<p>Yes, if you have a ranked list, you can use GSEA to calculate the enrichment of the strains along the ranked list. </p>

<p>Note that hypergeometric test is for count data, so you would test if there are more strains of one type that fit on certain conditions. </p>

<p>I would recommend <a href="https://doi.org/10.1371/journal.pcbi.1002375" rel="nofollow noreferrer">this article</a> comparing different enrichment methods to understand well what they do. </p>

CC BY-SA 4.0
2019-09-09T07:09:05.617Z
2019-09-09T07:09:05.617Z
llrs
<p>I have yeast growth data in various experimental conditions that are classified by the strain type. Can I use the GSEA tool from the Broad Institute to test for enrichment of specific groups of strains within the total population (i.e. gene sets)? If not, would something like a hypergeomtric test be useful for this kind of analysis?</p>

<gsea>
Can I use GSEA to look for enrichment in data that is grouped into sets but are not necessarily genes?
# Can I use GSEA to look for enrichment in data that is grouped into sets but are not necessarily genes?

(Asked by: username_0 on 2019-09-09)

I have yeast growth data in various experimental conditions that are classified by the strain type. Can I use the GSEA tool from the Broad Institute to test for enrichment of specific groups of strains within the total population (i.e. gene sets)? If not, would something like a hypergeomtric test be useful for this kind of analysis?

**Tags:** gsea

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## 1 answers

### Answer by username_1 on 2019-09-09. Score: 1

Yes, if you have a ranked list, you can use GSEA to calculate the enrichment of the strains along the ranked list.

Note that hypergeometric test is for count data, so you would test if there are more strains of one type that fit on certain conditions.

I would recommend [this article](https://doi.org/10.1371/journal.pcbi.1002375) comparing different enrichment methods to understand well what they do.


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