Painful stimuli evoke potentials recorded from the medial temporal lobe in humans
C. C. Liu, S. Ohara, P. Franaszczuk, N. Zagzoog, M. Gallagher, F. A. Lenz
The role of human medial temporal structures in fear conditioning has led to the suggestion that neurons in these structures might respond to painful stimuli. We have now tested the hypothesis that recordings from these structures will demonstrate potentials related to the selective activation of cutaneous nociceptors by a painful laser stimulus (laser evoked potential, LEP) (Kenton B, Coger R, Crue B, Pinsky J, Friedman Y, Carmon A (1980) Neurosci Lett 17:301-306). Recordings were carried out through electrodes implanted bilaterally in these structures for the investigation of intractable epilepsy. Reproducible LEPs were commonly recorded both bilaterally and unilaterally, while LEPs were recorded at contacts on the left (9/14, P=0.257) as commonly as on the right (5/14), independent of the hand stimulated. Along electrodes traversing the amygdala the majority of LEPs were recorded from dorsal contacts near the central nucleus of the amygdala and the nucleus basalis. Stimulus evoked changes in theta activity were observed at contacts on the right at which isolated early negative LEPs (N2*) responses could be recorded. Contacts at which LEPs could be recorded were as commonly located in medial temporal structures with evidence of seizure activity as on those without. These results demonstrate the presence of pain-related inputs to the medial temporal lobe where they may be involved in associative learning to produce anxiety and disability related to painful stimuli.
https://doi.org/10.1016/j.neuroscience.2009.11.026
Published - Feb 17 2010
hippocampal theta
laser evoked potential
10.1016/j.neuroscience.2009.11.026
Fingerprint Dive into the research topics of 'Painful stimuli evoke potentials recorded from the medial temporal lobe in humans'. Together they form a unique fingerprint.
Temporal Lobe Medicine & Life Sciences
Laser-Evoked Potentials Medicine & Life Sciences
Central Amygdaloid Nucleus Medicine & Life Sciences
Implanted Electrodes Medicine & Life Sciences
Nociceptors Medicine & Life Sciences
Drug Resistant Epilepsy Medicine & Life Sciences
Conditioning (Psychology) Medicine & Life Sciences
Amygdala Medicine & Life Sciences
Liu, C. C., Ohara, S., Franaszczuk, P., Zagzoog, N., Gallagher, M., & Lenz, F. A. (2010). Painful stimuli evoke potentials recorded from the medial temporal lobe in humans. Neuroscience, 165(4), 1402-1411. https://doi.org/10.1016/j.neuroscience.2009.11.026
Painful stimuli evoke potentials recorded from the medial temporal lobe in humans. / Liu, C. C.; Ohara, S.; Franaszczuk, P.; Zagzoog, N.; Gallagher, M.; Lenz, F. A.
In: Neuroscience, Vol. 165, No. 4, 17.02.2010, p. 1402-1411.
Liu, CC, Ohara, S, Franaszczuk, P, Zagzoog, N, Gallagher, M & Lenz, FA 2010, 'Painful stimuli evoke potentials recorded from the medial temporal lobe in humans', Neuroscience, vol. 165, no. 4, pp. 1402-1411. https://doi.org/10.1016/j.neuroscience.2009.11.026
Liu CC, Ohara S, Franaszczuk P, Zagzoog N, Gallagher M, Lenz FA. Painful stimuli evoke potentials recorded from the medial temporal lobe in humans. Neuroscience. 2010 Feb 17;165(4):1402-1411. https://doi.org/10.1016/j.neuroscience.2009.11.026
Liu, C. C. ; Ohara, S. ; Franaszczuk, P. ; Zagzoog, N. ; Gallagher, M. ; Lenz, F. A. / Painful stimuli evoke potentials recorded from the medial temporal lobe in humans. In: Neuroscience. 2010 ; Vol. 165, No. 4. pp. 1402-1411.
@article{8b683599303c4b52acc6fae07e99d71e,
title = "Painful stimuli evoke potentials recorded from the medial temporal lobe in humans",
abstract = "The role of human medial temporal structures in fear conditioning has led to the suggestion that neurons in these structures might respond to painful stimuli. We have now tested the hypothesis that recordings from these structures will demonstrate potentials related to the selective activation of cutaneous nociceptors by a painful laser stimulus (laser evoked potential, LEP) (Kenton B, Coger R, Crue B, Pinsky J, Friedman Y, Carmon A (1980) Neurosci Lett 17:301-306). Recordings were carried out through electrodes implanted bilaterally in these structures for the investigation of intractable epilepsy. Reproducible LEPs were commonly recorded both bilaterally and unilaterally, while LEPs were recorded at contacts on the left (9/14, P=0.257) as commonly as on the right (5/14), independent of the hand stimulated. Along electrodes traversing the amygdala the majority of LEPs were recorded from dorsal contacts near the central nucleus of the amygdala and the nucleus basalis. Stimulus evoked changes in theta activity were observed at contacts on the right at which isolated early negative LEPs (N2*) responses could be recorded. Contacts at which LEPs could be recorded were as commonly located in medial temporal structures with evidence of seizure activity as on those without. These results demonstrate the presence of pain-related inputs to the medial temporal lobe where they may be involved in associative learning to produce anxiety and disability related to painful stimuli.",
keywords = "amygdala, hippocampal theta, hippocampus, human, laser evoked potential, pain",
author = "Liu, {C. C.} and S. Ohara and P. Franaszczuk and N. Zagzoog and M. Gallagher and Lenz, {F. A.}",
doi = "10.1016/j.neuroscience.2009.11.026",
journal = "Neuroscience",
T1 - Painful stimuli evoke potentials recorded from the medial temporal lobe in humans
AU - Liu, C. C.
AU - Ohara, S.
AU - Franaszczuk, P.
AU - Zagzoog, N.
AU - Gallagher, M.
AU - Lenz, F. A.
N2 - The role of human medial temporal structures in fear conditioning has led to the suggestion that neurons in these structures might respond to painful stimuli. We have now tested the hypothesis that recordings from these structures will demonstrate potentials related to the selective activation of cutaneous nociceptors by a painful laser stimulus (laser evoked potential, LEP) (Kenton B, Coger R, Crue B, Pinsky J, Friedman Y, Carmon A (1980) Neurosci Lett 17:301-306). Recordings were carried out through electrodes implanted bilaterally in these structures for the investigation of intractable epilepsy. Reproducible LEPs were commonly recorded both bilaterally and unilaterally, while LEPs were recorded at contacts on the left (9/14, P=0.257) as commonly as on the right (5/14), independent of the hand stimulated. Along electrodes traversing the amygdala the majority of LEPs were recorded from dorsal contacts near the central nucleus of the amygdala and the nucleus basalis. Stimulus evoked changes in theta activity were observed at contacts on the right at which isolated early negative LEPs (N2*) responses could be recorded. Contacts at which LEPs could be recorded were as commonly located in medial temporal structures with evidence of seizure activity as on those without. These results demonstrate the presence of pain-related inputs to the medial temporal lobe where they may be involved in associative learning to produce anxiety and disability related to painful stimuli.
AB - The role of human medial temporal structures in fear conditioning has led to the suggestion that neurons in these structures might respond to painful stimuli. We have now tested the hypothesis that recordings from these structures will demonstrate potentials related to the selective activation of cutaneous nociceptors by a painful laser stimulus (laser evoked potential, LEP) (Kenton B, Coger R, Crue B, Pinsky J, Friedman Y, Carmon A (1980) Neurosci Lett 17:301-306). Recordings were carried out through electrodes implanted bilaterally in these structures for the investigation of intractable epilepsy. Reproducible LEPs were commonly recorded both bilaterally and unilaterally, while LEPs were recorded at contacts on the left (9/14, P=0.257) as commonly as on the right (5/14), independent of the hand stimulated. Along electrodes traversing the amygdala the majority of LEPs were recorded from dorsal contacts near the central nucleus of the amygdala and the nucleus basalis. Stimulus evoked changes in theta activity were observed at contacts on the right at which isolated early negative LEPs (N2*) responses could be recorded. Contacts at which LEPs could be recorded were as commonly located in medial temporal structures with evidence of seizure activity as on those without. These results demonstrate the presence of pain-related inputs to the medial temporal lobe where they may be involved in associative learning to produce anxiety and disability related to painful stimuli.
KW - amygdala
KW - hippocampal theta
KW - hippocampus
KW - laser evoked potential
KW - pain
U2 - 10.1016/j.neuroscience.2009.11.026
DO - 10.1016/j.neuroscience.2009.11.026
JO - Neuroscience
JF - Neuroscience