Current and historical return on equity (ROE) values for Lexicon Pharmaceuticals (LXRX) over the last 10 years. Return on equity can be defined as the amount of net income returned as a percentage of shareholders equity. Return on equity measures a corporation's profitability by revealing how much profit a company generates with the money shareholders have invested. Lexicon Pharmaceuticals ROE for the three months ending December 31, 2018 was -911.43%.