<p>I know there are existing GO slims predefined. But does anyone know how I can create my own collection of GO terms for enrichment analysis?</p>

CC BY-SA 3.0
2017-11-29T08:04:35.220Z
I have never created one, but a GO slims is just a list of GO associated with genes, so you just need to download the list of GO and associate them with your list of genes.  What have you tried/searched? What do you need that it is not covered in the [FAQ](http://www.geneontology.org/faq/how-do-i-create-user-defined-go-slim)?
llrs
CC BY-SA 3.0
2017-11-29T08:33:57.227Z
GO slims are just a subset of the gene ontology graph. Just a group of terms, no genes. We can't help you create one if you don't explain what terms you want and what sort of analysis you want to do.
terdon
CC BY-SA 3.0
2017-12-03T08:34:01.037Z
I have a list of genes enriched in kidney. So I want to get a list of kidney-related terms and see which of them are significantly enriched.
Code42
CC BY-SA 3.0
2017-12-05T09:17:37.193Z
@Dr_Hope Then what you really want is to test an enrichment in GO related to kidney  not create a GO slim. But if you only use a subset of genes and a subset of GOs the test would be biased (AFAIk) if you don't tell the suitable background population of genes and GO terms.
llrs
CC BY-SA 3.0
2017-12-12T17:27:58.047Z
I've already done a canonical GO to check the background. The enriched terms are mostly kidney-related because our sample is a kidney. That's why I need a GO slim to check kidney-only terms.
Code42
<gene><gene-ontology><ontology>
How can I create my own GO slim?
# How can I create my own GO slim?

(Asked by: username_0 on 2017-11-29)

I know there are existing GO slims predefined. But does anyone know how I can create my own collection of GO terms for enrichment analysis?

**Tags:** gene, gene-ontology, ontology
> **Comments:**
> **username_1**: I have never created one, but a GO slims is just a list of GO associated with genes, so you just need to download the list of GO and associate them with your list of genes.  What have you tried/searched? What do you need that it is not covered in the [FAQ](http://www.geneontology.org/faq/how-do-i-create-user-defined-go-slim)?  
> **username_2**: GO slims are just a subset of the gene ontology graph. Just a group of terms, no genes. We can't help you create one if you don't explain what terms you want and what sort of analysis you want to do.  
> **username_0**: I have a list of genes enriched in kidney. So I want to get a list of kidney-related terms and see which of them are significantly enriched.  
> **username_1**: @Dr_Hope Then what you really want is to test an enrichment in GO related to kidney  not create a GO slim. But if you only use a subset of genes and a subset of GOs the test would be biased (AFAIk) if you don't tell the suitable background population of genes and GO terms.  
> **username_0**: I've already done a canonical GO to check the background. The enriched terms are mostly kidney-related because our sample is a kidney. That's why I need a GO slim to check kidney-only terms.  

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## 0 answers

