<p>You want <a href="https://en.wikipedia.org/wiki/FASTA_format" rel="nofollow noreferrer">FASTA</a> files from <a href="ftp://ftp.ensembl.org/pub/release-101/fasta/homo_sapiens/dna/" rel="nofollow noreferrer">here</a>.</p>
<p>If you want the entirety of the genome, get the dna-toplevel file. Files with rm and sm have repeat sequences masked, the former by replacing the repeats with Ns (hard mask) the latter by designating repeats as lower case letters (soft masked).</p>
<p>See the <a href="ftp://ftp.ensembl.org/pub/release-101/fasta/homo_sapiens/dna/README" rel="nofollow noreferrer">README</a> for more info.</p>

CC BY-SA 4.0
2020-11-05T20:47:16.283Z
2020-11-05T20:47:16.283Z
Bastian Schiffthaler
<p>I'm currently working on testing some matching algorithms for strings. I would like to do some tests on raw genomic data as I expect different results from random strings given the lower entropy. How can I get a whole human genome sequence? (just the raw basis)</p>
<p>I have tried websites like <a href="https://www.ncbi.nlm.nih.gov/" rel="nofollow noreferrer">https://www.ncbi.nlm.nih.gov/</a> it seems very confusing and full of unnecessary information given that I just want to have the raw basis without annotations.</p>

CC BY-SA 4.0
2020-11-05T22:50:23.050Z
Its potentially an interesting project. I'm aware of comparable projects, but ... your question and investigation is ill-defined. Simply if you download 'fasta' format for any given sequence you will get the description on one line beginning with '>' and the sequence on the line below. Genbank is a good place to go
M__
CC BY-SA 4.0
2020-11-06T14:58:23.380Z
@Michael I'd be happy to have references to the comparable projects, thanks!
gcorso
CC BY-SA 4.0
2020-11-08T13:27:41.000Z
Just a small comment, "raw" usually in genomics means unprocessed sequencing reads: https://en.wikipedia.org/wiki/Read_(biology), the sequence you seem to be after is "genome assembly".
Kamil S Jaron
<fasta><genome><phylogenetics><human-genome>
Get raw genome sequence
# Get raw genome sequence

(Asked by: username_0 on 2020-11-05)

I'm currently working on testing some matching algorithms for strings. I would like to do some tests on raw genomic data as I expect different results from random strings given the lower entropy. How can I get a whole human genome sequence? (just the raw basis)

I have tried websites like <https://www.ncbi.nlm.nih.gov/> it seems very confusing and full of unnecessary information given that I just want to have the raw basis without annotations.

**Tags:** fasta, genome, phylogenetics, human-genome
> **Comments:**
> **username_1**: Its potentially an interesting project. I'm aware of comparable projects, but ... your question and investigation is ill-defined. Simply if you download 'fasta' format for any given sequence you will get the description on one line beginning with '>' and the sequence on the line below. Genbank is a good place to go  
> **username_0**: @Michael I'd be happy to have references to the comparable projects, thanks!  
> **username_2**: Just a small comment, "raw" usually in genomics means unprocessed sequencing reads: https://en.wikipedia.org/wiki/Read_(biology), the sequence you seem to be after is "genome assembly".  

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## 1 answers

### Answer by username_3 on 2020-11-05. Score: 3 | Accepted answer

You want [FASTA](https://en.wikipedia.org/wiki/FASTA_format) files from [here](ftp://ftp.ensembl.org/pub/release-101/fasta/homo_sapiens/dna/).

If you want the entirety of the genome, get the dna-toplevel file. Files with rm and sm have repeat sequences masked, the former by replacing the repeats with Ns (hard mask) the latter by designating repeats as lower case letters (soft masked).

See the [README](ftp://ftp.ensembl.org/pub/release-101/fasta/homo_sapiens/dna/README) for more info.


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