Transport chiefs and planners say the "ambitious and transformational" project will involve the creation of a new relief road and viaduct for the area.
But the plan, to begin construction in 2021, will involve the purchase and demolition of some homes as well as buying up surrounding "virgin" land.
Around 50 landowners - including householders and businesses - have been contacted by letter.
A council spokesperson said: "There are approximately 50 landowners who could be affected by one or more of the options in these proposals.
"Nine of these are actual properties. The rest are plots of undeveloped land.
"We have contacted everyone who could potentially be affected and at this current stage we're only anticipating that we would need less than a handful of properties in their entirety.
"For the size of the scheme and the benefit once it's complete, the overall impact on property and land is small."
Planners are putting forward three options including a "big build" involving a dual carriageway to the M62.
A second option includes a "spur" that links the relief road to the A6107 Bradley Road.
The spokesperson added: "With thousands using this route every day we know that people will be worried about the roadworks during construction.
"Whilst it would be impossible for us to make such a big change without there being some disruption, we will work with the contractor to make sure it's kept to a minimum.
"We'll have more details on this nearer the time, but already we know that the work will be done in phases rather than all at the same time and that some of the biggest parts of the scheme will be built alongside existing roads or on vacant land so won't affect current routes."
Simon Taylor, Head of Strategic Investment at Kirklees Council, described the programme as "the most expensive and the most critical piece of infrastructure to ensure that the district can grow as we have set out in the Local Plan."
Keith Bloomfield, programme manager for the West Yorkshire Transport Fund (for Kirklees Council), which is providing the money for the project, said: "This proposal will bring relief to areas of the highway where congestion has been a problem over the last 20 years."
And Clr Peter McBride, Kirklees Council's Cabinet member for regeneration and transport, said: "The A62/A644 link road will provide essential infrastructure to serve the majority of our industry and the large housing allocation in the Local Plan.
"It must be a relief to motorists. It should be a plus for local residents in terms of air quality and of a general benefit to the borough."
All of the options are now live online (via www.kirklees.gov.uk/majortransport ) and the survey is open until January 18, 2019.