<p>You can do functional enrichment analysis, for instance with <code>gProfiler</code> in R and see if your marker genes are enriched in any GO term related with the plasma membrane. </p>

<p>Alternatively, you can generate a list with genes whose product are located at the plasma membrane and perform Gene Set Enrichment Analysis, for instance with <code>fgsea</code> in R.</p>

CC BY-SA 4.0
2019-06-03T07:06:50.777Z
2019-06-03T07:23:30.197Z
2019-06-03T07:23:30.197Z
jxx_fa
<p>I have a list of cell markers differentially expressed between 2 groups of cells, that I got with the FindMarkers command in Seurat. I want to enrich for those genes that are expressed in the cell membrane. Are there any specific tools/commands I can use to do that? Thanks! </p>

CC BY-SA 4.0
2019-06-03T08:32:21.853Z
Could you explain what do you mean by "enrich" test if some group is differently expressed or retrieve more information about those genes from other sources?
llrs
<seurat>
Enrich for genes expressed in the plasma membrane
# Enrich for genes expressed in the plasma membrane

(Asked by: username_0 on 2019-06-02)

I have a list of cell markers differentially expressed between 2 groups of cells, that I got with the FindMarkers command in Seurat. I want to enrich for those genes that are expressed in the cell membrane. Are there any specific tools/commands I can use to do that? Thanks!

**Tags:** seurat
> **Comments:**
> **username_1**: Could you explain what do you mean by "enrich" test if some group is differently expressed or retrieve more information about those genes from other sources?  

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## 1 answers

### Answer by username_2 on 2019-06-03. Score: 1

You can do functional enrichment analysis, for instance with `gProfiler` in R and see if your marker genes are enriched in any GO term related with the plasma membrane.

Alternatively, you can generate a list with genes whose product are located at the plasma membrane and perform Gene Set Enrichment Analysis, for instance with `fgsea` in R.


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