The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors
Shinya Satoh, Ke Tang, Atsumi Iida, Mariko Inoue, Tatsuhiko Kodama, Sophia Y. Tsai, Ming Jer Tsai, Yasuhide Furuta, Sumiko Watanabe
Cone photopigments, known as opsins, are pivotal elements and the first detection module used in color vision. In mice, cone photoreceptors are distributed throughout the retina, and short-wavelength (S) and medium-wavelength (M) opsins have unique expression patterns in the retina with a gradient along the dorsoventral axis; however, the mechanisms regulating the spatial patterning of cone opsin expression have not been well documented. The purpose of this study was to define the mechanisms regulating the spatial patterning of cone opsin expression. By analyzing knock-outs for bone morphogenetic protein (BMP) signaling, we found an essential role for BMP in forming cone opsin expression patterns in the retina; however, BMP signaling is activated only transiently in the dorsal half of the retina during early retinal development. Thus, BMP is not likely to play a direct role in opsin gene expression, which starts at a later stage of retinal development.We identified the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) nuclear receptor as a link between BMP and opsin expression. BMP signaling is essential for the correct dorsoventral spatial expression of COUP-TFI and COUP-TFII. Through gain-and loss-of-function analyses, we found that both COUP-TFI and COUP-TFII are required to suppress S-opsin expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina. Based on these findings, we propose a new molecular cascade involving BMP and COUP-TFs that conveys dorsoventral information to direct the expression of cone opsins during retinal development.
https://doi.org/10.1523/JNEUROSCI.0951-09.2009
10.1523/JNEUROSCI.0951-09.2009
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COUP Transcription Factors Medicine & Life Sciences
Cone Opsins Medicine & Life Sciences
Opsins Medicine & Life Sciences
Bone Morphogenetic Proteins Medicine & Life Sciences
Cytoplasmic and Nuclear Receptors Medicine & Life Sciences
Retina Medicine & Life Sciences
Retinal Cone Photoreceptor Cells Medicine & Life Sciences
Color Vision Medicine & Life Sciences
Satoh, S., Tang, K., Iida, A., Inoue, M., Kodama, T., Tsai, S. Y., Tsai, M. J., Furuta, Y., & Watanabe, S. (2009). The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors. Journal of Neuroscience, 29(40), 12401-12411. https://doi.org/10.1523/JNEUROSCI.0951-09.2009
The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors. / Satoh, Shinya; Tang, Ke; Iida, Atsumi; Inoue, Mariko; Kodama, Tatsuhiko; Tsai, Sophia Y.; Tsai, Ming Jer; Furuta, Yasuhide; Watanabe, Sumiko.
In: Journal of Neuroscience, Vol. 29, No. 40, 07.10.2009, p. 12401-12411.
Satoh, S, Tang, K, Iida, A, Inoue, M, Kodama, T, Tsai, SY, Tsai, MJ, Furuta, Y & Watanabe, S 2009, 'The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors', Journal of Neuroscience, vol. 29, no. 40, pp. 12401-12411. https://doi.org/10.1523/JNEUROSCI.0951-09.2009
Satoh S, Tang K, Iida A, Inoue M, Kodama T, Tsai SY et al. The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors. Journal of Neuroscience. 2009 Oct 7;29(40):12401-12411. https://doi.org/10.1523/JNEUROSCI.0951-09.2009
Satoh, Shinya ; Tang, Ke ; Iida, Atsumi ; Inoue, Mariko ; Kodama, Tatsuhiko ; Tsai, Sophia Y. ; Tsai, Ming Jer ; Furuta, Yasuhide ; Watanabe, Sumiko. / The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors. In: Journal of Neuroscience. 2009 ; Vol. 29, No. 40. pp. 12401-12411.
@article{11edb35bd27f45e9860c72755e37e924,
title = "The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors",
abstract = "Cone photopigments, known as opsins, are pivotal elements and the first detection module used in color vision. In mice, cone photoreceptors are distributed throughout the retina, and short-wavelength (S) and medium-wavelength (M) opsins have unique expression patterns in the retina with a gradient along the dorsoventral axis; however, the mechanisms regulating the spatial patterning of cone opsin expression have not been well documented. The purpose of this study was to define the mechanisms regulating the spatial patterning of cone opsin expression. By analyzing knock-outs for bone morphogenetic protein (BMP) signaling, we found an essential role for BMP in forming cone opsin expression patterns in the retina; however, BMP signaling is activated only transiently in the dorsal half of the retina during early retinal development. Thus, BMP is not likely to play a direct role in opsin gene expression, which starts at a later stage of retinal development.We identified the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) nuclear receptor as a link between BMP and opsin expression. BMP signaling is essential for the correct dorsoventral spatial expression of COUP-TFI and COUP-TFII. Through gain-and loss-of-function analyses, we found that both COUP-TFI and COUP-TFII are required to suppress S-opsin expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina. Based on these findings, we propose a new molecular cascade involving BMP and COUP-TFs that conveys dorsoventral information to direct the expression of cone opsins during retinal development.",
author = "Shinya Satoh and Ke Tang and Atsumi Iida and Mariko Inoue and Tatsuhiko Kodama and Tsai, {Sophia Y.} and Tsai, {Ming Jer} and Yasuhide Furuta and Sumiko Watanabe",
doi = "10.1523/JNEUROSCI.0951-09.2009",
journal = "Journal of Neuroscience",
publisher = "Society for Neuroscience",
T1 - The spatial patterning of mouse cone opsin expression is regulated by bone morphogenetic protein signaling through downstream effector COUP-TF nuclear receptors
AU - Satoh, Shinya
AU - Tang, Ke
AU - Iida, Atsumi
AU - Inoue, Mariko
AU - Kodama, Tatsuhiko
AU - Tsai, Sophia Y.
AU - Tsai, Ming Jer
AU - Furuta, Yasuhide
AU - Watanabe, Sumiko
N2 - Cone photopigments, known as opsins, are pivotal elements and the first detection module used in color vision. In mice, cone photoreceptors are distributed throughout the retina, and short-wavelength (S) and medium-wavelength (M) opsins have unique expression patterns in the retina with a gradient along the dorsoventral axis; however, the mechanisms regulating the spatial patterning of cone opsin expression have not been well documented. The purpose of this study was to define the mechanisms regulating the spatial patterning of cone opsin expression. By analyzing knock-outs for bone morphogenetic protein (BMP) signaling, we found an essential role for BMP in forming cone opsin expression patterns in the retina; however, BMP signaling is activated only transiently in the dorsal half of the retina during early retinal development. Thus, BMP is not likely to play a direct role in opsin gene expression, which starts at a later stage of retinal development.We identified the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) nuclear receptor as a link between BMP and opsin expression. BMP signaling is essential for the correct dorsoventral spatial expression of COUP-TFI and COUP-TFII. Through gain-and loss-of-function analyses, we found that both COUP-TFI and COUP-TFII are required to suppress S-opsin expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina. Based on these findings, we propose a new molecular cascade involving BMP and COUP-TFs that conveys dorsoventral information to direct the expression of cone opsins during retinal development.
AB - Cone photopigments, known as opsins, are pivotal elements and the first detection module used in color vision. In mice, cone photoreceptors are distributed throughout the retina, and short-wavelength (S) and medium-wavelength (M) opsins have unique expression patterns in the retina with a gradient along the dorsoventral axis; however, the mechanisms regulating the spatial patterning of cone opsin expression have not been well documented. The purpose of this study was to define the mechanisms regulating the spatial patterning of cone opsin expression. By analyzing knock-outs for bone morphogenetic protein (BMP) signaling, we found an essential role for BMP in forming cone opsin expression patterns in the retina; however, BMP signaling is activated only transiently in the dorsal half of the retina during early retinal development. Thus, BMP is not likely to play a direct role in opsin gene expression, which starts at a later stage of retinal development.We identified the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) nuclear receptor as a link between BMP and opsin expression. BMP signaling is essential for the correct dorsoventral spatial expression of COUP-TFI and COUP-TFII. Through gain-and loss-of-function analyses, we found that both COUP-TFI and COUP-TFII are required to suppress S-opsin expression in the dorsal retina but that only COUP-TFI plays an essential role in suppressing M-opsin expression in the ventral retina. Based on these findings, we propose a new molecular cascade involving BMP and COUP-TFs that conveys dorsoventral information to direct the expression of cone opsins during retinal development.
U2 - 10.1523/JNEUROSCI.0951-09.2009
DO - 10.1523/JNEUROSCI.0951-09.2009
JO - Journal of Neuroscience
JF - Journal of Neuroscience