According to researchers, the suspected causes include viruses, protein deficiencies, genetic defects (especially in familial ALS), heavy metals, neurotoxins (especially in Guamanian ALS), immune - system abnormalities, and enzyme abnormalities.
Sipas studiuesve, shkaqet që dyshohen janë: viruset, mungesa e proteinave, defektet gjenetike (sidomos te ALS - ja familjare), metalet e rënda, neurotoksinat (sidomos te ALS - ja guameze), defektet e sistemit imunitar dhe të enzimave.