..1029). We conclude that RNF213 is a gene associated with susceptibility to ICAS in CADASIL patients. MRA follow-up and close observation are necessary for CADASIL patients with the RNF213 variant, as they may be predisposed to ICAS. ..
..These families provide new insights into the diagnosis and pathomechanisms of CADASIL. ..
..Ten mutations were unreported ones. We propose the new criteria of high sensitivity, which will help physicians to assess the need for genetic testing. ..