<p>My group is interested in genetically engineering mice with label for the Slc45a2 gene, since &quot;the protein is expressed in a high percentage of melanoma cell lines&quot;. (from Refseq)
How can I choose with high confidence the best isoform to use, i.e., the one that is most upregulated in melanoma cell lines?</p>
<p>Is there a curated database/ web-source of any kind that I can look it up?</p>

CC BY-SA 4.0
2022-11-16T15:11:50.487Z
Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.
Community
CC BY-SA 4.0
2022-11-16T16:18:41.710Z
MelGene database, https://pubmed.ncbi.nlm.nih.gov/25407435/
and then more recent studies, e.g.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927184/ . Just to note cancer isn't my thing, I just did a pubmed search.
M__
CC BY-SA 4.0
2022-11-17T09:32:40.287Z
Many Thanks. turns out this MelGene database no longer exists. at least I couldn't find any trace of it =\
Tom Gome
<isoform>
Good source for specific Isoforms overexpression in tumor cells (specifically, melanoma)
# Good source for specific Isoforms overexpression in tumor cells (specifically, melanoma)

(Asked by: username_0 on 2022-11-16)

My group is interested in genetically engineering mice with label for the Slc45a2 gene, since "the protein is expressed in a high percentage of melanoma cell lines". (from Refseq)
How can I choose with high confidence the best isoform to use, i.e., the one that is most upregulated in melanoma cell lines?

Is there a curated database/ web-source of any kind that I can look it up?

**Tags:** isoform
> **Comments:**
> **username_1**: Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking.  
> **username_2**: MelGene database, https://pubmed.ncbi.nlm.nih.gov/25407435/ and then more recent studies, e.g. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7927184/ . Just to note cancer isn't my thing, I just did a pubmed search.  
> **username_0**: Many Thanks. turns out this MelGene database no longer exists. at least I couldn't find any trace of it =\  

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## 0 answers

