Properties targeted include homes in Great Holm, Middleton, Monkston, Broughton, and Oakgrove.
Police are also advising people to look out for their neighbours' properties if they are known to be away, as some of the properties burgled were vacant.
Detective Inspector Mark Lacey from Milton Keynes Investigation Hub, said: "I am urging local residents to remain vigilant and report any suspicious activity to their neighbourhood team or call 101 and 999 if it is an emergency. I have extra patrols in the area after 15 burglaries were reported on Tuesday night.
"I would like to reassure the public that tackling burglaries is one of our priorities and an active investigation is on-going.
It is believed a number of these offences may be linked. Offenders have forced entry mainly through rear doors. A full itinerary of stolen goods is being compiled but items known to have been taken are jewellery, cash, and electronic goods.
Contact polie on 101 quoting reference number URN 896- 29/11/17, if you can help.
> Make efforts to restrict access into your rear garden by padlocking gates, repairing fences etc.
> Keep an eye out for any suspicious behaviour around your neighbours' houses or in your street.