<p><strong>To recover orthologous sequence for model species</strong></p>
<p>You should be able to find your orthologs using <a href="https://m.ensembl.org/info/data/biomart/index.html" rel="nofollow noreferrer">BioMart</a> and your gene IDs.</p>
<p>There are numerous way to do it, directly on the ensembl website or through API. You can start from these links (quite old though) :</p>
<ul>
<li><a href="http://www.ensembl.info/2009/01/21/how-to-get-all-the-orthologous-genes-between-two-species/" rel="nofollow noreferrer">http://www.ensembl.info/2009/01/21/how-to-get-all-the-orthologous-genes-between-two-species/</a></li>
<li><a href="https://www.youtube.com/watch?v=EwfOQsr2O-M" rel="nofollow noreferrer">https://www.youtube.com/watch?v=EwfOQsr2O-M</a> #Get orthologs via BioMart</li>
<li><a href="https://www.biostars.org/p/12245/" rel="nofollow noreferrer">https://www.biostars.org/p/12245/</a> #Finding Human/Yeast Orthologs Using Embl?</li>
</ul>
<p><strong>Which database should I use</strong></p>
<p>It is broad and depends on the nature of your work. In your case, working with &quot;major model species&quot;, <strong>DIOPT</strong> (the first line of the table in Quest For Orthology) has the very feature you need on its front page for going from mouse to human. More eukaryotic/viral oriented database will be used for taxonomic identification, annotation inference, etc.</p>
<p>I hope it helps.</p>

CC BY-SA 4.0
2020-09-03T23:55:34.323Z
Thanks a lot Paul!
Noob
CC BY-SA 4.0
2020-08-26T14:29:45.273Z
2020-08-26T16:41:27.953Z
2020-08-26T16:41:27.953Z
Paul Endymion
<p>I am working on four data sets of yeast genes and one data set of mouse gene. I need the list of human orthologs of those genes. There are a lot of databases available online which is in use for this purpose</p>
<p><a href="https://questfororthologs.org/orthology_databases" rel="nofollow noreferrer">https://questfororthologs.org/orthology_databases</a></p>
<p>I don't know which one to choose and why. Can anyone tell me on what basis should I choose a database over any other database? Thank you.</p>

<orthologues>
How to know which ortholog database is the best for my work?
# How to know which ortholog database is the best for my work?

(Asked by: username_0 on 2020-08-25)

I am working on four data sets of yeast genes and one data set of mouse gene. I need the list of human orthologs of those genes. There are a lot of databases available online which is in use for this purpose

<https://questfororthologs.org/orthology_databases>

I don't know which one to choose and why. Can anyone tell me on what basis should I choose a database over any other database? Thank you.

**Tags:** orthologues

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## 1 answers

### Answer by username_1 on 2020-08-26. Score: 0 | Accepted answer

**To recover orthologous sequence for model species**

You should be able to find your orthologs using [BioMart](https://m.ensembl.org/info/data/biomart/index.html) and your gene IDs.

There are numerous way to do it, directly on the ensembl website or through API. You can start from these links (quite old though) :

* <http://www.ensembl.info/2009/01/21/how-to-get-all-the-orthologous-genes-between-two-species/>
* <https://www.youtube.com/watch?v=EwfOQsr2O-M> #Get orthologs via BioMart
* <https://www.biostars.org/p/12245/> #Finding Human/Yeast Orthologs Using Embl?

**Which database should I use**

It is broad and depends on the nature of your work. In your case, working with "major model species", **DIOPT** (the first line of the table in Quest For Orthology) has the very feature you need on its front page for going from mouse to human. More eukaryotic/viral oriented database will be used for taxonomic identification, annotation inference, etc.

I hope it helps.

> **Comments:**
> **username_0**: Thanks a lot Paul!  

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