Figure 5. Hypothesized ACLy-AKT pathway crosstalk in SN38-resistant colorectal cancer cells, with a negative feedback loop between ACLy and AKT. SN38 activates AKT and ACLy in chemo-naïve cells. A negative feedback loop between ACLy and AKT is established in cells with acquired SN38 resistance. Question marks indicate mechanisms to be determined.
Figure 5. Hypothesized ACLy-AKT pathway crosstalk in SN38-resistant colorectal cancer cells, with a negative feedback loop between ACLy and AKT. SN38 activates AKT and ACLy in chemo-naïve cells. A negative feedback loop between ACLy and AKT is established in cells with acquired SN38 resistance. Question marks indicate mechanisms to be determined.