<p>I want to install annovar but in one particular part I always get this error</p>
<pre><code>i1d18@RBGO-Server2:/data2/RNASeq/Angel/annovar<span class="math-container">$ perl annotate_variation.pl -downdb -webfrom annovar avsnp147 humandb/
NOTICE: The --buildver is set as 'hg18' by default
NOTICE: Web-based checking to see whether ANNOVAR new version is available ... Done
NOTICE: Downloading annotation database http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.gz ... Failed
NOTICE: Downloading annotation database http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.idx.gz ... Failed
WARNING: Some files cannot be downloaded, including http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.gz, http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.idx.gz
fi1d18@RBGO-Server2:/data2/RNASeq/Angel/annovar$</span>
</code></pre>
<p>Googling did not return any clue</p>
<p>Any help please?</p>

CC BY-SA 4.0
2022-01-11T20:42:45.280Z
My first attempt would be to change the version of the genome build to something more recent than hg18.
Wouter De Coster
CC BY-SA 4.0
2022-01-12T14:42:35.820Z
I don't think hg18 is the issue, according to their documentation hg18 is supported. However, the commands you used are not exactly the same as they showed in [the tutorial](https://annovar.openbioinformatics.org/en/latest/user-guide/startup/). Did you try to do exactly what did suggested? If that still does not work, I would suggest to open [an issue](https://github.com/WGLab/doc-ANNOVAR/issues/new) on their github.
Kamil S Jaron
CC BY-SA 4.0
2022-01-14T11:01:35.953Z
Changing to hg38 solved the problem, thanks
Zizogolu
<vcf><sequence-annotation><maf><wes>
An error with annovar
# An error with annovar

(Asked by: username_0 on 2022-01-11)

I want to install annovar but in one particular part I always get this error
i1d18@RBGO-Server2:/data2/RNASeq/Angel/annovar$ perl annotate_variation.pl -downdb -webfrom annovar avsnp147 humandb/
NOTICE: The --buildver is set as 'hg18' by default
NOTICE: Web-based checking to see whether ANNOVAR new version is available ... Done
NOTICE: Downloading annotation database http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.gz ... Failed
NOTICE: Downloading annotation database http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.idx.gz ... Failed
WARNING: Some files cannot be downloaded, including http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.gz, http://www.openbioinformatics.org/annovar/download/hg18_avsnp147.txt.idx.gz
fi1d18@RBGO-Server2:/data2/RNASeq/Angel/annovar$

Googling did not return any clue
Any help please?

**Tags:** vcf, sequence-annotation, maf, wes
> **Comments:**
> **username_1**: My first attempt would be to change the version of the genome build to something more recent than hg18.  
> **username_2**: I don't think hg18 is the issue, according to their documentation hg18 is supported. However, the commands you used are not exactly the same as they showed in [the tutorial](https://annovar.openbioinformatics.org/en/latest/user-guide/startup/). Did you try to do exactly what did suggested? If that still does not work, I would suggest to open [an issue](https://github.com/WGLab/doc-ANNOVAR/issues/new) on their github.  
> **username_0**: Changing to hg38 solved the problem, thanks  

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## 0 answers

