NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN
Reaction [transition]
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Homo sapiens)
SBML |
BioPAX
Level 2 Level 3
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SVG |
| PPTX | SBGN
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Several ubiquitin ligases, including NEDD4 (Wang et al. 2007), STUB1 (CHIP) (Ahmed et al. 2012), WWP2 (Maddika et al. 2011) and XIAP (Van Themsche et al. 2009) can polyubiquitinate PTEN, targeting it for degradation.
21532586 WWP2 is an E3 ubiquitin ligase for PTEN
Maddika, S, Kavela, S, Rani, N, Palicharla, VR, Pokorny, JL, Sarkaria, JN, Chen, J
Nat. Cell Biol. 2011
19473982 X-linked inhibitor of apoptosis protein (XIAP) regulates PTEN ubiquitination, content, and compartmentalization
Van Themsche, C, Leblanc, V, Parent, S, Asselin, E
J. Biol. Chem. 2009
22427670 The chaperone-assisted E3 ligase C terminus of Hsc70-interacting protein (CHIP) targets PTEN for proteasomal degradation
Ahmed, SF, Deb, S, Paul, I, Chatterjee, A, Mandal, T, Chatterjee, U, Ghosh, MK
17218260 NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
Wang, X, Trotman, LC, Koppie, T, Alimonti, A, Chen, Z, Gao, Z, Wang, J, Erdjument-Bromage, H, Tempst, P, Cordon-Cardo, C, Pandolfi, PP, Jiang, X
Cell 2007
PTEN [cytosol] (Homo sapiens)
3 x Ub [cytosol] (Homo sapiens)
PolyUb-PTEN [cytosol] (Homo sapiens)
Regulation of PTEN stability and activity
Catalyst Activity
ubiquitin protein ligase activity of NEDD4,STUB1,WWP2 and XIAP [cytosol]
Physical Entity
NEDD4,STUB1,WWP2 and XIAP [cytosol]
ubiquitin protein ligase activity (0061630)
Orthologous Events
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Bos taurus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Caenorhabditis elegans)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Canis familiaris)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Danio rerio)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Dictyostelium discoideum)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Drosophila melanogaster)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Gallus gallus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Mus musculus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Rattus norvegicus)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Sus scrofa)
NEDD4, WWP2, CHIP and XIAP polyubiquitinate PTEN (Xenopus tropicalis)
Orlic-Milacic, M (2015-10-29)
Leslie, N (2016-09-30)
Kriplani, N (2016-09-30)
Carracedo, A (2016-08-11)
Salmena, L (2016-08-11)