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r,i=n(99),o=n(1).Model;t.exports=r=o.extend({defaults:{scheme:"taylor",colorBackground:!0,showLowerCase:!0,opacity:.6},initialize:function(t,e,n){return this.colors=new i({seqs:e,conservation:function(){return n.scale(n.conservation())}}),n.on("reset",function(){if("dyn"===this.getSelectedScheme().type){var t;if(t="reset",this.getSelectedScheme().indexOf(t)>=0)return this.getSelectedScheme().reset()}},this)},addStaticScheme:function(t,e){return this.colors.addStaticScheme(t,e)},addDynScheme:function(t,e){return this.colors.addDynScheme(t,e)},getScheme:function(t){return this.colors.getScheme(t)},getSelectedScheme:function(){return this.colors.getScheme(this.get("scheme"))}})},function(t,e,n){"use strict";var r,i=n(1).Model;t.exports=r=i.extend({initialize:function(t,e){return null==this.get("hidden")&&this.set("hidden",[]),this.stats=e},calcHiddenColumns:function(t){for(var e,n=this.get("hidden"),r=t,i=0;i<n.length;i++)e=n[i],e<=r&&r++;return r-t}})},function(t,e,n){"use strict";var r,i=n(1).Model;t.exports=r=i.extend({defaults:{registerMouseHover:!1,registerMouseClicks:!0,importProxy:"https://cors-anywhere.herokuapp.com/",importProxyStripHttp:!0,eventBus:!0,alphabetSize:20,dropImport:!1,debug:!1,hasRef:!1,bootstrapMenu:!1,manualRendering:!1}})},function(t,e,n){"use strict";var r,i=n(18),o=n(1).Model;t.exports=r=o.extend({initialize:function(t){return this.g=t},development:{"msa-tnt":"/node_modules/msa-tnt/build/bundle.js","biojs-io-newick":"/node_modules/biojs-io-newick/build/biojs-io-newick.min.js"},loadPackage:function(t,e){try{return e(n(156)(t))}catch(r){return i["default"].loadScript(this._pkgURL(t),e)}},loadPackages:function(t,e){var n=this,r=i["default"].joinCb(function(){return e()},t.length);return t.forEach(function(t){return n.loadPackage(t,r)})},_pkgURL:function(t){if(this.g.config.get("debug"))var e=this.development[t];else e="http://wzrd.in/bundle/"+t+"@latest";return e}})},function(t,e,n){"use strict";var r,i=n(1).Model;t.exports=r=i.extend({defaults:{searchText:""
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this.trigger("change:header")},this)},calcDefaults:function(t){if(t.length>0){var e=t.at(0),n=e.get("ids");if(void 0!==n&&0===Object.keys(n).length)return this.defaults.metaLinks=!1}}})},function(t,e,n){"use strict";var r,i=n(1).Model;t.exports=r=i.extend({constructor:function(t,e){return this.calcDefaults(e.model),i.apply(this,arguments),this.g=e.g,this.listenTo(this,"change:labelIdLength change:labelNameLength change:labelPartLength change:labelCheckLength",function(){return this.trigger("change:labelWidth",this.getLabelWidth())},this),this.listenTo(this,"change:metaLinksWidth change:metaIdentWidth change:metaGapWidth",function(){return 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n=e.name||e.url||"",r=n.split("."),i=r[r.length-1]||"",o=0;o<s.length;o++){var u=s[o](t,i);if(u)return u}return"unknown"};var n=function(t,e){return("CLUSTAL"===t.substring(0,7)||"clustal"==e||"aln"==e)&&"clustal"},r=function(t,e){return(">"===t.substring(0,1)||"fasta"==e||"fa"==e)&&"fasta"},i=function(t,e){return("("===t.substring(0,1)||"nwk"==e)&&"newick"},o=function(t,e){if(t.length<=10)return!1;var n=t.split("\n");return n[0].indexOf("gff")>=0||e.indexOf("gff")>=0?"gff":n[0].indexOf("#")<0&&2===n[0].split("\t").length&&"gff"},s=[n,r,i,o]},function(t,e,n){"use strict";function r(t){return t&&t.__esModule?t:{"default":t}}Object.defineProperty(e,"__esModule",{value:!0});var i=n(15),o=r(i),s=n(72).seq,u=n(48),a={_generateSequence:function(t){for(var e="",n=t-1,r=0;0<n?r<=n:r>=n;0<n?r++:r--)e+=a.getRandomChar();return e},getDummySequences:function(t,e){var n=[];"undefined"!=typeof t&&null!==t||(t=o["default"].getRandomInt(3,5)),"undefined"!=typeof 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i.adapters.msa({model:l,sel:u,msa:this.msa}),l.models.forEach(function(t){return delete t.collection,Object.setPrototypeOf(t,n(1).Model.prototype)}),this.msa.seqs.reset(l.models),console.log(this.msa.seqs)},require:function(t){function e(e){return t.apply(this,arguments)}return e.toString=function(){return t.toString()},e}(function(t){return n(157)(t)})};(0,i.extend)(s.prototype,u),e["default"]=s},function(t,e,n){"use strict";var r="function"==typeof Symbol&&"symbol"==typeof Symbol.iterator?function(t){return typeof t}:function(t){return t&&"function"==typeof Symbol&&t.constructor===Symbol?"symbol":typeof t},i=n(22),o=n(23),s=n(42),u=function(t,e){var 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this.listenTo(this.g[t],"all",function(e,n,r,i){if("change"!==e)return"undefined"!=typeof i&&null!==i?this.g.trigger(t+":"+e,r,n,i):this.g.trigger(t+":"+e,r,n)})},render:function(){return void 0===this.seqs||0===this.seqs.length,this.renderSubviews(),this.g.vis.set("loaded",!0),this}});e["default"]=F},function(t,e,n){"use strict";function r(t){return t&&t.__esModule?t:{"default":t}}Object.defineProperty(e,"__esModule",{value:!0});var i=n(134),o=r(i),s=n(143),u=r(s),a=n(4),l=a.extend({initialize:function(t){this.g=t.g;var e=new u["default"]({model:this.model,g:this.g});if(e.ordering=-1,this.addView("labelblock",e),this.g.vis.get("sequences")){var n=new o["default"]({model:this.model,g:this.g});n.ordering=0,this.addView("seqblock",n)}return this.listenTo(this.g.zoomer,"change:alignmentHeight",this.adjustHeight),this.listenTo(this.g.zoomer,"change:alignmentWidth",this.adjustWidth),this.listenTo(this.g.columns,"change:hidden",this.adjustHeight),this},render:function(){return this.renderSubviews(),this.el.className="biojs_msa_albody",this.el.style.whiteSpace="nowrap",this.adjustHeight(),this.adjustWidth(),this},adjustHeight:function(){return"auto"===this.g.zoomer.get("alignmentHeight")?this.el.style.height=this.g.zoomer.get("rowHeight")*this.model.length+5:this.el.style.height=this.g.zoomer.get("alignmentHeight")},adjustWidth:function(){return this.el.style.width=this.getWidth()},getWidth:function(){var t=0;return t+=this.g.zoomer.getLeftBlockWidth(),this.g.vis.get("sequences")&&(t+=this.g.zoomer.get("alignmentWidth")),t}});e["default"]=l},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0});var r=n(8),i=n(2),o=n(47),s=n(5),u=i.extend({className:"biojs_msa_overviewbox",tagName:"canvas",initialize:function(t){return this.g=t.g,this.listenTo(this.g.zoomer,"change:boxRectWidth change:boxRectHeight change:overviewboxPaddingTop",this.rerender),this.listenTo(this.g.selcol,"add reset 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u=this.model.at(s).get("seq"),a=0;if(i+=e,this.model.at(s).get("hidden"))this.ctx.fillStyle="grey",this.ctx.fillRect(0,i,u.length*t,e);else for(var l=0;l<u.length;l++){var c=u[l];r&&(c=c.toUpperCase());var f=this.color.getColor(c,{pos:l});n.indexOf(l)>=0&&(f="grey"),"undefined"!=typeof f&&null!==f&&(this.ctx.fillStyle=f,this.ctx.fillRect(a,i,t,e)),a+=t}}return this._drawSelection()},_drawSelection:function(){var t=this;if(!(this.dragStart.length>0)||this.prolongSelection){var e=this.g.zoomer.get("boxRectWidth"),n=this.g.zoomer.get("boxRectHeight"),r=n*this.model.length;this.ctx.fillStyle="#666666",this.ctx.globalAlpha=.9;for(var i=this.g.selcol.length,o=function(i){var o=t.g.selcol.at(i);if(!o)return"continue";var s=void 0,u=void 0;"column"===o.get("type")?t.ctx.fillRect(e*o.get("xStart"),0,e*(o.get("xEnd")-o.get("xStart")+1),r):"row"===o.get("type")?(s=t.model.filter(function(t){return t.get("id")===o.get("seqId")})[0],u=t.model.indexOf(s),t.ctx.fillRect(0,n*u,e*s.get("seq").length,n)):"pos"===o.get("type")&&(s=t.model.filter(function(t){return t.get("id")===o.get("seqId")})[0],u=t.model.indexOf(s),t.ctx.fillRect(e*o.get("xStart"),n*u,e*(o.get("xEnd")-o.get("xStart")+1),n))},s=0;s<i;s++)o(s);return this.ctx.globalAlpha=1}},_onclick:function(t){return this.g.trigger("meta:click",{seqId:this.model.get("id",{evt:t})})},_onmousemove:function(t){if(0!==this.dragStart.length){this.render(),this.ctx.fillStyle="#666666",this.ctx.globalAlpha=.9;var e=this._calcSelection(o.abs(t));return this.ctx.fillRect(e[0][0],e[1][0],e[0][1]-e[0][0],e[1][1]-e[1][0]),t.preventDefault(),t.stopPropagation()}},_onmousedown:function(t){var e=this;return this.dragStart=o.abs(t),this.dragStartRel=o.rel(t),t.ctrlKey||t.metaKey?this.prolongSelection=!0:this.prolongSelection=!1,s(document.body).on("mousemove.overmove",function(t){return e._onmousemove(t)}),s(document.body).on("mouseup.overup",function(t){return e._onmouseup(t)}),this.dragStart},_calcSelection:function(t){for(var e=[t[0]-this.dragStart[0],t[1]-this.dragStart[1]],n=0;n<=1;n++)e[n]=this.dragStartRel[n]+e[n];for(var r=[[this.dragStartRel[0],e[0]],[this.dragStartRel[1],e[1]]],i=0;i<=1;i++)r[i][1]<r[i][0]&&(r[i]=[r[i][1],r[i][0]]),r[i][0]=Math.max(r[i][0],0);return r},_endSelection:function(t){if(s(document.body).off(".overmove"),s(document.body).off(".overup"),0!==this.dragStart.length){for(var e=this._calcSelection(t),n=0;n<=1;n++)e[0][n]=Math.floor(e[0][n]/this.g.zoomer.get("boxRectWidth"));for(var n=0;n<=1;n++)e[1][n]=Math.floor(e[1][n]/this.g.zoomer.get("boxRectHeight"));e[0][1]=Math.min(this.model.getMaxLength()-1,e[0][1]),e[1][1]=Math.min(this.model.length-1,e[1][1]);for(var i=[],o=e[1][0];o<=e[1][1];o++){var u={seqId:this.model.at(o).get("id"),xStart:e[0][0],xEnd:e[0][1]};i.push(new r.possel(u))}return this.dragStart=[],this.prolongSelection?this.g.selcol.add(i):this.g.selcol.reset(i),this.g.zoomer.setLeftOffset(e[0][0]),this.g.zoomer.setTopOffset(e[1][0])}},_onmouseup:function(t){return this._endSelection(o.abs(t))},_onmouseout:function(t){return this._endSelection(o.abs(t))},_createCanvas:function(){var t=this.g.zoomer.get("boxRectWidth"),e=this.g.zoomer.get("boxRectHeight");return this.el.height=this.model.length*e,this.el.width=this.model.getMaxLength()*t,this.ctx=this.el.getContext("2d"),this.el.style.overflow="auto",this.el.style.cursor="crosshair"}});e["default"]=u},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0});var r=n(3),i=n(2),o=n(5),s=i.extend({initialize:function(t){return this.g=t.g,this.listenTo(this.g.zoomer,"change:columnWidth",this.render),this.toggleClass="msa-hide",this.isVisible=!0,this},attributes:{"class":"biojs_msa_scale"},events:{"change input":"updateSlider","click button.msa-btn-close":"hide","click button.msa-btn-open":"show","click button[data-action]":"clickButton"},template:(0,r.template)('\t<div class="msa-scale-minimised">\t  <button class="btn msa-btn msa-btn-open">Zoom</button>\t</div>\t<div class="msa-scale-maximised">\t  <button class="btn msa-btn msa-btn-close" style="float:right">&times; close</button>\t  <div>\t  <input type="range" \t    data-provide="slider" \t    min="<%= min %>" \t    max="<%= max %>" \t    step="<%= step %>" \t    value="<%= value %>" \t  >\t  </div>\t  <div class="btngroup msa-btngroup">\t    <button class="btn msa-btn" data-action="smaller"><span class="glyphicon-zoom-out"></span>-</button>\t    <button class="btn msa-btn" data-action="bigger"><span class="glyphicon-zoom-in"></span>+</button>\t    <button class="btn msa-btn" data-action="reset"><span class="glyphicon-repeat"></span>reset</button>\t  </div>\t</div>\t'),render:function(){var t=this.model.getSizeRange(),e={value:this.model.getSize(),min:t[0],max:t[1],step:this.model.step||1};return this.$el.html(this.template(e)),this.isVisible?this.show():this.hide(),this},updateSlider:function(t){var e=t.target,n=parseInt(o(e).val());this.model.setSize(n)},clickButton:function(t){var e=t.target,n=o(e).data("action");return this.model[n],"function"==typeof this.model[n]&&this.model[n](),this},hide:function(){this.isVisible=!1,this.$el.find(".msa-scale-minimised").removeClass(this.toggleClass),this.$el.find(".msa-scale-maximised").addClass(this.toggleClass)},show:function(){this.isVisible=!1,this.$el.find(".msa-scale-minimised").addClass(this.toggleClass),this.$el.find(".msa-scale-maximised").removeClass(this.toggleClass)}});e["default"]=s},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0});var r=n(8),i=n(4),o=n(14),s=(n(7),i.extend({initialize:function(t){return this.g=t.g,this.listenTo(this.g.user,"change:searchText",function(t,e){return this.search(e),this.render()}),this.sel=[],this.selPos=0},events:{scroll:"_sendScrollEvent"},render:function(){this.renderSubviews(),this.el.className="biojs_msa_searchresult";var t=this.g.user.get("searchText");return"undefined"!=typeof t&&null!==t&&t.length>0&&(0===this.sel.length?this.el.textContent="no selection found":(this.resultBox=o.mk("div"),this.resultBox.className="biojs_msa_searchresult_ovbox",this.updateResult(),this.el.appendChild(this.resultBox),this.el.appendChild(this.buildBtns()))),this},updateResult:function(){var t="search pattern: "+this.g.user.get("searchText");t+=", selection: "+(this.selPos+1);var e=this.sel[this.selPos];return t+=" (",t+=e.get("xStart")+" - "+e.get("xEnd"),t+=", id: "+e.get("seqId"),t+=")",this.resultBox.textContent=t},buildBtns:function(){var t=this,e=o.mk("button");e.textContent="Prev",e.addEventListener("click",function(){return t.moveSel(-1)});var n=o.mk("button");n.textContent="Next",n.addEventListener("click",function(){return t.moveSel(1)});var r=o.mk("button");r.textContent="All",r.addEventListener("click",function(){return t.g.selcol.reset(t.sel)});var i=o.mk("div");return i.appendChild(e),i.appendChild(n),i.appendChild(r),i.className="biojs_msa_searchresult_row",i},moveSel:function(t){var e=this.selPos+t;return e<0||e>=this.sel.length?-1:(this.focus(e),this.selPos=e,this.updateResult())},focus:function(t){var e=this.sel[t],n=e.get("xStart");return this.g.zoomer.setLeftOffset(n),this.g.selcol.reset([e])},search:function u(t){var e,u=new RegExp(t,"gi"),n=[],i=e=100042;return this.model.each(function(t){var e=t.get("seq");return function(){for(var o,s=[];o=u.exec(e);){var a=o.index,l={xStart:a,xEnd:a+o[0].length-1,seqId:t.get("id")};n.push(new r.possel(l)),s.push(i=Math.min(a,i))}return s}()}),this.g.selcol.reset(n),i===e&&(i=0),this.g.zoomer.setLeftOffset(i),this.sel=n}}));e["default"]=s},function(t,e,n){"use strict";function r(t){return t&&t.__esModule?t:{"default":t}}Object.defineProperty(e,"__esModule",{value:!0});var i=n(3),o=n(126),s=r(o),u=n(138),a=r(u),l=n(127),c=r(l),f=n(129),h=r(f),d=n(128),p=r(d),g=n(4),v=g.extend({initialize:function(t){return this.g=t.g,this.draw(),this.listenTo(this.g.stats,"reset",function(){return this.rerender()}),this.listenTo(this.model,"change:hidden",(0,i.debounce)(this.rerender,10)),this.listenTo(this.model,"sort",this.rerender),this.listenTo(this.model,"add",function(){return console.log("seq add")}),this.listenTo(this.g.vis,"change:sequences",this.rerender),this.listenTo(this.g.vis,"change:overviewbox",this.rerender),this.listenTo(this.g.visorder,"change",this.rerender),this.listenTo(this.g.zoomer,"change:columnWidth",this.rerender),this.listenTo(this.g.vis,"change:scaleslider",this.rerender),this},draw:function(){if(this.removeViews(),this.g.vis.get("overviewbox")){var t=new c["default"]({model:this.model,g:this.g});t.ordering=this.g.visorder.get("overviewBox"),this.addView("overviewBox",t)}var e=new a["default"]({model:this.model,g:this.g});e.ordering=this.g.visorder.get("headerBox"),this.addView("headerBox",e);var n=new h["default"]({model:this.model,g:this.g});n.ordering=this.g.visorder.get("searchBox"),this.addView("searchbox",n);var r=new s["default"]({model:this.model,g:this.g});if(r.ordering=this.g.visorder.get("alignmentBody"),this.addView("body",r),this.g.vis.get("scaleslider")){var i=new p["default"]({model:this.g.scale,g:this.g});i.ordering=this.g.visorder.get("scaleSlider"),this.addView("scaleSlider",i)}return this},render:function(t){return this.renderSubviews(),this.el.className="biojs_msa_stage",this},rerender:function(){if(!this.g.config.get("manualRendering"))return this.draw(),this.render()}});e["default"]=v},function(t,e,n){"use strict";function r(t,e){if(!(t instanceof e))throw new TypeError("Cannot call a class as a 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r.indexOf(n)>=0&&(0===i||r.indexOf(n-1)<0)?e._renderSelection({n:n,k:i,selection:r,mPrevSel:o,mNextSel:s,xZero:t.xZero,yZero:t.yZero,model:t.model}):void 0}())},c=0;0<a?c<=a:c>=a;0<a?c++:c--)l(c);return i}()}},_renderSelection:function(t){for(var e=t.xZero,n=t.yZero,r=t.n,i=t.k,o=t.selection,s=t.mPrevSel,u=t.mNextSel,a=0,l=t.model.get("seq").length-1,c=r;(r<l?c<=l:c>=l)&&o.indexOf(c)>=0;r<l?c++:c--)a++;var f=this.g.zoomer.get("columnWidth"),h=this.g.zoomer.get("rowHeight"),d=f*a+1,p=this.g.columns.get("hidden");this.ctx.beginPath();var g=this.ctx.lineWidth;this.ctx.lineWidth=3;var v=this.ctx.strokeStyle;this.ctx.strokeStyle="#FF0000",e+=i*f;for(var m=0,y=a-1,_=0;0<y?_<=y:_>=y;0<y?_++:_--){var b=r+_;p.indexOf(b)>=0||("undefined"!=typeof s&&null!==s&&s.indexOf(b)>=0||(this.ctx.moveTo(e+m,n),this.ctx.lineTo(m+f+e,n)),"undefined"!=typeof u&&null!==u&&u.indexOf(b)>=0||(this.ctx.moveTo(m+e,h+n),
this.ctx.lineTo(m+f+e,h+n)),m+=f)}return this.ctx.moveTo(e,n),this.ctx.lineTo(e,h+n),this.ctx.moveTo(e+d,n),this.ctx.lineTo(e+d,h+n),this.ctx.stroke(),this.ctx.strokeStyle=v,this.ctx.lineWidth=g},_getPrevNextSelection:function(t){var e=t.collection.prev(t),n=t.collection.next(t),r=void 0,i=void 0;return"undefined"!=typeof e&&null!==e&&(r=this._getSelection(e)),"undefined"!=typeof n&&null!==n&&(i=this._getSelection(n)),[r,i]}}),e["default"]=i},function(t,e,n){"use strict";function r(t){return t&&t.__esModule?t:{"default":t}}Object.defineProperty(e,"__esModule",{value:!0});var i=function(){function t(t,e){var n=[],r=!0,i=!1,o=void 0;try{for(var s,u=t[Symbol.iterator]();!(r=(s=u.next()).done)&&(n.push(s.value),!e||n.length!==e);r=!0);}catch(a){i=!0,o=a}finally{try{!r&&u["return"]&&u["return"]()}finally{if(i)throw o}}return n}return function(e,n){if(Array.isArray(e))return e;if(Symbol.iterator in Object(e))return t(e,n);throw new TypeError("Invalid attempt to destructure non-iterable 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e=Math.ceil(this.throttleTime/this.throttleCounts);return e*=1.2,e=Math.max(20,e),this.throttledDraw=_.throttle(this.draw,e)}},manageEvents:function(){var t={};return t.mousedown="_onmousedown",t.touchstart="_ontouchstart",this.g.config.get("registerMouseClicks")&&(t.dblclick="_onclick"),this.g.config.get("registerMouseHover")&&(t.mousein="_onmousein",t.mouseout="_onmouseout"),t.mousewheel="_onmousewheel",t.DOMMouseScroll="_onmousewheel",this.delegateEvents(t),this.listenTo(this.g.config,"change:registerMouseHover",this.manageEvents),this.listenTo(this.g.config,"change:registerMouseClick",this.manageEvents),this.dragStart=[]},_setColor:function(){return this.color=this.g.colorscheme.getSelectedScheme()},draw:function(){if(this.el.width=this.el.width,null!=this.seqDrawer&&this.model.length>0)return this.seqDrawer.drawLetters(),this.seqDrawer.drawRows(this.sel._appendSelection,this.sel),this.seqDrawer.drawRows(this.drawFeatures,this)},drawFeatures:function(t){var e=this,n=this.g.zoomer.get("columnWidth"),r=this.g.zoomer.get("rowHeight");if(t.model.attributes.height>1){var i=function(){var i=e.ctx;return t.model.attributes.features.each(function(e){i.fillStyle=e.attributes.fillColor||"red";var o=e.attributes.xEnd-e.attributes.xStart+1,s=(e.attributes.row+1)*r;return i.fillRect(e.attributes.xStart*n+t.xZero,s+t.yZero,n*o,r)}),i.fillStyle="black",i.font=e.g.zoomer.get("residueFont")+"px mono",i.textBaseline="middle",i.textAlign="center",{v:t.model.attributes.features.each(function(e){var o=e.attributes.xEnd-e.attributes.xStart+1,s=(e.attributes.row+1)*r;return i.fillText(e.attributes.text,t.xZero+e.attributes.xStart*n+o/2*n,t.yZero+.5*r+s)})}}();if("object"===("undefined"==typeof i?"undefined":o(i)))return i.v}},render:function(){return this.el.setAttribute("height",this.g.zoomer.get("alignmentHeight")+"px"),this.el.setAttribute("width",this.g.zoomer.getAlignmentWidth()+"px"),this.g.zoomer._checkScrolling(this._checkScrolling([this.g.zoomer.get("_alignmentScrollLeft"),this.g.zoomer.get("_alignmentScrollTop")]),{header:"canvasseq"}),this._setColor(),this.seqDrawer=new h["default"](this.g,this.ctx,this.model,{width:this.el.width,height:this.el.height,color:this.color,cache:this.cache}),this.throttledDraw(),this},_onmousemove:function(t,e){if(0!==this.dragStart.length){var n=v.abs(t),r=[n[0]-this.dragStart[0],n[1]-this.dragStart[1]],i=this.g.zoomer.get("canvasEventScale");e&&(i=3);for(var o=0;o<=1;o++)r[o]=r[o]*i;for(var s=[this.dragStartScroll[0]-r[0],this.dragStartScroll[1]-r[1]],u=0;u<=1;u++)s[u]=Math.round(s[u]);var a=this._checkScrolling(s);this.g.zoomer._checkScrolling(a,{origin:"canvasseq"});for(var l=0;l<=1;l++)a[l]!==s[l]&&(0===a[l]?(this.dragStart[l]=n[l],this.dragStartScroll[l]=0):this.dragStart[l]=n[l]-a[l]);return this.throttledDraw(),null!=t.preventDefault?(t.preventDefault(),t.stopPropagation()):void 0}},_ontouchmove:function(t){return this._onmousemove(t.changedTouches[0],!0),t.preventDefault(),t.stopPropagation()},_onmousedown:function(t){var e=this;return this.dragStart=v.abs(t),this.dragStartScroll=[this.g.zoomer.get("_alignmentScrollLeft"),this.g.zoomer.get("_alignmentScrollTop")],m(document.body).on("mousemove.overmove",function(t){return e._onmousemove(t)}),m(document.body).on("mouseup.overup",function(){return e._cleanup()}),t.preventDefault()},_ontouchstart:function(t){var e=this;return this.dragStart=v.abs(t.changedTouches[0]),this.dragStartScroll=[this.g.zoomer.get("_alignmentScrollLeft"),this.g.zoomer.get("_alignmentScrollTop")],m(document.body).on("touchmove.overtmove",function(t){return e._ontouchmove(t)}),m(document.body).on("touchend.overtend touchleave.overtleave touchcancel.overtcanel",function(t){return e._touchCleanup(t)})},_onmousewinout:function(t){if(t.toElement===document.body.parentNode)return this._cleanup()},_cleanup:function(){return this.dragStart=[],m(document.body).off(".overmove"),m(document.body).off(".overup"),m(document.body).off(".overout")},_touchCleanup:function(t){return t.changedTouches.length>0&&this._onmousemove(t.changedTouches[0],!0),this.dragStart=[],m(document.body).off(".overtmove"),m(document.body).off(".overtend"),m(document.body).off(".overtleave"),m(document.body).off(".overtcancel")},_onmousewheel:function(t){var e=v.wheelDelta(t);return this.g.zoomer.set("_alignmentScrollLeft",this.g.zoomer.get("_alignmentScrollLeft")+e[0]),this.g.zoomer.set("_alignmentScrollTop",this.g.zoomer.get("_alignmentScrollTop")+e[1]),t.preventDefault()},_onclick:function(t){var e=this._getClickPos(t);return"undefined"!=typeof e&&null!==e&&(null!=e.feature?this.g.trigger("feature:click",e):this.g.trigger("residue:click",e)),this.throttledDraw()},_onmousein:function(t){var e=this._getClickPos(t);return"undefined"!=typeof e&&null!==e&&(null!=e.feature?this.g.trigger("feature:mousein",e):this.g.trigger("residue:mousein",e)),this.throttledDraw()},_onmouseout:function(t){var e=this._getClickPos(t);return"undefined"!=typeof e&&null!==e&&(null!=e.feature?this.g.trigger("feature:mouseout",e):this.g.trigger("residue:mouseout",e)),this.throttledDraw()},_getClickPos:function(t){var e=v.rel(t);e[0]+=this.g.zoomer.get("_alignmentScrollLeft");var n=Math.floor(e[0]/this.g.zoomer.get("columnWidth")),r=this.seqDrawer._getSeqForYClick(e[1]),o=i(r,2),s=o[0],u=o[1];n+=this.g.columns.calcHiddenColumns(n),s+=this.model.calcHiddenSeqs(s),n=Math.max(0,n),s=Math.max(0,s);var a=this.model.at(s).get("id");if(!(u>0))return{seqId:a,rowPos:n,evt:t};var l=this.model.at(s).get("features").getFeatureOnRow(u-1,n);return 0!==l.length?{seqId:a,feature:l[0],rowPos:n,evt:t}:void 0},_checkScrolling:function(t){for(var e=[this.coordsCache.maxScrollWidth,this.coordsCache.maxScrollHeight],n=0;n<=1;n++)t[n]>e[n]&&(t[n]=e[n]),t[n]<0&&(t[n]=0);return t}});e["default"]=y},function(t,e,n){"use strict";Object.defineProperty(e,"__esModule",{value:!0});var r=function(){function t(t,e){var n=[],r=!0,i=!1,o=void 0;try{for(var s,u=t[Symbol.iterator]();!(r=(s=u.next()).done)&&(n.push(s.value),!e||n.length!==e);r=!0);}catch(a){i=!0,o=a}finally{try{!r&&u["return"]&&u["return"]()}finally{if(i)throw o}}return n}return function(e,n){if(Array.isArray(e))return e;if(Symbol.iterator in Object(e))return t(e,n);throw new TypeError("Invalid attempt to destructure non-iterable instance")}}(),i=n(3),o={updateConfig:function(){this.rectWidth=this.g.zoomer.get("columnWidth"),this.rectHeight=this.g.zoomer.get("rowHeight")},drawLetters:function(){return this.updateConfig(),this.ctx.globalAlpha=this.g.colorscheme.get("opacity"),this.drawSeqs(function(t){return this.drawSeq(t,this._drawRect)}),this.ctx.globalAlpha=1,this.rectWidth>=this.g.zoomer.get("minLetterDrawSize")&&this.drawSeqs(function(t){return this.drawSeq(t,this._drawLetter)}),this},drawSeqs:function(t,e){var n=this.g.columns.get("hidden");e=e||this;for(var i=this.getStartSeq(),o=r(i,2),s=o[0],u=o[1],a=s;a<this.model.length;a++){var l=this.model.at(a);if(!l.get("hidden")&&(t.call(e,{model:l,yPos:u,y:a,hidden:n}),u+=(l.attributes.height||1)*this.rectHeight,u>this.height))break}},drawRows:function(t,e){return this.drawSeqs(function(n){return this.drawRow(n,t,e)})},drawRow:function(t,e,n){var r=this.g.zoomer.get("columnWidth"),i=Math.max(0,Math.abs(Math.ceil(-this.g.zoomer.get("_alignmentScrollLeft")/r))),o=-Math.abs(-this.g.zoomer.get("_alignmentScrollLeft")%r),s=o-i*r,u=t.yPos;return e.call(n,{model:t.model,xZero:s,yZero:u,hidden:t.hidden})},getStartSeq:function(){for(var t=Math.max(0,Math.floor(this.g.zoomer.get("_alignmentScrollTop")/this.rectHeight))+1,e=0,n=0;e<t&&n<this.model.length;)e+=this.model.at(n).attributes.height||1,n++;return[n-1,-Math.max(0,this.g.zoomer.get("_alignmentScrollTop")-e*this.rectHeight+(this.model.at(n-1).attributes.height||1)*this.rectHeight)]},_getSeqForYClick:function(t){for(var e=this.getStartSeq(),n=r(e,2),i=n[0],o=n[1],s=o%this.rectHeight,u=Math.max(0,Math.floor((t-s)/this.rectHeight))+1,a=0,l=i;a<u&&l<this.model.length;)a+=this.model.at(l).attributes.height||1,l++;return[l-1,Math.max(0,Math.floor(t/this.rectHeight)-a+(this.model.at(l-1).get("height")||1))]},drawSeq:function(t,e){for(var n=t.model.get("seq"),r=t.yPos,i=this.rectWidth,o=this.rectHeight,s=Math.max(0,Math.abs(Math.ceil(-this.g.zoomer.get("_alignmentScrollLeft")/i))),u=-Math.abs(-this.g.zoomer.get("_alignmentScrollLeft")%i),a={rectWidth:i,rectHeight:o,yPos:r,y:t.y},l=this.width,c=s;c<n.length;c++){var f=n[c];if(f=f.toUpperCase(),a.x=c,a.c=f,a.xPos=u,t.hidden.indexOf(c)<0&&(e(this,a),u+=i,u>l))break}},_drawRect:function(t,e){var n=t.color.getColor(e.c,{pos:e.x,y:e.y});if("undefined"!=typeof n&&null!==n)return t.ctx.fillStyle=n,t.ctx.fillRect(e.xPos,e.yPos,e.rectWidth,e.rectHeight)},_drawLetter:function(t,e){return t.ctx.drawImage(t.cache.getFontTile(e.c,e.rectWidth,e.rectHeight),e.xPos,e.yPos,e.rectWidth,e.rectHeight)}},s=function(t,e,n,r){return this.g=t,this.ctx=e,this.model=n,this.width=r.width,this.height=r.height,this.color=r.color,this.cache=r.cache,this.rectHeight=this.g.zoomer.get("rowHeight"),this.rectWidth=this.g.zoomer.get("columnWidth"),this};(0,i.extend)(s.prototype,o),e["default"]=s},function(t,e,n){"use strict";function r(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&(e[n]=t[n]);return e["default"]=t,e}Object.defineProperty(e,"__esModule",{value:!0});var i="function"==typeof Symbol&&"symbol"==typeof 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u=(this.rectData,this.colorer(this.fillColor)),l=this.colorer(this.strokeColor),c=this.rectStyler,f=this.g.zoomer.get("stepSize"),h=this.g.columns.get("hidden"),d=0,p=0;p<e;)if(h.indexOf(p)>=0)p+=f;else{i=n*f;for(var g=0,v=f-1,m=0;0<v?m<=v:m>=v;0<v?m++:m--)g+=t[p];var y=r*(g/f),_={x:d,y:r-y,maxheight:r,width:i-n/4,height:y,rowPos:p},b=s.rect(_);b.style.stroke=l(_),b.style.fill=u(_),"function"==typeof c&&c(b,_),b.rowPos=p,o.appendChild(b),d+=i,p+=f}return this.el.appendChild(o),this},_onclick:function(t){var e=this,n=t.target.rowPos,r=this.g.zoomer.get("stepSize");return function(){for(var i=[],o=r-1,s=0;0<o?s<=o:s>=o;0<o?s++:s--)i.push(e.g.trigger("bar:click",{rowPos:n+s,evt:t}));return i}()},manageEvents:function(){var t={};return this.g.config.get("registerMouseClicks")&&(t.click="_onclick"),this.g.config.get("registerMouseHover")&&(t.mousein="_onmousein",t.mouseout="_onmouseout"),this.delegateEvents(t),this.listenTo(this.g.config,"change:registerMouseHover",this.manageEvents),this.listenTo(this.g.config,"change:registerMouseClick",this.manageEvents)},_onmousein:function(t){var e=this.g.zoomer.get("stepSize"*t.rowPos);return this.g.trigger("bar:mousein",{rowPos:e,evt:t})},_onmouseout:function(t){var e=this.g.zoomer.get("stepSize"*t.rowPos);return this.g.trigger("bar:mouseout",{rowPos:e,evt:t})}});e["default"]=l},function(t,e,n){"use strict";function r(t){if(t&&t.__esModule)return t;var e={};if(null!=t)for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&(e[n]=t[n]);return e["default"]=t,e}Object.defineProperty(e,"__esModule",{value:!0});var i=n(12),o=r(i),s=n(2),u=n(7),a=s.extend({className:"biojs_msa_gapview",initialize:function(t){return this.g=t.g,this.listenTo(this.g.zoomer,"change:stepSize 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i=[],o=r-1,s=0;0<o?s<=o:s>=o;0<o?s++:s--)i.push(e.g.trigger("gap:click",{rowPos:n+s,evt:t}));return i}()},manageEvents:function(){var t={};return this.g.config.get("registerMouseClicks")&&(t.click="_onclick"),this.g.config.get("registerMouseHover")&&(t.mousein="_onmousein",t.mouseout="_onmouseout"),this.delegateEvents(t),this.listenTo(this.g.config,"change:registerMouseHover",this.manageEvents),this.listenTo(this.g.config,"change:registerMouseClick",this.manageEvents)},_onmousein:function(t){var e=this.g.zoomer.get("stepSize"*t.rowPos);return this.g.trigger("gap:mousein",{rowPos:e,evt:t})},_onmouseout:function(t){var e=this.g.zoomer.get("stepSize"*t.rowPos);return this.g.trigger("gap:mouseout",{rowPos:e,evt:t})}});e["default"]=a},function(t,e,n){"use strict";function r(t){return t&&t.__esModule?t:{"default":t}}Object.defineProperty(e,"__esModule",{value:!0});var i=n(139),o=r(i),s=n(141),u=r(s),a=n(4),l=a.extend({initialize:function(t){var e=this;return 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