However, an incident in 1555 caused Plantin to change his career. While on the way to deliver a leather case ordered for the ruler of the Low Countries, King Philip II of Spain, Plantin was attacked on a street in Antwerp.
Aastal 1555 oli aga Plantin sunnitud ametit vahetama, kuna teel Madalmaade valitseja, Hispaania kuninga Felipe II juurde, et toimetada talle kätte tellitud nahkkarp, juhtus Plantiniga õnnetus.