The High Salt Precipitation Solution is used in the TRI Reagent® procedure to isolate RNA from samples containing large amounts of polysaccharides and/or proteoglycans. This molecular biology grade reagent contains sodium chloride and sodium citrate.
Chomczynski, P. and Mackey, K. Modification of the TRI Reagent procedure for isolation of RNA from polysaccharide- and proteoglycan-rich sources. BioTechniques. 19: 492-495. 1995.