Perinatal morphine I: Effects on synapsin and neurotransmitter systems in the brain
A. M. Di Giulio, B. Tenconi, M. L. Malosio, L. Vergani, A. Bertelli, A. Gorio
We have previously shown that rat perinatal exposure to morphine causes dopaminergic and met-enkephalin (ME) and substance P (SP) changes in the striatum during the early postnatal period (Tenconi et al.: Int J Dev Neurosci 10:517-526, 1992); in addition it increases the susceptibility to neurotoxic lesions and impairs regenerative capacity of the serotoninergic system (Gorio et al.: J Neurosci Res 34: 462-471, 1993). Our study shows that ME and SP levels increase postnatally in several areas of the rat brain, reaching the highest values between 30 and 60 days, after which the peptide content subsides to lower levels. Perinatal exposure to morphine increases such ME and SP levels during the early stages of postnatal life. No effect of morphine on 5-HT and NE is observed, while the dopaminergic system is mainly affected in the mesencephalon. The pre- and postnatal brain expression of synapsin I mRNA is gradually and progressively localized in discrete areas of the brain. In the brain of rats perinatally exposed to morphine, the abundance of synapsin I mRNA expression is markedly reduced. Therefore, perinatal exposure to morphine affects early postnatal synaptic development in the brain as shown by the altered peptidergic and monoaminergic content and by the reduced synapsin I mRNA expression.
Journal of Neuroscience Research
https://doi.org/10.1002/jnr.490420406
Synapsins
Methionine Enkephalin
Substance P
Mesencephalon
met-enkephalin
synapsin I
Di Giulio, A. M., Tenconi, B., Malosio, M. L., Vergani, L., Bertelli, A., & Gorio, A. (1995). Perinatal morphine I: Effects on synapsin and neurotransmitter systems in the brain. Journal of Neuroscience Research, 42(4), 479-485. https://doi.org/10.1002/jnr.490420406
Perinatal morphine I : Effects on synapsin and neurotransmitter systems in the brain. / Di Giulio, A. M.; Tenconi, B.; Malosio, M. L.; Vergani, L.; Bertelli, A.; Gorio, A.
In: Journal of Neuroscience Research, Vol. 42, No. 4, 1995, p. 479-485.
Di Giulio, AM, Tenconi, B, Malosio, ML, Vergani, L, Bertelli, A & Gorio, A 1995, 'Perinatal morphine I: Effects on synapsin and neurotransmitter systems in the brain', Journal of Neuroscience Research, vol. 42, no. 4, pp. 479-485. https://doi.org/10.1002/jnr.490420406
Di Giulio AM, Tenconi B, Malosio ML, Vergani L, Bertelli A, Gorio A. Perinatal morphine I: Effects on synapsin and neurotransmitter systems in the brain. Journal of Neuroscience Research. 1995;42(4):479-485. https://doi.org/10.1002/jnr.490420406
Di Giulio, A. M. ; Tenconi, B. ; Malosio, M. L. ; Vergani, L. ; Bertelli, A. ; Gorio, A. / Perinatal morphine I : Effects on synapsin and neurotransmitter systems in the brain. In: Journal of Neuroscience Research. 1995 ; Vol. 42, No. 4. pp. 479-485.
@article{796dedd350dd4fb98014d55462785484,
title = "Perinatal morphine I: Effects on synapsin and neurotransmitter systems in the brain",
abstract = "We have previously shown that rat perinatal exposure to morphine causes dopaminergic and met-enkephalin (ME) and substance P (SP) changes in the striatum during the early postnatal period (Tenconi et al.: Int J Dev Neurosci 10:517-526, 1992); in addition it increases the susceptibility to neurotoxic lesions and impairs regenerative capacity of the serotoninergic system (Gorio et al.: J Neurosci Res 34: 462-471, 1993). Our study shows that ME and SP levels increase postnatally in several areas of the rat brain, reaching the highest values between 30 and 60 days, after which the peptide content subsides to lower levels. Perinatal exposure to morphine increases such ME and SP levels during the early stages of postnatal life. No effect of morphine on 5-HT and NE is observed, while the dopaminergic system is mainly affected in the mesencephalon. The pre- and postnatal brain expression of synapsin I mRNA is gradually and progressively localized in discrete areas of the brain. In the brain of rats perinatally exposed to morphine, the abundance of synapsin I mRNA expression is markedly reduced. Therefore, perinatal exposure to morphine affects early postnatal synaptic development in the brain as shown by the altered peptidergic and monoaminergic content and by the reduced synapsin I mRNA expression.",
keywords = "brain development, met-enkephalin, morphine, substance P, synapsin I",
author = "{Di Giulio}, {A. M.} and B. Tenconi and Malosio, {M. L.} and L. Vergani and A. Bertelli and A. Gorio",
doi = "10.1002/jnr.490420406",
journal = "Journal of Neuroscience Research",
T1 - Perinatal morphine I
T2 - Effects on synapsin and neurotransmitter systems in the brain
AU - Di Giulio, A. M.
AU - Tenconi, B.
AU - Malosio, M. L.
AU - Vergani, L.
AU - Bertelli, A.
AU - Gorio, A.
N2 - We have previously shown that rat perinatal exposure to morphine causes dopaminergic and met-enkephalin (ME) and substance P (SP) changes in the striatum during the early postnatal period (Tenconi et al.: Int J Dev Neurosci 10:517-526, 1992); in addition it increases the susceptibility to neurotoxic lesions and impairs regenerative capacity of the serotoninergic system (Gorio et al.: J Neurosci Res 34: 462-471, 1993). Our study shows that ME and SP levels increase postnatally in several areas of the rat brain, reaching the highest values between 30 and 60 days, after which the peptide content subsides to lower levels. Perinatal exposure to morphine increases such ME and SP levels during the early stages of postnatal life. No effect of morphine on 5-HT and NE is observed, while the dopaminergic system is mainly affected in the mesencephalon. The pre- and postnatal brain expression of synapsin I mRNA is gradually and progressively localized in discrete areas of the brain. In the brain of rats perinatally exposed to morphine, the abundance of synapsin I mRNA expression is markedly reduced. Therefore, perinatal exposure to morphine affects early postnatal synaptic development in the brain as shown by the altered peptidergic and monoaminergic content and by the reduced synapsin I mRNA expression.
AB - We have previously shown that rat perinatal exposure to morphine causes dopaminergic and met-enkephalin (ME) and substance P (SP) changes in the striatum during the early postnatal period (Tenconi et al.: Int J Dev Neurosci 10:517-526, 1992); in addition it increases the susceptibility to neurotoxic lesions and impairs regenerative capacity of the serotoninergic system (Gorio et al.: J Neurosci Res 34: 462-471, 1993). Our study shows that ME and SP levels increase postnatally in several areas of the rat brain, reaching the highest values between 30 and 60 days, after which the peptide content subsides to lower levels. Perinatal exposure to morphine increases such ME and SP levels during the early stages of postnatal life. No effect of morphine on 5-HT and NE is observed, while the dopaminergic system is mainly affected in the mesencephalon. The pre- and postnatal brain expression of synapsin I mRNA is gradually and progressively localized in discrete areas of the brain. In the brain of rats perinatally exposed to morphine, the abundance of synapsin I mRNA expression is markedly reduced. Therefore, perinatal exposure to morphine affects early postnatal synaptic development in the brain as shown by the altered peptidergic and monoaminergic content and by the reduced synapsin I mRNA expression.
KW - brain development
KW - met-enkephalin
KW - morphine
KW - substance P
KW - synapsin I
U2 - 10.1002/jnr.490420406
DO - 10.1002/jnr.490420406
JO - Journal of Neuroscience Research
JF - Journal of Neuroscience Research
10.1002/jnr.490420406