Disease relevance of ECs0084
High impact information on ECs0084
Chemical compound and disease context of ECs0084
Biological context of ECs0084
Anatomical context of ECs0084
Associations of ECs0084 with chemical compounds
Analytical, diagnostic and therapeutic context of ECs0084
ECs0084 - DNA-binding transcriptional regulator FruR
Escherichia coli O157:H7 str. Sakai
Zhu, W. et al., Surber, M.W. et al., Ray, W.K. et al., Ryu, S. et al., Lynch, A.S. et al., et al.
Gomis-Rüth, Solà, Pérez-Luque, Acebo, Alda, González, Espinosa, del Solar, Coll, Hazlett, Rusnak, Kehres, Bearden, La Vake, La Vake, Maguire, Perry, Radolf, Becker, Thomas,
Here, we combine chromatin immunoprecipitation and high-density oligonucleotide microarrays to define the in vivo DNA targets of the LexA transcriptional repressor in Escherichia coli [1].
The maltose/maltodextrin regulon of Streptococcus pneumoniae. Differential promoter regulation by the transcriptional repressor MalR [2].
The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase [3].
The hrcA gene of Bacillus subtilis codes for a transcriptional repressor protein that negatively regulates expression of the heptacistronic dnaK and the bicistronic groE operon by binding to an operator-element called CIRCE [4].
An active ScrR-FruR hybrid repressor protein was constructed with the N-terminal part of the sucrose repressor of K. pneumoniae and the C-terminal part of the fructose repressor of Salmonella typhimurium LT2 [5].
Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS [6].
The PutA flavoprotein from Escherichia coli plays multiple roles in proline catabolism by functioning as a membrane-associated bi-functional enzyme and a transcriptional repressor of proline utilization genes [7].
This is the first report of a transcriptional repressor and a CoA-derived aromatic inducer controlling gene expression in the anaerobic catabolism of aromatic compounds [8].
The pts promoter region has a fructose repressor (FruR)-binding site (the FruR box) that partially overlaps with one of the CRP.cAMP-binding sites [9].
Divergently transcribed from this gene cluster is the gene agaR encoding a transcriptional repressor belonging to the DeoR/GlpR family of transcriptional regulators [10].
Osmoregulation in Lactococcus lactis: BusR, a transcriptional repressor of the glycine betaine uptake system BusA [11].
Regulation of expression of the ethanol dehydrogenase gene (adhE) in Escherichia coli by catabolite repressor activator protein Cra [12].
Catabolite regulation of two Escherichia coli operons encoding nitrite reductases: role of the Cra protein [13].
Salmonella typhimurium purR encodes a transcriptional repressor regulating gene expression of de novo purine nucleotide biosynthesis [14].
PutA is a multifunctional, peripheral membrane protein which functions both as an autogenous transcriptional repressor and the enzyme which catalyzes the two-step conversion of proline to glutamate in Salmonella typhimurium and Escherichia coli [15].
Plasmid pIP501 encoded transcriptional repressor CopR binds asymmetrically at two consecutive major grooves of the DNA [16].
The transcriptional repressor Fur binds to a 19-bp consensus sequence, 5'-GATAATGATAATCATTATC-3', under high iron conditions [17].
Altogether, this work shows that the switching of PutA from a transcriptional repressor to a membrane-bound protein involves W211 in a flexible domain near the PRODH active site and occurs on a time scale that is >10-fold slower than the turnover number of PutA [18].
These residues are extremely well conserved among the UmuD-like proteins involved in mutagenesis but are poorly conserved among the structurally related LexA-like transcriptional repressor proteins [19].
The nucleotide sequences of the 9-bp repeats are different for RK2 (an IncPalpha group plasmid) and R751 (IncPbeta group), but both DR regions are organized similarly, including an 11-bp spacer with identical 5'-CGCCA-3' cores and an adjacent binding site for KorB, a known partition protein and transcriptional repressor [20].
The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1 [21].
Mlc is a global transcriptional repressor involved in the regulation of genes linked to glucose metabolism [22].
The transformation of PutA from a transcriptional repressor of the proline utilization (put) regulon to a peripheral membrane associated enzyme is mediated by a proline-dependent conformational change [18].
Previous work has shown that FAD has a role in regulating the transcriptional repressor and membrane binding functions of the PutA protein [23].
PerR functions as a manganese-dependent, transcriptional repressor of the identified regulon [24].
BirA is the transcriptional repressor of biotin biosynthesis and a biotin holoenzyme synthetase [25].
Electrophoretic mobility shift assays and DNase I protection assays indicate that where the phosphorylated form of the ArcA protein (ArcA-P) is expected to act as a transcriptional repressor (e.g., of lctPRD and gltA-sdhCDAB), the effect is likely to be mediated by sequestration of cis-controlling transcriptional regulatory elements [26].
Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the pMV158-encoded plasmid transcriptional repressor protein CopG [27].
Genomic analysis of LexA binding reveals the permissive nature of the Escherichia coli genome and identifies unconventional target sites. Wade, J.T., Reppas, N.B., Church, G.M., Struhl, K. Genes Dev. (2005) [Pubmed]
The maltose/maltodextrin regulon of Streptococcus pneumoniae. Differential promoter regulation by the transcriptional repressor MalR. Nieto, C., Espinosa, M., Puyet, A. J. Biol. Chem. (1997) [Pubmed]
The Treponema pallidum tro operon encodes a multiple metal transporter, a zinc-dependent transcriptional repressor, and a semi-autonomously expressed phosphoglycerate mutase. Hazlett, K.R., Rusnak, F., Kehres, D.G., Bearden, S.W., La Vake, C.J., La Vake, M.E., Maguire, M.E., Perry, R.D., Radolf, J.D. J. Biol. Chem. (2003) [Pubmed]
Isolation and analysis of mutant alleles of the Bacillus subtilis HrcA repressor with reduced dependency on GroE function. Reischl, S., Wiegert, T., Schumann, W. J. Biol. Chem. (2002) [Pubmed]
Molecular analysis of two ScrR repressors and of a ScrR-FruR hybrid repressor for sucrose and D-fructose specific regulons from enteric bacteria. Jahreis, K., Lengeler, J.W. Mol. Microbiol. (1993) [Pubmed]
Thermoregulation of Shigella and Escherichia coli EIEC pathogenicity. A temperature-dependent structural transition of DNA modulates accessibility of virF promoter to transcriptional repressor H-NS. Falconi, M., Colonna, B., Prosseda, G., Micheli, G., Gualerzi, C.O. EMBO J. (1998) [Pubmed]
Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein. Lee, Y.H., Nadaraia, S., Gu, D., Becker, D.F., Tanner, J.J. Nat. Struct. Biol. (2003) [Pubmed]
BzdR, a repressor that controls the anaerobic catabolism of benzoate in Azoarcus sp. CIB, is the first member of a new subfamily of transcriptional regulators. Barragán, M.J., Blázquez, B., Zamarro, M.T., Mancheño, J.M., García, J.L., Díaz, E., Carmona, M. J. Biol. Chem. (2005) [Pubmed]
Effect of the FruR regulator on transcription of the pts operon in Escherichia coli. Ryu, S., Ramseier, T.M., Michotey, V., Saier, M.H., Garges, S. J. Biol. Chem. (1995) [Pubmed]
Application of AgaR repressor and dominant repressor variants for verification of a gene cluster involved in N-acetylgalactosamine metabolism in Escherichia coli K-12. Ray, W.K., Larson, T.J. Mol. Microbiol. (2004) [Pubmed]
Osmoregulation in Lactococcus lactis: BusR, a transcriptional repressor of the glycine betaine uptake system BusA. Romeo, Y., Obis, D., Bouvier, J., Guillot, A., Fourçans, A., Bouvier, I., Gutierrez, C., Mistou, M.Y. Mol. Microbiol. (2003) [Pubmed]
Regulation of expression of the ethanol dehydrogenase gene (adhE) in Escherichia coli by catabolite repressor activator protein Cra. Mikulskis, A., Aristarkhov, A., Lin, E.C. J. Bacteriol. (1997) [Pubmed]
Catabolite regulation of two Escherichia coli operons encoding nitrite reductases: role of the Cra protein. Tyson, K., Busby, S., Cole, J. Arch. Microbiol. (1997) [Pubmed]
Study of adaptive mutations in Salmonella typhimurium by using a super-repressing mutant of a trans regulatory gene purR. Yang, Z., Lu, Z., Wang, A. Mutat. Res. (2001) [Pubmed]
Regulation of flavin dehydrogenase compartmentalization: requirements for PutA-membrane association in Salmonella typhimurium. Surber, M.W., Maloy, S. Biochim. Biophys. Acta (1999) [Pubmed]
Plasmid pIP501 encoded transcriptional repressor CopR binds asymmetrically at two consecutive major grooves of the DNA. Steinmetzer, K., Brantl, S. J. Mol. Biol. (1997) [Pubmed]
Fur-DNA interactions at the bidirectional fepDGC-entS promoter region in Escherichia coli. Lavrrar, J.L., Christoffersen, C.A., McIntosh, M.A. J. Mol. Biol. (2002) [Pubmed]
Exploring the proline-dependent conformational change in the multifunctional PutA flavoprotein by tryptophan fluorescence spectroscopy. Zhu, W., Becker, D.F. Biochemistry (2005) [Pubmed]
Genetic and biochemical characterization of a novel umuD mutation: insights into a mechanism for UmuD self-cleavage. Sutton, M.D., Kim, M., Walker, G.C. J. Bacteriol. (2001) [Pubmed]
Host-specific incompatibility by 9-bp direct repeats indicates a role in the maintenance of broad-host-range plasmid RK2. Wilson, J.W., Figurski, D.H. Plasmid (2002) [Pubmed]
The transcriptional repressor Nkx6.1 also functions as a deoxyribonucleic acid context-dependent transcriptional activator during pancreatic beta-cell differentiation: evidence for feedback activation of the nkx6.1 gene by Nkx6.1. Iype, T., Taylor, D.G., Ziesmann, S.M., Garmey, J.C., Watada, H., Mirmira, R.G. Mol. Endocrinol. (2004) [Pubmed]
Membrane localization itself but not binding to IICB is directly responsible for the inactivation of the global repressor Mlc in Escherichia coli. Tanaka, Y., Itoh, F., Kimata, K., Aiba, H. Mol. Microbiol. (2004) [Pubmed]
Redox properties of the PutA protein from Escherichia coli and the influence of the flavin redox state on PutA-DNA interactions. Becker, D.F., Thomas, E.A. Biochemistry (2001) [Pubmed]
PerR controls oxidative stress resistance and iron storage proteins and is required for virulence in Staphylococcus aureus. Horsburgh, M.J., Clements, M.O., Crossley, H., Ingham, E., Foster, S.J. Infect. Immun. (2001) [Pubmed]
Thermodynamic analysis of small ligand binding to the Escherichia coli repressor of biotin biosynthesis. Xu, Y., Johnson, C.R., Beckett, D. Biochemistry (1996) [Pubmed]
Transcriptional control mediated by the ArcA two-component response regulator protein of Escherichia coli: characterization of DNA binding at target promoters. Lynch, A.S., Lin, E.C. J. Bacteriol. (1996) [Pubmed]
Overexpression, purification, crystallization and preliminary X-ray diffraction analysis of the pMV158-encoded plasmid transcriptional repressor protein CopG. Gomis-Rüth, F.X., Solà, M., Pérez-Luque, R., Acebo, P., Alda, M.T., González, A., Espinosa, M., del Solar, G., Coll, M. FEBS Lett. (1998) [Pubmed]