Generate a question about maritime trade in the 16th century.
What were the main trade routes and goods exchanged during maritime trade in the 16th century?
Below is an instruction that describes a task, write a response that appropriately completes the request.

### Instruction:
Generate a question about maritime trade in the 16th century.

### Response:
What were the main trade routes and goods exchanged during maritime trade in the 16th century?