A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice
Jacqueline Crawley, Richard Paylor
Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavioral paradigms, clustered by category. Included are multiple paradigms for each category, including learning and memory, feeding, analgesia, aggression, anxiety, depression, schizophrenia, and drug abuse models. Examples are given from the experiences of the authors, in applying these experimental designs to transgenic and knockout mice. Extensive references for each behavioral paradigm are provided, to allow new investigators to access the relevant literature on behavioral methodology.
Hormones and Behavior
https://doi.org/10.1006/hbeh.1997.1382
Psychology(all)
Crawley, J., & Paylor, R. (1997). A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Hormones and Behavior, 31(3), 197-211. https://doi.org/10.1006/hbeh.1997.1382
A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. / Crawley, Jacqueline; Paylor, Richard.
In: Hormones and Behavior, Vol. 31, No. 3, 06.1997, p. 197-211.
Crawley, J & Paylor, R 1997, 'A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice', Hormones and Behavior, vol. 31, no. 3, pp. 197-211. https://doi.org/10.1006/hbeh.1997.1382
Crawley J, Paylor R. A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. Hormones and Behavior. 1997 Jun;31(3):197-211. https://doi.org/10.1006/hbeh.1997.1382
Crawley, Jacqueline ; Paylor, Richard. / A proposed test battery and constellations of specific behavioral paradigms to investigate the behavioral phenotypes of transgenic and knockout mice. In: Hormones and Behavior. 1997 ; Vol. 31, No. 3. pp. 197-211.
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