<p>I want to do <strong>meta-analysis of alpha diversity</strong> between test and control groups across 10 different populations. I want to see what is the summed effect (pool effect) of intervention between the two groups for alpha diversity. For that, first I need the intervention effect on test group's alpha diversity for individual population dataset. How should I calculate this? Should I calculate this by difference in the log transformed mean values of the groups (<strong>log2FC</strong>) or should I calculate <strong>SMD</strong> for each study?
Thanks</p>

CC BY-SA 4.0
2021-05-16T15:27:18.010Z
Cross-posted on biostars: https://www.biostars.org/p/9468060/
Ram RS
CC BY-SA 4.0
2022-02-09T21:54:09.863Z
what is the measure of alpha-diversity? counts or proportion?
Subhash C. Davar
<r><meta-analysis>
How to decide between standardized mean difference (SMD) and log2fold change (log2FC) before doing meta-analysis?
# How to decide between standardized mean difference (SMD) and log2fold change (log2FC) before doing meta-analysis?

(Asked by: username_0 on 2021-04-29)

I want to do **meta-analysis of alpha diversity** between test and control groups across 10 different populations. I want to see what is the summed effect (pool effect) of intervention between the two groups for alpha diversity. For that, first I need the intervention effect on test group's alpha diversity for individual population dataset. How should I calculate this? Should I calculate this by difference in the log transformed mean values of the groups (**log2FC**) or should I calculate **SMD** for each study?
Thanks

**Tags:** r, meta-analysis
> **Comments:**
> **username_1**: Cross-posted on biostars: https://www.biostars.org/p/9468060/  
> **username_2**: what is the measure of alpha-diversity? counts or proportion?  

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