<p><em>Answer from @devon-ryan, converted from comments:</em></p>
<p>The common presumption in such cases is that there's a feedback loop on most genes to control their expression level. It doesn't have to be specific to arm-level expression.</p>

CC BY-SA 4.0
2021-07-14T11:56:24.953Z
2021-07-14T11:56:24.953Z
gringer
<p>It is almost common sense that local amplification of gene increase the its mRNA expression . I recently heard that large scale SCNA (such as arm-level amplification) does not increase the mRNA expression level of gene within the region. I did some analysis (SCNA is determined by SNP array and NGS, mRNA expression is measured by RNA-Seq) and found that this is indeed the case. I further did some research and did not found any explanations. it seems like a common acknowledgement. Is there any technical bias or biological explanation that I am missing here? Or is it something that has not have a answer yet?</p>
<p>I have no clue about this at all. Can you recommend this papers on this?</p>

<rna><cnv>
Arm-level SCNA does not change mRNA expression level?
# Arm-level SCNA does not change mRNA expression level?

(Asked by: username_0 on 2019-11-24)

It is almost common sense that local amplification of gene increase the its mRNA expression . I recently heard that large scale SCNA (such as arm-level amplification) does not increase the mRNA expression level of gene within the region. I did some analysis (SCNA is determined by SNP array and NGS, mRNA expression is measured by RNA-Seq) and found that this is indeed the case. I further did some research and did not found any explanations. it seems like a common acknowledgement. Is there any technical bias or biological explanation that I am missing here? Or is it something that has not have a answer yet?

I have no clue about this at all. Can you recommend this papers on this?

**Tags:** rna, cnv

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## 1 answers

### Answer by username_1 on 2021-07-14. Score: 1

*Answer from @devon-ryan, converted from comments:*

The common presumption in such cases is that there's a feedback loop on most genes to control their expression level. It doesn't have to be specific to arm-level expression.


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