In December 1492, his principal vessel, Santa María, struck ground off the north coast of the island of Española, known today as the island of Hispaniola, shared by Haiti and Dominican Republic.
Tema lipulaev „Santa María ” randus 1492. aasta detsembris Española, hiljem paiguti Hispaniola nime all tuntud ning Haiti ja Dominikaani Vabariigi halduses oleva saare põhjarannikul.