Data Mining [Complete Guide]

Data mining is the process of sorting through large data sets to identify patterns and relationships that can help solve business problems through data analysis. Different techniques and tools of data mining allow companies to predict future trends and make more informed business decisions.

What is Data Mining?

Data mining is a key part of data analysis as a whole and one of the basic disciplines of data science. It uses advanced analytical techniques to find useful information and understandable patterns in data sets.

what is data mining

Furthermore, data mining is a step in the Knowledge Discovery in Databases (KDD) process, a data science method for collecting, processing, and analyzing data. Data mining and KDD are sometimes referred to interchangeably but are often considered separate subjects.

History and Origins of Data Mining

Data warehousing, BI, and analytics technologies began to emerge in the late 1980s and early 1990s, providing an increased ability to analyze the growing volumes of data that organizations were creating and collecting. they did The term data mining was used until 1995, when the first International Conference on Knowledge Discovery and Data Mining was held in Montreal.

The event is sponsored by the Association for the Advancement of Artificial Intelligence, or AARI, which also holds the conference annually for the next three years. Since 1999, this conference, is commonly known as KDD 2021. It is organized primarily by SIGKDD, the Special Interest Group on Knowledge Discovery and Data Mining in the Society for Computing Machinery.

A technical journal called Data Mining and Knowledge Discovery published its first issue in 1997. Originally quarterly, it is now published bi-monthly and contains peer-reviewed articles on data mining and knowledge discovery theories, techniques, and practices. Another publication, the American Journal of Data Mining and Knowledge Discovery, was launched in 2016.

Why is Data Mining Important?

Data mining is an important part of successful analytics initiatives in organizations. The information it generates can be used in business intelligence (BI) and advanced analytics applications. It includes historical data analysis, as well as real-time analytics applications that continuously examine data over time as it is created or collected.

importance of data mining

Effective data mining contributes to various aspects of business strategy planning and operations management. These topics include customer-facing functions such as marketing, advertising, sales, and customer support, as well as manufacturing, supply chain management, finance, and human resources.

Data mining also supports fraud detection, risk management, cybersecurity planning, and many other critical use cases. It also plays an important role in healthcare, government, scientific research, mathematics, sports, etc.

Features of Data Mining

The advantage that we get from data mining are:

  • We can filter out redundant and irrelevant data noise.
  • It helps to make proper use of this information and to correctly evaluate possible outcomes.
  • Increases the speed of informed decision-making.

What are Data Sources?

Data sources can include databases, data warehouses, the web, and other information repositories or data that are dynamically distributed across the system.

Stages of Data Mining

In this part, we want to briefly get to know the general steps in a data mining process. These steps are briefly:

  • Data extraction, transfer, and storage in multidimensional databases.
  • Creating access for business layer data by means of data mining software.
  • Displaying the results of data analysis in the form of graphs or charts.

Types of Data Mining

Each of the following data mining techniques addresses several different business problems and provides different insights into each. However, understanding the type of trading problem you have to solve will also help you know which technique to use is your best choice and will yield the best results.

types of data mining

Types of data mining can be divided into two basic parts as follows:

1. Predictive Analytics

2. Descriptive Analysis

Predictive Data Mining

As the name suggests, predictive data mining analytics works on data that can help predict what might happen in the future in the company. Predictive data mining can be divided into the following five types:

  • Classification analysis
  • Regression analysis
  • Serious analysis of time
  • Predictive analysis
  • Analysis of neural networks

Descriptive Data Mining

The main purpose of descriptive data mining tasks is to summarize or transform assumed data into relevant information. Descriptive data mining tasks can also be divided into four types as follows:

  • Cluster analysis or clustering
  • Summary analysis
  • Analysis of communication rules
  • Analysis and discovery of sequence patterns
  • Data mining with the decision tree method

Data Mining Techniques And Methods

Data Mining Techniques And Methods

By using data mining techniques, the speed of calculations and the required space in memory (RAM) are significantly improved. In general, data mining techniques can be placed in one of the following 3 categories or a combination of them.

In this type of learning, data is labeled based on defined features and placed into different classes. This algorithm is able to learn the labeling model and use the intelligent learning system to label new samples and separate them. This separation is considered a form of learning and the algorithm can apply its model to new data after this learning.

In this case, the algorithm groups the data based on their nature. For example, it divides the customers of an online store into different clusters based on their similarities (age, gender, level of education, etc.).

Reinforcement Learning

In this learning, the algorithm continuously discovers information and learns by exchanging information and operations with the surrounding environment. For example, consider an algorithm that intelligently designs different types of shopping cart forms by interacting with the environment and simulating it to create the best design for customers and ultimately increase sales and profit

Data Mining Tools

data mining tools

Data scientists use several data mining tools to store, organize, and visualize data. Here are some of the most common ones in use today.

Python is a multi-purpose language that is often used for web development and application development. The language is versatile, easy to learn, and supports many Internet protocols. Because Python is compatible with many libraries and packages used for data analysis, visualization, and machine learning.  It is one of the most important languages for data mining. Python is also open source and free to install, making it a good first language to learn.

SQL or Structured Query Language is essential for data scientists. SQL (sometimes pronounced “sequential”) is a standard language used to communicate with relational databases. Tasks, like adding, deleting, and retrieving data and creating new databases, are done using SQL.

Since data mining requires the ability to work with databases, SQL is an outstanding language. In addition, it is a very common language in business, especially e-commerce where websites store and link large amounts of data about products and customers.

NoSQL (not just SQL) differs from SQL because it works with non-relational databases. Unlike relational databases that store data in tables, non-relational databases can store data based on other methods (such as values or documents). The NoSQL databases can capture structured and unstructured data. As a result, organizations that collect different types of data use NoSQL to manage it.

R is a popular programming language for statistical modeling and graphics generation. Basically, the world of R revolves around data. It includes tools for storing, managing, and analyzing data, as well as tools for displaying the results of that analysis.

In addition, R offers an advanced set of free packages (reusable basic units of code) that can be used for tasks such as visualization, statistical analysis, data manipulation, and more.

Apache Spark

Apache Spark calls itself ” an integrated analytics engine for large-scale data processing,”. An engine that works with many of the platforms listed here. Originally developed at the University of California, Apache Spark runs SQL queries and comes with a machine learning library compatible with other frameworks. It performs streaming analytics. Apache Spark also has a large community that contributes to its open-source code.

Hadoop is a framework for storing large amounts of data on multiple servers, creating a distributed storage network. Data is also copied across different networks as a safety measure. A set of Hadoop modules are used to process and analyze data and can be integrated into many other software platforms (such as Microsoft Excel).

One of the advantages of Hadoop is that it can be scaled to work with any data set, from one on a single computer to those stored on many servers.

Java is a well-known language that runs on multiple devices from laptops to large-scale data centers and mobile phones.

In fact, Java is so widely used that many data mining tools (including Hadoop) are written in Java and installed on top of it. In addition, Java programs can be written on one system and run on any other system running Java.

Why do Businesses Need Data Mining?

With the advent of big data, data mining has become more widespread. Big data or big data are very large collections of data that can be analyzed by computers to reveal certain patterns, sequences, associations, and trends that are perceptible to humans. Big data contains detailed information about different types and contents.

Therefore, with this amount of data, simple manual statistical analysis will not work. This need is met by the data mining process. This work leads to the movement from simple data statistics to complex data mining algorithms.

The data mining process extracts relevant information from raw data such as transactions, photos, videos, and flat files and automatically processes the information to create useful reports for businesses.

Therefore, the process of data mining is crucial for businesses to make better decisions by discovering patterns and trends in data, summarizing them, and understanding relevant insights.

Benefits of Data Mining

Benefits of Data Mining

The benefits of data mining include the following:

More effective marketing and sales: Data mining helps marketers better understand customer behavior and preferences, enabling them to create targeted marketing and advertising campaigns. Similarly, sales teams can use data mining results to improve lead conversion rates and sell additional products and services to existing customers.

Better customer service thanks to data mining: Companies can identify potential customer service issues faster and provide up-to-date information to call center agents to use in calls and online chats with customers.

Improved supply chain management: Organizations can identify market trends and forecast product demand more accurately, enabling them to better manage inventory and resources. Supply chain managers can also use data mining information to optimize warehousing, distribution, and other logistics operations.

Increase production time by extracting operational data from sensors on production machines and other industrial equipment: supports predictive maintenance programs to identify potential problems before they occur and helps prevent unplanned downtime.

Stronger risk management: Business and risk managers can better assess a company’s financial, legal, cybersecurity, and other risks and plan to manage them.

Lower costs: Data mining helps save money by reducing redundancies and waste in company expenses and operational efficiency in business processes.

Ultimately, data mining initiatives can lead to increased revenue and profits as well as competitive advantages that differentiate companies from their business rivals.

How Does Data Mining Work?

We said about the application of data mining, data mining is a method of solving problems based on available data. At the beginning of this process, your business problems are found. After finding the problems, the information recorded in your organization or production line is received.

How does data mining work

Based on the obtained information, the mechanisms related to your business are modeled. Then, using machine learning methods, solutions to eliminate the problems of the organization will be provided to you in the framework of the document report and software.

Based on the mentioned contents, solving the problem with the help of the data mining process takes place in 6 steps, which we will examine in the following:

1- Correct understanding of business

In this case, the employer knows that there is a problem and defect in his work, but he is unable to recognize the problem. Therefore, he raises the problem with the data mining expert, this is the starting point and the first step to solving the problem.

2- Examining and understanding the data

At this stage, the data mining specialist receives data and business information from the employer and reviews them. According to the volume and quality of the data, he modifies the issue raised in the previous stage so that the result of data mining and investigation is presented more realistically.

3- Data preparation

At this stage, the data mining specialist prepares the data, including identifying and removing incomplete and wrong data, integrating different data repositories in the business, etc.

4- Modeling

In the fourth stage, according to different solutions and methods, different models are made and the best model is selected according to the data mining expert.

5- Model testing and evaluation

Now, the formed models are tested and evaluated, and a suitable model is selected that fits the problem raised in the first stage. After this, it is necessary to check the effectiveness of the chosen model during a meeting with the employer.

If the selected model is not suitable and does not help to solve the problems, the process is repeated from the beginning.

6- Development of the final model

If the tests and evaluations are favorable and satisfactory, a number of solutions are provided in the form of developing the final model. The final model specifies how the behavior of the collection should be in the face of the problems raised.

Examples of Data Mining Industry

Data mining techniques are widely accepted among business intelligence and data analytics teams, helping them to extract knowledge for their organization and industry. Examples of data mining applications are:

Online retailers mine customer data and Internet clickstream records to help them target marketing campaigns, promotions, and promotional offers to individual shoppers. Data mining and predictive modeling also power recommendation engines that recommend inventory and supply chain management activities as well as potential purchases to website visitors.

Financial Services

Credit card companies and banks use data mining tools to identify fraudulent transactions, build financial risk models, and apply for loans and credits. Data mining also plays a key role in marketing and identifying potential opportunities to increase sales with existing customers.

Insurers rely on data mining to help price insurance policies and make decisions about approving policy applications, including risk modeling and management for prospects.

Data mining applications for manufacturers include efforts to improve operational time and efficiency in manufacturing plants, supply chain performance, and product safety.

Streaming services perform data mining to understand what users watch or listen to and provide personalized recommendations based on people’s viewing and listening habits.

Data mining helps doctors diagnose medical conditions, treat patients, and analyze X-rays and other medical imaging results. Medical research also relies heavily on data mining, machine learning, and other forms of analytics.

Sales and Marketing

Companies collect vast amounts of data about their customers and prospects. By observing consumer demographics and online user behavior, companies can use the data to optimize marketing campaigns, improve segmentation, cross-sell offers, and customer loyalty programs, and drive more efficiency in marketing efforts. Predictive analytics define the expectations of teams with their stakeholders and provide an estimate of the return on any increase or decrease in marketing investment.

Educational institutions to understand their student population as well as enabling environments; They have started collecting data to improve their performance and process. As courses continue to move to online platforms, they can use different dimensions and metrics to view and evaluate performance; Such as: keystrokes, student profiles, classes, universities, time spent, etc.

Safety is the main driver of data mining in the transportation industry. Cities and communities can conduct traffic studies to determine the busiest roads and intersections, and public transit agencies can mine the data to understand their busiest areas and travel times.

Operational optimization

Process mining uses data mining techniques to reduce costs in operational functions and enables organizations to work more efficiently. This process has helped improve decision-making among business leaders and identify costly bottlenecks.

Fraud detection

While providing valuable insight to teams through recurring patterns in data, observing data anomalies helps companies detect fraud. While this is a known use case in banks and other financial institutions, SaaS-based companies are also starting to adopt these methods to remove fake user accounts from their dataset.

Problems and Challenges of Data Mining

Despite the high importance of data mining in today’s businesses and the important achievements that this science creates for organizations, there are also challenges and problems along the way.

In the following, we will mention some of the most important challenges of data mining and then we will describe some of these cases. The main challenges of data mining are:

  • Security and privacy issues
  • Facing incomplete and scattered data
  • Difficulty discovering complexities in some data
  • Methodological challenges
  • The necessity of choosing the right analysis method to extract efficient results
  • Scalability of algorithms
  • Difficulty in providing intuitive concepts for some phenomena hidden in the data

Future of Data Mining

We live in a world of data; The amount of data we create, copy, use, and store is increasing exponentially. We have already passed the threshold of creating 1.7 megabytes of new information every second for every human on the planet.

This means that the future is bright for data mining and data science. With so much data to sort through, we need more sophisticated methods and models to gain meaningful insights and help make a business decision.

Final Words

Hope you understand the topic completely. If you still have any questions write us in the comment section. we will answer you very soon. Do share with your friends if you like this. Thanks.

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Logistics without footprint

The globalisation of the economy is possible thanks to liberalising international trade and reducing barriers to the movement of goods and capital. Logistics and transport are among the pillars of change that have enabled the economy to reach its current state.

Transporting products, raw materials or components over long distances, ensuring continuity of supply by storing reserves, organising and supervising supply chains is essential. It consumes many resources, including energy. It has a significant impact on the environment due to its scale. One of its manifestations is the emission of greenhouse gases, including carbon dioxide. If we can reduce the carbon footprint of logistics and transportation processes, the effect will be felt by all of us.

Where to look for a footprint?

Let’s start with electricity and heating. Large logistics centres consume considerable amounts of energy, which is necessary for lighting, heating, air conditioning, internal transport, machinery operation, IT systems etc. Each kilowatt hour is important, both for the company’s financial result and for the environment. Savings in this area can be achieved in a number of ways: by replacing inefficient light sources with modern and energy-efficient ones, modernising machinery, building zero-emission, passive warehouse buildings, sorting plants etc.

Road, sea and air transportation are significant sources of carbon dioxide emissions. Wherever technically possible, rail and intermodal freight transport should be used, provided that rail lines with an electric overhead contact system are available. More and more all-electric delivery vans are on the road and the market is awaiting the launch of electric trucks. Replacing combustion engines with this alternative will be the next big step towards sustainable, environmentally neutral transport. This will only happen provided that one condition is met: the electricity stored in the vehicles’ batteries must come from clean, preferably renewable, sources.

Before the dream of electric trucks comes true, it is worth taking a look at the available fleet and choose carriers which use vehicles meeting the highest standards as regards exhaust emission. This change will be good for both the environment and your wallet because in many countries a cleaner engine means lower transportation fees.

Reducing energy consumption, and in this way also carbon footprint, is easier for companies that use advanced IT tools to plan routes and prepare transportation schedules. Every kilometre driven, every minute spent in traffic jams, every journey with or without a load, or with a load of incorrect size, counts.

Use repeatedly

Logistics without packaging does not exist. A box, a sack, a pallet or a barrel – they have all been produced and a certain amount of carbon dioxide has been emitted because of that. This can be reduced if the packaging is not thrown away after delivery but it is returned to the shipper to be reused.

Preventing global climate change requires action on a global scale. The effectiveness of the measures taken depends on the motivation of the companies and their customers have a lot to say in this respect. If you have a choice, choose a logistics or transportation company that can do a lot for the environment – and therefore also for you!

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Friday Fiction Challenge: 7-4-14

A challenge to help you write, get you thinking, and spark some creativity! Add a link to your response in the comments below and link back to this post. If you just decide to answer the question, and it’s not a full length post, feel free to just comment with your answer. Be creative and have fun!

In honor of the birth of America… and Captain America.

The Question – The Country

Which foreign country would you want to visit?

The Challenge – The Country

Write a tale about your unfortunate experience in this foreign country. Do you get stranded in the middle of nowhere? Or do you find yourself stuck on the Autobahn (or some other super highway)?

Bonus! The Question – The Captain

Would you rather go back in time to the 1940s during World War II or would you rather eat nothing but fondue for the rest of your life?

Bonus! The Challenge – The Captain

Write a fictional story about your time in World War II. Or the rest of your life while you eat fondue. 😀

The Answer

“Please wake up, Betsy,” Alice whispered.

Alice gripped her sister’s hand as she listened to the heart monitor beep. She hadn’t slept in days while her sister was in the hospital, and her face was pale and drawn. Her sister’s white face looked so small on the pillow. Alice bowed her head in silent prayer.

“God, please, heal my sister,” she pleaded silently. “I need her so much. My parents told me when I was young that you listen to every prayer, and that you’ll answer. I know I haven’t been the most faithful,” she gulped back tears, “but I need you to heal Betsy.” Alice laid her head on the hospital bed, struggling to hold back tears. She drifted off to sleep, not noticing when the heart monitor’s beeping slowed and then, finally, stopped.

“Miss Alice?” a nurse asked softly, gently shaking Alice awake. Alice sat up, struggling to hold back a yawn. She looked down at her sister’s still figure. The hand she was still grasping was icy cold.

“I’m sorry, Miss Alice,” the nurse whispered sympathetically. “She-she died only a few minutes ago.

Later that day, Alice dragged her feet in through the autumn leaves that had fallen and covered the sidewalk. She looked up at the gray cloud-covered sky. A single raindrop fell and landed on the end of her nose. She wiped it away harshly.

“God, why didn’t you answer me? I asked you to heal Betsy, but you didn’t,” she whispered angrily.

A voice deep inside her soul whispered to her. I did answer. But I have something better in mind for both of you. Just trust Me.

A poker chip. A pair of dice. A screwdriver. A rock. All hidden in an old, rotten box shoved in an old, rotten tree.

The collection wasn’t much. Just a boy’s favorite treasures, dirty and smudged. The woman traced the A. H. carved on the lid of the box. A tear slipped down her cheek as she fondled each of her son’s precious memoirs.

“Goodbye, Alex,” she whispered softly, stroking the smooth rock. “I’ll take care of your treasures, and I’ll see you again in heaven someday.”

The little girl next to her looked down into the box.” I hope he’s got better treasures in heaven than he left us down here.”

“Do not store up for yourselves treasures on earth, where moths and vermin destroy, and where thieves break in and steal.But store up for yourselves treasures in heaven, where moths and vermin do not destroy, and where thieves do not break in and steal.”

Matthew 6:19-20

Singing Lessons: A Novella

This is an excerpt (the entire first part) of a novella I wrote for a friend for her birthday. It was the first longer-than-a-short-story project that I finished completely. Enjoy, and please let me know what you think in the comments below.

“Mo-o-om!” Emily Noble insisted. “You know that I don’t like singing in front of people!”

Her mother looked up from her newspaper. “But, Emily, you have such a beautiful voice. You should share it! Why don’t you try out for choir?”

“I don’t like singing, or being in front of a whole bunch of people.” Emily sighed.

“You could take singing lessons,” her mom suggested.

Emily groaned. “Please, Mom, don’t make me,” she begged.

Her mom sighed, too. “All right, it’s your decision.”

Emily nodded and smiled gratefully at her mom. She knew that her mom wished that her daughter was interested in performing, but she hated being in front of people. Her mom realized that, though, so she allowed Emily to be herself, although she still encouraged Emily to perform, especially as a singer.

“Do you have any homework to work on?” her mom asked her meaningfully as Emily reached for the television remote. She looked up at her mom guiltily.

“Yeah,” she admitted.

Her mother gave her a fake stern look. “Homework first,” she ordered.

Emily grinned at her mom and headed upstairs to her room. She plopped down in her desk chair, flipping on her purple desk lamp. She didn’t have much homework left since she’d finished most of it in study hall.

“Write an essay about your siblings, or another close family member if you are an only child…” Emily muttered as she read over the homework assignment for her English class. She sighed. She only had one sibling, her older brother, Adrian, and she hadn’t seen him since his college graduation. How was she supposed to write an essay about the brother that she hadn’t seen in two years? She checked her notes. The essay wasn’t due until Monday, so she had five days. Emily didn’t normally procrastinate, especially with English since it was her favorite subject, but she really wasn’t looking forward to writing an essay about her brother.

Emily finally finished her homework and leaned back in her chair. She flipped the switch on her boom box, turning on the radio. Upbeat Christian music swelled and filled the room as she adjusted the volume, turning it down so she wouldn’t bother her parents. She stood up, grabbing one of her many novels, and flopped down on the bed on her stomach. She flipped a couple of pages distractedly, and then set the book down. She closed her eyes and rested her chin on the bed, soaking in the music. The DJ came on and started talking. She tuned him out, thinking about her essay that she had to work on. What was she going to do?

“… and here’s one of Manafest’s hits!” the DJ announced. Emily rolled over onto her back. The familiar beat made her close her eyes and bite back tears. Her brother had been one of Manafest’s biggest fans. He’d listened to their music all of the time, so she knew all of their songs by heart. The two of them used to sing along with the songs at the top of their lungs. Emily hadn’t listened to Manafest since Adrian had left. Now the memories of all of their good times came flooding back, and Emily could barely hold back the tears.

She wanted her brother back.

Emily slid into her chair at the dining room table. The dining room was one of her favorite rooms, other than her own. She loved the wooden furniture and the paintings hanging on the wall that her mother had painted while she was in college. Her dad came in and smiled at her, plopping down into his chair.

“How was your day, sweetheart?” he asked.

“Good,” Emily replied. She traced the edge of the lacy table cloth with her finger.

Her mom swept into the dining room with a dish in her arms. “Dinner’s ready!” she announced brightly as she set the dish down on the table.

“Ooh, chicken spaghetti casserole!” Emily’s dad exclaimed, licking his lips. The family bent their heads to pray over the meal.

Adrian’s favorite, Emily thought, but she didn’t mention it out loud. It was her favorite, too. She wished that he was with them now. She made up her mind then and there: she was going to find Adrian.


Molly Schlobohm

Molly Schlobohm MSW

Sees Adults and Couples

I am excited to work with people seeking to improve their mental health, make behavioral changes, and actively create a mindset for greater fulfillment in life. I believe in the profound ability the human brain has for change and partner with my clients to help them achieve the positive growth and transformation they are working toward.

At Vanda Counseling, I provide therapy for adults and couples. I work holistically, offering both psychotherapy and lifestyle changes. My approach is often centered in parts work and cognitive behavioral therapy, but I come to the therapeutic relationship with the understanding that each individual has his or her own unique needs and strengths when addressing mental health care.

Every person has a valuable story to tell, and whether it includes extreme trauma or the challenges that come with change, it is my honor to listen and help. I look forward to partnering with you to help support your best life.

Location(s) of Practice: Golden Valley

Visit Types: In-person and Telehealth

Accepting New Clients: YES

Molly does keep a waitlist.
To be added to Molly's waitlist, please email at


Is goonier a Scrabble word?

Yes, goonier is a Scrabble word!

...and is worth 8 points in Scrabble, and 10 points in Words with Friends

Goonier is a valid Scrabble word.

Table of Contents

What Scrabble words can I make with the letters in goonier?

2 Letter Words

Words that can be created with an extra letter added to goonier:

Unscramble the letters in goonier

There are 2 words that can be made by adding another letter to 'goonier'.


Chicken and Plum Tray Bake with Smashed Potatoes

  1. Preheat oven to 200°C (or 180°C fan-forced). Line a baking tray with baking paper for the potatoes.
  2. Peel and cut the potatoes into quarters and trim the green beans. Crush the garlic.
  3. Combine hoisin and soy sauces and garlic in a large bowl. Season with black pepper. Cut chicken into 8 pieces (discarding backbone) and toss through hoisin mixture. Place chicken pieces in large baking dish in a single layer and bake for 30 minutes.
  4. Halve the plums and remove the stones. Add plums to the baking tray, cut-side up and bake for a further 15 minutes or until the chicken is cooked and plums soft. Remove from oven and set aside for 5 minutes before serving.
  5. As soon as you have put the chicken into the oven to cook, boil the potato pieces in salted boiling water for 10-12 minutes until just tender, then drain.
  6. Place potatoes on a baking tray and lightly squash with a potato masher or fork. Drizzle with remaining oil and season with salt and black pepper. Bake in oven along with the chicken for 30 minutes or until golden and crisp.
  7. Remove chicken and increase oven temperature to 220°C (or 200°C fan-forced). Cook potatoes for another 5 minutes to get them extra crisp.
  8. Lightly steam the green beans over boiling water for approximately 3-4 minutes until bright and tender. Serve alongside the chicken, plums and potatoes.

TIP: Garnish the chicken with fresh rosemary sprigs.


Review On Pit of Goblins

Drew Petriello

The jokes in this are incredibly well set-up. The running gag of the talent show had me rolling. Also, the show does a great job of constantly juxtaposing the way our psychopathic main character is with the way he perceives himself. The dissonance generates a lot of laughter.

In fact, all the characters Mitchell plays are well-realized and distinct, each having a clear purpose and arc to them. There is a one-scene wonder Alex Jonesalike who is goddamn hysterical.

Speaking of arcs - my god, I loved the emotional arc of this piece. It's very dark comedy for most of the show, but then... well, not to spoil, but by the end, things get very bleak in a way that I found delictable. Some people might not be able to balance the horrible fucked-upedness with the slightly absurd tone of the rest of the show, but it was entirely my jam.

The video aspect was hit or miss. There were a couple of video segments that contained gags, information, or moved the plot forward, but there were a few that seemed to be there to fill space, likely so Mitchell could have a break from constant talking/change outfits. It was apparent based off audience reactions that one of them was an in-joke that I didn't get. Most of the time the video worked, but a couple of times it put a halt to things just when the action was picking up.

The frame of the main character speaking with the doctor in the woods didn't quite work for me. I like the idea of him talking with someone so that he's not just spouting off to the audience, but it raised a lot more questions to me along the lines of, how are the goblins preventing the doctor from going straight to the cops?

This show was right up my dark, twisted alley. If you like your humor pitch black or are a fan of well-produced, well-performed solo shows, here is a piece for you.


The Case Against Styrofoam Cups

Why is it that chains like Timothy's as well as independent coffee shops like Shai's in Kensington Market still serve their coffee is styrofoam, er, polystyrene cups only? Haven't they noticed that Starbucks, and recently Second Cup are now only serving up java in the paper variety?

I don't ask the question just for environmental reasons. First and foremost, it's a health issue. Research shows that drinking hot beverages in styrofoam cups is bad for you. Rather than repeat the claims here, I'll refer you to various articles on the subject.

The sad thing is that most coffee shop owners probably don't know any better. The person I spoke to at Shai's fained ignorance on the matter. He claims they chose styrofoam because it makes the cups easier to hold.

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The Federal Deposit Insurance Corporation (FDIC) issued its March 2021 edition of Supervisory Highlights. This edition of the Supervisory Highlights includes a summary of the FDIC’s approach to supervision in response to the Covid-19 pandemic, a description of the most frequently cited violations, information on regulatory developments, and a summary of resources available to financial institutions.


Emerging means allow customers to opt for renewable energy to meet charging needs, aligning energy source availability and savings settings.

FREMONT, CA: Currently, the global energy system is facing enormous challenges. The transport fleet is changing to electric vehicles, where energy usage is greener in this context. Electric cars and renewable energy synergies are important today for ensuring energy security, prohibiting pollution, and promoting energy-saving and emission reduction. As per Climate Week NYC, transportation is going in the right direction by seeing to combine the profits of electric vehicles and renewable energy.

Following is an exploration of emerging renewable energy charging options presently offered.

• Network Charging

Sometimes, customers can access the station's network to charge their EVs with renewable energy. For example, energy technology developers have developed a network setting program that permits customers to source their charging electricity from solar and wind power. Customers can enroll in this network charging option in a pay-as-you-go or membership plan.

• Managed Charging

Using managed-to-charge programs, customers can manage the timing of electric vehicle charging with renewable energy availability and grid requirements while still meeting customer needs. This means customers can delay setting for up to an hour each day to better align with available renewable energy in a swap for lower charging rates.

• Charging with On-Site Renewables

Electric vehicle charging can be bonded with on-site renewable energy production by co-locating vehicles with on-site solar energy systems and batteries. This program provides customers access to charging stations, and when not in use, the energy is stored in battery systems.

Numerous cities and companies have established objectives to convert their vehicles to EVs and power them with renewable energy sources. Therefore, exploring new ways to charge EVs with renewable energy sources is crucial to maximizing emission reductions with this rising trend.


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Here is an interview I took with Hilla Ovil-Brenner, CEO of WhiteSmoke Inc.
Could you please tell us something about the origin of name "WhiteSmoke", how did it emerge?

Hilla Ovil-Brenner:
Well, as WhiteSmoke is a software aiding people to communicate in English, we looked for a concept that relates to communication. The Native American usage of smoke puffs to communicate alerts across vast distances and language groups fit just perfectly. This traditional practice reflects the way our software enables our global users to communicate clearly and effectively, overcoming any English language difficulties encountered by native speakers of different languages."
So the name Whitesmoke refers to the way people from different parts of the world exchange their thoughts with each other. Who founded the company and when?

Hilla Ovil-Brenner:
Hilla Ovil-Brenner, who was raised in South Africa, established WhiteSmoke in 2002 with husband Liran Brenner after her father complained about the poor quality of English in e-mails he received from foreign colleagues. Brenner, a computer engineer, brought with him five years experience at instant messaging pioneer ICQ. From humble beginnings in their apartment with a small investment and a lot of enthusiasm, WhiteSmoke is now a 30+ employee operation of international scope, and continues to grow monthly.

A lot of our users ask us how they can improve their writing skills. What do you think is the best method to learn how to compose effective and grammatically correct emails, memos, sales letters and other business documents?

Hilla Ovil-Brenner:
According to my experience, the best way to improve your writing skills is to practice writing as much as possible and get feedback on what you write. It's true that you can always take English language or writing courses, and even programs like Microsoft Word can be of some help with their limited text correction features. Of course, I use WhiteSmoke when writing emails and business documents, and it is great for picking up hard-to-find grammar and spelling errors, and for suggesting words when I get stuck. I also work with templates for serious business documents -- having a well-written model when sitting down to write is an excellent tip for producing more professional texts. But ultimately, there is no one “best method” -- everyone needs to find their own, but I stand behind WhiteSmoke!"

I understand that there different versions of Whitesmoke for different purposes and markets. Do you have a primary target group?

Hilla Ovil-Brenner:
WhiteSmoke has a very broad “target group” – anybody writing in English! We designed it to cater to any level of English proficiency, but we also know that writers in different professional fields have specific needs. These are usually related to word choice and register rather than grammar, which is more universal. That's why our R&D teams developed specially tailored versions for business, legal, medical, creative, and academic writing styles. Each version works with a different database and dictionary containing field-specific language, such as legal terms or business jargon. This is the source for context-specific spelling corrections and text enrichment suggestions. A general version is available for the home user, and a very popular executive package for more professional users includes all the other versions' features.

Which version of WhiteSmoke would be best for users who speak English as second language?

The choice of version depends on the needs of the individual ESL learner. Of course, ESL learners do make different kinds of mistakes to many native speakers, but these are all covered by the grammar engine, which is common to all versions. The differences mainly lie in text enrichment. So, let's say a person studies English for general use, then the general version could be enough. But if you want to focus on, for example, Business English, then your best option would be the business version, since its enrichment suggestions are totally relevant to business jargon – its algorithms are trained with business texts. This helps ESL learners with an interest in business to expand their vocabulary in the field. Likewise for the other versions – the ESL learner can use a version of WhiteSmoke closely tailored to his or her requirements.

Is it possible for a native speaker of English to distinguish between a text that has been written without Whitesmoke and one that was created with the software? I mean, how natural does a text sound that was composed with the help of Whitesmoke?

Hilla Ovil-Brenner:
Well, I think that a native speaker will not necessarily be able to distinguish whether a text was written with WhiteSmoke or not. Maybe if the reader is familiar with the writer's level of English, like with English teachers and their students, it would be possible. The less proficient a writer is in English, the less natural the text will look. When a non-native English speaker writes, there are bound to be more mistakes on many text levels. Our software corrects errors of grammar, spelling, and punctuation at the level of the sentence, and really does a great job doing that. But a text is actually a very complex structure with many layers. There are things like idiomatic language, more complex sentence structures, and paragraph organization that no software is able to improve. This is why how natural the text sounds depends on the writer's level, with or without the editing features WhiteSmoke currently offers."

On your website you mention that Whitesmoke uses patented natural language procession technology. How exactly is Whitesmoke''s NLP technology different from that other text processing software programs?

Hilla Ovil-Brenner:
Well, I am always proud to say that the beauty of WhiteSmoke is that it uses state-of-the-art technology unique only to us! Other text editing software programs are based on a pre-dictated list of grammar and spelling rules. They simply compare the user's text to these, and mark basic mistakes. But we've challenged this approach by creating smart artificial intelligence algorithms that perform both rule- and statistical-based analysis of real mistakes users actually make in real life. Any language expert knows that language can generate an infinite number of sentences with an infinite number of potential mistakes. No list can cover all the mistakes, so why not focus on what people actually write, and try to work with that? Because the algorithms are trained by scanning texts, the resulting text changes relate to how words relate to one another – the context, not just micro-level simple mistakes! This kind of outside-the-box thinking has also had some unexpected positive results, for instance, we managed to rank the most common mistakes and re-direct research efforts. We also saw that when we trained our patented algorithms on texts from different professional fields, such as business or law, we got different results for text enrichment. This made our numerous professional versions possible.

I''ve heard from some Whitesmoke users that if you launch the program from within MS Word, you can''t edit your Word document since Whitesmoke works in plain text mode only. Is that true?

Hilla Ovil-Brenner:
Yes, that's true. If a user writes a document in any word processor and then wants WhiteSmoke to work on the text, pressing F2 locks the original word processing software. This actually helps to prevent synchronization problems between the original document and the WhiteSmoke edit window, and is not related to using plain text mode. After the user saves the changes in the edit window and closes it, the original text gets automatically updated. The user can then continue writing another piece of text in the word processor and repeat the same process. This creates an organized workflow. According to our experience, a situation where users were able to edit text in two programs simultaneously would be very problematic technically, and simply confusing.

When I used the trial version of WhiteSmoke I noticed that the text enrichment feature often suggests words that don''t necessarily fit into the given context. How is a user who speaks English as a second language supposed to know which of the ''enrichment'' options they should select?

Hilla Ovil-Brenner:
Let me explain a little about how text enrichment works. Text Enrichment as WhiteSmoke implements it comprises two areas - "synonyms" and "adverbs and adjectives". Until the latest version of WhiteSmoke (released in the last month), alternative synonyms, adverbs, and adjectives were automatically offered to users based on WhiteSmoke''s analysis of the text.
The new version of WhiteSmoke has introduced "Enrichment on Demand", which runs in conjunction with the standard text enrichment suggestions. For users, this means that synonyms can be selected manually for practically every word, giving them greater control over the feature, to use or not use according to their needs. The standard automatic enrichment feature has been revamped to compliment only highly targeted words with adverbs and adjectives. Our testing found that this approach greatly improved the experience of enrichment for native and non-native speakers alike.
Of course, making a selection between a number of synonyms, adverbs and adjectives may not be an easy choice for some English as a second language speakers. However, it is important that we do offer the capability, as it is a very useful feature for our large native-speaking customer base. English as a second language speakers who are using WhiteSmoke can also keep in mind that Text Enrichment is there as an aid, but it is not correcting mistakes, like the spelling and grammar engines. In cases where a user is unsure about the relevancy of a particular enrichment suggestion, he or she can simply ignore the suggestion.

If you have any English grammar or vocabulary questions,
please post them on this English Grammar Forum.

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• Taking plastic additives out of the equation

Environmental Laboratory

Taking plastic additives out of the equation

Mar 01 2021

In January 2021, the European Chemicals Agency (ECHA) updated its candidate list of substances of very high concern (SVHCs) to people and the environment to include two additional plastic additives. But this does not constitute a ban — these substances will still be used in everyday products, eventually leaching into our soils and waterways. Here biodegradable biopolymer innovator Teysha Technologies, discusses how we can outlaw harmful additives altogether by exploring the potential of tuneable biopolycarbonates.

Since 2016, companies have been legally obliged to apply for permission from the ECHA under the Waste Framework Directive if their products contain SVHCs. The 211-chemical candidate list of SVHCs includes many plastic additives used in products such as inks and toners, cosmetics, pharmaceuticals, plastic consumables and tyres.

For example, one recently added SVHC dibutylbis pentane is commonly used in adhesives and sealants, as well as to enhance certain properties in plastics, like mouldability and strength. Other SVHC examples include viscosity regulators in cosmetics and antioxidants in polymer packaging resins, which delay oxidative degradation if exposed to ultraviolet light. In some product types, additives are necessary for product longevity. While additives are great for making plastics versatile and durable, their toxicity has yet to be fully appreciated.

Why are additives harmful?
Many plastics emit potentially toxic substances into the air, water and soil in at every stage of their lifecycle. Examples of additives from plastics recently found in soil include phthalates (plasticisers used to make PVC flexible), brominated flame retardants and BPA. These substances are present on the ECHA’s candidate list, and while some studies concluded that concentrations found in the environment were lower than the legal guidelines, often they greatly exceeded them.

Data from two 2018 studies suggest that toxic additives adversely affect reproduction in many animal models. For instance, laboratory studies saw plastic additives disrupting hormone secretion in certain species of marine biota. What’s more, studies in pigs found that egg cell maturation was compromised after exposure to toxins such as BPA. The main conclusions here are that even in low concentrations, additives used in refining plastics can still cause harm.

Unfortunately, expanding SVHC legislation does not fully solve the issue. In cases where permission has been granted by the ECHA, companies will be authorised to use toxic chemicals in their plastics if they can provide safety data sheets to their customers and consumers. These must recommend appropriate disposal measures to adequately control the risk of exposure to humans and the environment.

This is all very well, but a recommendation does not ensure that consumers comply. As a result, contaminants will continue to build up, threaten our ecosystems and affect the food chain. Eco-friendly alternatives must be sought out before it is too late.

The biopolymer revolution
“Polymer additives play a crucial role in many consumable products like cosmetics and pharmaceuticals,” explained Matthew Stone, managing director of Teysha Technologies. “Despite the overwhelming evidence of their negative impact on the environment, manufacturers are still being permitted to use them.

“To counter this, Teysha has been leading research into the development of biopolymers that don’t need refining with toxic additives,” continued Stone. “An additional benefit of these materials is that they can biodegrade naturally without the need for resource-intensive industrial catalysts. The result of our research is AggiePol®, a versatile biopolycarbonate made from natural-product monomers and various co-monomers that modify the properties of the final polymer. With our platform, harmful additives can be outlawed completely, so we can start to move away from environmentally damaging consumables.”

Though a step in the right direction, updated legislation that still enables businesses to use SVHCs in their products is not enough — we must look at stopping their use altogether. As the ECHA expands its candidate list, companies can look at swapping to biodegradable, sustainable polycarbonates as an alternative to toxic additives. Once the transition is made, companies will find the time spent applying for permission to use SVHCs can be better used for building profits — as well as creating a healthier, greener planet.

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Where To Stake NEAR Protocol: 5 Best Places In 2022

Updated: Aug 10th, 2022
Kevin Groves
Kevin Groves
Where To Stake NEAR Protocol: 5 Best Places In 2022

The anticipated growth of the NEAR Protocol alongside web3 as well as its relatively non-volatile price action of the coin has attracted many crypto investors. NEAR operates on the Proof-of-Stake (PoS) protocol which means that it can be staked on-chain wallet or on supporting cryptocurrency exchanges. In this article, we explain how to stake NEAR and the best places to stake to do so.

Best Places To Stake NEAR Protocol In 2022

Based on our reviews and comparisons, these are the best places for staking NEAR to earn passive rewards:

  1. Binance (best overall exchange for staking NEAR)
  2. KuCoin (best NEAR staking platform for traders)
  3. Huobi Global (best alternate exchange for staking)
  4. Cuvar Wallet (best NEAR wallet for staking)
  5. Sender Wallet (best wallet for ease of use)

This post contains affiliate links with our partners who may compensate us. Read our disclaimer for further information.

What is NEAR Protocol?

The NEAR Protocol was established in 2017 with the goal of solving common problems that other smart contracts-supporting blockchains failed to address, including low transaction speeds, low throughput, and poor cross-compatibility with other blockchains. NEAR is the native token of the NEAR Protocol and is primarily used for incentivizing nodes and powering transactions on the platform.

The NEAR Protocol is a Proof of stake (PoS) blockchain meant to improve scalability and reduce costs. The blockchain utilizes a unique technology called 'sharding' that essentially separates strings of data to speed up processing, with the consensus mechanism called ‘Doomslug’.

Can You Stake NEAR Protocol?

The NEAR token operates on a Proof-of-Stake consensus protocol to validate transactions. Token holders can stake their crypto to obtain rewards up to 30% APY while contributing to the security of the network. Holders of NEAR who stake their tokens and therefore validators, contribute to the governance of the network and are rewarded with staking payments. Several platforms and crypto exchanges support the staking of NEAR as a delegator. At the time of writing, Near Protocol has a staking market cap of approximately $1.5 billion with 39% of token holders staking the coin.

NEAR staking market capNEAR staking market capNEAR staking market cap. Source: stakingrewards.com

NEAR can also be staked as a validator on the network but requires considerable capital but also advanced technical expertise. Therefore, becoming a delegator on the NEAR network is a more convenient option for passive cryptocurrency investors. Validators receive NEAR tokens from delegators, helping the validator's staking pool to be chosen and start contributing to the operation of the NEAR Protocol. Token rewards are then distributed to the validator account and delegators proportionally. In this article, we’ll take a look at the best platforms to choose for staking NEAR tokens.

How Much Can You Earn Staking NEAR?

The rewards on staking are represented in percentage terms by a term called Annual Percentage Yield, APY. This APY is dynamic and a calculated projection from the rewards historically received. The rewards are decided by factors such as the method of staking and the platform used. The amount of staked tokens, along with the commission charged by the validators, also play an important role in deciding the APY.

Adjusted rewards for staking NEARAdjusted rewards for staking NEARAdjusted rewards for staking NEAR. Source: Stakingrewards.com

While the APY for staking keeps on changing, the average annualized staking benefit across most exchanges revolves around 6-8% APY for staking NEAR. This figure is an approximate average though, as Binance offers up to 23.76% of yield on its locked staking products at the time of writing and is a popular staking coin for this reason.

How to Stake NEAR?

There are various ways to stake NEAR such as becoming a validator, using an exchange, or using a wallet. Among all of these, using a trustworthy crypto exchange is the easiest and most convenient way to stake NEAR or any crypto for that matter.

Here’s a step-by-step process on how to stake the token NEAR using the staking platform, Binance:

  1. Choose a reliable exchange that supports the staking of NEAR such as Binance and create an account.
  2. Either transfer NEAR tokens from an external wallet or purchase them using a fiat currency.
  3. Go to Binance Staking and select NEAR.
  4. Choose the staking duration between 21, 30, 60, 90, and 120 days.
  5. Enter the amount of NEAR to stake.
  6. Accept the terms and conditions, and click 'Confirm'.

Where To Stake NEAR: 2022 Reviews

1. Binance - Best Overall NEAR Staking Platform

Binance is one of the most well-known and reputable crypto exchanges in the world. The robust and feature-laden platform provides over 30 million investors and traders with exceptional crypto products and services. NEAR became a staking option for Binance customers in October 2021. Currently, Binance offers Locked Staking for NEAR tokens which will remain inaccessible for the duration. Staking durations and their corresponding Annual Percentage Yields (APYs) are listed below:

  • 21 days (30.99% APY)
  • 30 days (10.79% APY)
  • 60 days (12.89% APY)
  • 90 days (24.39% APY)
  • 120 days (29.99% APY)
Binance staking yields for NEAR tokensBinance staking yields for NEAR tokens

The staking payments for locked term durations range between 10.79% APY and 30.99% APY and are fairly reasonable compared to other platforms. Users should that the on-chain staking rewards are adjusted daily. When the locked-in period ends, the users NEAR tokens will be automatically transferred into the wallet. The principal balance of the NEAR tokens can be redeemed prior to the cessation of the duration, however, the staking rewards will be deducted.

Prospective traders who want to stake their NEAR tokens should note that the minimum amount that can be staked depends on the duration of staking. With the minimum limit ranging from 0.001 to 0.1 NEAR tokens, investors with small amounts of capital can take part in earning passive rewards.

Investors located in the United States of America (USA) should note that staking NEAR tokens on Binance.US is currently not supported. As such, an alternative crypto exchange such as Huobi may be considered.

2. KuCoin - Best NEAR Staking Option For Traders

KuCoin is a highly popular crypto exchange present in more than 200 countries. The exchange grew exponentially considering it was launched in 2017. It is often referred to as the People's Exchange since it is trusted by a quarter of crypto holders worldwide.

KuCoin staking for NEAR protocolKuCoin staking for NEAR protocol

KuCoin has a soft-staking feature, where users aren’t required to lock their crypto. But the rewards there are lesser when compared to fixed-duration staking programs. These staking programs come with a redemption period - the time between users stopping staking and gaining access to their crypto. Some coins don’t have this redemption period.

Users can stake their NEAR tokens on KuCoin and earn rewards with an estimated APY of 11.84% and 7.25% on terms of 14 and 7 days, respectively. A flexible wallet is available where a lower APY of 5.17% is offered in exchange for the option of redeeming NEAR tokens at any time.

3. Huobi Global - Best Alternate Platform For Staking NEAR Tokens

Huobi Global was founded in 2013 and has become one of the largest crypto exchanges by trading volume and user base. The Hong Kong Stock Exchange listed platform provides customers around the world with easy access to over 560 digital assets, a variety of trading markets including spot, margin, and futures, and staking.

The estimated APY for staking NEAR tokens is 8.82%. If 100 NEAR tokens are delegated to staking pools then the passive rewards are approximately 0.0241 NEAR each day. The APY rewards are not as lucrative as Binance's offering. Furthermore, a minimum of 1,300 NEAR tokens are required to get started, and this is a significant amount of capital that is needed upfront.

NEAR staking with HuobiNEAR staking with Huobi

At the time of writing, NEAR tokens will be locked for a period of 4 days and cannot be redeemed by the user for other purposes such as trading or withdrawing them to an external wallet. The advantage, however, is that staking rewards is generated daily and distributed to the investor's wallet the following day. Another important aspect to consider with Huobi is that it provides a link to the validator node that most other exchanges don’t provide. This link can be inspected using Blockchain Explorer. Meaning the delegated tokens on the network will be completely transparent and lowers the risk of scams.

Comparison of Exchanges To Stake NEAR

Staking NEAR Using A Wallet

Staking NEAR tokens using a supporting wallet is a viable option for those who want to mitigate some of the potential risks associated with staking. Whilst the wallet holder retains complete ownership of the NEAR tokens, the staking process is a little more complicated than using a crypto exchange that provides the staking infrastructure. This is primarily because the user is responsible for choosing a validator to delegate the NEAR token.

Here are a few aspects to assess when deciding on a validator:

  • Self-Delegated Assets: Validators are rewarded for confirming blocks, failing to do so or any malicious behavior encountered gets the validator slashed. When a validator is slashed, they get blocked for a certain amount of time and do not receive any rewards. These rules differ from blockchain to blockchain, but the basic idea is still the same. And therefore the more invested the NEAR validator is, the better it is.
  • Commission: Validators charge the delegator pool fees for the rewards earned. This helps validators pay for the operation and maintenance costs.
  • Participants: Generally if a staking pool has more participants, it’s expected to be better and safer than the others. The only downside is that their rewards are relatively lesser than independent delegators.

Which Crypto Wallets Support NEAR Staking?

1. Cuvar Wallet

Cuvar Wallet is a popular wallet for staking NEAR tokens. The wallet app can be downloaded to iOS and Android mobile devices. Seed recovery, biometric login, and a strong password are security measures that will need to be set up.

Staking NEAR with Cuvar walletStaking NEAR with Cuvar wallet

The minimum amount of tokens staked is 0.1 NEAR. Users have the option to deposit NEAR or buy tokens using several fiat currencies including AUD, GBP, CAD, and JPY. To commence staking, users will need to browse and select a validator from the list. In doing so, users will be able to view validator transaction fees which typically range between 1% and 10%. Once a validator is set, the number of NEAR tokens can be entered and the delegation confirmed. Overall, Cuvar is a good NEAR wallet for staking.

2. Sender Wallet

Rather than downloading an app for a mobile device, the Sender wallet provides NEAR holders to stake their tokens using a Chrome extension. Once the extension is downloaded, an account can be made and funded with NEAR tokens. Similar to Cuvar, a validator will need to be selected in order to commence NEAR staking. The staking payouts for some validators are quite lucrative where they can be as high as 20% APY. Enter the amount of NEAR to stake and confirm the transaction. The NEAR wallet is ideal for beginners that can also explore the wider ecosystem of the blackchain protocol.

Sender Wallet for NEAR protocolSender Wallet for NEAR protocol

Frequently Asked Questions

Binance offers the greatest Return On Investment (ROI) with rewards for staking ranging between 10.79% and 30.99% APY. Additionally, Binance provides investors with a great deal of staking flexibility with its staking pools. Moreover, it is a highly secure and reputable crypto exchange for token holders.

Yes, staking NEAR tokens can be profitable as the highest Annual Percentage Yields (APYs) can be above 30% at the time of writing. Although, the returns are dictated by market conditions, and investors should take into account the amount of time they’re comfortable committing. Under a bear market, the overall returns on investment for NEAR token holders can be much lower.

Like most other proof of stake coins, staking does involve some amount of risk. Risk of slashing, malicious attacks and restricted liquidity are a few risks that are most prominent. Using an official NEAR wallet to stake can help mitigate these risks to some extent.

Staking is a relatively recent way to make money with crypto, and with NEAR investors can earn rewards on their crypto investment. Additionally, users also participate in enabling the growth of the ecosystem, while benefiting themselves simultaneously. Investment decisions should be made by considering all the risks & tokens rewards associated with the currency.

You might also be interested in
Kevin GrovesKevin GrovesKevin Groves

Kevin started in the cryptocurrency space in 2016 and began investing in Bitcoin before exclusively trading digital currencies on various brokers, exchanges and trading platforms. In 2019, he started HedgewithCrypto to publish informative guides about Bitcoin and share his experiences with using a variety of crypto exchanges around the world.

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Tales of Herding Gods

Tales Of Herding Gods | Chapter 734 - Seven Celestial Venerables in the Jade Pool

The old bull followed behind both of them, and huge beads of sweat kept rolling down his forehead. Qin Mu and Founding Emperor's qi activity kept changing, and even though they didn't fight in the open, they were challenging each other secretly and not giving way to each other!

'Both of them are stubborn donkeys!'

The old bull kept raising his hand to wipe off his sweat. 'I shouldn't have listened to old master about bringing Qin Mu to meet Goddess of Heavenly Yin, I should have stayed beside old master and slowly drank my tea while I enjoyed my water pipe. If Founding Emperor loses, it's not good, if Qin Mu loses, it's also not good. I can't give an answer if I go back like this! I can't possibly tell old master that I sent Qin Mu to the ancient gods' celestial heavens and Qin Mu beat Founding Emperor up...'

He didn't know who he should be helping now.

According to how close he was to both of them, he should be helping Founding Emperor.

But Qin Mu was a very good youth, and he was always very polite to him. He always called him Senior Brother Sanduo, and from his inner thoughts, he was closer to Qin Mu.

He was truly troubled.

However, he could see that both Qin Mu and Founding Emperor were geniuses. Both of their qi activities had a myriad of changes and any slight movement from their corporeal body, any slight ripple from their primordial spirit's consciousness, or any slight change in vital qi, would result in being sensed by the other party's qi and be responded to accordingly.

Every step they walked, there would be dozens of transformations, and because their horizons were too high, their transformations were aimed directly at the flaws of the opponent. As a result, when their qi clashed, they started walking crookedly.

Both of them were like drunk men as they walked forward. They became more and more wretched, but they couldn't stop as it was impossible to stop halfway.

Luckily, they were already nearing the head of the big kun. In just two to three miles and they would be able to come to Son of Heaven Yin's side.

Son of Heaven Yin looked at Goddess of Heavenly Yin's carriage, which was driving towards him, in excitement. Most of the people were also gathered on the big kun's head, and they raised their heads in wonder.

Qin Mu and Founding Emperor stumbled over, and steam was rising from both of their bodies. The steam became thicker and thicker as both of them walked forward involuntarily.

Son of Heaven Yin suddenly seemed to sense something and hurriedly turned back to look. He saw Qin Mu and Founding Emperor walking over, and he instantly sensed two different qis clashing. These two qis were from Qin Mu and Founding Emperor.

'Why have both of them started fighting? It's a good thing that both of them are fighting, I can make friends on both sides and make them shed tears of gratitude.'

Son of Heaven Yin was astonished, and he felt delighted in finding his prey. 'The fighting methods of these two people are very strange, it's still my first time seeing such fighting methods. Why don't I separate both of them and let them be grateful to me!'

His qi burst forth and sliced between both of them. He said with a smile, "Brother Qin, Brother Mu, let me be a media..."

Just as his qi sliced between them, Qin Mu and Founding Emperor's qis, which were like a flood, suddenly found a drain and poured towards him!

Before Son of Heaven Yin could finish his words, he got pressured by the two qis, and his mind turned blank. He couldn't have any thoughts!

He could only feel the heaven and earth splitting in an instant and crumbling. He fell from an incomparably high height and below him was darkness, boundless darkness.

He struggled helplessly and could only continue to fall. Slowly, he saw two faces against each other in the darkness and those were the faces of 'Mu Qing' and 'Qin Kai' with one on the left and one on the right.

These two faces were incomparably huge, and he was located between both of them. He was incomparably small and was currently falling into the endless darkness.

Right at this moment, Qin Mu's voice rang out, "Brother Yin, Brother Yin!"

The hallucinations in front of Son of Heaven Yin's eyes vanished, and Qin Mu's kind face gradually appeared in front of him. Qin Mu was currently holding onto his left arm while Founding Emperor was holding onto his right arm to prevent him from falling.

Son of Heaven Yin's body was filled with sweat as though he was just fished out of the water.

"Is Brother Yin's body uncomfortable?" Qin Mu asked in concern.

"I'm skilled in the art of healing, I can help treat Brother Yin. As the saying goes, a healer treats their patients like their parents would..."

Founding Emperor said with a smile, "Brother Yin was caught between us, so he's just in shock, he's not ill. Medicine is also thirty percent poison, if he eats your medicine, he will be ill even if he wasn't. Brother Mu..."

"Don't call me Brother Mu!"

Veins popped on his forehead, and he resisted the urge in his heart. Founding Emperor was his old ancestor, so how could he call him brother?

Founding Emperor understood and said coldly, "I originally wanted to bury the hatchet with you yet you don't appreciate it, do you really think I'm afraid of you? Your abilities are indeed very high, but they might not be higher than mine!"

Qin Mu sneered and said, "My abilities might not be higher than yours, but my Dao heart is. I won't be as useless as you."

Son of Heaven Yin felt his head aching, and he hurriedly said, "Goddess of Heavenly Yin's carriage is here, stop quarreling, can't both of you just talk things out?"

Dragon roars came ringing out, and he saw huge dragons pulling along an incomparably gorgeous carriage over, and every dragon was much larger than the big kun under their feet. They rode the wind and clouds to fly past their heads.

Those dragons were clad with green-colored armor, and they were treasures forged using Metal of Heavenly Yin; as a result, precious light shone intensely from their bodies. The carriage was also mainly forged using Metal of Heavenly Yin and decorated with clouds. Under the canopy hung beads and every bead was bright. They were refined using planets and were refined to a perimeter of over thirty yards.

The clouds floated among the hanging beads, and the clouds and beads blocked everyone's vision. They could only faintly see a goddess sitting under the canopy.

Son of Heaven Yin stared with his eyes wide open and was in a daze. Only after the huge dragons pulled the carriage to the center of the celestial heavens, did he mutter, "When can I be so awe-inspiring as well?"

Everyone in the surroundings laughed.

Even that big kun under his feet burst out into loud laughter.

Son of Heaven Yin's face flushed and he stuttered, "D-don't laugh at me, I will definitely be so awe-inspiring and impressive in the future! When the future comes, hehe, all of you will have to bow at my feet..."

Everyone's laughter became even louder.

Son of Heaven Yin turned even redder and was about to argue more when Founding Emperor said, "Brother Yin, there are countless people under the world, but those that can do big things and leave their names down in history are only three to five people. They don't have this ambition so they will only laugh at others with ambition, don't take it to heart."

Son of Heaven Yin was very grateful and said, "The bramblings don't know the ambitions of swans, I won't stoop down to their level."

Qin Mu took a glance at Founding Emperor and thought to himself, 'Is he explaining his ambition or is he thinking for these people so Son of Heaven Yin won't take revenge on them in the future? Maybe it's both. Now that I've returned to the past, could I kill Son of Heaven Yin and change the future?'

There was a slight hesitation in his heart.

The big kun ferried them to fly past the palaces, and they then met several impressive and extraordinary carriages of ancient gods passing by, which raised wave after wave of envy.

Finally, they reached the Jade Pool of the celestial heavens.

The celestial heavens were simply too vast, and even with the big kun's flying speed, he still had to fly for a long time before coming to the Jade Pool.

The big kun slowly stopped and docked at the side of the white jade platform beside the Jade Pool. Everyone stopped, and Son of Heaven Yin helped Qin Mu pay the fare by giving the big kun some more Jade Dragon Pills. The big kun then flew towards the celestial river in the sky and plopped into the river before swimming away.

Even though the Jade Pool had the word pool, to Qin Mu and the rest, it was like an ocean in the celestial heavens. The clouds here were fleeting, and there were countless immortal mountains on the ocean. There were also huge sea turtles carrying sacred mountains and roaming in the Jade Pool.

There were also unbelievably huge lotus flowers in the ocean that took up several hundred fields of land. Some of the flowers had bloomed, and the white and red petals were very alluring. Some were still flower buds that were slender and elegant. They were in green, in white, and in pink, which made them look very beautiful.

Numerous divine arts practitioners were playing near the Jade Pool, and these divine arts practitioners were all people from the lower bound. There were also some that were half-gods that Son of Heaven Yin had mentioned. They didn't morph into humans and appeared with their divine beast forms.

To the people of the future generations, these half-gods were divine beasts, and to the people now, they were half-gods that possessed supreme bloodlines and had high positions. When divine arts practitioners met them, they would have to be respectful.

Beside the Jade Pool, numerous people called the huge turtles over and paid some spirit pills to board the sacred mountains on the turtle. The turtle carried the sacred mountains to swim into the depths of the Jade Pool.

And those lotus flowers on the ocean actually had small countries. Many people went over there to play.

"To ancient gods, this is the Jade Pool, to us, this is the Jade Sea."

Son of Heaven Yin said, "During this Celestial Heavens Meeting, many people have come up to play from the lower bounds and see the world, these were all ordinary people. However, Celestial Venerable Yu and the rest of the Dao friends are different. They have lofty ambitions, and they took this chance to invite all of the talents from the lower bounds by hosting this Jade Pool Meeting. Even though we are inferior to the ancient gods, we still have to carve out our names!"

His eyes were sparkling, and Qin Mu saw it in his eyes. His heart stirred slightly. 'Son of Heaven Yin was also a youth with ambition back then. But this was right, his attainments in the future generation were extremely high, he was one of the rare strong practitioners on Emperor's Throne, so he naturally has his own abilities.'

Son of Heaven Yin called a huge turtle over and said, "We are here on Celestial Venerable Yu's invitation to attend the Jade Pool Meeting."

That old turtle said, "Celestial Venerable Yu instructed not to take spirit pills from those coming to the Jade Pool Meeting. Please come onboard."

Qin Mu was astonished and asked, "Is Celestial Venerable Yu's position in the celestial heavens very high?"

Son of Heaven Yin said with a smile, "Celestial Venerable Yu is the leader of us, the lowly races, so his position is naturally extremely high. Even the ancient gods refer to him as Dao friend and feel that he is the person who can develop the paths, skills, and divine arts."

They got up on the sacred mountain which was on the back of the turtle, and the old turtle immediately swam towards the depths of the Jade Pool. The scenery around them was indescribably pleasant.

"Celestial Venerable Yu is the first person to open the Spirit Embryo Divine Treasure, the cultivation of divine treasures originates from him. After he opened the divine treasures, heaven and earth changed and astonished the world. At that time, numerous ancient gods projected themselves down and surrounded him with praises, praising him for being the founder of an important era."

Son of Heaven Yin said, "Heaven Duke called him Celestial Venerable Yu, Earth Count granted him life, making him immortal and undying. However, there are still people who could be on par with him. Celestial Venerable Hao has opened up the Five Elements Divine Treasure. His surname isn't Hao, and instead, his name has the word Hao, thus the ancient gods conferred him as Celestial Venerable Hao. There's also Celestial Venerable Ling who has opened up the Six Directions Divine Treasure, Celestial Venerable Yue who has opened up the Seven Stars Divine Treasure, Celestial Venerable Huo who has opened up the Celestial Being Divine Treasure, Celestial Venerable You who has opened up the Life and Death Realm, and Celestial Venerable Yun who has opened up the Divine Bridge Divine Treasure. They are known as the Seven Celestial Venerables, and after they succeeded, the Great Dao of Heaven and Earth changed, and Celestial Emperor permitted their titles."

Qin Mu muttered and said, "Truly an era that fascinates people, these people truly deserve to be called Celestial Venerables for being able to establish the cultivation system of divine treasures. No matter how much the future generations create, it will be hard to surpass them..."

Founding Emperor had the same sentiments and said, "To be able to see the Seven Celestial Venerables, this trip is not for naught."

Both of them crossed gaze, and they suddenly snorted to turn their heads away.

The old bull was stuck between them and instantly felt the pressure multiplying. He groaned to himself. 'Both fellows are stubborn donkeys, I hope both of you don't create any more trouble and put me in a dilemma...'

In front, a cluster of palaces shone brilliantly and looked very grand. The old tortoise carrying the sacred mountain came to the front of the palaces and said, "We have arrived at the Jade Pool Secret Territory."

Son of Heaven Yin hastened his footsteps and said loudly, "Celestial Venerable Yu, Little Brother Yin Chaojin is here to attend the meeting!"

Qin Mu and Founding Emperor also walked forward. The old bull braced himself and walked between both of them to prevent them from creating any nuisance. He thought to himself, 'As long as they don't beat each other up, that would be my merit!"

The palaces were bustling with activity as numerous people walked to and fro; they must be divine arts practitioners from all worlds that had come to attend the meeting.

Qin Mu's mind trembled. 'Exactly how many world-shaking big figures will be born from these people here?'

Suddenly, he was slightly stunned. He saw a monk, and beside him was a Daoist.

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Rolling Korea

Rolling Korea Language School was founded in 2012 to teach Korean to foreigners. Since then, we have developed unique educational content and activities to provide the best experience for our students. Our program ensures an equal focus on learning Korean and experiencing Korean culture so that our students can make the most of their time in Korea.

Compared to other Korean language schools, our curriculum weighs heavily on the practical Korean learning experience. Learning a language from a textbook is not enough. We believe the fastest way to master a language is to get much practice with proper feedback. Afternoon social programs and activities will offer you the perfect opportunities to learn Korean in a friendly environment.

Our main goal is to make your Korean fluent. With our comfortable facility, friendly staff, and professional instructors, we here at Rolling Korea Korean Language School guarantee you a successful learning experience.

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 UAE Business Awards 2020

UAE Business Awards 2020

36 MEA MARKETS / 2020 UAE Business Awards , Best Global Citizenship & Residency Advisory Firm 2020 RIF Trust For high-net-worth individuals, the ability to travel visa-free around the world is incredibly valuable. For those with a “weaker passport”, obtaining a second passport or EU residency is a life changing decision. RIF Trust is the leading government-approved citizenship and residency by investment advisory in theMiddle East and Africa, specialising in breaking down borders for their clients. We profile the firm to find out more. With 12 offices globally and its headquarters based in Dubai, RIF Trust aspires to improve the lives of their clients. RIF Trust have successfully assisted high-net- worth individuals (HNWI) and their families with obtaining a second passport in the Caribbean or European residency in order to gain visa-free travel around the world, access the top schools and universities abroad for their children, and the ability to expand their businesses in Europe. What sets RIF Trust apart is that they put their client at the centre of their business. When they first meet with a client, their advisors listen to their needs, goals, and motivations to better understand the client’s individual profile and then proceed to advise their client on their best residency or citizenship options based on their personal preferences, requirements and limitations. Comprehensive due diligence screening ensures that clients have the best chance of a successful application, saving them both time and money. The investment migration industry has become increasingly competitive, with many unlicensed, inexperienced and small operators, entering the industry each month. However, clients are also becoming a lot more selective with who they work with and can identify the legitimate and experienced advisories, like RIF Trust, from the smaller advisory in the industry. The rapid spread of COVID-19 might seem like a major problem for a business committed to helping people travel internationally, but when the virus passes, RIF Trust will become an essential business for a large number of HNWI to ensure the continued security and mobility of their family in case of another life changing event. There will also be a great opportunity for RIF Trust to grow through consolidation and merging with both small and large organisations who will see the benefits of collaborating with RIF Trust to improve their service level, stability and financial position. In the long term, RIF Trust’s government advisory team will be working hard to assist governments to secure more foreign direct investment through new investment migration programmes to offset the financial impact through the loss of tourism and increased debt they have incurred during this global shutdown. RIF Trust offers a unique service that has helped over 1,000 clients and their families. Despite uncertain times, its current success seems unabated and set to continue for a long time to come. Company: RIF Trust Contact: [email protected] Website: www.riftrust.com

http://www.mea-markets.com/ http://www.rainternationalservices.com/ http://www.riftrust.com/ http://www.stu.ae/


1. Signaling Pathways
  2. Neuronal Signaling
    Protein Tyrosine Kinase/RTK
  3. Trk Receptor

Trk Receptor

Trk receptors are a family of three receptor tyrosine kinases (TrkA, TrkB, and TrkC), each of which can be activated by one or more of four neurotrophins-nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophins 3 and 4 (NT3 and NT4).

TrkA, TrkB, and TrkC are transmembrane proteins that comprise the TRK receptor family. These receptor tyrosine kinases are expressed in human neuronal tissue, and play an essential role in both the physiology of development and function of the nervous system through activation by neurotrophins (NTs). The latter are specific ligands known as NGF for TrkA, BDGF, and NT-4/5 for TrkB and NT3 for TrkC, respectively.

The binding of the ligand to the receptor triggers the oligomerisation of the receptors and phosphorylation of specific tyrosine residues in the intracytoplasmic kinase domain. This event results into the activation of signal transduction pathways leading to proliferation, differentiation and survival in normal and neoplastic neuronal cells.

Trk Receptor Related Products (67):

Cat. No. Product Name Effect Purity
  • HY-12678
    Inhibitor 99.26%
    Entrectinib (NMS-E628) is a potent, orally available, and CNS-active pan-Trk, ROS1, and ALK inhibitor. Entrectinib inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Antitumor activity.
  • HY-12866
    Inhibitor 99.92%
    Larotrectinib (LOXO-101) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
  • HY-12497
    Antagonist 99.91%
    ANA-12 is a potent and selective TrkB antagonist with IC50s of 45.6 nM and 41.1 μM for the high and low affinity sites, respectively.
  • HY-N6732
    Inhibitor 99.45%
    K-252a, a staurosporine analog, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.
  • HY-W013372
    Agonist 99.90%
    7,8-Dihydroxyflavone is a potent and selective TrkB agonist that mimics the physiological actions of Brain-derived neurotrophic factor (BDNF). Displays therapeutic efficacy toward various neurological diseases.
  • HY-145587
    Paltimatrectinib (compound I-147) is a potent tyrosine kinase inhibitor with an IC50 of <10 nM for tropomyosin kinases A (TrkA). Paltimatrectinib has the potential for cancer and inflammatory diseases.
  • HY-146749
    FLT3/TrKA-IN-1 is a potent FLT3/TrKA dual kinase inhibitor with the IC50s of 43.8 nM, 97.2 nM, 92.5 nM and 23.6 nM for FLT3, FLT3-ITD, FLT3-TKD and TrKA, respectively. FLT3/TrKA-IN-1 induces cell cycle arrest at the G0/G1 phase as well as apoptosis and shows antiproliferative activity in vitro. FLT3/TrKA-IN-1 has the potential for the research of Acute myeloid leukemia (AML).
  • HY-146523
    TRK-IN-17 is a potent inhibitor of TRK. Tropomyosin-related kinases (Trks) are a family of receptor tyrosine kinases activated by neurotrophins, a group of soluble growth factors including Nerve Growth Factor (NGF), Brain-Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5). TRK-IN-17 has the potential for the research of cancer diseases (extracted from patent WO2021148807A1, compound 3).
  • HY-16961
    Inhibitor 99.59%
    Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment.
  • HY-103022
    Inhibitor 99.81%
    Repotrectinib (TPX-0005) is a potent ROS1 (IC50=0.07 nM) and TRK (IC50=0.83/0.05/0.1 nM for TRKA/B/C) inhibitor. Repotrectinib potently inhibits WT ALK (IC50=1.01 nM). Repotrectinib has anti-cancer activity.
  • HY-18314
    GW 441756
    Inhibitor 98.65%
    GW 441756 is a potent and specific nerve growth factor (NGF) receptor tyrosine kinases A (TrkA) inhibitor (IC50=2 nM), which eliminates the BmK NSPK-induced neurite outgrowth.
  • HY-B0527A
    Amitriptyline hydrochloride
    Agonist 99.56%
    Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.
  • HY-101977
    Inhibitor 99.90%
    Selitrectinib (LOXO-195) is a next-generation TRK kinase inhibitor, with IC50s of 0.6 nM and <2.5 nM for TRKA and TRKC, respectively.
  • HY-13491
    Inhibitor 99.45%
    GNF-5837 is a potent, selective, and orally bioavailable pan-tropomyosin receptor kinase (TRK) inhibitor which display antiproliferative effects in cellular Ba/F3 assays ( IC50 values of 7 nM, 9 nM and 11 nM for cells containing the fusion proteins Tel-TrkC, Tel-TrkB and Tel-TrkA, respectively) .
  • HY-50867
    Inhibitor 99.92%
    Lestaurtinib (CEP-701;KT-5555) is an ATP-competitive multi-kinase inhibitor with potent activity against the Trk family of receptor tyrosine kinases. Lestaurtinib inhibits JAK2, FLT3 and TrkA with IC50s of 0.9, 3 and less than 25 nM, respectively.
  • HY-104047
    Activator 99.72%
    LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo.
  • HY-12866A
    Larotrectinib sulfate
    Inhibitor 99.57%
    Larotrectinib sulfate (LOXO-101 sulfate; ARRY-470 sulfate) is an ATP-competitive oral, selective inhibitor of the tropomyosin-related kinase (TRK) family receptors, with low nanomolar 50% inhibitory concentrations against all three isoforms (TRKA, B, and C).
  • HY-114358
    Inhibitor 99.38%
    ONO-7475 is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. ONO-7475 sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. ONO-7475 combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).
  • HY-15590
    Inhibitor 98.57%
    AZ-23 is an ATP-competitive and orally bioavailable Trk kinase A/B/C inhibitor with IC50s of 2 nM (TrkA), 8 nM (TrkB), 24 nM (FGFR1), 52 nM (Flt3), 55 nM (Ret), 84 nM (MuSk), 99 nM (Lck), respectively.
  • HY-17622
    Agonist 99.62%
    Tavilermide is a selective, partial agonist of TrkA, or a nerve growth factor (NGF) mimetic.
Isoform Specific Products

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