Determine the missing numbers in the sequence.
The missing number in the sequence is 8. The sequence is a pattern of doubling the previous number: starting with 2, doubling it gives 4, doubling 4 gives 8, doubling 8 gives 16. So the sequence is 2, 4, 8, 16. There is no missing number.
2, 4, 8, __, 16
Below is an instruction that describes a task, paired with an input that provides further context. Write a response that appropriately completes the request.

### Instruction:
Determine the missing numbers in the sequence.

### Input:
2, 4, 8, __, 16

### Response:
The missing number in the sequence is 8. The sequence is a pattern of doubling the previous number: starting with 2, doubling it gives 4, doubling 4 gives 8, doubling 8 gives 16. So the sequence is 2, 4, 8, 16. There is no missing number.