Amsterdam fans out south from the Amsterdam Centraal station and Damrak, the main street off the station. The oldest area of the town is known as De Wallen (English: "The Quays"). It lies to the east of Damrak and contains the city's famous red-light district. To the south of De Wallen is the old Jewish quarter of Waterlooplein.

The medieval and colonial age canals of Amsterdam, known as grachten, embraces the heart of the city where homes have interesting gables. Beyond the Grachtengordel are the former working-class areas of Jordaan and de Pijp. The Museumplein with the city's major museums, the Vondelpark, a 19th-century park named after the Dutch writer Joost van den Vondel, as well as the Plantage neighbourhood, with the zoo, are also located outside the Grachtengordel.

Several parts of the city and the surrounding urban area are polders. This can be recognised by the suffix -meer which means lake, as in Aalsmeer, Bijlmermeer, Haarlemmermeer and Watergraafsmeer.