<p>In the <a href="http://cancerres.aacrjournals.org/content/72/14/3499.full" rel="nofollow noreferrer">article</a> describing Cellminer says about the cross-correlations:</p>

<blockquote>
  <p>... a cross-correlation table of the resultant z-scores can be
  generated ...</p>
</blockquote>

<p>On page 3503</p>

<p>And the z-scores are defined previously as:</p>

<blockquote>
  <p>The tool output includes relative transcript intensity presented
  as z-scores...</p>
</blockquote>

CC BY-SA 3.0
2017-06-20T08:34:17.377Z
2017-06-20T08:34:17.377Z
llrs
<p>I have seen one of <a href="https://discover.nci.nih.gov/cellminer/" rel="nofollow noreferrer">Cellminer tools</a>. I am not sure how do they calculate the cross correlation of the genes, what does it actually mean? Based on what databases? </p>

<p>For example if I take their example input (<a href="http://www.genenames.org/" rel="nofollow noreferrer">HUGO</a> format): </p>

<pre><code>abcb1
BRCA2
CNBP
</code></pre>

<p>I get the following cross correlation matrix (based on what signals).</p>

<pre><code>Identifier      abcb1   BRCA2   CNBP
abcb1           1      -0.142   0.069
BRCA2          -0.142   1       0.176
CNBP           0.069    0.176   1
</code></pre>

CC BY-SA 3.0
2017-08-18T09:00:31.037Z
You're probably best asking the authors
ithinkiam
<r><gene>
How does Cellminer's "Cross-correlations of transcripts, drugs, and microRNAs" work
# How does Cellminer's "Cross-correlations of transcripts, drugs, and microRNAs" work

(Asked by: username_0 on 2017-06-10)

I have seen one of Cellminer tools. I am not sure how do they calculate the cross correlation of the genes, what does it actually mean? Based on what databases? 
For example if I take their example input (HUGO format): 
abcb1
BRCA2
CNBP

I get the following cross correlation matrix (based on what signals).
Identifier      abcb1   BRCA2   CNBP
abcb1           1      -0.142   0.069
BRCA2          -0.142   1       0.176
CNBP           0.069    0.176   1

**Tags:** r, gene
> **Comments:**
> **username_1**: You're probably best asking the authors  

---

## 1 answers

### Answer by username_2 on 2017-06-20. Score: 2 | Accepted answer

In the [article](http://cancerres.aacrjournals.org/content/72/14/3499.full) describing Cellminer says about the cross-correlations:

> ... a cross-correlation table of the resultant z-scores can be
> generated ...

On page 3503

And the z-scores are defined previously as:

> The tool output includes relative transcript intensity presented
> as z-scores...


---

