<p>Where/How can I download all proteins in the UniProt with signal peptide annotated? I downloaded the uniref50.xml. However, the annotation information is not contained.</p>
<p>In an XML record of a protein, the signal peptide information is contained in <code>&lt;feature type=&quot;signal peptide&quot; evidence=&quot;2&quot;&gt; &lt;/feature&gt;</code>. The uniref.xml does not have this information. uniprot annotates this feature with signalp mainly.</p>

CC BY-SA 4.0
2023-02-01T02:26:28.040Z
Please edit the question to limit it to a specific problem with enough detail to identify an adequate answer.
Community
CC BY-SA 4.0
2023-02-01T17:08:39.300Z
Do you have a reason to expect that the signal peptide should be annotated there? Can you point us to more information about how uniprot annotates such features?
Maximilian Press
<uniprot>
Where/How can I download all proteins in the UniProt with signal peptide annotated?
# Where/How can I download all proteins in the UniProt with signal peptide annotated?

(Asked by: username_0 on 2023-02-01)

Where/How can I download all proteins in the UniProt with signal peptide annotated? I downloaded the uniref50.xml. However, the annotation information is not contained.

In an XML record of a protein, the signal peptide information is contained in . The uniref.xml does not have this information. uniprot annotates this feature with signalp mainly.

**Tags:** uniprot
> **Comments:**
> **username_1**: Please edit the question to limit it to a specific problem with enough detail to identify an adequate answer.  
> **username_2**: Do you have a reason to expect that the signal peptide should be annotated there? Can you point us to more information about how uniprot annotates such features?  

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