The attack late on Tuesday targeted a Taliban residential compound in Dargamandi village in a tribal area bordering Afghanistan.
At least 10 people have been killed after a suspected US drone fired missiles into Pakistan’s North Waziristan region, Pakistani intelligence has said.
It was not immediately clear whether any Taliban fighters were present in the area at the time.
The United States has fired scores of missiles from unmanned drones into the tribal regions since last year in a campaign targeting al-Qaeda and Taliban commanders.
Al Jazeera's Kamal Hyder reporting from Islamabad, the Pakistani capital, said: "No one is clear under what mandate the Americans are carrying out such strikes because this is the month of Ramadan and there is going to be a considerable backlash not just in those areas, but from across Pakistan.
"People are angered by the way the Americans are conducting their affairs in this particular conflict . This is an infringement of sovereignty.
"Aircraft with no pilots onboard are constantly flying into Pakistani aerospace and attacking targets within Pakistan ... it creates a very complex situation for the Pakistani military itself.
"The signal the Pakistanis want to send across is that they want to be able to work within their territory without outside interference."
Tuesday's attack was the second in the North Waziristan tribal region in less than 24 hours.
A similar strike targeting a madrassa (Islamic school) and an adjoining house in Machikhel village killed at least five people on Monday.
Residents on Tuesday said they had seen the drone hovering in the sky and had been expecting the missile attack.
Washington alleges Al-Qaeda and Taliban rebels who fled Afghanistan after the 2001 US-led invasion are holed up in the semi-autonomous tribal belt.
Pakistani officials have stated that a missile strike — suspected to have been launched from an American  (UAV) — killed at least ten militants in , a tribal area near Pakistan's border with Afghanistan on Tuesday.

The attack targeted a Taliban-operated compound in the village of Dargamandi. It was the second attack in the vicinity within 24 hours. On Monday, five people were killed following a similar attack targeting a Islamic school in the Machikhel village.

Unmanned aircraft operated by the US are believed to have launched over forty missiles into northwestern Pakistan, a stronghold of the Taliban in the past few months.

The strikes were initiated after a suicide bomber killed at least 21 people at a border checkpoint last week.