In any case, after a difference between Barnabas and Paul over John Mark, Paul chose Silas, who was in Antioch at that time, for a new journey aimed initially at revisiting cities where Paul had preached during his first missionary tour. ​ — Acts 15: 36 - 41.
Igal juhul pärast Barnabase ja Pauluse vahelist erimeelsust Johannes Markuse pärast valis Paulus enda reisikaaslaseks Siilase, kes oli sel ajal Antiookias. Uue reisi algseks eesmärgiks oli külastada uuesti linnu, kus Paulus oli kuulutanud oma esimese misjonireisi ajal.