<p>I'd like to do a targeted screening analysis for trace contaminates.  However, due to the nature of the sample preparations, the retention times I'm getting drift a lot from run to run and XCMS isn't properly identifying my standards and thus affecting my ability to evaluate my samples.</p>

<p>Is there some trick to getting XCMS to identify the proper retention time that I'm missing?</p>

<p>Is there some other software I should be using? (We have several different instruments from different vendors so it's better if it's not tied to the particular MS)</p>

CC BY-SA 4.0
2018-05-11T07:37:28.520Z
I'm not an expert of mass spectrometry, but perhaps showing the figures or some data might provide an expert with some clues to help you.
llrs
CC BY-SA 4.0
2018-05-13T10:00:39.793Z
As Llopis said, some more details should help to attract an answer. Particularly, which version of XCMS and showing XIC's from some of your standards to show the run-run variation.
Michael_A
<software-recommendation><software-usage><mass-spectrometry>
XCMS isn't evaluating the proper peak due to retention time drift
# XCMS isn't evaluating the proper peak due to retention time drift

(Asked by: username_0 on 2018-05-10)

I'd like to do a targeted screening analysis for trace contaminates. However, due to the nature of the sample preparations, the retention times I'm getting drift a lot from run to run and XCMS isn't properly identifying my standards and thus affecting my ability to evaluate my samples.

Is there some trick to getting XCMS to identify the proper retention time that I'm missing?

Is there some other software I should be using? (We have several different instruments from different vendors so it's better if it's not tied to the particular MS)

**Tags:** software-recommendation, software-usage, mass-spectrometry
> **Comments:**
> **username_1**: I'm not an expert of mass spectrometry, but perhaps showing the figures or some data might provide an expert with some clues to help you.  
> **username_2**: As Llopis said, some more details should help to attract an answer. Particularly, which version of XCMS and showing XIC's from some of your standards to show the run-run variation.  

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## 0 answers

