<p>The paper <a href="https://www.nature.com/articles/s41467-018-03424-4#Sec19" rel="nofollow noreferrer">A comprehensive evaluation of module detection methods for gene expression data</a> says that: &quot;We first want to provide an overview of the characteristics and performance of current module detection methods to guide the biologist in their choice&quot;.</p>
<p>My problem is that I have no gold standards for my gene dataset and I would like to know if I can use the paper results to choose a module detection method without the need of external validation measures and how can I justificate this generalization? I am not finding the justificative about how can I use this guiding.</p>

CC BY-SA 4.0
2022-04-25T02:15:00.763Z
Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.
Community
CC BY-SA 4.0
2022-04-26T04:26:44.330Z
How does your dataset compare to the dataset in the paper? Without that information we can't answer the question (as noted also in your previously posted SE bio question).
Maximilian Press
<gene-expression><clustering>
Can I use a benchmark to choose a clustering or module detection method for a gene dataset?
# Can I use a benchmark to choose a clustering or module detection method for a gene dataset?

(Asked by: username_0 on 2022-04-24)

The paper [A comprehensive evaluation of module detection methods for gene expression data](https://www.nature.com/articles/s41467-018-03424-4#Sec19) says that: "We first want to provide an overview of the characteristics and performance of current module detection methods to guide the biologist in their choice".

My problem is that I have no gold standards for my gene dataset and I would like to know if I can use the paper results to choose a module detection method without the need of external validation measures and how can I justificate this generalization? I am not finding the justificative about how can I use this guiding.

**Tags:** gene-expression, clustering
> **Comments:**
> **username_1**: Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.  
> **username_2**: How does your dataset compare to the dataset in the paper? Without that information we can't answer the question (as noted also in your previously posted SE bio question).  

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## 0 answers

