<p>The enzyme EC:1.6.1.2 is an NAD(P) transhydrogenase and consists of two subunits. The two subunits are encoded by two different genes <a href="http://www.genome.jp/dbget-bin/www_bget?sco+SCO7623" rel="nofollow noreferrer">pntA</a> and <a href="http://www.genome.jp/dbget-bin/www_bget?sco:SCO7622" rel="nofollow noreferrer">pntB</a>.</p>

<p>So in terms of computer logic I would say AND, both subunits are necessary for a functional NAD(P) transhydrogenase enzyme (EC:1.6.1.2).</p>

CC BY-SA 3.0
2017-12-12T15:13:26.117Z
This was only an example, is there a way of knowing in general?
5norre
CC BY-SA 3.0
2017-12-12T15:23:39.153Z
With enzymes from KEGG there is not, I am afraid. In your example it becomes clear that we see 2 subunits, and hence form the same protein. However, if you look for example at human isocitrate dehydrogenase (IDH) [EC 1.1.1.42](http://www.genome.jp/dbget-bin/www_bget?ec:1.1.1.42), you will see that two different genes (IDH1 and IDH2) are listed. These 2 genes are not subunits of the same protein but are 2 different proteins (one in mitochondrium and the other in cytosol). With KEGG the interest in enzyme, not gene.
benn
CC BY-SA 3.0
2017-12-11T21:16:38.073Z
2017-12-11T21:16:38.073Z
benn
<p>How do I know if it is a AND or OR relationship between genes associated with the same enzyme in KEGG? E.g., for EC:1.6.1.2 (<a href="http://www.genome.jp/dbget-bin/www_bget?ec:1.6.1.2" rel="nofollow noreferrer">http://www.genome.jp/dbget-bin/www_bget?ec:1.6.1.2</a>) does the bacterium <em>Streptomyces coelicolor</em> (SCO) need SCO7622 AND SCO7623 or SCO7622 OR SCO7623? <a href="https://i.sstatic.net/zIaRw.png" rel="nofollow noreferrer"><img src="https://i.sstatic.net/zIaRw.png" alt="enter image description here"></a> </p>

<gene><kegg>
AND or OR gene - protein logical relation in KEGG
# AND or OR gene - protein logical relation in KEGG

(Asked by: username_0 on 2017-12-11)

How do I know if it is a AND or OR relationship between genes associated with the same enzyme in KEGG? E.g., for EC:1.6.1.2 (<http://www.genome.jp/dbget-bin/www_bget?ec:1.6.1.2>) does the bacterium *Streptomyces coelicolor* (SCO) need SCO7622 AND SCO7623 or SCO7622 OR SCO7623? [![enter image description here](https://i.sstatic.net/zIaRw.png)](https://i.sstatic.net/zIaRw.png)

**Tags:** gene, kegg

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## 1 answers

### Answer by username_1 on 2017-12-11. Score: 1

The enzyme EC:1.6.1.2 is an NAD(P) transhydrogenase and consists of two subunits. The two subunits are encoded by two different genes [pntA](http://www.genome.jp/dbget-bin/www_bget?sco+SCO7623) and [pntB](http://www.genome.jp/dbget-bin/www_bget?sco:SCO7622).

So in terms of computer logic I would say AND, both subunits are necessary for a functional NAD(P) transhydrogenase enzyme (EC:1.6.1.2).

> **Comments:**
> **username_0**: This was only an example, is there a way of knowing in general?  
> **username_1**: With enzymes from KEGG there is not, I am afraid. In your example it becomes clear that we see 2 subunits, and hence form the same protein. However, if you look for example at human isocitrate dehydrogenase (IDH) [EC 1.1.1.42](http://www.genome.jp/dbget-bin/www_bget?ec:1.1.1.42), you will see that two different genes (IDH1 and IDH2) are listed. These 2 genes are not subunits of the same protein but are 2 different proteins (one in mitochondrium and the other in cytosol). With KEGG the interest in enzyme, not gene.  

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