<p>The different V numbers are just different number of SNPs as far as I'm aware. So there's not going to be a service which just imputes the variants to make e.g. V3 into V5.</p>
<p>The <a href="https://imputationserver.sph.umich.edu/index.html#!" rel="nofollow noreferrer">Michigan Imputation Server</a> uses the Haplotype Reference Consortium to impute genotypes and allows input in 23andme format. You'll end up with many more SNPs than in the V5 chip, but filtering out the other ones should be easy.</p>

CC BY-SA 4.0
2022-02-15T16:04:25.680Z
Thanks, I see what you mean. I'm now curious what coverage of v5 you get from v3 :-)
Dan Bolser
CC BY-SA 4.0
2022-02-15T10:47:24.473Z
2022-02-15T10:54:28.157Z
2022-02-15T10:54:28.157Z
user438383
<p>The 23andMe version 3 data (v3) is now quite 'old' and new data is being collected on the updated v5 Illumina SNP-Chip (<a href="https://www.mygenefood.com/blog/understanding-23andme-chip-versions-why-v3-v4-v5-and-others-can-differ/#how_do_the_various_chips_differ" rel="nofollow noreferrer">details here</a>).</p>
<p>Is there an online service for imputing 23andMe v3 files to v4 and v5?</p>
<p>Seems this would be quite handy!</p>

CC BY-SA 4.0
2022-02-15T13:37:28.640Z
I am seriously not sure why is this getting downvoted, I find the post-edit question a clear cut reasonable
Kamil S Jaron
CC BY-SA 4.0
2022-02-16T16:15:32.177Z
Thanks Kamil, I was surprised... Good to know it's not just me :-)
Dan Bolser
<vcf><imputation>
Imputing 23andMe 3v data to v4 and v5?
# Imputing 23andMe 3v data to v4 and v5?

(Asked by: username_0 on 2022-02-11)

The 23andMe version 3 data (v3) is now quite 'old' and new data is being collected on the updated v5 Illumina SNP-Chip ([details here](https://www.mygenefood.com/blog/understanding-23andme-chip-versions-why-v3-v4-v5-and-others-can-differ/#how_do_the_various_chips_differ)).

Is there an online service for imputing 23andMe v3 files to v4 and v5?

Seems this would be quite handy!

**Tags:** vcf, imputation
> **Comments:**
> **username_1**: I am seriously not sure why is this getting downvoted, I find the post-edit question a clear cut reasonable  
> **username_0**: Thanks Kamil, I was surprised... Good to know it's not just me :-)  

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## 1 answers

### Answer by username_2 on 2022-02-15. Score: 2 | Accepted answer

The different V numbers are just different number of SNPs as far as I'm aware. So there's not going to be a service which just imputes the variants to make e.g. V3 into V5.

The [Michigan Imputation Server](https://imputationserver.sph.umich.edu/index.html#!) uses the Haplotype Reference Consortium to impute genotypes and allows input in 23andme format. You'll end up with many more SNPs than in the V5 chip, but filtering out the other ones should be easy.

> **Comments:**
> **username_0**: Thanks, I see what you mean. I'm now curious what coverage of v5 you get from v3 :-)  

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