ACTEIN
I14QO4LW9V
Molecular Formula C37H56O11
Defined Stereocenters 19 / 19
C[C@]1([H])C[C@@]2([C@@]3([H])[C@@](C)([C@@]([H])(O)O2)O3)O[C@@]4([H])C[C@@]5(C)[C@]6([H])CC[C@@]7([H])C(C)(C)[C@]([H])(CC[C@]87C[C@@]68C[C@]([H])([C@]5(C)[C@@]14[H])OC(=O)C)O[C@@]9([H])[C@@]([H])([C@]([H])([C@@]([H])(CO9)O)O)O
InChIKey=NEWMWGLPJQHSSQ-PSDKAYTQSA-N
InChI=1S/C37H56O11/c1-17-12-37(29-34(7,47-29)30(42)48-37)46-20-13-32(5)22-9-8-21-31(3,4)23(45-28-27(41)26(40)19(39)15-43-28)10-11-35(21)16-36(22,35)14-24(44-18(2)38)33(32,6)25(17)20/h17,19-30,39-42H,8-16H2,1-7H3/t17-,19-,20+,21+,22+,23+,24-,25+,26+,27-,28+,29-,30+,32+,33-,34+,35-,36+,37-/m1/s1
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27483235 | https://www.ncbi.nlm.nih.gov/pubmed/18755149 | https://www.ncbi.nlm.nih.gov/pubmed/28128733
Actein is tetracyclic triterpenoid compound isolated from the rhizome of Cimicifuga foetida L. In North America, the cimicifuga species had a long medicinal history, mainly used to treat diarrhea, sore throat, and rheumatism. Actein inhibits the activity of the Na,K-ATPase, which affects calcium metabolism. The primary target of actein may relate to calcium metabolism since this agent altered the expression of several genes related to calcium. Although actein was shown to exhibit other pathological functions, such as prevention of oxidative damage to osteoblast and regulation of lipid disorder, the major role of actein is played on its anticancer activity, particularly in breast cancer.
Linde, H.
Sources: DOI: 10.1002/ardp.19683010206
Target ID: WP254
Sources: https://www.ncbi.nlm.nih.gov/pubmed/28128733
Target ID: Release of calcium into the cytoplasm
Sodium/potassium-transporting ATPase
Target ID: CHEMBL2095186
11.2 µM [IC50]
Highest Phase
[Actein, a fluid extract from Actaea racemosa, in the medical therapy of peripheral arteriopathies].
Actein inhibits the Na+-K+-ATPase and enhances the growth inhibitory effect of digitoxin on human breast cancer cells.
New potential beneficial effects of actein, a triterpene glycoside isolated from Cimicifuga species, in breast cancer treatment.
Actein alleviates 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated cellular dysfunction in osteoblastic MC3T3-E1 cells.
US20120034217 A1
Sample Use Guides
In Vivo Use Guide
Mouse: 10-15 mg/kg for 28 days
In Vitro Use Guide
MC3T3-E1 osteoblastic cells were pretreated with actein (0.01–1 uM) for 1 h and then exposed to 100 nM 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for 48 h. Cell viability was again measured using the water-soluble tetrazolium (WST) assay. Actein-pretreated cells had increased viability compared to those treated with TCDD only, in a concentration-dependent manner. The TCDD-induced increased apoptosis was also restored to a level similar to that in the control group by pretreatment with 1 uM actein. Pretreatment with actein also prevented TCDD-induced autophagic activity in a concentration-dependent manner. Taking these findings together, pretreatment with actein protected MC3T3-E1 osteoblastic cells from TCDD-induced apoptosis
USP-RS
26S-ACTEIN
ACTEIN [USP-RS]
26S-ACTEIN (CONSTITUENT OF BLACK COHOSH) [DSC]
ACTEIN, (-)-
SHENGMATING
ACTEIN [WHO-DD]
.BETA.-D-XYLOPYRANOSIDE, (3.BETA.,12.BETA.,16.BETA.,23R,24R,25S,26S)-12-(ACETYLOXY)-16,23:23,26:24,25-TRIEPOXY-26-HYDROXY-9,19-CYCLOLANOSTAN-3-YL
USP_CATALOG
PRIMARY USP-RS
K73E24S6X9