As I mentioned in the introduction we'll be using a lot of gain today. I'll be playing the Les Paul on the bridge pickup and running it through a modeled Mesa Boogie amp with the gain cranked, so we get a ton of distortion - also knows as a "hi-gain" sound.
Furthermore I've turned the EQ knob controlling the mid-range almost all the way down. This is a classic metal trick called "scooping the mids" referring to the graphic EQ where the curve dips down in the middle of the frequency chart.
This leaves us with mostly bass and treble in our tone and really makes the guitar blend in with the bass and drums, almost as a third rhythm instrument. This is a great trick to use, when it's appropriate stylistically!