<p>Harry Boutselakis addressed the question via the customer support of the COSMIC web site.</p>

<hr>

<blockquote>
  <p>Dear Ivan, Thank you for using COSMIC.</p>
  
  <blockquote>
    <p>I would like to know why there are different entries for the same mutation   in COSMIC, for example COSM6954941 and COSM12833 both refer
    to ERBB4   c.908C>A.</p>
    
    <p>In this specific case the field Gene name in the two entries is different,   COSM6954941 report ERBB4_ENST00000402597 while COSM12833
    report ERBB4,</p>
  </blockquote>
  
  <p>The mutations are annotated onto two different isoforms of ERBB4. So
  this annotation refers to two different transcripts. In these cases
  the consequence of the mutation on the mRNA and polypeptide is the
  same reflected by the syntax.</p>
  
  <blockquote>
    <p>but there are many cases in which the Gene name is the same, for example   COSM1361 and COSM1219.</p>
  </blockquote>
  
  <p>This case the consequence one mutation on the mRNA is unknown , but
  the amino acid change is the same on both cases.</p>
  
  <p>The information stored in COSMIC is curated from experimental data,
  depending on the evidence and experimental methodology used, the
  mutations are differentiated accordingly. I hope this answers your
  question.</p>
  
  <p>Kind regards,</p>
  
  <p>Harry</p>
</blockquote>

CC BY-SA 4.0
2019-01-09T11:57:09.963Z
2019-01-09T12:17:30.580Z
2019-01-09T12:17:30.580Z
mox
<p>I would like to know why there are different entries for the same mutation in COSMIC, for example <a href="https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=6954941" rel="nofollow noreferrer">COSM6954941</a> and <a href="https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=12833" rel="nofollow noreferrer">COSM12833</a> both refer to ERBB4 c.908C>A.</p>

<p>In this specific case the field <strong>Gene name</strong> in the two entries is different, COSM6954941 report ERBB4_ENST00000402597 while <a href="https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=12833" rel="nofollow noreferrer">COSM12833</a> report ERBB4, but there are many cases in which the <strong>Gene name</strong> is the same, for example <a href="https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1361" rel="nofollow noreferrer">COSM1361</a> and <a href="https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1219" rel="nofollow noreferrer">COSM1219</a>.</p>

CC BY-SA 4.0
2018-11-30T15:51:40.450Z
Welcome to the site! Please [edit] your question and add links to these cosmic entries so we can check what you mean more easily. You might not be able to link to all of them (there are some restrictions on how many links new users can include, to limit spam). If you have issues with that, just add the links as text (remove the "https://:") and I will add them for you.
terdon
CC BY-SA 4.0
2019-01-09T11:54:57.530Z
Hi @terdon, I added the links as you requested. Please note that I ave got an answer via email that I report using the "answer your question" button.
mox
CC BY-SA 4.0
2019-01-09T11:56:10.440Z
Great! And thank you for remembering to come back and post the answer. That's very helpful and might help future users with the same problem.
terdon
<variation>
multiple COSMIC id for the same mutation
# multiple COSMIC id for the same mutation

(Asked by: username_0 on 2018-11-30)

I would like to know why there are different entries for the same mutation in COSMIC, for example [COSM6954941](https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=6954941) and [COSM12833](https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=12833) both refer to ERBB4 c.908C>A.

In this specific case the field **Gene name** in the two entries is different, COSM6954941 report ERBB4\_ENST00000402597 while [COSM12833](https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=12833) report ERBB4, but there are many cases in which the **Gene name** is the same, for example [COSM1361](https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1361) and [COSM1219](https://cancer.sanger.ac.uk/cosmic/mutation/overview?id=1219).

**Tags:** variation
> **Comments:**
> **username_1**: Welcome to the site! Please [edit] your question and add links to these cosmic entries so we can check what you mean more easily. You might not be able to link to all of them (there are some restrictions on how many links new users can include, to limit spam). If you have issues with that, just add the links as text (remove the "https://:") and I will add them for you.  
> **username_0**: Hi @terdon, I added the links as you requested. Please note that I ave got an answer via email that I report using the "answer your question" button.  
> **username_1**: Great! And thank you for remembering to come back and post the answer. That's very helpful and might help future users with the same problem.  

---

## 1 answers

### Answer by username_0 on 2019-01-09. Score: 3

Harry Boutselakis addressed the question via the customer support of the COSMIC web site.

---

> Dear Ivan, Thank you for using COSMIC.
>
> > I would like to know why there are different entries for the same mutation in COSMIC, for example COSM6954941 and COSM12833 both refer
> > to ERBB4 c.908C>A.
> >
> > In this specific case the field Gene name in the two entries is different, COSM6954941 report ERBB4\_ENST00000402597 while COSM12833
> > report ERBB4,
>
> The mutations are annotated onto two different isoforms of ERBB4. So
> this annotation refers to two different transcripts. In these cases
> the consequence of the mutation on the mRNA and polypeptide is the
> same reflected by the syntax.
>
> > but there are many cases in which the Gene name is the same, for example COSM1361 and COSM1219.
>
> This case the consequence one mutation on the mRNA is unknown , but
> the amino acid change is the same on both cases.
>
> The information stored in COSMIC is curated from experimental data,
> depending on the evidence and experimental methodology used, the
> mutations are differentiated accordingly. I hope this answers your
> question.
>
> Kind regards,
>
> Harry


---

