the bomber drove his car into the wall of Dost Muhammad Khosa's home, damaging it. Khosa and his relatives, however, were not at home, Farooq added. The house was reportedly close to a market, which also suffered from the explosion.

A reporter for Al Jazeera, however, noted that it wasn't immediately clear if Khosa was intended as a target in Tuesday's attack.

"There are many people trapped in the rubble after the powerful blast demolished some 10 shops ... The rescue work is under way and we fear the toll may go up. It was a terrorist activity, similar to those being carried out in other parts of the country," said town commisioner Hasan Iqbal.

A local resident, Raza Khan, was witness to the chaos that resulted after the detonation. "The whole market has collapsed. There is smoke and people running here and there," he said to the Associated Press. A local health official told Agence France-Presse news agency that "the hospital in the town has been crowded by people looking for their relatives. Rescue efforts are still going on."