David Rowley
drowley
Rowley, Ph.D.
drowley@bcm.edu
Dan L Duncan Comprehensive Cancer Center
Department of Molecular and Cellular Biology
Faculty Senator
Education Committee Chair
Houston, Texas United States
Leader, Cancer Biology Program
Assistant Dean of the Foundational Sciences
BCM-MD Anderson Hall (Office)
Room: BCMA-514B
BS from University of Iowa
05/1975 - Iowa City, Iowa United States
Graduated with Honors
PhD from University Of Iowa
Postdoctoral Fellowship at Baylor College of Medicine
01/1984 - Houston, Texas United States
Faculty Excellence Award
Teaching and Evaluation
Fullbright and Jaworski L.L.P. (01/2001 - 01/2002)
Outstanding Teacher Award
John T. McGovern (01/2004 - 01/2005)
Presidential Award for Excellence in Education
Barbara and Corbin J. Roberston, Jr. (01/2007 - 01/2008)
The John K. Lattimer Award
The American Urological Association (01/2009 - 01/2009)
Excellence in Graduate Education Award
Marc Dresden (01/2011 - 01/2012)
Mechanisms of reactive stroma in cancer progression.
Professional Statement
Dr. Rowley is a leader in the field of stromal-epithelial interactions and the genesis of reactive stroma in the tumor microenvironment. His laboratory was the first to identify and characterize reactive stroma myofibroblasts as a key component of the microenvironment in prostate cancer and benign hyperplasia (BPH). He has focused on prostate cancer research for over 30 years. His laboratory has focused on the evolution of microenvironment stroma from stem cells and how this affects disease progression using several novel model systems that address the origins of CAFs / myofibroblasts and their biology. Dr. Rowley has been involved in many individual investigator grant projects and has lead both U54 and U01 Tumor Microenvironment Network (TMEN) NCI funded group projects. In addition, Dr. Rowley has many years of experience as an educator and mentor to graduate students and medical students at the bench and in the classroom.
Kim W, Barron DA, San Martin R, Chan KS, Tran LL, Yang F, Ressler SJ, Rowley DR "RUNX1 is essential for mesenchymal stem cell proliferation and myofibroblast differentiation." Proc Natl Acad Sci USA. 2014 November 18; 111 (46): 16389-16394. Pubmed PMID: 25313057
Yang F, Zhang Y, Ressler SJ, Ittmann MM, Ayala GE, Dang TD, Wang F, Rowley DR "FGFR1 is Essential for Prostate Cancer Progression and Metastasis.." Cancer Res.. 2013 April 10; : Pubmed PMID: 23576558
Ressler SJ, Dang TD, Wu SM, Tse DY, Gilbert BE, Vyakarnam A, Yang F, Schauer IG, Barron DA, Rowley DR. "WFDC1 Is a Key Modulator of Inflammatory and Wound Repair Responses." Am J Pathol. 2014 184 (11): 2951-2964. Pubmed PMID: 4215025
Rowley D.R. "Reprogramming the tumor stroma: a new paradigm." Cancer Cell. 2014 26 (4): 451-2. Pubmed PMID: 25314074