Honorary Editor-in-Chief
Early View
Diabetes and Endocrinology (DE) ISSN: 2639-8176 (Online)
Yoshifumi Saisho(Editor-in-Chief)
DOI:10.24983/scitemed.de
The Diabetes and Endocrinology (DE) Journal is dedicated to providing global, authoritative, and independent forum for high impact clinical research and opinion. This journal covers all visible and underlying facts about endocrinology, diabetes, metabolism, obesity, osteoporosis, and bone metabolism. Details and other specifics about thyroid, lipid and adrenal disorders are likewise reviewed and discussed.
The journal's main objective is to publish contents that have a high-impact on medical practice, which can influence its better performance and outcome. Relatively, the scope of the journal is to deliver essential research, expert review, and candid commentaries that would provide the proper context and perspective on significant advances that shape these fields.
To properly ensure the clinical relevance and scientific merit of the diabetes and endocrinology journal, meticulous steps are taken to stringently edit its diverse contents and are peer reviewed on a regular basis.
Yoshifumi Saisho, MD, PhD
Professor Saisho received his medical degree in 1998 and his PhD degree in 2009, both from the Keio University School of Medicine in Tokyo. Before obtaining his current position as assistant professor, Dr. Saisho completed a three-year postdoctoral fellowship at the Larry L. Hillblom Islet Research Center at the University of California-Los Angeles's David Geffen School of Medicine (Prof. Peter C. Butler). Dr. Saisho has served as chief resident in the Department of Internal Medicine at Shizuoka City Shimizu Hospital in Shizuoka and at Hiratsuka Municipal Hospital in Hiratsuka, Japan and was also a clinical fellow in the Division of Nephrology, Endocrinology and Metabolism at Keio University School of Medicine's Department of Internal Medicine. Dr. Saisho is the author or coauthor of more than 60 publications. He is a member of the Fellows' Association of the Japanese Society of Internal Medicine, the Fellows' Association of the Japan Diabetes Society, the Japan Endocrine Society, and the Japan Atherosclerosis Society. Dr. Saisho's area of interest is Diabetology, especially beta cell dysfunction in diabetes.
Yoshifumi Saisho, M.D., Ph.D.
Division of Nephrology, Endocrinology & Metabolism
Department of Internal Medicine
Keio University School of Medicine, Tokyo, Japan
Sangeeta Dhawan, PhD
Assistant Professor, Department of Translational Research and Cellular Therapeutics
Diabetes and Metabolism Research Institute
Dr. Sangeeta Dhawan received her Ph.D. in Molecular and Developmental Biology from Indian Institute of Science, Bangalore, India, where she studied the developmental biology. She did her postdoctoral training at Harvard Medical School and UCLA. Her training at UCLA focused on understanding the mechanisms of beta cell mass regulation. This work was supported by an advanced postdoctoral fellowship from JDRF. She is also a recipient of the Start-up Award and the Smookler Award for Diabetes Research from the Larry L. Hillblom Foundation, as well as a Transition Award from JDRF. She has served as a reviewer for journals such as Diabetes. Research in Dhawan laboratory focuses on understanding the epigenetic and cellular signaling pathways that regulate the formation, function, regeneration and survival of pancreatic beta cells during development, and under circumstances that warrant the repair/regeneration of beta cells.
Noboru Fukuda, MD, PhD
Professor, Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine
Nihon University Research Center
Dr. Noboru Fukuda earned his MD degree in 1981 and earned PhD degree from Nihon University School of Medicine. From 2009 to present, he is working as a Professor in Division of Nephrology Hypertension and Endocrinology, Department of Medicine, Nihon University School of Medicine. From 2009 to present, He is also Professor in Division of Cell Regeneration and Transplantation, Department of Functional Morphology, Nihon University School of Medicine. He has performed researches in fields of the Nephrology, Hypertension and Endocrinology. He performed clarification of pathogenesis of cardiovascular and renal diseases. He recently established that complement 3 is involved in the activation of tissue renin-angiotensin systems by dedifferentiation of mesenchymal tissues and mesenchymal transformation from epithelial cells to induce organ fibrosis and sclerosis. He has developed novel gene silencer pyrrole-imidazole (PI) polyamides based on the chemical biology for renal diseases and cancers, and are performing the practical study for PI polyamides targeting human TGF-1 as practical medicines using non human primate. He also has developed the regenerative medicines. He found the immunosuppressive effects and tissue repair effects of the differential fat cells. Moreover, he has established the conservative regenerative medicines with antioxidative medicines and foods to prolong life span of progenitor cells and stem cells.
Tomoyasu Fukui, MD, PhD
Department of Medicine, Division of Diabetes, Metabolism and Endocrinology
Showa University School of Medicine
Dr. Tomoyasu Fukui graduated from Showa University School of Medicine in Japan in March 2000. He is currently an assistant professor at the Department of Diabetes, Metabolism and Endocrinology, Showa University Hospital, Japan. His main research theme is the elucidation of type 1 diabetes pathogenesis, especially in slowly progressive type 1 diabetes. Dr. Tomoyasu Fukui is a member of the Japan Diabetes Society, the Japan Endocrine Society, the Japanese Society of Internal Medicine, and Asian Association for the Study of Diabetes. Dr. Tomoyasu Fukui is an investigative research associate for the research of origins, diagnosis, pathology and treatment of type 1 diabetes in Japanese. He is a part-time researcher at Okinaka Memorial Institute for Medical Research since April 2015. His research focuses on the pathogenesis of type 1 diabetes with Professor Kobayashi Testsuro.
Yoshiaki Kido, PhD
Professor, Department of Biophysics
Kobe University Graduate School of Health Sciences
Dr. Yoshiaki Kido is a professor at Division of Metabolism and Disease, Department of Biophysics, Kobe University Graduate School of Health Sciences, Japan. Dr. Yoshiaki Kido earned a Ph.D. in molecular biology from Kobe University, Japan (Prof. Masato Kasuga), and did a postdoctoral fellow in the laboratory of Prof. Domenico Accili at NIH, MD, and Columbia University, NY, United States, to elucidate the molecular mechanisms of the onset of Diabetes. Then, Dr. Yoshiaki Kido worked on the project to clarify the regulation mechanism of pancreatic β cell mass as an assistant professor at Kobe University, Japan. Dr. Yoshiaki Kido was appointed professor of Kobe University Graduate School of Health Sciences, Japan from 2010. Currently, His main research theme is the elucidation of the regulation mechanism of pancreaticβ cell mass from aspect such as insulin signaling pathway, endoplasmic reticulum stress, disease susceptibility genes, epigenetics, drug action and so on. Dr. Yoshiaki Kido is a member of the Japan Diabetes Society, the Japan Endocrine Society, the Japanese Society of Internal Medicine, Japan Society of Metabolism and Clinical Nutrition, the Molecular Biology Society of Japan, American Diabetes Association, European Association for the Study of Diabetes, and Asian Association for the Study of Diabetes.
Taiyi Kuo, PhD
Department of Medicine Endocrinology
Dr. Taiyi Kuo received her PhD in Endocrinology and Metabolic Biology from University of California, Berkeley. She gained a solid background in studying transcriptional regulation by glucocorticoid receptor during her graduate studies at UC Berkeley. Dr. Taiyi Kuo co-authored 9 papers, including 4 first-author research articles, 2 review articles and a book chapter. She was a recipient of Tobacco-Related Disease Research Program Dissertation Award, and got Endocrine Society Meeting scholarship. Dr. Taiyi Kuo joined Prof. Domenico Accili's laboratory at the Columbia University Diabetes Research Center to study pancreatic beta cell dedifferentiation and diabetes. Identification of circulating biomarker that correlates with beta cell function is essential to monitor the progression of diabetes. She is investigating the epigenomic landscape of stressed pancreatic beta cell lacking transcription factor FoxO1, as these beta cells show dedifferentiation and diabetic phenotype.
Beatriz Tavira Iglesias, PhD
Division of Pediatrics, Department of Clinical and Experimental Medicine
Linköping University
Beatriz Tavira received her Bachelors degree in Biology and Ph.D in Genetics from the University of Oviedo. She started to work in science as research assistant at the Department of Molecular Genetics of Hospital Universitario Central of Asturias in 2008. In 2011 she did a predoctoral fellowship from the Government of Asturias "Severo Ochoa Ph.D program" to perform her pre-doctoral studies in pharmacogenetics, kidney transplantation and type 2 diabetes risk at Hospital Universitario Central of Asturias. In 2012, she spent 3 months at Mayo Clinic (Rochester, Minnesota, USA) at Department of Nephrology and Hypertension. She has been working in Sweden at University of Linköping from 2015, focus on the immunology of type 1 diabetes in patients participating in on-going clinical trials. She had high quality experienced in Molecular Genetics, Immunology, Clinical Trials and Translational Medicine. She has participated in several European Conferences: Pharmacogenetics Spanish Society (2010-2011), American Society of Nephrology (2012), The European Society of Human Genetics (2013-2014), Annual Meeting of the Scandinavian Society for the Study of Diabetes (2016). She has got more than 22 publications in different research areas as pharmacogenetics, kidney transplantation, type 1 and type 2 diabetes.
Giuseppe Mancia, MD, PhD
Professor, Department of Internal Medicine
University Milano-Bicocca
Giuseppe Mancia is the Professor Emeritus at the University Milano-Bicocca, after being for 20 years Chairman of the Division and Department of Internal Medicine at the same University at the San Gerardo Hospital in Monza and Director of the Interuniversity (Universities of Milano, Milano-Bicocca and Pavia) Center for Clinical Physiology and Hypertension. He has been Chairman (2001, 2003, 2005, 2007, 2009, 2011 and 2013) of the Scientific and Organizing Committee of ESH meetings, and past President of the ISH, ESH, European Society of Clinical Investigation and Italian Society of Hypertension. He has chaired the Task Force of the ESH/ESC Hypertension Guidelines in 2003, 2007, 2009 and 2013. He is currently Chairman of the ESH Foundation and the Hypertension Center, Policlinico of Monza. He is honorary member of several hypertension and cardiovascular societies and has received many Awards, including the Heymans Award of the International Society of Pharmacology, the Volhard and Tigersted. Awards of the ISH, the Folkow Award of the ESH, the International Recordati Prize, the Invernizzi Price of Medicine, the Spinoza Honorary Professorship of the University of Amsterdam, the Gold Medal of the Lorenzini Foundation, the Honorary Professorship of the University of Cordoba, a Honoris Causa Doctorate in Medicine from the University of Gdansk, Bucharest (Carol Davila) and Glasgow, the Hariri Memorial Lecture and Award and the Mac Donald Award of the McMaster University (Hamilton). Professor Mancia's research focuses on the epidemiology, pathophysiology, diagnosis and treatment of hypertension, heart failure, coronary and other cardiovascular diseases. He is interested in ambulatory blood pressure monitoring, neural control of the circulation, large artery mechanics, hemodynamic of cardiovascular drugs, and clinical trials. He has edited several books on hypertension and cardiovascular diseases, and has published over 1.800 papers in international Journals. His papers have received more than 117.000 citations (H-index 148), for which he is in the Thompson Reuters list of the world highly cited scientists.
Aleksey Matveyenko, PhD
Department of Physiology and Biomedical Engineering
Mayo Clinic School of Medicine
The work in the laboratory of Aleksey Matveyenko, Ph.D., is focused on understanding physiological and molecular mechanisms underlying the decline in beta cell function and mass in patients with diabetes. To accomplish these research goals, the laboratory uses an integrative approach ranging from cellular and molecular level studies in vitro to translational studies in vivo. The underlying goals of the research program are to develop novel therapeutic and preventive approaches to attenuate beta cell dysfunction and loss in patients with diabetes.
Lixin Na, PhD
Assistant Director, Department of Nutrition and Food Hygiene
Public Health College, Harbin Medical University
Dr. Lixin Na is a Research Scientist at Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, China. Dr. Lixin Na earned a Ph.D. in Nutrition and Food Hygiene from Harbin Medical University, China (Prof. Changhao Sun). She did a postdoctoral fellow in the Nutritional Immunology Laboratory, the USDA Jean Mayer Human Nutrition Research Center on Aging, USA, to study the anti-influenza effects of mushroom and wolfberry. Then, Dr. Lixin Na worked on the project to clarify the association of diet and nutrition with risk of obesity and type 2 diabetes through chohort study at Harbin Medical University, China. By focusing on the pathophysiological roles of dietary fatty acids and minerals on insulin resistance, Dr. Lixin Na currently conducting basic research to elucidate the mechanisms underlying the onset and progression of obesity and type 2 diabetes induced by malnutrion, thereby providing the novel predicting markers or preventive strategies for obesity and type 2 daibetes. Dr. Lixin Na also works on characterizing the effects of anti-diabetic phytochemicals, thereby finding out the novel beneficial effects of these phytochemicals. Dr. Lixin Na is a member of the Basic Nutrition Branch of Chinese Nutrition Society, the Public Heath Branch of Chinese Medical Association.
Akinobu Nakamura
Assistant Professor, Department of Rheumatology, Endocrinology and Nephrology
Hokkaido University Graduate School of Medicine
Dr. Akinobu Nakamura is an Assistant Professor at Department of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. Dr. Akinobu Nakamura earned a Ph.D. from Hokkaido University, Japan. Then, Dr. Akinobu Nakamura worked on the project to the effect of glucokinase on glucose metabolism, beta cell function and mass as an assistant professor at Yokohama City University, Japan (Prof. Yasuo Terauchi). By focusing on the pathophysiology and therapeutic research of type 2 diabetes, Dr. Akinobu Nakamura is currently interested in basic and clinical research about pathophysiology of type 2 diabetes such as insulin secretion and insulin resistance, and clinical trials about oral hypoglycemic agents. Dr. Akinobu Nakamura is a member of European Association for the Study of Diabetes, The Asian Association for the Study of Diabetes, The Japanese Society of Internal Medicine, Japan Diabetes Society, The Japan Endocrine Society, Japan Society for Metabolism and Clinical Nutrition, Japan Society for the Study of Obesity, The Japan Society of Experimental Diabetes and Obesity, and The Japan Society of Molecular Medicine.
Costes Safia, MD, PhD
Institute for Functional Genomics
Dr. Safia Costes received her PhD degree in Endocrinology in 2007 from the University of Montpellier, France. Before obtaining her current position as a tenured researcher, Dr. Costes completed a five-year postdoctoral fellowship (2008-2012) followed by a two-year position as an assistant researcher (2012-2014) at the Larry L. Hillblom Islet Research Center at the University of California - Los Angeles's David Geffen School of Medicine (Prof. Peter C. Butler). Since 2015, she has been recruited as a researcher by the National Institute of Health and Medical Research in Montpellier (France), focusing her research on the physiopathology of pancreatic beta-cells. Dr. Costes is the author or coauthor of more than 30 publications in different research areas such as diabetes, cell death, autophagy, signaling pathways. She is a member of the French Diabetes Society and the European Association for the Study of Diabetes. Dr. Costes's main area of interest is pancreatic beta-cell dysfunction and apoptosis in type 2 diabetes.
Masaya Sakamoto, MD, PhD
Associate Professor, Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine
Jikei University School of Medicine
Masaya Sakamoto MD, PhD is currently working as an Associate Professor, Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. Before joining to Jikei University, He was a guest investigator of Department of Cardiovascular Medicine at the University of Tokyo Graduate School of Medicine and Guest investigator of Department of Cardiovascular Medicine at the University of Chiba Graduate School of Medicine. He is specialized in cardiomyopathy in Diabetic model in basic research and also in clinical research type 2 diabetic patients with hypertension. He is a member of The Japan Diabetes Society (specialist, supervisory doctor), the Japanese society of hypertension (specialist),the Japan Endocrine Society (specialist, supervisory doctor),the Japan Atherosclerosis Society and the Japanese Society of Diabetes and Pregnancy.
Moklesur Rahman Sarker, PhD
Head of Academic and Research Affairs, Department of Pharmacy
Bangladesh (বাংলাদেশ)
Professor Moklesur Rahman Sarker is the Head of Academic and Research Affairs of the Department of Pharmacy in the State University of Bangladesh. Before joining to State University, he served as Associate Professor and Head of Pharmacology Department, Faculty of Pharmacy, Lincoln University College Malaysia where he significantly contributed as the Coordinator for Post-Graduate Program of Pharmacy Faculty, Chairman of Animal Ethics Committee, and Head of Animal Experiment Facility of the university. Prof. Moklesur obtained his PhD degree in Pharmaceutical Sciences from Okayama University, Japan in 2010. During his 17 years outstanding career in different academic and research institutions he holds the position of head of the Pharmacy department, head of research division, lead several research projects as the Principal Investigator.
Masashi Tanaka, PhD
Department of Physical Therapy
Health Science University
Dr. Masashi Tanaka earned a Ph.D. in molecular genetics from Tohoku University, Japan. Dr. Tanaka did a postdoctoral fellow in the laboratory of Prof. John R. Battista at Louisiana State University, LA, United States, to elucidate the molecular mechanisms of DNA repair and mutagenesis. Dr. Masashi Tanaka then worked on the project to clarify the pathophysiological roles of inflammatory immune cells in autoimmune diseases as an assistant professor at Kagoshima University, Japan. Dr. Masashi Tanaka then worked as a Research Scientist at National Center for Global Health and Medicine, Japan, and at National Hospital Organization Kyoto Medical Center, Japan. By focusing on the pathophysiological roles of inflammatory immune cells, Dr. Masashi Tanaka is currently conducting basic and clinical research to elucidate the mechanisms that is underlying the onset and progression of diabetic/obese complications including cardiovascular diseases and cognitive dysfunction, thereby leading to the development of the novel predicting markers and therapeutic strategies for these complications. Dr. Masashi Tanaka is also working on characterizing the effects of antidiabetic medications, thereby finding out the novel pleiotropic beneficial effects of these medications. Dr. Masashi Tanaka is a member of the Japan Endocrine Society, the Japan Society for the Study of Obesity, the Japan Atherosclerosis Society, the Japanese Society of Anti-Aging Medicine, the Japanese Society for Immunology, and the Japanese Radiation Research Society.
David Viola, MD
Department of Clinical and Experimental Medicine
University of Pisa
Dr. David Viola is a MD researcher at the Endocrinology Unit of the Department of Clinical and Experimental Medicine, University of Pisa. He obtained Doctor of Medicine Degree from University of Pisa. Dr. Viola specializes in Endocrinology, he completed his clinical training as an assistant to Prof. Aldo Pinchera (former President of several European and Italian Scientific Societies) and Prof. Rossella Elisei, he received fundamental science research training at the Biomedical Research Center "Alberto Sols", of the Spanish Superior Scientific Research Council Center (CSIC) and the Autonomous University of Madrid (UAM) with Prof. Pilar Santisteban now President of the European Thyroid Association. His main field of research is thyroid cancer (papillary, follicular, medullary, poorly differentiated and anaplatic thyroid carcinoma) from early diagnosis to the treatment of advanced metastatic patients with tyrosine kinase inhibitors also in the context of clinical trials.
Qingtong Wang, MD, PhD
Associate Professor, Department of Clinical Pharmacology
Anhui Medical University
Professor Wang's research focuses on signaling integration of a converged network of insulin receptor and adrenergic receptors, and their roles in different clinical conditions including diabetes and cardiovascular complication respectively. Prof. Wang and her team apply an arsenal of advanced approaches ranging from single molecular study and live cell imaging to in vivo manipulation and patient's sample examination to understand physiology and pathophysiological roles of the receptors, and their implication in drug discovery and clinical therapy. She also works on anti-inflammatory and immunopharmacology and has extensively characterized the pathological mechanism of rheumatoid arthritis and the pharmacological action of antirheumatic drugs.
Relationship Between Islet Autoantibodies and Pancreatic Volume in Type 1 Diabetes in Japanese Population
Ayako FukaseTomoyasu FukuiYusaku MoriHiroe NagaikeSatoshi GotoToshiyuki HayashiTakeshi YamamotoMakoto OharaHiroto SasamoriTsutomu Hirano
A higher titer of IA-2Ab reflects a reduced pancreatic size in the patients with Type 1 diabetes (T1D), especially in those with the acute-onset form of the disease. The potential mechanisms underlying the reduced pancreatic size might differ between acute-onset T1D and slowly progressive insulin-dependent diabetes mellitus. The authors investigated the relationship between islet autoimmunity and pancreatic size in the Japanese patients with T1D.
Diabetes and Endocrinology. 2019;2(1):1
DOI: 10.24983/scitemed.de.2019.00101
Article Type: Original Article
From Bench to Bedside as well as to "The Society": An Open Discussion is Critical for Progress of Medicine
Yoshifumi Saisho
The purpose of Diabetes and Endocrinology is to provide an opportunity to discuss among the researchers for a better understanding of diabetes and endocrinology. Open discussion is critical for the progress of medicine. We accept a broad range of manuscripts including original article, review, editorial, commentary, opinion and perspective regarding any aspects of diabetes and endocrinology, both basic as well as clinical studies.
Article Type: Editorial
Changing Our Concept of Type 2 Diabetes
A paradigm shift in type 2 diabetes may contribute to the reinforcement of new research questions and further improvement of diabetes care in clinical practice.
Effect of Hemoglobin Levels and Sex on HbA1c Levels among Japanese Population
Tomoko NakagamiJunko OyaTadasu KasaharaYasuko Uchigata
HbA1c levels decreased with increasing Hb levels, independent of age, sex, BMI, FPG, and smoking and alcohol habits in Japanese men and women without diabetes or anemia. There was an interaction between sex and hemoglobin in the effects on HbA1c. The interpretation of HbA1c values should be cautious in the screening of glucose intolerance.
Efficiency and Safety of New Insulin Infusion Protocol for Japanese Patients After Open-Heart Surgery
Jun InaishiShu MeguroArata ItohYoshifumi SaishoJunichiro IrieMasami TanakaToshihide KawaiAkinori HiranoMikihiko KudoHideyuki ShimizuHiroshi Itoh
The authors examined the appropriateness of an IIP, which was modified to fit the Japanese population, who were usually less obese and less insulin-resistant. This IIP maintained blood glucose levels within the target range in patients who underwent open-heart surgery as equally well as the previous empirical therapy. These findings confirm the efficiency and safety of our IIP with less burden in blood glucose management of Japanese patients.
Ten Tips for Healthy Longevity
A healthy lifestyle includes appropriate caloric intake, reduced intake of saturated fat and sugar-containing snacks and beverages, increased intake of vegetables and unsaturated fat, an increase in physical activity, and possibly avoiding even a small amount of alcohol intake.