Low confirmed last week that the World Cup-winning trio will not be part of his plans for their Euro 2020 qualifying campaign, which starts against Netherlands on March 24, four days after a friendly with Serbia.
Low has instead turned to RB Leipzig defender Lukas Klostermann, Hertha Berlin midfielder Niklas Stark and Werder Bremen's exciting forward Maximilian Eggestein as he looks to reverse Die Mannschaft's fortunes after a calamitous World Cup campaign in Russia last year.
Barcelona goalkeeper Marc-Andre ter Stegen and Manchester City's Ilkay Gundogan have been recalled after missing the squad for November's Nations League meeting with Netherlands and friendly against Russia.
Germany squad in full: Manuel Neuer (Bayern Munich), Marc-Andre ter Stegen (Barcelona) Kevin Trapp (Eintracht Frankfurt - on loan from Paris Saint-Germain); Matthias Ginter (Borussia Monchengladbach), Thilo Kehrer (Paris Saint-Germain), Antonio Rudiger (Chelsea), Nico Schulz (Hoffenheim), Niklas Sule (Bayern Munich), Jonathan Tah (Bayer Leverkusen), Marcel Halstenberg (RB Leipzig), Lukas Klostermann (RB Leipzig), Niklas Stark (Hertha Berlin); Julian Brandt (Bayer Leverkusen), Leon Goretzka (Bayern Munich), Kai Havertz (Bayer Leverkusen), Joshua Kimmich (Bayern Munich), Ilkay Gundogan (Manchester City), Serge Gnabry (Bayern Munich), Toni Kroos (Real Madrid), Marco Reus (Borussia Dortmund), Leroy Sane (Manchester City); Timo Werner (RB Leipzig), Maximilian Eggestein (Werder Bremen).