<p>try somalier: <a href="https://github.com/brentp/somalier" rel="nofollow noreferrer">https://github.com/brentp/somalier</a></p>
<p><a href="https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00761-2" rel="nofollow noreferrer">https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00761-2</a> :</p>
<blockquote>
<p>The sites files include informative variants on the X and Y chromosomes so that Somalier can also estimate a sample’s sex from the genotypes.</p>
</blockquote>

CC BY-SA 4.0
2024-08-08T08:47:47.083Z
2024-08-08T08:47:47.083Z
Pierre
<p>I have human samples VCF files that I want to infer the sex of. I do not have sequencing information or information about coverage. What's the best way to go about this? I'm looking for a robust and reliable method. Tools are okay, and conceptual or algorithmic ideas about what to do are also okay.</p>

<vcf><snp><plink><algorithms><human-genome>
How do I infer sex from a VCF file?
# How do I infer sex from a VCF file?

(Asked by: username_0 on 2024-08-06)

I have human samples VCF files that I want to infer the sex of. I do not have sequencing information or information about coverage. What's the best way to go about this? I'm looking for a robust and reliable method. Tools are okay, and conceptual or algorithmic ideas about what to do are also okay.

**Tags:** vcf, snp, plink, algorithms, human-genome

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## 1 answers

### Answer by username_1 on 2024-08-08. Score: 1

try somalier: <https://github.com/brentp/somalier>

<https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-020-00761-2> :

> The sites files include informative variants on the X and Y chromosomes so that Somalier can also estimate a sample’s sex from the genotypes.


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