user
Instruction
This is a table fact verification task. The goal of this task is to distinguish whether the given statement is entailed or refuted by the given table.


Table
Table Title: porphyrin
Table Content:
| enzyme | location | substrate | product | chromosome | ec | omim | porphyria |
| --- | --- | --- | --- | --- | --- | --- | --- |
| ala synthase | mitochondrion | glycine , succinyl coa | δ - aminolevulinic acid | 3p21.1 | 2.3.1.37 | 125290 | none |
| ala dehydratase | cytosol | δ - aminolevulinic acid | porphobilinogen | 9q34 | 4.2.1.24 | 125270 | ala - dehydratase deficiency |
| pbg deaminase | cytosol | porphobilinogen | hydroxymethyl bilane | 11q23.3 | 2.5.1.61 | 176000 | acute intermittent porphyria |
| uroporphyrinogen iii synthase | cytosol | hydroxymethyl bilane | uroporphyrinogen iii | 10q25.2 - q26.3 | 4.2.1.75 | 606938 | congenital erythropoietic porphyria |
| uroporphyrinogen iii decarboxylase | cytosol | uroporphyrinogen iii | coproporphyrinogen iii | 1p34 | 4.1.1.37 | 176100 | porphyria cutanea tarda |
| coproporphyrinogen iii oxidase | mitochondrion | coproporphyrinogen iii | protoporphyrinogen ix | 3q12 | 1.3.3.3 | 121300 | coproporphyria |
| protoporphyrinogen oxidase | mitochondrion | protoporphyrinogen ix | protoporphyrin ix | 1q22 | 1.3.3.4 | 600923 | variegate porphyria |


Statement
substrate coproporphyrinogen iii be locate in the mitochondrion


Answer Format
The final answer should be either "entailed" or "refuted" and use the following format:
```json
{
    "answer": "entailed" or "refuted"
}
```
rule
["entailed"]