 The most widely used treatment options for GERD include proton-pump inhibitors (PPIs) and H2-receptor antagonists (H2RAs). However, the current treatment guidelines do not provide clear treatment guidance to all the types of healthcare professionals a patient may consult, and treatment decisions vary  Assessing patient perception of treatment using a large observational study will help clinicians make treatment decisions using real-world data.  Our study objective was to assess patient satisfaction with PPIs and H2RAs among a community-based population in the US.
(TSQM)3, a 14-item reliable and valid instrument to assess patients' satisfaction with medication, providing scores on four scales—Effectiveness, Side Effects, Least Square Means (LsMean) obtained using ANCOVA models after adjusting for patient age, gender, self-reported severity and number of concomitant medications Convenience and Global Satisfaction.
 A total of 1,896 patients comprised the analysis population for this study, of which 1,629 patients were on PPIs, and 267 patients were on H2RAs.
score on Convenience compared to patients on omeprazole.
 Figure 3 compares the TSQM scale scores between the PPI and H2RA class of drugs. After adjusting for covariates, patients on PPIs had significantly higher Least Square Means (LsMean) obtained using ANCOVA models after adjusting for Least Square Means (LsMean) obtained using ANCOVA models after adjusting for patient age, gender, self-reported severity and number of concomitant medications patient age, gender, self-reported severity and number of concomitant medications scores on Effectiveness (p<0.0001), Convenience (p=0.0007) and Global Satisfaction (p=0.0003) as compared to patients on H2RAs.
 This large observational study found some significant differences in treatment satisfaction with different GERD treatment classes and 1. Sharma P. Wani Sm Yvonne R, Johnson D, Hamilton F. Racial and Geographic Issues in Gastroesophageal Reflux Disease. The American Journal of 2. Tytgat GN, McColl K, Tack J, et al. New Algorithm for the Treatement of Gastroesophageal Reflux Disease. Aliment Pharmacol Ther. 2008; 27: 249–256 This real-world feedback from patients can assist clinicians in making treatment decisions.