Pharmacological Activity of Ibuprofen Release from Measoporous Silica
Y. Lang, D. Finn, A. Pandit, Pamela Walsh
School of Chemistry and Chemical Engineering
Novel drug delivery systems (DDS) to improve the pharmacokinetic profile of hydrophobic drugs following oral administration are an area of keen interest in drug research. An ideal DDS should not adversely affect drug activity, be capable of delivering a therapeutic dose of drug, and allow homogenous drug loading and drug release. Mesoporous silica has been proposed for this application, with ibuprofen employed as the model drug. It was hypothesised that mesoporous silica MCM-41 is capable of delivering a pharmacologically therapeutic dose of ibuprofen. Ibuprofen-loaded MCM-41 can be prepared reproducibly at a drug to carrier ratio of 30% (wt/wt). The release profile was seen to be 90% within 2 h. Initial assessment of COX-1 inhibitory activity suggests the absence of adverse effects attributable to drug-carrier interaction. The results of this study provide further evidence in support of the proposed use of mesoporous silica in drug delivery.
Journal of Materials Science: Materials in Medicine
Dive into the research topics of 'Pharmacological Activity of Ibuprofen Release from Measoporous Silica'. Together they form a unique fingerprint.
Ibuprofen Medicine & Life Sciences 100%
Silicon Dioxide Medicine & Life Sciences 96%
Silica Engineering & Materials Science 86%
Drug Delivery Systems Engineering & Materials Science 83%
Multicarrier modulation Engineering & Materials Science 71%
Pharmacology Medicine & Life Sciences 56%
Pharmacokinetics Engineering & Materials Science 40%
Lang, Y., Finn, D., Pandit, A., & Walsh, P. (2012). Pharmacological Activity of Ibuprofen Release from Measoporous Silica. Journal of Materials Science: Materials in Medicine, 23(1), 73-80. https://doi.org/10.1007/s10856-011-4488-z
Lang, Y. ; Finn, D. ; Pandit, A. ; Walsh, Pamela. / Pharmacological Activity of Ibuprofen Release from Measoporous Silica. In: Journal of Materials Science: Materials in Medicine. 2012 ; Vol. 23, No. 1. pp. 73-80.
@article{b8d8b32b34e449888e6186f52e812046,
title = "Pharmacological Activity of Ibuprofen Release from Measoporous Silica",
abstract = "Novel drug delivery systems (DDS) to improve the pharmacokinetic profile of hydrophobic drugs following oral administration are an area of keen interest in drug research. An ideal DDS should not adversely affect drug activity, be capable of delivering a therapeutic dose of drug, and allow homogenous drug loading and drug release. Mesoporous silica has been proposed for this application, with ibuprofen employed as the model drug. It was hypothesised that mesoporous silica MCM-41 is capable of delivering a pharmacologically therapeutic dose of ibuprofen. Ibuprofen-loaded MCM-41 can be prepared reproducibly at a drug to carrier ratio of 30% (wt/wt). The release profile was seen to be 90% within 2 h. Initial assessment of COX-1 inhibitory activity suggests the absence of adverse effects attributable to drug-carrier interaction. The results of this study provide further evidence in support of the proposed use of mesoporous silica in drug delivery.",
author = "Y. Lang and D. Finn and A. Pandit and Pamela Walsh",
journal = "Journal of Materials Science: Materials in Medicine",
Lang, Y, Finn, D, Pandit, A & Walsh, P 2012, 'Pharmacological Activity of Ibuprofen Release from Measoporous Silica', Journal of Materials Science: Materials in Medicine, vol. 23, no. 1, pp. 73-80. https://doi.org/10.1007/s10856-011-4488-z
Pharmacological Activity of Ibuprofen Release from Measoporous Silica. / Lang, Y.; Finn, D.; Pandit, A.; Walsh, Pamela.
In: Journal of Materials Science: Materials in Medicine, Vol. 23, No. 1, 01.2012, p. 73-80.
T1 - Pharmacological Activity of Ibuprofen Release from Measoporous Silica
AU - Lang, Y.
AU - Finn, D.
AU - Pandit, A.
AU - Walsh, Pamela
N2 - Novel drug delivery systems (DDS) to improve the pharmacokinetic profile of hydrophobic drugs following oral administration are an area of keen interest in drug research. An ideal DDS should not adversely affect drug activity, be capable of delivering a therapeutic dose of drug, and allow homogenous drug loading and drug release. Mesoporous silica has been proposed for this application, with ibuprofen employed as the model drug. It was hypothesised that mesoporous silica MCM-41 is capable of delivering a pharmacologically therapeutic dose of ibuprofen. Ibuprofen-loaded MCM-41 can be prepared reproducibly at a drug to carrier ratio of 30% (wt/wt). The release profile was seen to be 90% within 2 h. Initial assessment of COX-1 inhibitory activity suggests the absence of adverse effects attributable to drug-carrier interaction. The results of this study provide further evidence in support of the proposed use of mesoporous silica in drug delivery.
AB - Novel drug delivery systems (DDS) to improve the pharmacokinetic profile of hydrophobic drugs following oral administration are an area of keen interest in drug research. An ideal DDS should not adversely affect drug activity, be capable of delivering a therapeutic dose of drug, and allow homogenous drug loading and drug release. Mesoporous silica has been proposed for this application, with ibuprofen employed as the model drug. It was hypothesised that mesoporous silica MCM-41 is capable of delivering a pharmacologically therapeutic dose of ibuprofen. Ibuprofen-loaded MCM-41 can be prepared reproducibly at a drug to carrier ratio of 30% (wt/wt). The release profile was seen to be 90% within 2 h. Initial assessment of COX-1 inhibitory activity suggests the absence of adverse effects attributable to drug-carrier interaction. The results of this study provide further evidence in support of the proposed use of mesoporous silica in drug delivery.
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
Lang Y, Finn D, Pandit A, Walsh P. Pharmacological Activity of Ibuprofen Release from Measoporous Silica. Journal of Materials Science: Materials in Medicine. 2012 Jan;23(1):73-80. https://doi.org/10.1007/s10856-011-4488-z