Voglibose is an alpha-glucosidase inhibitor used for lowering post-prandial blood glucose levels in people with diabetes mellitus. It is made in India by Ranbaxy Labs and sold under the trade name Volix.
Slowly and poorly absorbed. The reported pharmacokinetic parameters of voglibose with metformin are Cmax corresponds to 1.38 mcg/ml while AUC is 8.17 mcg.h/ml and tmax is of 2.5 hours.
The half-life of voglibose is very similar to the one found for metformin and it is reported to be of 4.08 hours.
2,4-thiazolidinedione The risk or severity of hypoglycemia can be increased when Voglibose is combined with 2,4-thiazolidinedione.
5-(2-methylpiperazine-1-sulfonyl)isoquinoline The therapeutic efficacy of Voglibose can be increased when used in combination with 5-(2-methylpiperazine-1-sulfonyl)isoquinoline.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline may increase the hypoglycemic activities of Voglibose.
Acarbose The risk or severity of hypoglycemia can be increased when Acarbose is combined with Voglibose.
Acetazolamide The therapeutic efficacy of Voglibose can be increased when used in combination with Acetazolamide.
Acetohexamide The risk or severity of hypoglycemia can be increased when Acetohexamide is combined with Voglibose.
Acetyl sulfisoxazole The therapeutic efficacy of Voglibose can be increased when used in combination with Acetyl sulfisoxazole.
Acetylsalicylic acid Acetylsalicylic acid may increase the hypoglycemic activities of Voglibose.
Agmatine The risk or severity of hypoglycemia can be increased when Agmatine is combined with Voglibose.
AICA ribonucleotide The risk or severity of hypoglycemia can be increased when AICA ribonucleotide is combined with Voglibose.
Heinz G. Floss, Sungsook Lee, Ingo Tornus, "Valiolone, a method of preparing it, and its use to prepare acarbose and voglibose." U.S. Patent US6150568, issued October, 1995.
This compound belongs to the class of organic compounds known as aminocyclitols. These are cyclitols with at least one hydroxyl group replace by an amino group.