Two of our development programs were licensed from established and respected organizations that have already conducted pre-clinical research and, in some cases, clinical research. Our science and regulatory teams are leveraging this research to speed development and commercialization timelines across our growing portfolio.
ART27.13 is a clinic-ready, potent, peripherally restricted dual synthetic agonist. Existing clinical data with ART27.13 suggests meaningful potential for the treatment of cancer-related anorexia and weight loss.
In five Phase I clinical studies including over 200 subjects, ART27.13 demonstrated a statistically significant and dose-proportional increase in body weight. In ongoing consultation with regulatory authorities, we plan to advance ART27.13 as a multi-modal supportive care therapy for cancer patients suffering from anorexia and weight loss.
Our team and scientific collaborators discovered a novel cocrystal composition that has anti-inflammatory and neuroprotectant activities. We are pursuing development of ART12.11 for multiple indications, including PTSD and inflammatory bowel diseases (e.g., Colitis and Crohn's), as well as rare diseases.
Through an exclusive agreement and in collaboration with The Research Foundation of the State University of New York Stony Brook, we are developing a Fatty Acid Binding Protein 5 (FABP5) inhibitor for the treatment of cancer, inflammation, and pain.
Fatty Acid Binding Proteins have been identified as intracellular transporters for the endocannabinoid anandamide (AEA), a neurotransmitter produced in the brain. Inhibition of FABP5 is expected to lead to higher levels of AEA and may have significant potential in treating pain. Animal studies have demonstrated that elevated levels of endocannabinoids can result in beneficial pharmacological effects on stress, pain, and inflammation, and may ease the effects of drug withdrawal.
Additionally, FABP5 and PPARß/δ are critical mediators of epidermal growth factor receptor-induced carcinoma cell growth. We are working with Stony Brook University to optimize a FABP5 inhibitor for the treatment of breast and prostate cancers.