New insights into vertebrate skin regeneration
Ashley W. Seifert, Malcolm Maden
Regeneration biology has experienced a renaissance as clinicians, scientists, and engineers have combined forces to drive the field of regenerative medicine. Studies investigating the mechanisms that regulate wound healing in adult mammals have led to a good understanding of the stereotypical processes that lead to scarring. Despite comparative studies of fetal wound healing in which no scar is produced, the fact remains that insights from this work have failed to produce therapies that can regenerate adult human skin. In this review, we analyze past and contemporary accounts of wound healing in a variety of vertebrates, namely, fish, amphibians, and mammals, in order to demonstrate how examples of skin regeneration in adult organisms can impact traditional wound-healing research. When considered together, these studies suggest that inflammation and reepithelialization are necessary events preceding both scarring and regeneration. However, the extent to which these processes may direct one outcome over another is likely weaker than currently accepted. In contrast, the extent to which newly deposited extracellular matrix in the wound bed can be remodeled into new skin, and the intrinsic ability of new epidermis to regenerate appendages, appears to underlie the divergence between scar-free healing and the persistence of a scar. We discuss several ideas that may offer areas of overlap between researchers using these different model organisms and which may be of benefit to the ultimate goal of scar-free human wound healing.
International Review of Cell and Molecular Biology
https://doi.org/10.1016/B978-0-12-800180-6.00004-9
Acomys
Regeneration biology
Skin regeneration
Spiny mouse
Wound repair
10.1016/B978-0-12-800180-6.00004-9
Dive into the research topics of 'New insights into vertebrate skin regeneration'. Together they form a unique fingerprint.
Adult Nursing and Health Professions 100%
Wound Healing Medicine and Dentistry 83%
Scar Medicine and Dentistry 66%
Skin Medicine and Dentistry 66%
Regeneration Biochemistry, Genetics and Molecular Biology 66%
Introspection Medicine and Dentistry 33%
Scar Formation Medicine and Dentistry 33%
Organisms Biochemistry, Genetics and Molecular Biology 33%
Seifert, A. W., & Maden, M. (2014). New insights into vertebrate skin regeneration. In International Review of Cell and Molecular Biology (pp. 129-169). (International Review of Cell and Molecular Biology; Vol. 310). https://doi.org/10.1016/B978-0-12-800180-6.00004-9
Seifert, Ashley W. ; Maden, Malcolm. / New insights into vertebrate skin regeneration. International Review of Cell and Molecular Biology. 2014. pp. 129-169 (International Review of Cell and Molecular Biology).
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title = "New insights into vertebrate skin regeneration",
abstract = "Regeneration biology has experienced a renaissance as clinicians, scientists, and engineers have combined forces to drive the field of regenerative medicine. Studies investigating the mechanisms that regulate wound healing in adult mammals have led to a good understanding of the stereotypical processes that lead to scarring. Despite comparative studies of fetal wound healing in which no scar is produced, the fact remains that insights from this work have failed to produce therapies that can regenerate adult human skin. In this review, we analyze past and contemporary accounts of wound healing in a variety of vertebrates, namely, fish, amphibians, and mammals, in order to demonstrate how examples of skin regeneration in adult organisms can impact traditional wound-healing research. When considered together, these studies suggest that inflammation and reepithelialization are necessary events preceding both scarring and regeneration. However, the extent to which these processes may direct one outcome over another is likely weaker than currently accepted. In contrast, the extent to which newly deposited extracellular matrix in the wound bed can be remodeled into new skin, and the intrinsic ability of new epidermis to regenerate appendages, appears to underlie the divergence between scar-free healing and the persistence of a scar. We discuss several ideas that may offer areas of overlap between researchers using these different model organisms and which may be of benefit to the ultimate goal of scar-free human wound healing.",
keywords = "Acomys, Axolotl, Dermis, Fish, Regeneration biology, Regenerative medicine, Scarring, Skin regeneration, Spiny mouse, Wound healing, Wound repair, Xenopus",
author = "Seifert, {Ashley W.} and Malcolm Maden",
doi = "10.1016/B978-0-12-800180-6.00004-9",
series = "International Review of Cell and Molecular Biology",
booktitle = "International Review of Cell and Molecular Biology",
Seifert, AW & Maden, M 2014, New insights into vertebrate skin regeneration. in International Review of Cell and Molecular Biology. International Review of Cell and Molecular Biology, vol. 310, pp. 129-169. https://doi.org/10.1016/B978-0-12-800180-6.00004-9
New insights into vertebrate skin regeneration. / Seifert, Ashley W.; Maden, Malcolm.
International Review of Cell and Molecular Biology. 2014. p. 129-169 (International Review of Cell and Molecular Biology; Vol. 310).
T1 - New insights into vertebrate skin regeneration
AU - Seifert, Ashley W.
AU - Maden, Malcolm
N2 - Regeneration biology has experienced a renaissance as clinicians, scientists, and engineers have combined forces to drive the field of regenerative medicine. Studies investigating the mechanisms that regulate wound healing in adult mammals have led to a good understanding of the stereotypical processes that lead to scarring. Despite comparative studies of fetal wound healing in which no scar is produced, the fact remains that insights from this work have failed to produce therapies that can regenerate adult human skin. In this review, we analyze past and contemporary accounts of wound healing in a variety of vertebrates, namely, fish, amphibians, and mammals, in order to demonstrate how examples of skin regeneration in adult organisms can impact traditional wound-healing research. When considered together, these studies suggest that inflammation and reepithelialization are necessary events preceding both scarring and regeneration. However, the extent to which these processes may direct one outcome over another is likely weaker than currently accepted. In contrast, the extent to which newly deposited extracellular matrix in the wound bed can be remodeled into new skin, and the intrinsic ability of new epidermis to regenerate appendages, appears to underlie the divergence between scar-free healing and the persistence of a scar. We discuss several ideas that may offer areas of overlap between researchers using these different model organisms and which may be of benefit to the ultimate goal of scar-free human wound healing.
AB - Regeneration biology has experienced a renaissance as clinicians, scientists, and engineers have combined forces to drive the field of regenerative medicine. Studies investigating the mechanisms that regulate wound healing in adult mammals have led to a good understanding of the stereotypical processes that lead to scarring. Despite comparative studies of fetal wound healing in which no scar is produced, the fact remains that insights from this work have failed to produce therapies that can regenerate adult human skin. In this review, we analyze past and contemporary accounts of wound healing in a variety of vertebrates, namely, fish, amphibians, and mammals, in order to demonstrate how examples of skin regeneration in adult organisms can impact traditional wound-healing research. When considered together, these studies suggest that inflammation and reepithelialization are necessary events preceding both scarring and regeneration. However, the extent to which these processes may direct one outcome over another is likely weaker than currently accepted. In contrast, the extent to which newly deposited extracellular matrix in the wound bed can be remodeled into new skin, and the intrinsic ability of new epidermis to regenerate appendages, appears to underlie the divergence between scar-free healing and the persistence of a scar. We discuss several ideas that may offer areas of overlap between researchers using these different model organisms and which may be of benefit to the ultimate goal of scar-free human wound healing.
KW - Acomys
KW - Axolotl
KW - Dermis
KW - Fish
KW - Regeneration biology
KW - Regenerative medicine
KW - Scarring
KW - Skin regeneration
KW - Spiny mouse
KW - Wound healing
KW - Wound repair
KW - Xenopus
U2 - 10.1016/B978-0-12-800180-6.00004-9
DO - 10.1016/B978-0-12-800180-6.00004-9
T3 - International Review of Cell and Molecular Biology
BT - International Review of Cell and Molecular Biology
Seifert AW, Maden M. New insights into vertebrate skin regeneration. In International Review of Cell and Molecular Biology. 2014. p. 129-169. (International Review of Cell and Molecular Biology). doi: 10.1016/B978-0-12-800180-6.00004-9