Definition : Immunoassay reagents intended to perform qualitative and/or quantitative analyses on a body fluid sample (e.g., serum, plasma) to determine imipramine, a tertiary tricyclic amine drug with therapeutic use as an antidepressant and sedative. Imipramine is administered as imipramine hydrochloride for attention deficit disorder, enuresis, chronic pain, anxiety, and bulimia. Imipramine metabolism produces physiologically active metabolites (e.g., secondary tricyclic amines with antidepressant activity such as desipramine), these metabolites should be measured simultaneously. Reagents used to determine antidepressant concentration in blood differentiate therapeutic levels (typically very low) from toxic levels due to overdose.
Entry Terms : "Imipramine Determination Reagents" , "Reagents, Immunoassay, Toxicology, Antidepressant, Imipramine"