The city reached particular prominence during the reign of the last Macedonian dynasty, the Antigonids (306 - 168 B.C.E.), who were eventually overthrown by Rome.
Eriti mõjukaks sai linn Makedoonia viimase dünastia Antigoniidide ajal (306 – 168 e.m.a), kelle tõukasid lõpuks troonilt roomlased.